Shared Elements Research Articles

HAMLET AND GJORG BERISHA: A COMPARATIVE STUDY OF CHARACTERS

The art of literature has brought together the experiences of human society and foregrounded various artistic values. The effort to examine the elements of universalization in literature through the perspective of juxtaposition is an innovation of this study. The purpose of this paper is to highlight this type of universalization, recognizing two characters from different literatures, genres, and cultures. The work is based on the main theme, which is revenge, but it also deals with some key elements such as life, death, justice, honor, love, passion, etc., through which the characters are compared as a whole. The study provides a comparative perspective, where systematic juxtaposition assists in identifying shared and distinctive elements throughout the logical flow of the narrative. The compared elements are of different natures and different in contextual and social aspects (events, situations, psychological aspects, space-time, etc.). For the comparison of these elements, a blend of comparative methodology, juxtaposition, as well as methods of variation and inclusion have been employed. The study holds a novel scientific value, as it extensively delves into comparison through juxtaposition, and aims to explore universal literary issues by recognizing two characters, Gjorg Berisha and Hamlet.

Shared and specific competing endogenous RNAs network mining in four digestive system tumors

BackgroundDigestive system malignancies, including esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), liver hepatocellular carcinoma (LIHC), and colon adenocarcinoma (COAD), pose significant global health challenges. Identifying shared and distinct regulatory mechanisms across these cancers can lead to improved therapies. This study aims to construct and compare competing endogenous RNA (ceRNA) networks across ESCA, STAD, LIHC, and COAD to identify RNA biomarkers that could serve as precision therapeutic targets to enhance clinical outcomes and advance personalized cancer care. MethodsClinical and transcriptomic data from The Cancer Genome Atlas (TCGA) were analyzed to predict differentially expressed RNAs using edgeR package. The ceRNA networks were constructed using the miRcode and ENCORI databases. Functional enrichment analysis and prognostic RNA screening were performed with ConsensusPathDB and univariate Cox regression analysis. Resultswe identified 6, 88, 55, and 41 RNA biomarkers in ESCA, STAD, LIHC, and COAD, respectively. Network analysis revealed shared and specific elements, with shared nodes enriched in cell cycle and mitotic processes. Several biomarkers, including HMGB3 and RGS16 (ESCA), COL4A1 and COL6A3 (STAD), CDCA5 and CDCA8 (LIHC), and LIMK1 and OSBPL3 (COAD), were consistent with prior studies, while novel biomarkers, such as C3P1 (ESCA), P2RY6 (STAD), and N4BP2L1 and PPP1R3B (LIHC), were discovered. Based on RNA correlation analysis, 1, 23, and 2 potential ceRNA regulatory axes were identified in STAD (PVT1/miR-490-3p/HMGA2), LIHC (DLX6-AS1/miR-139-5p/TOP2A, etc.), and COAD (STRCP1 & LINC00488/miR-142-3p/GAB1), respectively. ConclusionsThis study advances the understanding of ceRNA networks in digestive cancers, highlighting RNA biomarkers with potential as therapeutic targets for personalized treatment strategies.

Nepal-India Relations: Exploring the Dichotomy between 'Big Brother' and 'Brotherhood'

The historical relationship between Nepal and India is deeply rooted in their geographic proximity and shared elements such as religion, culture, language, and socio-economic interests. While Nepal borders both China and India, its closeness with India is accentuated by these shared attributes and mutual opportunities. The two countries share an open border of around 1,780 kilometers along Nepal's eastern, western, and southern regions. Despite India's larger size, population, and more advanced economic development, Nepal maintains its sovereignty and equal status as an independent nation. However, India's role is often perceived as that of a "big brother" to Nepal, reflecting the disparity in size and influence. Nonetheless, all sovereign nations, regardless of their geographic or economic differences, are regarded as equals in status. In an era defined by globalization, scientific advancements, and technological progress, Nepal aspires to build a strong relationship with India based on mutual friendship and economic cooperation, particularly through foreign investment and the exchange of technology. While occasional tensions arise, usually from the Indian side, they have not escalated into major conflicts and are unlikely to do so. It is widely understood that while friendships may fluctuate, the bond between neighbors remains constant. This article examines the various aspects and dynamics of Nepal-India relations within this context.

