Shared Vulnerability Research Articles

Common Genetic Influence on the Relationship Between Gaming Addiction and Attention Deficit Hyperactivity Disorder in Young Adults: A Twin Study.

Although the relationship between gaming addiction (GA) and attention deficit hyperactivity disorder (ADHD) is well established, the causal mechanism of this relationship remains ambiguous. We aimed to investigate whether common genetic and/or environmental factors explain the GA-ADHD relationship. We recruited 1413 South Korean adult twins (837 monozygotic [MZ], 326 same-sex dizygotic [DZ], and 250 opposite-sex DZ twins; mean age = 23.1 ± 2.8 years) who completed an online survey on GA and related traits. Correlational analysis and bivariate model-fitting analysis were conducted. Phenotypic correlation between GA and ADHD in the present sample was 0.55 (95% CI [0.51, 0.59]). Bivariate model-fitting analysis revealed that genetic variances were 69% (95% CI [64%, 73%]) and 68% (95% CI [63%, 72%]) for ADHD and GA respectively. The remaining variances (ADHD: 31%; GA: 32%) were associated with nonshared environmental variances, including measurement error. Genetic and nonshared environmental correlations between ADHD and GA were 0.68 (95% CI [0.62, 0.74]) and 0.22 (95% CI [0.13, 0.30]) respectively, which indicates that shared genes can explain 82% of the phenotypic correlation between ADHD and GA. Our study demonstrated that the ADHD-GA association was largely due to shared genetic vulnerability.

For the “Briefly Gorgeous” Moment: Imagism and Queer Aesthetics in Ocean Vuong’s On Earth We’re Briefly Gorgeous

ABSTRACT Ocean Vuong’s epistolary novel On Earth We’re Briefly Gorgeous is distinguished by its highly sensory, descriptive, and fragmented linguistic style, coupled with an anachronic, multi-line narrative strategy. These stylistic elements exemplify salient modernist aesthetics, particularly resonating with the tenets of the Imagist movement. Through the presentation of fleeting images and juxtaposed scenes across temporal and spatial boundaries, Vuong’s fiction delineates the narrator’s transient, synesthetic recollections which merge into a dynamic flow of conscious duration, constituting a notable queer racial formalist work. Moreover, Vuong’s richly sensory and affective portrayal facilitates an embodied engagement with external spaces, unraveling the complex layers of the protagonist’s Asian American queer identity. By integrating a corporeal perspective into the aesthetic process of receiving and composing, Vuong reconfigures the traditionally passive bottom role toward a more dynamic and inclusive queer performance, thus challenging the entrenched heteronormative constructions that comply with Western imperialist and masculinist discourses. Beyond empowering the “abject” bottom, Vuong’s novel also posits a shared vulnerability inherent in queer bodies, envisioning a side path for the minoritarian groups.

Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample.

Externalizing psychopathology in childhood is a predictor of poor outcomes across the lifespan. Children exhibiting elevated externalizing symptoms also commonly show emotion dysregulation and callous-unemotional (CU) traits. Examining cross-sectional and longitudinal neural correlates across dimensions linked to externalizing psychopathology during childhood may clarify shared or distinct neurobiological vulnerability for psychopathological impairment later in life. We used tabulated brain structure and behavioural data from baseline, year 1, and year 2 timepoints of the Adolescent Brain Cognitive Development Study (ABCD; baseline n = 10,534). We fit separate linear mixed effect models to examine whether baseline brain structures in frontolimbic and striatal regions (cortical thickness or subcortical volume) were associated with externalizing symptoms, emotion dysregulation, and/or CU traits at baseline and over a two-year period. The most robust relationships found at the cross-sectional level was between cortical thickness in the right rostral middle frontal gyrus and bilateral pars orbitalis was positively associated with CU traits (β = |0.027-0.033|, pcorrected = 0.009-0.03). Over the two-year follow-up period, higher baseline cortical thickness in the left pars triangularis and rostral middle frontal gyrus predicted greater decreases in externalizing symptoms ((F = 6.33-6.94, pcorrected = 0.014). The results of the current study suggest that unique regions within frontolimbic and striatal networks may be more strongly associated with different dimensions of externalizing psychopathology. The longitudinal findings indicate that brain structure in early childhood may provide insight into structural features that influence behaviour over time.

Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites

Parasitic diseases, particularly malaria (caused by Plasmodium falciparum) and theileriosis (caused by Theileria spp.), profoundly impact global health and the socioeconomic well-being of lower-income countries. Despite recent advances, identifying host metabolic proteins essential for these auxotrophic pathogens remains challenging. Here, we generate a novel metabolic model of human hepatocytes infected with P. falciparum and integrate it with a genome-wide CRISPR knockout screen targeting Theileria-infected cells to pinpoint shared vulnerabilities. We identify key host metabolic enzymes critical for the intracellular survival of both of these lethal hemoparasites. Remarkably, among the metabolic proteins identified by our synergistic approach, we find that host purine and heme biosynthetic enzymes are essential for the intracellular survival of P. falciparum and Theileria, while other host enzymes are only essential under certain metabolic conditions, highlighting P. falciparum’s adaptability and ability to scavenge nutrients selectively. Unexpectedly, host porphyrins emerge as being essential for both parasites. The shared vulnerabilities open new avenues for developing more effective therapies against these debilitating diseases, with the potential for broader applicability in combating apicomplexan infections.

The Politics of Vulnerability and the School for Peace

This paper uses the School for Peace in Israel-Palestine as an example of what it might look like to develop a global community rooted in a recognition of shared human vulnerability. Part I offers a phenomenological account of vulnerability, putting Butler’s work into dialogue with Merleau-Ponty’s concept of “intercorporeality” and phenomenology of perception. Part II argues that family systems theory offers a framework through which to articulate the nature of our shared vulnerability, allowing us to see the manners in which problems reside not “in” individuals, but within the dynamic systems of which they are a part. Part III analyzes School for Peace “encounters” in order to explore the ways in which liberatory political change occurs through shifts in the behavioral dynamics at play in the political status quo. I conclude by arguing that our political identities are most fully realized through, rather than in spite of, our inherent vulnerability.

Digital Death

This paper reflexively unpicks digital ethnographic methods employed during ongoing online fieldwork on ‘digital deaths’. To do so, this research delves into the digital afterlife, exploring the fate of online traces and social media profiles after death, and how social media has changed our relationship with death and grieving. Anthropological studies of online death and grief faced new challenges even before COVID-19 moved research projects online. These include shared vulnerabilities and the ethnographer’s position, online field sites, omnipresent online traces and posthumous personhood, and ethical algorithms and duty to the dead. By transparently detailing my research methods whilst conducting research with Facebook and Instagram users navigating loss, this article contributes an honest and extensive debate on processes, challenges, ethics, and research collaboration. Guided by visual and media anthropology, I advocate for a set of methods rooted in shared anthropology (Rouch 1995) which fosters ongoing dialogue with participants. Thus, this article offers a new perspective on digital death, rooted in collaborative storytelling and reflexive methodologies, facilitating discussions on a still-contentious subject in certain societies. Leveraging the benefits of digital ethnography’s multi-sited nature, the research widens its geographical reach and comments on the sociocultural impacts of digital death. Keywords: digital afterlife, digital death, digital ethnography, social media, reflexive ethnography, shared anthropology, grief, methodology

Complex association between post-COVID-19 condition and anxiety and depression symptoms.

