Shahid Sadoughi Hospital Research Articles

The role of mir-214-5p and mir-548-5p expressions in endometriosis.

Endometriosis is a benign gynecological disease that affects about 1% of all women and up to 15% of women of childbearing age. To date, none of the proposed theories exhaustively explain the pathophysiology of the disease or the associated clinical manifestations. As part of efforts to introduce new methods for the early and non-invasive diagnosis of endometriosis, this project investigated changes in the expression of miR-214-5p and miR-548-5p in ectopic and eutopic tissue compared to normal endometrial tissue. Forty-five samples (15 eutopic, 15 ectopic and 15 healthy controls) from women referred to Shahid Sadoughi Hospital (Yazd, Iran). RNA extraction was performed using an RNA extraction kit, and cDNA was synthesized. Two-step qRT-PCR was performed according to the manufacturer's instructions. GraphPad Prism 8 software and Two-Way ANOVA test were used to compare fold-change expression. The results indicate a significant down-regulation of miR-214-5p expression levels (P-value < 0.05) and an increase in miR-548-5p expression levels (P-value < 0.05) in endometriosis samples compared to those in control tissues. miR-214-5p and miR-548-5p may regulate the pathogenesis of endometriosis. The down-regulation of miR-214-5p in people with endometriosis compared to healthy individuals may indicate its suppressive role. The upregulation of miR-548-5p could confirm the oncogenic role of this microRNA in endometriosis. The development of new therapeutic strategies targeting these miRNAs could be promising in the treatment of this disease.

Investigate the Relationship between Occupational Stress and the General Health of Nurses Affiliated with Shahid Sadoughi Hospital of Yazd City during the COVID-19 Pandemic

Investigate the Relationship between Occupational Stress and the General Health of Nurses Affiliated with Shahid Sadoughi Hospital of Yazd City during the COVID-19 Pandemic

Effect of Covid-19 on the Pattern of the Patients Referring to the Emergency Department of Shahid Sadoughi Hospital in Yazd in 2019-2021

Effect of Covid-19 on the Pattern of the Patients Referring to the Emergency Department of Shahid Sadoughi Hospital in Yazd in 2019-2021

Impact of Vitamin D Supplementation on Pain Management in Sickle Cell Disease Patients

Background: Vitamin D deficiency is prevalent among patients with sickle cell disease, regardless of their age or the season. Since there has been no extensive research on the impact of vitamin D on pain in sickle cell disease, this study aimed to evaluate how vitamin D supplementation influences pain management in these patients. Materials and Methods: This retrospective study was conducted on children (12.3±4.45 years old) with definitive diagnosis of sickle cell. The study was done in the Department of Oncology of Shahid Sadoughi Hospital, Yazd, Iran, over the years 2019-2021. Thirty patients (14 boys and 16 girls) with vitamin D insufficiency and deficiency entered the study and 50000 IU vitamin D was given weekly for 16 weeks. The measurement of vitamin 25(OH) D3 before and after intervention was done by ELISA method (Monobind kit, USA). Pain intensity assessment was also done. Other relevant data were extracted from the patients’ medical records. Results: In this study, amomg 30 patients, 46.6% of them had vitamin D deficiency. A significant reduction in pain intensity was observed in patients following the intervention (p&lt;0.05). Conclusion: Based on the findings of this study, vitamin D was effective in reducing pain intensity in these patients. Therefore, vitamin D can be used in the pain management of these patients.

Investigating the Relationship between Communication Skills of Treatment Staff and Patient’s Safety Culture: A Cross-Sectional Study