Debts of Gratitude in Cross‐Cultural Perspective: Confucian and Western Ethics

ABSTRACTThis article examines the contrasting conceptions of gratitude in Early Confucian and Western philosophy. It focuses on a key difference: the presence of the notion of ‘debts of gratitude’ in Western thought and its absence in Confucianism. We explore how this difference is rooted in contrasting ethical outlooks and values. Western philosophy often conceives of gratitude as a duty of reciprocation, furthering the values of social equality and individual autonomy. By contrast, Early Confucians viewed gratitude as proper acknowledgement that strengthens social relationships that are part of an ongoing collective project, spanning generations. This view reflects the importance of values such as community, harmony, and ritual propriety in Confucianism. Unlike the Western context, in the Early Confucian social world, there was no role for ‘debts of gratitude’ to play. There were no Confucian values that ‘debts of gratitude’ would help to realize, or would be responsive to, in the way that debts of gratitude further the values of equality and independence in the West. We conclude by noting that some Western philosophers express ideas about gratitude in collaborative contexts that align with Confucian ideas, suggesting some shared elements between Confucian and Western ethical outlooks.

An extension to Kendall’s Tau metric to evaluate dissimilarities between data series

Data analysis is performed to examine, interpret, and extract information from data series, and it includes applying various methods and techniques to understand patterns and compare data. An approach to compare data is to use rank metrics that help identify how distinct two data series are when compared to each other according to patterns, formats, criteria, and dimensions in both data series. Among these metrics, Kendall’s Tau metric stands out, as it is robust and inexpensive, widely used in analyzing sequences and genomes, to detect errors in flash memories, and to compare distributions and top-k ranked values. However, a challenge arises when comparing lists with different lengths or when lists do not share the same elements. This happens, for example, when lists are defined by top-k elements, commonly called k-list. In this case, there is no guarantee that two k-lists share the same set of elements. Traditional metrics like Kendall’s Tau are designed to quantify differences only between shared elements in lists. Recognizing this limitation, a possible solution is to apply the metric to the shared elements of the lists. Another solution, named the generalization of Kendall’s Tau, proposed by Fagin et al., considers all elements in two lists. However, this generalization of Kendall Tau is a semi-metric, as it does not satisfy the triangular inequality. To solve this problem, we propose the Extended Kendall Tau (EKT) metric that meets all the conditions of a metric and simultaneously considers the distinct elements of the compared lists. The proposed metric was evaluated by applying conventional Kendall’s Tau and the extended Kendall’s Tau over 40 text files divided into five different languages (eight files per language). We compared KT and EKT measures within the ”same language” and across ”other language” files for the two scenarios. The results revealed that both methods could accurately identify the differences between the groups of texts of the ”same language” and ”other language”. However, the numerical results show that EKT is able to more significantly highlight the difference between groups of texts of different languages.

Editorial for the special issue on "Prediction, Creativity, and Cultural Evolution in Music Cognition".

Music making across cultures arguably involves a blend of innovation and adherence to established norms. This integration allows listeners to recognise a range of innovative, surprising, and functional elements in music, while also associating them to a certain tradition or style. In this light, musical creativity may be seen to involve the novel recombination of shared elements and rules, which can in itself give rise to new cultural conventions. Put simply, future norms rely on past knowledge and present action; this holds for music as it does for other cultural domains. A key process permeating this temporal transition, with regards to both music making and music listening, is prediction. Recent findings suggest that as we listen to music, our brain is constantly generating predictions based on prior knowledge acquired in a given enculturation context. Those predictions, in turn, can shape our appraisal of the music, in a continual perception-action loop. This dynamic process of predicting and calibrating expectations may enable shared musical realities, that is, sets of norms that are transmitted, with some modification, either vertically between generations of a given musical culture, or horizontally between peers of the same or different cultures. As music transforms through cultural evolution, so do the predictive models in our minds and the expectancy they give rise to, influenced by cultural exposure and individual experience. Thus, creativity and prediction are both fundamental and complementary to the transmission of cultural systems, including music, across generations and societies. For these reasons, prediction, creativity and cultural evolution were the central themes in a symposium we organised in 2022. The symposium aimed to study their interplay from an interdisciplinary perspective, guided by contemporary theories and methodologies. This special issue compiles research discussed during or inspired by that symposium, concluding with potential directions for the field of music cognition in that spirit.

