Shanghai Area Research Articles

Research on developmental strategy of medical science and technology of districts and counties in Shanghai

By studying the developmental strategy of the revonal medical science and technology and implementation condition from 2001 to 2004 as well as systematically studying the national policy of the scientific and technical field,we proposed the developmental strategy of medical science and technology in Shanghai that the priority for the introduction,the application and the popularization of new or suitable technology should be given,also continuous advancement in technology should be kept.As a result,it is possible to provide the people a safer,more effective,convenient and moderately priced public health and basic medical service.During the past 5 years.we made an experimental work in selected Pudong in Shanghai.It Was proved that the strategy tallies with the actual situation of Pudong and is effectual in practice. Key words: Shanghai area and county; Medical technology; Developmental strategy

Extrauterine growth retardation in premature infants in Shanghai: a multicenter retrospective review

Intrauterine growth retardation (IUGR) represents the degree of body growth and development decided by genes and by placental function. Extrauterine growth retardation/restriction (EUGR) refers to severe nutritional deficits during the first weeks of life that result in growth that is less than expected based on intrauterine growth rates (growth values < or =10th percentile of intrauterine growth expected in accordance with the estimated gestational age). The deficits affect not only weight but also head circumference and height. As is well known, a nutrition support team (NST) is a multidisciplinary team comprised of physicians, nurses, dietitians, pharmacists, social workers, and medical technologists who provide nutritional management. In this study, we review 2,015 premature infants (1,209 boys and 806 girls) from four hospitals in the Shanghai area from January 1, 2003 to December 31, 2006, two of which had NSTs. The overall incidence of EUGR was 56.8% assessed by weight, while the incidence of IUGR was 26.1%. Higher incidence of EUGR was associated with lower birth weight, but higher gestational age. There was a significant relationship between EUGR incidence and NST availability (chi(2) = 60.630, p < 0.001), though there was no similar finding for IUGR incidence. The incidence of EUGR was 44% in NST hospitals and 62.6% in non-NST hospitals. According to logistic regression, the following five factors were related to EUGR: male gender, gestational age at birth, birth weight, length of hospital stay, and NST availability. NSTs reduced the risk of EUGR by a magnitude of 0.47. EUGR remains a serious problem in premature infants in Shanghai, but NSTs can reduce EUGR incidence.

Molecular identification and the complete nucleotide sequence of TYLCV isolate from Shanghai of China

Tomato yellow leaf curl virus (TYLCV) belongs to the genus Begomovirus, family Geminiviridae. It is transmitted by the whitefly Bemisia tabaci. A pair of primers was designed according to the specific sequence of the TYLCV gene and used in the PCR detection of the virus in the infected tissues of tomato grown in the Shanghai area of China. DNA was extracted from leaves, fruits, seeds, and roots of infected tomato plants separately. The results showed that the target fragment of about 570 bp could be isolated from the leaves, fruits, roots of infected tomato plants, but not from the seeds. Thus, the PCR-based detection technology for the Shanghai TYLCV (TYLCV-Sh10) has been established. Primers were then designed based on the sequence of the 570 bp fragment to obtain the complete DNA-A sequence of TYLCV-Sh10 by genome walking. Sequencing results indicated that the DNA-A sequence of TYLCV-Sh10 contained 2781 nt that included six ORFs. BLAST results showed that DNA-A of TYLCV-Sh10 had low homology with the characterized TYLCV in China (TYLCCNV) except TYLCV-ZJ8 (TYLCV isolated from Zhejiang China). But it was most closely related to TYLCV-USA (99.28% sequence identity). TYLCV-Sh10, TYLCV-ZJ8, TYLCV-USA, TYLCV-Mex, and TYLCV-Eg formed an independent branch by pairwise comparison and phylogenetic analysis. All these results strongly suggested that Sh10 was an isolate of America or Africa TYLCV.