To assess the associations between anxiety and depressive symptoms and post-COVID-19 condition (PCC) by exploring the direction of these associations and their relevance in the definition of PCC. Nationwide survey among French adults, recruited between March and April, 2022, using a quota method to capture a representative sample of the general population with regard to sex, age, socioeconomic status, size of the place of residence, and region. We included all participants who met the World Health Organization (WHO) definition of PCC in addition to a random sample of participants infected with SARS-COV-2 for at least 3months but without PCC. Self-reported anxiety and depressive symptoms, chronic anxiety and depression (for more than 3years), and anxiety and depression were measured using the GAD-2 and PHQ-2 questionnaires, respectively. In a sample of 1,095 participants with PCC and 1,021 participants infected with SARS-COV-2 without PCC, 21% had self-reported anxiety and 18% self-reported depression, whereas 33% and 20% had current measured symptoms of anxiety and depression, respectively. The high prevalence of these symptoms cannot only be explained by the characterization of PCC, as only 13.4% of anxiety symptoms and 7.6% of depressive symptoms met the WHO criteria for PCC. Only one participant met the WHO criteria based on self-reported anxiety or depressive symptoms alone, as these were always combined with other symptoms in patients with PCC. Chronic symptoms were associated with PCC (aOR 1.27; 95% CI: 1.00-1.61). In addition, measured anxiety was associated with PCC (aOR=1.29; 95% CI: 1.02-1.62). Pre-COVID-19 chronic anxiety and depression may play a role in the development of PCC or share vulnerability factors with it. Our results challenge the inclusion of anxiety and depression in the definition of PCC.

Prosocial Interventions and Health Outcomes

Prosocial interventions encourage voluntary actions that benefit others. Community solidarity in response to the COVID-19 pandemic, expanding mutual aid programs, and health workforce issues have accelerated prosocial health interventions. To investigate the association of prosocial interventions with health outcomes in clinical trials and observational studies. In this systematic review and meta-analysis informed by the Cochrane Handbook for Systematic Reviews of Interventions, 5 databases (MEDLINE [via PubMed], Embase, CINAHL, PsycInfo, and Scopus) were searched from database inception through February 23, 2023. The search included terms for altruism and prosocial behaviors, health outcomes, and study type. Included studies, determined by multiple reviewers, compared health outcomes in a prosocial intervention group with a nonintervention group. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline, data extraction and synthesis captured quantitative and qualitative data. To pool data from quantitative studies, random-effects meta-analyses were used to estimate the impact of prosocial interventions. To combine data from quantitative and qualitive studies, data were transformed into qualitative narratives using meta-aggregation. The main outcome was whether prosocial interventions were associated with improved health outcomes. Barriers to and facilitators of implementation of these interventions were assessed. The search identified 5229 citations; 30 studies were included in the synthesis. Studies indicated that prosocial interventions were associated with positive health outcomes for givers (17 studies [56.7]) and recipients (8 [26.7%]). Prosocial interventions included acts of kindness (12 studies [40.0%]), cash gifts (7 [23.3%]), pay-it-forward approaches (6 [20.0%]), and expressions of kindness (5 [16.7%]). Improvements were reported in depression, testing for sexually transmitted diseases, vaccine uptake, physical activity, and individual biomarkers. Data from 6 studies (20.0%) demonstrated that pay-it-forward approaches were associated with increased uptake of diagnostic tests or vaccines among vulnerable groups (moderate certainty of evidence). Data from 14 studies (46.7%) suggested that community connectedness facilitated prosocial interventions. Shared vulnerabilities among groups (eg, sexual minority individuals, older adults) may provide a context for collective mobilization to improve health in local communities. This systematic review and meta-analysis found that prosocial interventions were associated with improved health outcomes among vulnerable groups and have been useful for addressing health disparities. Further research is needed to develop and evaluate prosocial interventions.

Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comprise a spectrum of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is characterized by loss of nuclear TDP-43 and accumulation of cytoplasmic TDP-43 inclusions that ultimately cause RNA processing defects including dysregulation of splicing, mRNA transport and translation. Complementing our previous work in motor neurons, here we report a novel model of TDP-43 proteinopathy based on overexpression of TDP-43 in a subset of Drosophila Kenyon cells of the mushroom body (MB), a circuit with structural characteristics reminiscent of vertebrate cortical networks. This model recapitulates several aspects of dementia-relevant pathological features including age-dependent neuronal loss, nuclear depletion and cytoplasmic accumulation of TDP-43, and behavioral deficits in working memory and sleep that occur prior to axonal degeneration. RNA immunoprecipitations identify several candidate mRNA targets of TDP-43 in MBs, some of which are unique to the MB circuit and others that are shared with motor neurons. Among the latter is the glypican Dally-like-protein (Dlp), which exhibits significant TDP-43 associated reduction in expression during aging. Using genetic interactions we show that overexpression of Dlp in MBs mitigates TDP-43 dependent working memory deficits, conistent with Dlp acting as a mediator of TDP-43 toxicity. Substantiating our findings in the fly model, we find that the expression of GPC6 mRNA, a human ortholog of dlp, is specifically altered in neurons exhibiting the molecular signature of TDP-43 pathology in FTD patient brains. These findings suggest that circuit-specific Drosophila models provide a platform for uncovering shared or disease-specific molecular mechanisms and vulnerabilities across the spectrum of TDP-43 proteinopathies.

Shared Vulnerabilities.

Shared Vulnerabilities.

Location-Aware Measurement for Cyber Mimic Defense: You Cannot Improve What You Cannot Measure

Cyber mimic defense is designed to ensure endogenous security, effectively countering unknown vulnerabilities and backdoors, thereby addressing a significant challenge in cyberspace. However, the immense scale of real-world networks and their intricate topology pose challenges for measuring the efficacy of cyber mimic defense. To capture and quantify defense performance within specific segments of these expansive networks, we embrace a partitioning approach that subdivides large networks into smaller regions. Metrics are then established within an objective space constructed on these smaller regions. This approach enables the establishment of several fine-grained metrics that offer a more nuanced measurement of cyber mimic defense deployed in complex networks. For example, the common-mode index is introduced to highlight shared vulnerabilities among diverse nodes, the transfer probability computes the likelihood of risk propagation among nodes, and the failure risk assesses the likelihood of cyber mimic defense technology failure within individual nodes or entire communities. Furthermore, we provide proof of the convergence of the transfer probability. A multitude of simulations are conducted to validate the reliability and applicability of the proposed metrics.

Perfection is a sad and lonely place: A study of existential vulnerability in the life stories of persons struggling with perfectionism

ABSTRACT Under what life conditions do individuals turn to perfectionistic striving and ideals as a solution? The present paper examines how people with perfectionism narrate their relationship to our shared existential vulnerability; that we are vulnerable as human beings, and that the ways we relate to this vulnerability have consequences for psychological health. In the present qualitative study, we explored the life narratives told by nine students with perfectionism, drawing on semi-structured life-story interviews. We conducted an explorative-reflexive thematic analysis and identified five themes: 1) Outside—Feeling Alienated, 2) Relating to Chaos, 3) Trying to Control the Painful and Uncontrollable, 4) Islands of Just Being and Positive Contact, and 5) Heading Toward a Balance Between Doing and Being. Their perfectionism can be seen as a way of handling existential vulnerability at a point in their lives where relational resources needed to stay firm in a vulnerable state are lacking. Perfectionistic themes influence their personal identity in the domain of narrative constructions, values, belongingness, and embodiment. Accomplishments were dominant themes in the plots of their narrative self-constructions and values. They felt their “self-made” identities kept others at a distance. However, we also found strivings for a more fulfilling life with broader self-definitions.

Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.