The shared role of neutrophils in ankylosing spondylitis and ulcerative colitis.

This study aimed to analyze single-cell sequencing data to investigate immune cell interactions in ankylosing spondylitis (AS) and ulcerative colitis (UC). Vertebral bone marrow blood was collected from three AS patients for 10X single-cell sequencing. Analysis of single-cell data revealed distinct cell types in AS and UC patients. Cells significantly co-expressing immune cells (P < 0.05) were subjected to communication analysis. Overlapping genes of these co-expressing immune cells were subjected to GO and KEGG analyses. Key genes were identified using STRING and Cytoscape to assess their correlation with immune cell expression. The results showed the significance of neutrophils in both diseases (P < 0.01), with notable interactions identified through communication analysis. XBP1 emerged as a Hub gene for both diseases, with AUC values of 0.760 for AS and 0.933 for UC. Immunohistochemistry verified that the expression of XBP1 was significantly lower in the AS group and significantly greater in the UC group than in the control group (P < 0.01). This finding highlights the critical role of neutrophils in both AS and UC, suggesting the presence of shared immune response elements. The identification of XBP1 as a potential therapeutic target offers promising intervention avenues for both diseases.

O-058 Newly identified female mutations causing oocyte maturation defect and embryo developmental arrest

Abstract Female infertility is a complex issue affecting a significant number of women. In the United States, among married women aged 15–49 years with no prior births, approximately one in five (19%) were unable to get pregnant after one year of trying. In addition, approximately one in four (26%) women in this group had difficulty getting pregnant or carrying a pregnancy to term. For women under 35 years of age, infertility is defined as a lack of success within one year, while for women aged 35 and older, it is within six months. Various factors, such as genetic, endocrine, physiological, anatomical, and immunological irregularities within the reproductive system, can affect a woman's chances of achieving pregnancy and delivering a healthy child. Among these factors, oocyte maturation is an important prerequisite for successful fertilization and subsequent embryonic development. In Medically Assisted Reproduction (MAR), the meiotic maturation of oocytes is induced by human chorionic gonadotropin (hCG) injection, which mimics the natural endogenous luteinizing hormone (LH) surge during the menstrual cycle. Although it is common for a few oocytes to remain immature despite ovarian stimulation and hCG administration, generally, immature oocytes have the competency to spontaneously mature in vitro. However, oocyte maturation is a sophisticated process involving multiple genes or protein molecules. Therefore, pathogenic variations in the genomic sequence or functional defects in any molecule that affects meiosis may lead to impaired oocyte maturation. While complete failure of all oocytes to mature in vivo is extremely rare, understanding the molecular aetiology of oocyte maturation is crucial for addressing infertility issues related to this process and improving fertility outcomes. The transition from the cleavage to the blastocyst stage often represents a significant bottleneck, with nearly 10% of fertilized eggs arrested at the cleavage stages. Developmental arrest of the preimplantation embryo is characterized by the cessation of cellular division for at least 24 h. Various factors originating from both embryonic and parental sources contribute to arrest of early stage embryo development. The genetic roots of developmental arrest were examined by considering both the parental causes of infertility and factors within the embryo. Examination revealed shared elements, regardless of the source of origin. Chromosomal abnormalities, abnormal preimplantation development, and monogenic variations have been reported to cause embryonic developmental arrests. Recently, deficiencies in oocyte maturation and embryo development have been categorized as part of the oocyte/zygote/embryo arrest (OZEMA) phenotype in the Online Mendelian Inheritance in Man (OMIM) database. A latest extensive review of monogenic causes associated with female infertility identified 23 genes with a total of 27 gene disease relationships (GDRs) for the OZEMA phenotype. Seventeen GDRs were classified as having at least moderate evidence of involvement in OZEMA, in addition to ten GDRs with less substantial evidence. Several additional genes were subsequently identified. This presentation will provide an overview of gene defects linked to the OZEMA phenotype, discuss the current status and future prospects of pre-MAR screening of females with OZEMA, and assess a novel workflow for modern genetic diagnosis to maximize the benefit of the patient.

Bone Loss in Diabetes Mellitus: Diaporosis.

