SF-36 Quality Of Life Questionnaire Research Articles

#2870 Association between frailty and a history of falls in patients on hemodialysis

Abstract Background and Aims Patients with end-stage renal disease on hemodialysis have a higher prevalence of frailty that is associated with relevant outcomes such as disability, hospitalization, and mortality. Moreover, these patients have musculoskeletal and physical function impairments that contribute to a higher risk of falling. Therefore, the aim of this study was to evaluate the association between frailty and a history of falls in patients on hemodialysis. Method This cross-section multicenter study included patients aged ≥18 years who were undergoing regular hemodialysis treatment for at least three months. Patients were excluded if presented severe and unstable comorbidities, psychiatric or cognitive disorders, and physical limitations including neurological, musculoskeletal and osteoarticular diseases which prevented the correct execution of the physical function tests. Frailty was assessed by Fried phenotype and the criteria were as follows: unintentional weight loss ≥ 4.5 kg in the past year; exhaustion was assessed using the vitality domain of the SF-36 quality of life questionnaire; weakness was measured using a handgrip dynamometer; walking speed was assessed by timing the 4.6 m distance covered at the participant's normal pace; and physical activity level was measured by the Human Activity Profile questionnaire. Patients were stratified into three groups: a score of 0/5 for non-frail, a score of 1-2/5 for pre-frail, and a score of 3-5/5 for frail. The retrospective history of falls was assessed for the last 12 months, and a fall was defined as an “unexpected event in which the individual comes to rest on the ground, floor or lower level”. The association between frailty stratification and a history of falls was analyzed using multivariate multinomial logistic regression model with non-frail group as reference. Then, a model adjusted for potential confounders was constructed. Results This study included 199 patients (59.1 ± 12.5 years, 41.2% female). The prevalences of frailty and pre-frailty were 17.6% and 54.8%, respectively. Patients classified as non-frail showed lower prevalence of a history of falls compared to patients classified as pre-frail and frail (26%, 36% and 54%, respectively, p < 0.001). The absence of a history of falls decreased the chance of patients being classified as frail (OR = 0.23, 95% CI = 0.07-0.78, p = 0.018). After adjusting for age, educational level, time on dialysis, hemoglobin and presence of cardiovascular disease, this association remained significant (OR = 0.16, 95% CI = 0.04-0.57, p = 0.005). Conclusion The prevalence of pre-frailty was approximately three times higher than that of frailty in patients on hemodialysis. A history of falls was associated with frailty in these patients.

Effect of an online posture exercise program during the COVID-19 pandemic on students' musculoskeletal pain and quality of life.

Prolonged sitting and poor posture can contribute to musculoskeletal pain and have a negative effect on health-related quality of life (HRQoL) among young adults. Any prolonged posture leads to static loading of soft tissues and causes discomfort. Seated posture leads to inactivity causing an accumulation of metabolites, accelerating disk degeneration and musculoskeletal pain. Regular exercise has major contributions to the prevention and treatment of some health problems such as musculoskeletal disorders. This study aimed to assess the impact of online posture exercises on musculoskeletal pain and health related quality of life among university students receiving distance education during the COVID-19pandemic. This randomized controlled trial involved 72students divided into intervention (n= 35) and control (n= 37) groups. The intervention group followed an 8-week online stretching and posture exercise program. Baseline and 8-week results were measured using the SF-36 QoL Questionnaire and Cornell Musculoskeletal Discomfort Questionnaire (CMDQ). Students spent an average of 5.4 ± 2.5hours daily at computers. While there was no difference between the scores of any region in the CMDQ in the control group, there was a decrease in the neck, right shoulder, left shoulder, waist, left upper leg, right lower leg, and left lower leg discomfort scores in the intervention group (p< 0.05). There was a significant difference between the intervention and control groups in the total score of SF-36 and the sub-dimensions of vitality and mental health (p< 0.05). The online posture exercise program led to notable reductions in musculoskeletal pain and improvements in QoL among university students. Examining the effectiveness of online exercise programs in different age groups is important for health benefits during quarantines.