Opioid use disorder (OUD) and mental disorders are often comorbid, with increased morbidity and mortality. The causes underlying this relationship are poorly understood. Although these conditions are highly heritable, their shared genetic vulnerabilities remain unaccounted for. We applied the conditional/conjunctional false discovery rate (cond/conjFDR) approach to analyse summary statistics from independent genome wide association studies of OUD, schizophrenia (SCZ), bipolar disorder (BD) and major depression (MD) of European ancestry. Next, we characterized the identified shared loci using biological annotation resources. OUD data were obtained from the Million Veteran Program, Yale-Penn and Study of Addiction: Genetics and Environment (SAGE) (15 756 cases, 99 039 controls). SCZ (53 386 cases, 77 258 controls), BD (41 917 cases, 371 549 controls) and MD (170 756 cases, 329 443 controls) data were provided by the Psychiatric Genomics Consortium. We discovered genetic enrichment for OUD conditional on associations with SCZ, BD, MD and vice versa, indicating polygenic overlap with identification of 14 novel OUD loci at condFDR < 0.05 and 7 unique loci shared between OUD and SCZ (n = 2), BD (n = 2) and MD (n = 7) at conjFDR < 0.05 with concordant effect directions, in line with estimated positive genetic correlations. Two loci were novel for OUD, one for BD and one for MD. Three OUD risk loci were shared with more than one psychiatric disorder, at DRD2 on chromosome 11 (BD and MD), at FURIN on chromosome 15 (SCZ, BD and MD) and at the major histocompatibility complex region (SCZ and MD). Our findings provide new insights into the shared genetic architecture between OUD and SCZ, BD and MD, indicating a complex genetic relationship, suggesting overlapping neurobiological pathways.

Guarding Against Catastrophic Biological Risks: Preventing State Biological Weapon Development and Use by Shaping Intentions.

Guarding Against Catastrophic Biological Risks: Preventing State Biological Weapon Development and Use by Shaping Intentions.

Lessons From A Witness Tree

This article uses reflections from childhood memories of sensory experiences and interactions with the multispecies community to explore how the more-than-human world bears witness to one’s presence. They are also used to discuss how a greater sensory awareness of the more-than-human world increases one’s sensitivity to shared but unequal vulnerabilities in a changing and precarious climate. The author suggests that how we interact and come to know a place through the senses matters in the traces we leave and the kinds of relationships that form as a result.

Multi-modal quantification of pathway activity with MAYA

Signaling pathways can be activated through various cascades of genes depending on cell identity and biological context. Single-cell atlases now provide the opportunity to inspect such complexity in health and disease. Yet, existing reference tools for pathway scoring resume activity of each pathway to one unique common metric across cell types. Here, we present MAYA, a computational method that enables the automatic detection and scoring of the diverse modes of activation of biological pathways across cell populations. MAYA improves the granularity of pathway analysis by detecting subgroups of genes within reference pathways, each characteristic of a cell population and how it activates a pathway. Using multiple single-cell datasets, we demonstrate the biological relevance of identified modes of activation, the robustness of MAYA to noisy pathway lists and batch effect. MAYA can also predict cell types starting from lists of reference markers in a cluster-free manner. Finally, we show that MAYA reveals common modes of pathway activation in tumor cells across patients, opening the perspective to discover shared therapeutic vulnerabilities.

Alpha-synuclein at the interface between depression and neurodegeneration: Evidence from epidemiological and genetic data

Parkinson’s disease (PD) and Alzheimer’s disease (AlzD) are the two most common neurodegenerative disorders. Although these two disorders differ in terms of their underlying pathophysiology, clinical features, and course, there is a certain degree of overlap between them. This overlap may be partly related to alpha-synuclein (α-synuclein)-mediated neuropathological changes. Recent evidence has found that depression is associated with increased subsequent risk of both these neurological disorders and α-synuclein may also play a pathogenic role in depression. In the current study, epidemiological, population genetic, and environmental exposure data were examined in relation to the estimated prevalence of depressive disorders, PD, and AlzD using a cross-sectional, country-level analysis. The results showed a significant relationship between depressive disorders and neurodegenerative disorders, a possible shared genetic vulnerability related to the functional polymorphisms of SNCA gene, and potential gene-environment interactions involving fine particulate matter pollution. The significance of these results is discussed in light of existing translational, clinical, and epidemiological research on the links between these disorders.