Prevalence of four different subgenotypes of genotype 4 hepatitis E virus among swine in the Shanghai area of China

BackgroundHepatitis E virus (HEV) is a zoonotic pathogen of which swine was reported as major reservoirs. HEV has been divided into 4 different genotypes according to phylogenetic analysis. Recent reports showed that genotype 4 HEV is freely transmitted between humans and swine in eastern China, including Shanghai area. This paper investigated the recent infection status of HEV among swine population of Shanghai area in China.Methods480 swine faecal specimens were collected from 23 farms which distribute all over Shanghai from September to November, 2007 and tested for the presence of HEV RNA by the polymerase chain reaction (PCR).ResultsOur results showed that 26.1% (6/23) of the swine farms were positive for HEV RNA and the positive rate of the six farms were ranged from 9.1% to 33.3%. The HEV RNA positive rate for total samples were 5% (24/480). The resulted positive band specific for HEV was sequenced and sequence analysis indicated that all of these isolates belonged to genotype 4 HEV. Phylogenetic analysis showed that the 24 isolates clustered into 4 distinct subgroups, sharing 83.3–89.7% inter-subgroup and 97–99% intra-subgroup identities. More over, isolates in three of the four subgroups closely clustered with previous identified strains, sharing up high to 97% identity with them.ConclusionThese results suggested that there were 4 different subgenotypes of HEV prevalent in Shanghai, and some of them may not be indigenous to Shanghai but introduced from other geographic regions.

Model test study of land subsidence caused by high-rise building group in Shanghai

The paper discusses the influence of a group of high-rise buildings on land subsidence, based on a modeling exercise. The model consisted of five layers of soils typical of the Shanghai area, with the buildings placed on piles set in the upper silty sand horizon. It was loaded to represent the construction sequence of the four buildings. The main settlement was observed to be in the underlying clayey layer. The model demonstrated the increase in pore water pressure with staged loading, its effect on deformation and the increase in effective stress over time. It indicated the largest amount of settlement over time occurs between the buildings.

An innovation wall model based on interlayer ventilation

The thermal characteristics of the external wall are important to the energy consumption of the air conditioning system. Great attention should also be paid to the energy loss of the air exhaust. An innovation wall model based on interlayer ventilation is presented in this paper. The interlayer ventilation wall combines the wall and air exhaust of heating, ventilating and air conditioning (HVAC). The results of the experiment show that the energy loss of the exhaust air can be fully recovered by the interlayer ventilation wall. The cooling load can be reduced greatly because the temperature difference between the internal surface of the interlayer ventilation wall and the indoor air is very small. Clearly, the small temperature difference can enhance thermal comfort. In order to popularize the interlayer ventilation wall, technical and economical analysis is presented in this paper. Based on the buildings in the Shanghai area and a standard air conditioning system, a 4 years payback period for interlayer ventilation wall implementation was found according to the analysis.

Prevention of caries in children of Shanghai area by topical application of fluoride

由于氟化物的广泛使用,许多国家尤其是发达国家龋病患病率显著下降.2006年世界卫生组织、世界牙科联盟和国际牙科研究会联合召开了应用氟化物促进口腔健康全球磋商会议,再一次敦促了各国政府和有影响力的组织采取行动推进氟化物使用,以进一步改善全球居民的口腔健康状况,提高生命质量[1].

Moisture analysis of a squall line case based on precipitable water vapor data from a ground-based GPS network in the Yangtze River Delta