Background: One of the most important effective factors in increasing patient satisfaction and improving health and treatment results is proper communication between physician and nurse, and the patient. The present study was conducted with the aim of determining the relationship between the communication skills of the medical staff and patient’s safety culture. Methods: This was an analytical study conducted among 277 working medical staff including nurses, paramedics, full-time geographical employment doctors and anesthesia, and operating room technicians in Shahid Sadoughi Hospital in Yazd by stratified random sampling in 2022. The instrument used was the safety culture standard questionnaire made by the health care quality and research agency and communication skills of Barton J. Data analysis was done with SPSS 25 software, Mann-Whitney, Kruskal-Wallis, and multiple linear regression tests. Results: The overall mean and standard deviation of patient safety culture was 3.04 ± 0.23, which indicates the average status of safety culture in the studied hospital, and the overall mean of communication skills among medical staff was 3.36 ± 0.40. Which reports a relatively strong level of this skill. The results of linear regression showed that 2 components of communication skills (listening and feedback) have a positive and significant effect on the improvement of patient safety culture, so that they are able to explain 33 percent of the variance of patient safety culture changes. Conclusion: Based on the findings of the research, the communication skills of the medical staff have a significant effect on patient's safety culture. Therefore, in order to improve the patient’s safety culture among them, special attention should be paid to communication skills because effective communication is considered a vital element in effective care, and in the medical system it has a significant effect on the quality of care and consequently increases the satisfaction of patients.

Identifying the Components of Organizational Culture in Hospital Environments: A Qualitative Study

Background: Weak organizational culture is one of the main factors of inefficiency in hospitals. Identifying the type of organizational culture of hospitals is an important step in increasing productivity. Therefore, this study was conducted with the aim of identifying the components of organizational culture. Methods: This qualitative study was conducted in Shahid Sadoughi Hospital in Yazd in 1400. The statistical population included the nurses of Shahid Sadoughi Hospital in Yazd. The sampling method used in this study was purposive and snowball sampling. To collect data, semi-structured interviews were used. The content analysis method was used to analyze the texts using MAXQDA version 10 software. Results: In this study, 13 experts were interviewed. The results of the data analysis showed that the 11 main components of organizational culture at Yazd University of Medical Sciences are rational, ideological, agreement and participation, hierarchical, constructive, passive, work and open culture, club, stronghold, flexible, Learner, and value orientation. Conclusion: The identified components of organizational culture can help healthcare managers and policymakers to improve service quality, job satisfaction, and organizational commitment of employees, improve organizational performance, and increase patient satisfaction.

Analysis of how Serum Ferritin and the Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) are correlated to Hepatic MRI T2* Findings in Children with Beta-Thalassemia Major

Background: Iron overload is a major complication in patients with beta-thalassemia major. Excessive iron accumulation leads to organ dysfunction. The regular assessment of iron is crucial to effectively manage iron overload in these patients. This study evaluated the correlation between serum ferritin levels, the Aspartate Aminotransferase-to-Platelet Ratio Index (APRI), and hepatic MRI T2* findings in children with beta-thalassemia major. Materials and Methods: This retrospective analytical study was conducted at Shahid Sadoughi Hospital in Yazd in 2023. The research population comprised all the children under the age of 15 with beta-thalassemia major who had undergone multiple blood transfusions (at least ten units of blood). Results: The participants in this study were 70 children with beta-thalassemia major, including 35 males and 35 females. Their mean age was 3.52 ± 10.76 years. The mean relaxation time of liver MRI T2* was 4.42 ± 4.91 ms. The participants also had the APRI score of 0.55 ± 1.90, the aspartate aminotransferase (AST) level of 23.82 ± 36.29, and the serum ferritin level of 285.01 ± 3244.04 (ng/mL). Based on MRI T2* results, 30% of the patients had a severe liver iron overload, 27.1% had a moderate overload, 21.4% had a severe overload, 18.6% had a mild overload, and 2.9% had near-normal iron levels.The AST level demonstrated a significant association with the type of chelation treatment (P = 0.003). The duration of blood transfusion (in years) showed a strong positive correlation with the patients' age (Pearson's coefficient = 0.996). Conclusion: This study indicates the elevated serum ferritin levels and APRI scores in patients with beta-thalassemia major, most of whom have abnormal MRI T2* findings. However, no significant correlation was observed between the APRI score, serum ferritin level, and MRI T2* results.