The objective of this review is to examine the connection between osteoporosis and diabetes, compare the underlying causes of osteoporosis in various forms of diabetes, and suggest optimal methods for diagnosing and assessing fracture risk in diabetic patients. This narrative review discusses the key factors contributing to the heightened risk of fractures in individuals with diabetes, as well as the shared elements impacting the treatment of both diabetes mellitus and osteoporosis. Understanding the close link between diabetes and a heightened risk of fractures is crucial in effectively managing both conditions. There are several review articles of meta-analysis regarding diaporosis. Nevertheless, no review articles showed collected and well-organized medications of antidiabetics and made for inconvenient reading for those who were interested in details of drug mechanisms. In this article, we presented collected and comprehensive charts of every antidiabetic medication which was linked to fracture risk and indicated plausible descriptions according to research articles.

“A so-and-so master…”. The presence of Norwid in late lyrics by Tadeusz Różewicz

At the beginning of the 1990s,Tadeusz Różewicz prepared his own selection of poems by Norwid. Although this personal anthology was never published, a trace of it lingers in the form of the essay “To, co zostało z nienapisanej książki o Norwidzie” [What remains of the book on Norwid I never wrote], and more deeply – in the shape of numerous references to Norwid’s poetry and biography in Różewicz’s lyricism from the last quarter of his literary career. This article attempts to reconstruct Różewicz’s dialogue with his nineteenth-century precursor, which he initiatedlate in his life. Analysis incorporates several aspects of Harold Bloom’s theory of literary influence,indicating shared elements and polemical issues. Interpretations revolve primarily around works from those poetry books by Różewicz that contain particularly clear references to Norwid: Płaskorzeźba, Szara strefa, Nożyk profesora, Zawsze fragment. Recykling, and Wyjście. Conclusions drawn from a number of detailed, comparatist readings make it possible to establish thematic similarities (e.g. existential lack and incompleteness affecting both the lyrical subject and the poems’ protagonists, a predilection for developing figures who are misunderstood, inconspicuous, and hollowed out, etc.) andformal preferences (e.g. the use of ellipsis,terse and precise imagery, and consideration for the poem’s visual dimension). However, Różewicz also identifies in Norwid’s poetry certain things that repel him, e.g. lofty poetics, self-restraint with regard to sensuality, and the tendency to obscure the literal character of evil with symbolic images.

Paradoxes: Cholesterol and Hypoxia in Preeclampsia.

Preeclampsia, a hypertensive disease of pregnancy of unknown etiology, is intensely studied as a model of cardiovascular disease (CVD) not only due to multiple shared pathologic elements but also because changes that develop over decades in CVD appear and resolve within days in preeclampsia. Those affected by preeclampsia and their offspring experience increased lifetime risks of CVD. At the systemic level, preeclampsia is characterized by increased cellular, membrane, and blood levels of cholesterol; however, cholesterol-dependent signaling, such as canonical Wnt/βcatenin, Hedgehog, and endothelial nitric oxide synthase, is downregulated indicating a cholesterol deficit with the upregulation of cholesterol synthesis and efflux. Hypoxia-related signaling in preeclampsia also appears to be paradoxical with increased Hypoxia-Inducible Factors in the placenta but measurably increased oxygen in maternal blood in placental villous spaces. This review addresses the molecular mechanisms by which excessive systemic cholesterol and deficient cholesterol-dependent signaling may arise from the effects of dietary lipid variance and environmental membrane modifiers causing the cellular hypoxia that characterizes preeclampsia.

Cyanamide-inducible expression of homing nuclease I−SceI for selectable marker removal and promoter characterisation in Saccharomyces cerevisiae

In synthetic biology, microbial chassis including yeast Saccharomyces cerevisiae are iteratively engineered with increasing complexity and scale. Wet-lab genetic engineering tools are developed and optimised to facilitate strain construction but are often incompatible with each other due to shared regulatory elements, such as the galactose-inducible (GAL) promoter in S. cerevisiae. Here, we prototyped the cyanamide-induced I−SceI expression, which triggered double-strand DNA breaks (DSBs) for selectable marker removal. We further combined cyanamide-induced I−SceI-mediated DSB and maltose-induced MazF-mediated negative selection for plasmid-free in situ promoter substitution, which simplified the molecular cloning procedure for promoter characterisation. We then characterised three tetracycline-inducible promoters showing differential strength, a non-leaky β-estradiol-inducible promoter, cyanamide-inducible DDI2 promoter, bidirectional MAL32/MAL31 promoters, and five pairs of bidirectional GAL1/GAL10 promoters. Overall, alternative regulatory controls for genome engineering tools can be developed to facilitate genomic engineering for synthetic biology and metabolic engineering applications.