A squall line swept eastward across the area of the Yangte River Delta and produced gusty winds and heavy rain from the afternoon to the evening of 24 August 2002. In this paper, the roles of moisture in the genesis and development of the squall line were studied. Based on the precipitable water vapor (PWV) data from a ground-based GPS network over the Yangtze River Delta in China, plus data from a Pennsylvania State University/National Atmospheric Center (PSU/NCAR) mesoscale model (MM5) simulation, initialized by three-dimensional variational (3D-VAR) assimilation of the PWV data, some interesting features are revealed. During the 12 hours prior to the squall line arriving in the Shanghai area, a significant increase in PWV indicates a favorable moist environment for a squall line to develop. The vertical profile of the moisture illustrates that it mainly increased in the middle levels of the troposphere, and not at the surface. Temporal variation in PWV is a better precursor for squall line development than other surface meteorological parameters. The characteristics of the horizontal distribution of PWV not only indicated a favorable moist environment, but also evolved a cyclonic wind field for a squall line genesis and development. The “+2 mm” contours of the three-hourly PWV variation can be used successfully to predict the location of the squall line two hours later.

Reformation in Chinese healthcare: lessons to be learned from US best practices in consulting, education and development of health system change

Since the early 1990s there has been strong interest by the Chinese healthcare establishment to engage US healthcare leaders on a variety of educational and consultative services. This exchange has occurred on both sides of the Pacific, with Chinese delegations visiting US health systems, government agencies, and university programmes in health administration. US scholars and practitioners have also travelled to China for consultative and management services. Despite heavy dialogue between officials and industry experts from both countries, little is written on best practices for dealing with this work. This paper explores this question using the authors' experiences as consultants and educators with Chinese healthcare administrators and officials in the greater Shanghai area.

Studies on Dialects in the Shanghai Area: Their Phonological Systems and Historical Developments (review)

Studies on Dialects in the Shanghai Area: Their Phonological Systems and Historical Developments (review)

Surgical management to conjoined twins in Shanghai area

Conjoined twins are very rare congenital malformation. The aim of this study was to summarize our experiences of surgical separation on seven sets of conjoined twins, and improve the treatment of conjoined twins in the future. A retrospective review of surgical separation included data of prenatal diagnosis, associated malformation, timing of separation, intra- and postoperative management, and follow-up of six sets of conjoined twins at Shanghai Xin-Hua Hospital from 1980 to 2005 and one set at Shanghai Children's Hospital in 2002. Surgical separation was performed on seven sets of conjoined twins; six sets of thoracopagus-omphalapagus (including four sets of xipho-omphalopagus) and one set of ischiopagus. All sets presented varying degrees of severity of congenital cardiac malformations. Four sets were diagnosed prenatally by ultrasonography. Two sets of conjoined twins (case 2 and case 3) required emergent separation within 7 days after birth; both members of case 2 died within 2 days post operation, one member of case 3 died during operation while the other member survived. Five sets had scheduled separation undertaken more than 30 days after birth. One member of a set (case 6B) died 13 days after operation due to severe congenital cardiovascular anomalies. All other members of conjoined twins survived. Case 6A had a severe defect of the anterior thoracic cage and prosthesis of titanium alloy scaffold filled with silicone rubber was used to repair the defects successfully. Following up from 1980 to 2005, one member of a set (case 1A) died 4 years after operation due to pneumonia. Contact was lost to the surviving member of case 3 (ischiopagus). Other survivors of the separations had normal development. (1) Timing of operation and separation plan should be given according to the circumstances and the nature of the organ shared in each individual set of twins. (2) Prosthesis of titanium alloy scaffolds filled with silicone rubber may become one of viable methods for repairing severe defects of the thoracic cage.

Community-acquired pneumonia in Shanghai, China: microbial etiology and implications for empirical therapy in a prospective study of 389 patients