Maternal autoimmune diseases and mental disorders in children and adolescents

IntroductionThe influence of maternal autoimmunity mediators on child development and brain function has been the subject of several studies. Clinically, most have focused on the association between maternal autoimmunity and the diagnosis of autism in children. On the other hand, data are rarer concerning the rest of the mental disorders and mainly, they are obtained from small cohorts.ObjectivesThe aim of this study is to discuss the association between the presence of autoimmune pathology in the mother and the development of mental disorders in the childMethodswe conducted our study through a descriptive study of six clinical cases.Results80 % the patients treated were male57% had a characterized depressive disorder34% had ADHD9 % had ASDConclusionsMaternal autoimmune diseases were associated with increased mental disorders in children. These results suggest a possible shared genetic vulnerability between the two conditions or a potential role of maternal immune activation in the expression of neurodevelopmental disorders in children.Disclosure of InterestNone Declared

Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences.

Although the co-occurrence of cannabis and depression is well established, less is known about the temporal sequence of cannabis use and depression. The present study had three main aims: to test a symptom-driven pathway in which depression may drive increases in cannabis use, to test a substance-induced pathway in which cannabis use may drive increases in depression and to assess a shared vulnerability model assessing associations between individuals who have (and have not) experienced adverse childhood experiences (ACEs). Data are from an ongoing, longitudinal, cohort study (n = 2234). Data were set up in an accelerated longitudinal design from age 17 to 24 years. Initial sample was recruited from Southern California, USA. The majority of participants still live in Southern California. On average, participants were aged 18 years at wave 8, with more than half identifying as female (54.3%; n = 1350). Most participants identified as Hispanic (1127; 45.4%), followed by non-Hispanic white (510; 20.5%), Asian (503; 20.2%), multi-racial/other (284; 11.4%) and non-Hispanic black (60; 2.2%). Primary outcomes were past-month days of cannabis use and depression symptoms [patient health questionnaire (PHQ)-8]. The Adverse Childhood Experiences scale was used as our main grouping measure. In the full sample, we showed that prior levels of depression symptoms were associated with a decrease in cannabis use [opposite to the proposed symptom driven model; B = -0.33 (-0.58, -0.09)]. Dynamic coupling parameters noted individuals who evidenced greater increases in cannabis use between two prior ages reported greater increases in depressive symptoms between subsequent ages [support for a substance-induced pathway; B = 0.53 (0.18, 0.89)]. Similar to the overall sample, for those who had not experienced ACEs, as cannabis use increased we saw a steady increase in depression [support for a substance induced pathway; B = 0.14 (0.04, 0.29)]. However, for those who experienced ACEs, as cannabis use increased we saw a consistent decrease in depression [opposite to the proposed substance-induced pathway; B = -0.18 (-0.28, -0.08)]. There is mixed support for both symptom-driven and substance-induced pathways between cannabis use and depression.

Creating equitable and sustainable opportunities for nature immersion to support restoration from stress within mental health nursing: A critical interpretive synthesis.

In the face of global environmental changes threatening health, and despite increased calls for nurses to broker access to nature-based well-being interventions for people with mental health difficulties, there is a surprising absence of literature examining the nature-nursing relationship, inhibiting its inclusion within nursing curricula and practice. This critical interpretive synthesis supports the notion that nature immersion has the capacity to increase positive affect, reduce negative affect, provide restoration from everyday stress, promote meaning-making, enhance belonging, and foster an interest in caring for the natural world. Yet, critical examination of the literature reveals multiple social and environmental inequalities and unmasks latent anthropocentric, gendered, and colonialist thinking, which threatens the delivery of equitable and just sustainable practice. Recommendations are made for a transdisciplinary, systemic approach, which recognizes and responds to our shared humanity and vulnerability in pursuit of planetary health.