Deciphering the Molecular Nexus: An In-Depth Review of Mitochondrial Pathways and Their Role in Cell Death Crosstalk.

Cellular demise is a pivotal event in both developmental processes and disease states, with mitochondrial regulation playing an essential role. Traditionally, cell death was categorized into distinct types, considered to be linear and mutually exclusive pathways. However, the current understanding has evolved to recognize the complex and interconnected mechanisms of cell death, especially within apoptosis, pyroptosis, and necroptosis. Apoptosis, pyroptosis, and necroptosis are governed by intricate molecular pathways, with mitochondria acting as central decision-makers in steering cells towards either apoptosis or pyroptosis through various mediators. The choice between apoptosis and necroptosis is often determined by mitochondrial signaling and is orchestrated by specific proteins. The molecular dialogue and the regulatory influence of mitochondria within these cell death pathways are critical research areas. Comprehending the shared elements and the interplay between these death modalities is crucial for unraveling the complexities of cellular demise.

Metabolic Tug-of-War between Glycolysis and Translation Revealed by Biochemical Reconstitution.

Inside cells, various biological systems work cooperatively for homeostasis and self-replication. These systems do not work independently as they compete for shared elements like ATP and NADH. However, it has been believed that such competition is not a problem in codependent biological systems such as the energy-supplying glycolysis and the energy-consuming translation system. In this study, we biochemically reconstituted the coupling system of glycolysis and translation using purified elements and found that the competition for ATP between glycolysis and protein synthesis interferes with their coupling. Both experiments and simulations revealed that this interference is derived from a metabolic tug-of-war between glycolysis and translation based on their reaction rates, which changes the threshold of the initial substrate concentration for the success coupling. By the metabolic tug-of-war, translation energized by strong glycolysis is facilitated by an exogenous ATPase, which normally inhibits translation. These findings provide chemical insights into the mechanism of competition among biological systems in living cells and provide a framework for the construction of synthetic metabolism in vitro.

Do French speakers have an advantage in learning English vocabulary thanks to familiar suffixes?

Previous research has shown that languages from nearby families are easier to learn as second languages (L2) than languages from more distant families, attributing this difference to the presence of shared elements between the native language (L1) and L2. Building on this idea, we hypothesised that suffixes present in L1 might facilitate complex word acquisition in L2. To test this hypothesis, we recruited 76 late French-English bilinguals and tasked them with learning a set of 80 English-derived words containing suffixes that also exist in French (e.g., -able) or are unique to English (e.g., -ness). Consolidation of the learned words was assessed 1 week after the last learning session. The results showed a significant learning effect across the learning trials and consolidation, suggesting that the bilingual participants were able to acquire the derived words. However, contrary to our hypothesis, suffixes also existing in French did not give a significant advantage over English-unique suffixes. Further analysis revealed that this was due to variations in the consistency of familiar suffixes from L1. While some translation pairs shared the same suffix (e.g., amazement-étonnement), others had different suffixes (e.g., slippage-glissement). The type of translation pair with inconsistent suffix overlap (slippage-glissement) carried learning costs, preventing the bilingual participants from benefitting from the presence of familiar suffixes in L2 words. These findings suggest that shared information can be used effectively for L2 learning only if the mapping between L1 and L2 is consistent.

Interwoven Legacies: Exploring the Rich Textile Traditions of Korea and Tamil Nadu (India) through Cross-Cultural Influences

This paper explores the textile traditions in Korea and Tamil Nadu, delving into their historical evolution, cultural significance, and cross-cultural influences. Korea, known for its deep-rooted traditions, and Tamil Nadu, celebrated for its ancient Dravidian culture, offer unique insights into the world of textiles. This research examines potential historical connections and cultural exchanges between these traditions. It also highlights shared elements in weaving techniques, materials, and symbolism. The study emphasizes the contemporary relevance of these traditions and the challenges and opportunities they face in a modern context. Ultimately, it unveils the intertwined legacies of Korean and Tamil Nadu textiles.

Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies.

