This research paper presents a comprehensive experimental and statistical approach for the analysis of vibration amplitudes in a high-speed rotating shaft employing a squeeze film damper (SFD). The research combines a comprehensive analysis that connects input parameters and response parameters, with a special emphasis on vibration amplitudes along the X and Z axes. This research utilizes the rigorous procedures of Response Surface Methodology (RSM) together with a Box-Behnken design and harnesses the capabilities of Artificial Neural Network (ANN) optimization techniques. The variables under scrutiny encompass critical factors such as shaft rotational speed, extending up to 8000 rpm, oil pressure, with a range extending up to 100 bar, and various oil mix ratios, spanning from 10 % to 50 %. Various statistical measures are computed to assess the errors and coefficients of determination of the projected models. The artificial neural network (ANN) model has shown somewhat reduced prediction errors and a greater coefficient of determination compared to the Response Surface Methodology (RSM) for both the x and z axes of vibration amplitude. The values of mean absolute error (MAE), root mean squared error (RMSE), and coefficient of determination (R-squared) are found for both x and z axes from RSM (3.50, 3.77), (4.50, 4.72), and (0.81, 0.79), (1.88, 1.70), (2.41, 2.12), and (0.94, 0.95), respectively, using the ANN model. The overall mean absolute percentage error (MAPE) from the ANN model of both the x and z axes (9.73 %, 9.38 %) is found to be lower compared to the RSM model (18.18 %–20.50 %). The conclusive research reveals that the artificial neural network (ANN) prediction model outperforms the regression model based on Response Surface Methodology (RSM), exhibiting superior accuracy in predicting vibration amplitudes. The ANN approach is an excellent option for calculating vibration amplitudes in high-speed rotating shafts. Additionally, it provides significant benefits in terms of effectiveness and time economy. This research provides valuable new insights into the most efficient modeling approaches for vibration management and highlights the benefits of using Artificial Neural Networks (ANN) for predictive assessments in this context. Particle Swarm Optimization is used to minimize the vibration amplitude of the shaft along the x and z axes using experimental data.