Bayesian Parametric Survival Analysis of Patients With Non-Hodgkin’s Lymphoma in Yazd, Iran, During 2009-2019

Background and aims: Non-Hodgkin’s lymphoma (NHL) is one of two main types of lymphoma. This present study aimed to investigate the survival rate in patients with NHL. Methods: This analytical survival-type study examined 372 patients with NHL referred to Shahid Sadoughi Hospital in Yazd in 2009-2019. The data were extracted from patients’ files. STATA/17 software, the Kaplan-Meier method, and Bayesian parametric survival analysis were used for data analysis. Results: The overall survival rate and the mean overall survival time were 65% and 129±17.94 months, respectively. According to the Kaplan-Meier method, the survival rates of 1, 2, 3, 5, and 10 years were 86%, 80%, 76%, 69.5%, and 52%. The results revealed that men, people over 70 years old, patients with the NHL.T-cell subtype, patients with involvement in the chest, inguinal, and abdominal-pelvic regions, and patients in stage III or IV of the disease had a shorter survival time. In addition, survival time was shorter in patients with disease recurrence at the primary site. The variables of gender (hazard ratio [HR]=0.65; 95% confidence interval [CI]: 0.44‒0.93), type of treatment (HR=3.43; 95% CI: 1.58‒6.16), stage of disease (HR=2.87; 95% CI: 2.09‒3.57), and involvement site (HR=1.45:95%; CI: 1.03‒1.99) had a significant effect on survival time using the Bayesian parametric regression model. Conclusion: If patients are identified at an early stage, they have the best chance of survival. In chronic lymphocytic leukemia (CLL) patients, the best survival is achieved without treatment. At the same time, in other types of cancer, chemotherapy offers the best survival.

The effect of Henna (Lawsonia inermis) vaginal suppository combined with antibiotic therapy in the treatment of cervicitis: An RCT.

Cervicitis is a prevalent gynecologic disease, which does not usually respond to conventional treatments. Long-term cervicitis can cause serious health problems such as inflammation, infertility, and cancer. Henna oil, an herbal product in Persian medicine, is recommended for uterine diseases like cervicitis. This study aims to evaluate the efficacy of Henna oil as a vaginal suppository in combination with an antibiotic regimen in the treatment of cervicitis. This randomized placebo-controlled trial, included 92 non-menopausal women with cervicitis at the Baqaipur Clinic of Shahid Sadoughi hospital in Yazd and the Persian Medicine Health Center in Ardakan, Yazd, Iran. Participants were further divided into either the Henna oil vaginal suppository group or the placebo group (n = 46/each group). During the study, the antibiotic treatment was administered to both groups. Cervicitis symptoms were compared between the groups and within each group. Of 92 included individuals, 41 in each group completed the study. Results revealed that significant differences were observed in some outcomes, including vaginal discharge (p 0.001), cervical ulcer size (p 0.001), dyspareunia (p = 0.046), and postcoital bleeding (p 0.001), indicating that the treatment was more effective in the henna group compared to the placebo group. Findings supported that the vaginal suppository of Henna oil in combination with antibiotic therapy could be effective in the improvement of clinical symptoms of cervicitis regardless of its pathology.

A survey on mean glandular dose in mammography examination and the factors affecting it in Shahid Sadoughi Hospital, Yazd, Iran.

mammography is the gold standard in the early detection of breast cancer. Due to the increase in the rate of women suffering from this malignancy all over the world, this imaging modality has been widely used. Considering the side effects caused by ionizing radiation to measure the carcinogenic risk of mammography X-rays, mean glandular dose (MGD) is the best parameter to evaluate the dose received by patients undergoing mammography. The aims of this study were to measure MGD in mammography in mammographic craniocaudal (CC) and mediolateral oblique (MLO) projections and investigate the relationship of MGD with compressed breast thickness (CBT), body mass index, age of the patient, and device exposure conditions. this cross-sectional analytical study was conducted on women aged 30-70 referring to the mammography unit of Shahid Sadoughi Hospital in Yazd city from May to August 2022. The TLD-GR 200 (thermoluminescence dosimeter) was placed on the breast of the patients for CC and MLO projections, and then the MGD was obtained by multiplying the entrance surface dose and the normalized glandular dose. Analysis of data (such as demographic information of patients, CBT, kVp, and mAs) was done by SPSS 23 software. The normality of the data was checked using Shapiro-Wilk tests. It was found that except for age, other variables did not have a normal distribution; therefore, equivalent parametric and nonparametric tests were used. In this regard, Spearman's correlation was used to assess the correlation between variables. P-value < .05 was considered as level of significance. The mean±standard deviation (SD) age of patients was 47.3±7.1years. The median±IQR (the interquartile range (IQR) is a measure of statistical dispersion, which is the spread of the data. It is defined as the difference between the 75th and 25th percentiles of the data.) (mean±SD) value of MGD per woman was 1.2±0.4mGy (1.3±0.3mGy). The median±IQR MGD in the MLO and CC projections was 1.6±0.6mGy and 0.9±0.4mGy, respectively. Significant relationships (P-value ≤ .001) were observed between MGD with CBT (R=0.62) and age (R=-0.85). The results showed that the mammography unit at Shahid Sadoughi Hospital in Yazd is functioning properly. The calculated median±IQR MGD per woman referring to this unit (1.2±0.4mGy) was clearly below the dose limit recommended by American College of Radiology and International Commission on Radiological Protection (3mGy). Moreover, among the factors affecting MGD, the highest correlation was seen between MGD and age (R=-0.85).