The aim of this multicenter study was to identify the causative pathogens of community-acquired pneumonia (CAP) in Shanghai, China, and to determine their susceptibility to antimicrobial agents. Pathogens obtained from 389 patients with documented CAP during 2001-2003 were identified by multiple diagnostic tools that included bacterial culture, polymerase chain reaction (PCR), and specific immunological assays. Susceptibility of the bacterial isolates was tested by the broth microdilution method. A specific pathogen was identified in 39.8% (155/389) of the patients: Haemophilus influenzae (n=80), Klebsiella spp. (n=15), Streptococcus pneumoniae (n=12), Staphylococcus aureus (n=6), Moraxella catarrhalis (n=1), other gram-negative organisms (n=9), and atypical pathogens that comprised Mycoplasma pneumoniae (n=42), Chlamydia pneumoniae (n=17), and Legionella pneumophila (n=2). Most H. influenzae isolates were susceptible to ampicillin (88.3%), and all were susceptible to macrolides. Of the S. pneumoniae isolates, 75% (9/12) were susceptible to penicillin, while 25% (3/12) were intermediately susceptible. H. influenzae and atypical pathogens are among the most important pathogens of CAP. Ampicillin, cephalosporins, and the newer fluoroquinolones can be used as empirical therapy for CAP in the Shanghai area. The efficacy of monotherapy with newer macrolides for CAP caused by S. pneumoniae requires further evaluation.

PIXE study on ancient pottery from Chinese Shanghai area

Shanghai is the largest city in China, and it also has a very long history. Archaeologists have found that six thousand yeas ago, there were ancient people living at Songze, Qingpu County, Shanghai. This paper reports the study of ancient potteries unearthed from the Guangfulin site located at Songjiang, Shanghai. The potteries unearthed from Guangfulin site belonged to two different culture types: the Liangzhu culture type (local culture) and a new culture, which might be derived from elsewhere. PIXE has been used to measure the chemical compositions of samples and factor analysis was used. Experimental results show that the compositions of the pottery from the two phases are different from each other. It means that the raw materials used to make the ancient pottery originate from different places. This results support the idea suggested by archaeologists that a group of ancient people migrated to the Shanghai area from some other place 4000years ago.

Using characteristic spectral bands of OMIS1 imaging spectrometer to retrieve urban land surface temperature

According to the reflectance spectra of various materials, this paper mainly studies the relations between inherent features indicated by different combinations of characteristic spectral bands and surface temperature for five land surface cover types in the Shanghai area. On the basis of above‐analysis results, we used the built optimum regression models to retrieve surface temperature, and then the precision and feasibility of the correlation method were evaluated. Results show that a clear and high correlativity exists between characteristic spectral bands and surface temperature. The maximum error is about 2.0 K by using correlation models to estimate urban land surface temperature, and main error of retrieved temperature results from mistakenly classification and existent mixture pixels. This indicates that characteristic spectral bands can be used as a modulating parameter for the estimation of surface temperature.

3D water-vapor tomography with Shanghai GPS network to improve forecasted moisture field

The vertical structure of water vapor in atmosphere is one of the initial information of numerical weather forecast model. Because of the strong variation of water vapor in atmosphere and limited spatio-temporal solutions of traditional observation technique, the initial water vapor field of numerical weather forecast model can not accurately be described. At present, using GIPS slant observations to study water vapor profile is very popular in the world. Using slant water vapor(SWV) observations from Shanghai GIPS network,we diagnose the three-dimensional(3D) water vapor structure over Shanghai area firstly in China. In water vapor tomography, Gauss weighted function is used as horizontal constraint, the output of numerical forecast is used as apriori information, and boundary condition is also considered. For the problem without exact apriori weights for observations, estimation of variance components is introduced firstly in water vapor tomography to determine posteriori weights. Robust estimation is chosen for reducing the effect of blunders on solutions. For the descending characteristic of water vapor with height increasing, non-equal weights are used along vertical direction. Comparisons between tomography results and the profile provided by numerical model (MM5) show that the forecasted moisture fields of MM5 can be improved obviously by GPS slant water vapor. Using GIPS slant observations to study 3D structure of atmosphere in near real-time is very important for improving initial water vapor field of short-term weather forecast and enhancing the accuracy of numerical weather forecast.

