Load and resistance factor design (LRFD) is a limit state design method that has been applied worldwide. Because the data for determining LRFD factors in Korea has been insufficient, the resistance factors suggested by American Association of State Highway and Transportation Officials (AASHTO) in the US have been used for design in Korea; however, these resistance factors were defined based on the characteristics of the predominant bedrock types in the U.S. As such, it remains necessary to determine resistance factors that reflect the bedrock conditions in Korea. Accordingly, in this study, LRFD resistance factors were determined using 13 sets of drilled shaft load test data. To obtain accurate resistance factors, calibration of the elastic modulus of the drilled shaft and the equivalent load–displacement curve considering the axial load and elastic settlement was conducted. After determining accurate resistance values, a reliability analysis was performed. The resistance factors were determined to be within 0.13–0.32 of the AASHTO factors for the shaft resistance, 0.19–0.29 for the base resistance, and 0.28–0.42 for the total resistance. This is equivalent to being 30–60% of the AASHTO-recommended values for the shaft resistance and 40–60% of the AASHTO-recommended values for the base resistance. These differences in resistance factors were entirely the result of discrepancies in the conditions of the rock in the US and Korea in which the shafts were founded.