Investigating the Relationship between Religiosity and Post-Traumatic Stress Disorder in Mothers of Children with Cancer Admitted to t Pediatric Oncology Department of Shahid Sadoughi Hospital , Yazd , 2019

Introduction: Religiosity can help in adapting to difficult situations and provide better care. Therefore, this study was conducted to determine the relationship between religiosity and post-traumatic stress disorder in mothers of children with cancer. Methods: This was a cross-sectional and descriptive-correlational study conducted on 115 mothers of children with cancer who were admitted to Shahid Sadoughi Hospital, in Yazd, in 2019. Sampling was done through convenience sampling method. Data collection tools were the demographic information questionnaire, and Mississippi PTSD and Glock and Stark questionnaires. . Descriptive (mean and standard deviation) and analytical (Pearson's correlation, chi-square) statistical tests and indicators were used; data were investigated and statistically analyzed using SPSS 21 software with a confidence level of 95%. Results: The findings showed that in the post-traumatic stress disorder questionnaire, the average score was 97/61±36/78 and the average score of the religiosity questionnaire was 26/77±61/85. Pearson's correlation coefficient showed a negative relationship between religiosity and PTSD (p= 0/160, r= -0/132). The average score of PTSD and religiosity among mothers was not significantly different according to various variables such as mother's occupation, child's gender, and education level. The difference in the average score of PTSD in mothers was different according to the characteristics such as education level and occupation. The average score of religiosity was more different when comparing working mothers with housewives. The average stress score after the accident showed a greater difference in mothers according to the type of child's illness. The average PTSD score was 83/87±25/79 for neuroblastoma and 92/33±24/98 for solid tumor disease. Conclusion: PTSD among mothers was close to the cut-off point for the disorder. Although there was no significant relationship between PTSD and mothers' religiosity, it can be said that the severity of mental situation of mothers with severe cancer was effective in the study.

The Prevalence of Congenital Heart Diseases and Associated Risk Factors among Neonates Admitted to the NICU of Shahid Sadoughi Hospital, Yazd, Iran from 2022 to 2023: A Cross-Sectional Study

Background: Congenital heart defects (CHDs) are among the most prevalent congenital defects observed in neonates, leading to structural and functional abnormalities in the heart. This research examines the prevalence of CHDs and its various subcategories among neonates admitted at Shahid Sadoughi Hospital in Yazd, Iran, from 2022 to 2023. The study also aims to assess the presence of risk factors among infants diagnosed with CHDs. Methods: This is a descriptive cross-sectional study, encompassing all neonates diagnosed with CHDs. Echocardiography was conducted to classify the specific type of CHDs, and a questionnaire was administered to the parents of neonates with CHDs to identify potential risk factors. Results: Out of 1149 newborns admitted to the hospital in one year, 29 (2.52%) were diagnosed with CHDs, and 9 of them died from the condition. The prevalence of CHDs and the mortality rate were 2.5% and 0.78%, respectively. The most common defect was atrial septal defect (ASD), affecting 19 newborns (65.5% of cases), and 15 newborns exhibited multiple defects within the subtypes of CHDs. Conclusion: Our research reveals that the incidence of CHDs among newborns in our area was 2.52%, with a mortality rate of 0.78% within a one-year timeframe. More than half of CHD cases were found in offspring of consanguineous unions, suggesting a potential risk factor within the Yazd community, likely linked to the prevalent custom of consanguineous marriages in the region.