The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement of oxidative stress and cellular senescence emerges as key drivers of pathogenesis in both conditions. Uncovering these shared elements not only has the potential to enhance our understanding of intricate neurodegenerative diseases but also sets the stage for pioneering therapeutic approaches in AMD.

Exploring social remittances: A comprehensive review and recommendations for future research

This paper combines a variety of academic perspectives on social remittances, analyzing several key studies in the field. Each article is critically reviewed for its primary findings, methods, and limitations, focusing on identifying both the distinct contributions and shared elements among them. The comparative analysis brings to light the various ways social remittances influence and are present in both sending and receiving communities across cultural, economic, political, and social aspects. The paper concludes with strategic recommendations for future research, promoting a multidisciplinary approach, integrating technological advancements, and recognizing the changing nature of global migration. This review aims to provide a detailed guide for future investigations in the area of social remittances, seeking to deepen our comprehension of their complex role in the context of global migration.

Spine surgeons facing second opinions: a qualitative study

BACKGROUND CONTEXTThe social and technological mutation of our contemporary period disrupts the traditional dyad that prevails in the relationship between physicians and patients. PURPOSEThe solicitation of a second opinion by the patient may potentially alter this dyad and degrade the mutual trust between the stakeholders concerned. The doctor-patient relationship has often been studied from the patient's perspective, but data are scarce from the spine surgeon's point of view. STUDY DESIGN/SETTINGThis qualitative study used the grounded theory approach, an inductive methodology emphasizing field data and rejecting predetermined assumptions. PATIENT SAMPLEWe interviewed spine surgeons of different ages, experiences, and practice locations. We initially contacted 30 practitioners, but the final number (24 interviews; 11 orthopedists and 13 neurosurgeons) was determined by data saturation (the point at which no new topics appeared). OUTCOME MEASURESThemes and subthemes were analyzed using semistructured interviews until saturation was reached. METHODSData were collected through individual interviews, independently analyzed thematically using specialized software, and triangulated by three researchers (an anthropologist, psychiatrist, and neurosurgeon). RESULTSIndex surgeons were defined when their patients went for a second opinion and recourse surgeons were defined as surgeons who were asked for a second opinion. Data analysis identified five overarching themes based on recurring elements in the interviews: (1) analysis of the patient's motivations for seeking a second opinion; (2) impaired trust and disloyalty; (3) ego, authority, and surgeon image; (4) management of a consultation recourse (measurement and ethics); and (5) the second opinion as an avoidance strategy. Despite the inherent asymmetry in the doctor-patient relationship, surgeons and patients share two symmetrical continua according to their perspective (professional or consumerist), involving power and control on the one hand and loyalty and autonomy on the other. These shared elements can be found in index consultations (seeking high-level care/respecting trust/closing the loyalty gap/managing disengagement) and referral consultations (objective and independent advice/trusting of the index advice/avoiding negative and anxiety-provoking situations). CONCLUSIONSThe second opinion often has a negative connotation with spine surgeons, who see it as a breach of loyalty and trust, without neglecting ego injury in their relationship with the patient. A paradigm shift would allow the second opinion to be perceived as a valuable resource that broadens the physician-patient relationship and optimizes the shared surgical decision-making process.

A Cross-Cultural Exploration of Student Development in Higher Education: Acknowledging, Exercising, and Enhancing Agency

Purpose Students develop and grow throughout higher education. However, the underlying mechanism remains unclear. Building on the premise that individuals develop and grow through interacting with the world, this study explores how students develop, grow, and become empowered in higher education through the lens of I–world interactions. Design/Approach/Methods This study employs a multicultural and multidisciplinary approach by first examining different cultural philosophical approaches to I–world interactions. This is followed by an elaboration of what the interactions mean for individual development and growth in higher education by drawing on psychology, sociology, and educational research. Findings This study argues that there are three essential elements of I–world interactions across three philosophical approaches: acknowledged, exercised, and enhanced individual agency. In higher education, students are strong agents, as demonstrated by sociological theories of agency and psychological evidence of agentic human functioning. Students actively exercise their agency, particularly when interacting with the environment. If organized and practiced well, universities can help students enhance their agency. Originality/Value The three shared elements and empirical evidence together form the foundation for understanding how students become empowered in higher education and for positioning the enhancement of students’ agency at the center of higher education across contexts.