Serum adiponectin concentration in relation to body fat distribution and tissue insulin sensitivity in the glucose clamp study

To study serum adiponectin level in relation to body fat distribution and tissue insulin sensitivity by using the extended hyperinsulinemic euglycemic clamp technique. Extended hyperinsulinemic euglycemic clamp was performed in 44 Chinese individuals with normal glucose tolerance from Shanghai area, including 12 subjects with normal weight [body mass index (BMI) < 25 kg/m(2)], 19 with overweight (25 kg/m(2) < or = BMI < 30 kg/m(2)), and 13 with obesity (BMI > or = 30 kg/m(2)). The rate of insulin-mediated glucose disposal (Rd) during the steady state of glucose clamp was used to assess the peripheral tissue insulin sensitivity. Total body fat depots [BMI, percentage of body fat (FAT%), and body fat mass (FM)], regional body fat depots [waist circumference (W), hip circumference (H), W and H ratio (WHR), abdominal subcutaneous fat area (SA), intra-abdominal fat area (VA), and femoral subcutaneous fat area (FA)] were measured on all subjects. Fasting serum adiponectin level was determined by radioimmunoassay. (1) After the adjustment for age and sex, the serum adiponectin concentrations in the overweight and obesity groups were (8.7 +/- 4.8) mg/L and (6.7 +/- 0.8) mg/L, both significantly lower than that in the normal weight group [(15.7 +/- 1.8) mg/L, both P < 0.01]. (2) Serum adiponectin concentration was negatively correlated with BMI, W, WHR, FAT%, FM and VA, especially with W and VA (r = -0.46, P < 0.01, and r = -0.53, P < 0.01). (3) Serum adiponectin concentration was positively correlated with Rd (r = 0.52, P < 0.01) and the rate of glycogen synthesis (r = 0.36, P < 0.05), and was negatively correlated with free fatty acid level (r = -0.41, P < 0.05). (4) Stepwise regression analysis indicated that in addition to sex, BMI, WHR or VA and SA, serum adiponectin level was also the independent contributing factor for Rd, which explains 3.52% and 4.84% of the variance respectively (P all < 0.05). (1) The decrease in serum adiponectin level is associated with the increase of total body fat depot, especially the increase of total body fat depot in intra-abdominal fat area. (2) Serum adiponectin level is an independent contributing factor for insulin sensitivity.

Effect of osteoprotegerin gene polymorphism on bone mass in postmenopausal women

To investigate the effect of promoter region polymorphism of osteoprotegerin (OPG) gene on bone mineral density (BMD) and markers of bone turnover in postmenopausal women. The OPG genotype were determined by PCR-RFLP in 259 postmenopausal women of Han race in Shanghai area, and BMD at lumbar-spine, femoral neck, trochanter and Ward's triangle etc., were measured by dual-energy X-ray absorptiometry (DEXA). Some markers of bone turnover were also detected. Hardy-Weinberg equilibrium was evident for OPG polymorphism. The frequency of the genotype is as following: TT59%, TC28%, CC13%. Postmenopausal women were divided into two groups. Women aged less than 65 years old were in group I, and aged 65 years old and over were in group II. In group I the BMD at femur neck area was 0.64 g/cm(2) +/- 0.11 g/cm(2), 0.67 g/cm(2) +/- 0.11 g/cm(2), 0.68 g/cm(2) +/- 0.14 g/cm(2) of TT, TC, CC genotypes respectively, among which a significant difference was observed (P < 0.05 by ANOVA), and the significant difference also presented after adjusted by age and BMI, but not found the significant difference in other markers. In group II, significant link was not observed between OPG polymorphism and BMD with markers of bone turnover. OPG polymorphism may have an effect on the BMD of postmenopausal women aged less than 65. It is possibly that the role of OPG gene mainly on the obtaining of peak BMD in women.