Comparison of Treatment Outcomes of High-Flow Nasal Cannula and Nasal Continuous Positive Airway Pressure in Preterm Neonates with Respiratory Distress Syndrome in the NICU of Shahid Sadoughi Hospital in Yazd

Background: Neonatal respiratory distress syndrome (RDS) is a common and urgent condition in newborns, caused by a lack of surfactant production and secretion. This study aimed to compare two non-invasive methods, nasal continuous positive airway pressure (nCPAP) and highflow nasal cannula (HFNC), for managing RDS. Methods: The study was conducted in the Neonatal Intensive Care Unit (NICU) of Shahid Sadoughi Hospital between 2020 and 2021 and included 49 premature neonates (with gestation ≤34 weeks and birth weight ≤2,000 g) diagnosed with RDS. The neonates were randomly assigned to either the HFNC group (n = 24) or the nCPAP group (n = 25). Results: No significant differences in demographic features were observed between the two groups. The HFNC group had lower rates of intubation, shorter hospitalization duration, and less need for full nutritional support and oxygen therapy compared to the nCPAP group, but these differences were not statistically significant. Additionally, there were no significant differences in complications such as traumatic nasal injury, apnea, necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), pneumothorax, pulmonary hemorrhage, and mortality between the two groups. Conclusion: The results of this study suggest that both HFNC and nCPAP are equally effective in treating premature neonates with RDS, with no significant differences in clinical outcomes. Given the cost-effectiveness of HFNC, medical staff expertise, and equipment accessibility, this approach could be considered a viable alternative to nCPAP.

Prevalence of Trichomonas Infection in Relation to Human Papillomavirus (HPV) in Pap Smear Samples of Female Patients Referred to Shahid Sadoughi Hospital, Yazd (Iran).

Objectives Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections have been proposed as risk factors for cervical cancer. This study has been conducted with the aim of investigating the prevalence of TV and its relationship with HPV in women who underwent Pap smear testing as part of cancer screenings. Materials and methods The sampling of liquid-based cervical tissue was conducted among 500 women referred to the women's clinic of Shahid Sadoughi Hospital in Yazd, Iran. The studied samples were examined for Pap smear tests and microscopic identification of TV, as well as HPV-DNA detection and the determination of high-risk and low-risk HPV types by the polymerase chain reaction (PCR) method. The results were analyzed using the IBM SPSS Statistics for Windows, Version 24 (Released 2016; IBM Corp., Armonk, New York) software. Results The individuals included in the study were 16-72 years old. The prevalence rate of TV infection in this population was found to be 29.2%, and the frequency rate of HPV was reported to be approximately 19.4%, with high-risk HPV, including HPV-56, having the highest frequency. The Pap smear test results were reported as abnormal in 20.2%, anda significant correlation was observed between HPV infection and an abnormal Pap smear test (P < 0.05). In addition, a notable correlation was detected between TV infection and high-risk and low-risk HPV (P < 0.05). Conclusion According to the significant relationship found between the two pathogens, TV and HPV, in the abnormal Pap smear test results, TV infection can be considered a risk factor for HPV infection, as well as uterine lesions and cancer.

Analyzing the health information needs of families with children suffering from cancer in the city of Yazd

Background: It is of paramount significance to address the needs of parents who have children with cancer. This research aims to analyze the health information needs of families with children suffering from cancer in Yazd city.&#x0D; Materials and Methods: This descriptive-analytical study was conducted on a total of 248 individuals from families whose children underwent cancer treatment at Shahid Sadoughi Hospital in Yazd. The participants were selected through a non-random, purposeful, and voluntary sampling method. The data were collected using a comprehensive questionnaire consisting of 48 items. The data analysis was performed with the SPSS software version 25 and through t-tests, chi-square, ANOVA, and correlation analyses.&#x0D; Result: Through a meticulous comparison of the scores obtained with a predetermined threshold of 3, all levels of information needs were satisfactorily met. However, it became evident that the parents needed more information to be given by the treatment staff regarding cancer and called for social, economic and spiritual support (p≤0.5). Moreover, the study identified and prioritized the information needs based on the average scores across the four examined factors. The highest-priority need was identified as “the information about cancer provided by the treatment staff"(2.99±0.7). The second most important need was found to be "social, economic and spiritual support"(2.98±0.7). The third priority was assigned to “the accessibility and exchange of relevant health information"(2.77±0.62). Lastly, the fourth priority pertained to"health facilities, services and counseling"(2.61±0.63). Furthermore, the independent t-test revealed that the average score on the total health information needs of the families with cancer-affected children was significantly higher for the women (140.5±20.4) than for the men (117.7± 11.55).&#x0D; Conclusion: When handling children with cancer, it is crucial for the treatment staff to provide information about cancer and give social, economic and spiritual support in order to fully meet the information requirements of the families involved.

