Stroke is a critical global health issue characterized by the interruption of blood flow to the brain, resulting in a depletion of oxygen and nutrients and causing severe damage or death to brain cells. Early detection and intervention are pivotal in preventing adverse outcomes. Diagnostic imaging modalities like CT and MRI are essential for accurate diagnosis and treatment planning. However, precise segmentation of stroke lesions remains challenging due to variations in appearance, size, location, and intensity within the brain, exacerbated by noise and variability in manual segmentation. To address these challenges, we propose a novel deep neural network model for automatic stroke segmentation. Our model features an encoder–decoder architecture, combining the robust deep and multi-scale feature extraction capabilities of the ResUnet++ encoder with a modified UNet decoder that enhances segmentation accuracy and preserves spatial information effectively. Incorporating the Atrous Spatial Pyramidal Pooling (ASPP) block in the bottleneck strengthens the model, enabling efficient capture of multi-scale contextual information and improving its capability to handle diverse object sizes and shapes in semantic segmentation tasks. We evaluate the model on the Ischemic Stroke Lesion Segmentation Challenge 2015 (SISS 2015) and ISLES 2022 databases. During training, our model achieves a Dice coefficient of 0.85 ± 0.18 on SISS 2015 and 0.85 ± 0.11 on ISLES 2022. For testing on SISS 2015, it achieves 0.80 ± 0.33, surpassing current state-of-the-art results for these datasets.
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