Eastern Asian emissions of anthropogenic halocarbons deduced from aircraft concentration data

The Montreal Protocol restricts production of ozone‐depleting halocarbons worldwide. Enforcement of the protocol has relied mainly on annual government statistics of production and consumption of these compounds (bottom‐up approach). We show here that aircraft observations of halocarbon:CO enhancement ratios on regional to continental scales can be used to infer halocarbon emissions, providing independent verification of the bottom‐up approach. We apply this top‐down approach to aircraft observations of Asian outflow from the TRACE‐P mission over the western Pacific (March–April 2001) and derive emissions from eastern Asia (China, Japan, and Korea). We derive an eastern Asian carbon tetrachloride (CCl4) source of 21.5 Gg yr−1, several‐fold larger than previous estimates and amounting to ≃30% of the global budget for this gas. Our emission estimate for CFC‐11 from eastern Asia is 50% higher than inventories derived from manufacturing records. Our emission estimates for methyl chloroform (CH3CCl3) and CFC‐12 are in agreement with existing inventories. For halon 1211 we find only a strong local source originating from the Shanghai area. Our emission estimates for the above gases result in a ≃40% increase in the ozone depletion potential (ODP) of Asian emissions relative to previous estimates, corresponding to a ≃10% global increase in ODP.

The econometrics analysis of the main 4-regional population migration and their economic effects in China

The purpose of this paper is the model analysis of main 4-regions in China. We take up 4-regins. (1) Beijing area (Beijing, Tianjin, Hebei), (2) Shanghai area (Shanghai, Jiangsu), (3) Guangdong area (Guangdong). These three are expanding coastal region and face with big inflow of population. (4) Sichuan area (Sichuan, Chongqing), which is a retarded inland region and an origin of the biggest population outflow. We try to analyze population migration among these 4-regions, and their impacts on economic growth..Since 1950's under strict family register system, population migration was severely restricted in China, it started to grow only after 1978 due to liberalization trend. Since 1990's foreign investment rushed to coastal region, so the interregional difference with the retarded inland region has rapidly expanded. Inland rural areas (villages) are very poor, and excess workers are increasing. As restrictions of migrations were relaxed largely in 1990s, rural population started to migrate to urban and coastal regions. The current population movement is a serious policy issue. On the other hand, statistical information and quantitative studies about it are very scarce.We estimate the population migration function and construct 4-regions growth models, and divide each region into urban and rural areas and formal and informal sectors. By simulation studies combining these functions, we analyze the trend of population migration and assess their economic impacts on regional economic growth. This is a part of continuous research project, and an extension of earlier papers (Suzuki, and Fukuchi, 2000, 2001, and 2002).

Relationship between human leukocyte antigen-DRB1 and autoimmune hepatitis type I in Chinese patients.

To analyze the association of human leukocyte antigen (HLA)-DRB1 with autoimmune hepatitis type I (AIH) among Chinese patients in the Shanghai area. In 32 patients and 48 healthy controls, polymerase chain reaction amplified with sequence-specific primers (PCR-SSP) was performed to elucidate the relevance of certain alleles or polymorphic sequences of HLA-DRB1 with autoimmune hepatitis. The HLA-DRB1 typing by PCR-SSP showed that DR4 had a significantly increased frequency among patients with AIH versus that of healthy controls (46.9 vs 20.8%; relative risk = 3.35, P = 0.014). In the subtypes of DR4, there was a trend of an increase in the gene frequency of DRB1*0405 in patients with AIH versus that of healthy controls (21.9 vs 6.3%, P = 0.04, but corrected P (Pc) = 0.08). In addition, our analysis indicated a significant increase in the alleles frequency encoding Leu-Leu-Glu-Gln-Lys-Arg (LLEQRR) from the third hyperpolymorphic region (HVR3) of DR4 in the patients with AIH (86.7% of DR4 positive patients vs 40.0% in DR4 positive controls, P = 0.016, Pc = 0.028, relative risk (RR) = 9.75). Type I AIH among Chinese patients is associated with HLA-DR4. There is a relevance of type I AIH and LLEQRR sequence within the third hyperpolymorphic region of the DRB1 allele.