Blood Features Associated with Viral Infection Severity: An Experience from COVID-19-Pandemic Patients Hospitalized in the Center of Iran, Yazd.

Pandemics such as coronavirus disease 2019 (COVID-19) can manifest as systemic infections that affect multiple organs and show laboratory manifestations. We aimed to analyze laboratory findings to understand possible mechanisms of organ dysfunction and risk stratification of hospitalized patients in these epidemics. Methods. This retrospective study was conducted among patients admitted to COVID-19 referral treatment center, Shahid Sadoughi Hospital, Yazd, Iran, from April 21 to November 21, 2021. It was the fifth peak of COVID-19 in Iran, and Delta (VOC-21APR-02; B.1-617.2) was the dominant and most concerning strain. All cases were positive for COVID-19 by RT-PCR test. Lab information of included patients and association of sex, age, and outcome were analyzed, on admission. Results. A total of 466 COVID-19 patients were included in the study, the majority of whom were women (68.9%). The average age of hospitalized patients in male and female patients was 57.68 and 41.32 years, respectively (p < 0.01). During hospitalization, abnormality in hematological and biochemical parameters was significant and was associated with the outcome of death in patients. There was incidence of lymphopenia, neutrophilia, anemia, and thrombocytopenia. The changes in neutrophil/lymphocyte (N/L) and hematocrit/albumin (Het/Alb) ratio and potassium and calcium levels were significant. Conclusion. Based on these results, new biochemical and hematological parameters can be used to predict the spread of infection and the underlying molecular mechanism. Viral infection may spread through blood cells and the immune system.

Impact of Service Innovation and its Quality on Patients' Satisfaction and Loyalty during the Covid-19 Pandemic

Introduction: In today's societies, the health sector is growing rapidly, and hospitals, as institutions that provide health and survival of the society and provide health services, have experienced many changes over time. People have understood that health is a valuable service for their lives, especially when the spread of new diseases threatens the life and health of society. Therefore, the main goal of this research was to investigate the relationship between innovation and service quality on customer satisfaction and loyalty during the Covid-19 pandemic.&#x0D; Methods: The present research has focused on the impact of service innovation and its quality on patients' satisfaction and loyalty during the Covid-19 pandemic in Yazd Shahid Sadoughi Hospital. The statistical population of the present study was the patients admitted to Shahid Sadoughi Hospital in Yazd, Iran. Because the size of the population was uncertain, Cochran's formula was used to calculate the number of samples, which resulted in 384 people. SPSS and Smart PLS3 software were also used for data analysis.&#x0D; Results: Among the patients with corona virus, service innovation had a positive and significant effect on the patient satisfaction and 0.11 (p&lt;0.05) on loyalty, respectively. Likewise, service quality has affected the satisfaction and loyalty of the patients by 0.77 and 0.45 with (P&lt;0.05); the effect of the patient satisfaction on loyalty was positive and significant at the rate of 0.41 (P&lt;0.05).&#x0D; Conclusion: The results have shown that the relationship between service innovation and its quality had a positive and significant effect on patients' satisfaction and loyalty during the Covid-19 pandemic. The reason is that if the quality of the services provided is in accordance with the expectations of the patients, it will cause the satisfaction of the patients and will lead to their loyalty.

Evaluation of diagnostic value of pelvic MRI in endometriosis in comparison with surgical findings: A cross-sectional study.

Endometriosis is a multifocal gynecologic disorder during the fertility period in women. Magnetic resonance imaging (MRI) is an important diagnostic modality for this disease and can either be used alone or along with transvaginal ultrasonography. This study aims to compare the accuracy of pelvis MRI in pelvic deep endometriosis with laparoscopic findings in women referred to Shahid Sadoughi hospital in one year. This cross-sectional study was conducted on 40 women suspicious of endometriosis who referred to Shahid Sadoughi hospital, Yazd, Iran from November 2020-2021. Based on clinical findings and history, participants were referred to the imaging center for pelvic MRI. Finally, the results of MRI and diagnostic laparoscopy were compared with pathologic findings. The sensitivity and specificity of MRI for pelvic endometriosis were 94.8% and 20%, respectively. Also, the positive predictive value and negative predictive value of MRI were 90.2% and 33.3%, respectively. Laparoscopy is still the gold standard of endometriosis diagnosis, but MRI with susceptibility-weighted imaging sequence is the best noninvasive diagnostic method.

Prediction of underweight, short stature, and microcephaly based on brain diffusion-weighted imaging sequence in neonates with stage.2 of hypoxic-ischemic encephalopathy: A follow-up study.

Hypoxic-ischemic encephalopathy (HIE), caused due to reduced oxygenation and brain blood flow, occurs in 1-8 per 1000 live full-term births in developed countries and up to 26 per 1000 live in the developing world. The growth status of survivors of birth HIE has not been evaluated sufficiently. This study evaluated, the growth parameters (weight, height, and head circumference) of neonates with Sarnat stage.2 of HIE at 6, 10, and 12 months and its relationship with findings of neonatal brain diffusion-weighted imaging (DWI) sequence. Medical records and growth parameters of 35 neonates with gestational age 34 wk who were admitted with stage.2 of HIE in Neonatal Intensive Care Unit of Shahid Sadoughi hospital, Yazd, Iran from March 2021-March 2022, and its relationship with neonatal brain DWI sequence finding was evaluated. 15 girls and 20 boys with a mean birth weight of 2880.3 221.8 gr were evaluated. Conventional magnetic resonance imaging and DWI were found to be abnormal in 6 (17.1%) and 18 neonates (51.4%). The most abnormal finding of DWI was high signal in basal ganglia/thalamus in 9 neonates (25.7%). Abnormal DWI is more frequent in neonates with seizures and low birth weight. Hospital stay days were more prolonged in neonates with abnormal DWI. Microcephaly at 12 months was more frequent in children with abnormal DWI. In survivors of moderate neonatal HIE, abnormal brain DWI sequence might predict inappropriate head growth, and need close medical and nutritional interventions for growth improvement.

Evaluation of Brain MRI Findings in Patients Referred with Seizures

Introduction: Seizures are one of the common and warning signs of brain diseases, which doctors often use CT-scan or MRI for diagnose. The present study was conducted with the aim of evaluation of brain MRI of the patients referred with seizures in order to determine their brain lesions and involvement.&#x0D; Methods: The study was carried out using a retrospective cross-sectional descriptive method. All the patients with seizures referred for MRI to the Radiology Department of Shahid Sadoughi Hospital in Yazd City, Iran during 2016-2020 were examined. By referring to the archives of the radiology department, the records and MRI of the patients referred with seizures were extracted. Then, the data were extracted from the Hospital Information System and the patients' files; after that they were analyzed with SPSS version 16.&#x0D; Results: The present study was conducted on 105 patients with seizures for brain MRI. 48.6% (51 people) of patients were male and 51.4% (54 people) were female. The average age of the patients was 34.17 ± 10.50 years. MRI was normal in 59% of the patients. 16.2% Non-Specific, 6.7% Mass and 4.8% evidence of Encephalomalacia were also reported. The most lesions with 10.5% were related to left frontal lobe and 2.9% were related to right frontal lobe. 99% of seizures were unspecified convulsion and 1% were postprocedural disorder of nervous system. There was no significant relationship between the gender of the patients and their diagnosis (P&gt;0.471).&#x0D; Conclusion: Wide abnormalities such as mass, edema, encephalomalacia and demyelination are observed in the MRI of the patients with seizures and are often located in the frontal lobe. In general, seizures can cause transient and reversible brain abnormalities in MRI.