The Association Between Appetite and Quality of Life in Adults with Obesity or Severe Obesity Post-Sleeve Gastrectomy Procedure: A Cross-Sectional Study.

Sleeve gastrectomy (SG) is considered as the most common bariatricprocedure in Saudi Arabia. It is a non-reversibleprocedure defined as removal of a large portion of the stomach. The objective of the current study is to compare the appetite and quality of life (QoL) between adults' post-sleeve gastrectomy and obese/morbidly obese adults (pre-SG). A cross-sectional study design was conducted in adults (aged between 18 and 65 years), post-sleeve gastrectomy (n = 80, 41 Males and 39 Females) and obese group (n = 60, 28 Males and 32 Females). The study population was recruited from the bariatric surgery clinic of King Abdullah Bin Abdul-Aziz University Hospital. A self-reported questionnaire was collected that included a visual analogue scale (VAS) to assess the appetite level, and SF-36 QoL questionnaire. No significant differences were found in age and gender between the study groups (p > 0.05). The median score feeling of fullness was significantly higher in the SG group (77.5, IQR: 48 and 50, IQR: 40, respectively) than in the obese group (p < 0.001). The amount of food eaten was statistically lower in the SG group (30, IQR: 20) than the obese group (50, IQR: 60) (p = 0.005). Patients post SG had significantly higher QoL scores in all physical and mental scales, physical component summary and mental component summary (p < 0.003). Patients post SG have improved appetite and QoL. Satiety, less prospective food consumption, BMI, age, gender and comorbidities are associated with QoL. Future studies are needed to compare the QoL in post-SG patients with the normative values of the QoL in Saudi Arabia.

The Influence of the Time Factor and Marital Status on the Quality of Life of Patients After Kidney Transplantation in Uzbekistan

Background: Currently, compared to program hemodialysis and peritoneal dialysis, kidney transplantation is considered to be the preferred method of renal replacement therapy in patients with end-stage chronic kidney disease (CKD) in terms of patient survival and improvement in their quality of life (QOL). This study aimed to investigate the influence of the post-transplantation period and marital status on the health-related QOL of patients with CKD who underwent kidney transplantation.Methods and Results: A cross-sectional study was conducted among 78 patients who had received a kidney transplant from living related donors in the Republican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation between January and April 2022. Kidney transplant recipients (KTRs) were divided into four groups depending on the time after kidney transplantation: 3, 6, 12 months, and 2 years or more after surgery. The study used 2 questionnaires. The first included questions about the sociodemographic data of patients; the second was the standardized health-related QOL questionnaire SF-36. This study of the QOL of KTRs, residents of the Republic of Uzbekistan, showed an improvement in most scales of physical and mental health components 12 months and 2 years or more after kidney transplantation. On the scales of physical and mental health components, unmarried KTRs had a higher self-assessment of QOL than married KTRs, and among married KTRs, those with children had higher QOL indicators.Conclusion: Clarifying how the time after kidney transplantation and individual sociodemographic and medical factors influence QOL indicators requires further research (including longitudinal studies) in a wider КTR population.

Factors associated with quality of life in patients with coronary artery disease before coronary artery bypass surgery

Relevance. The outcomes of coronary artery bypass surgery (CABG) for coronary artery disease (CAD) depend on different factors, including patient’s quality of life (QoL) before CABG.Aim: To study QoL and associated factors in CAD patients before CABG.Material and Methods. A single-center observational study involved CAD patients who were admitted for elective CABG. All patients completed generic quality of life questionnaire SF-36 and specific questionnaire SAQ. Statistical methods included parametric and non-parametric comparisons and multiple regression analysis.Results. The study included 240 CAD patients (median age 65 years, males – 69%). More than half of the patients had poor physical and psychological health before CABG. Physical limitations and perception of the disease as well as role functioning were most impaired. QoL was worse in women, older patients, with obesity, comorbidity, long-lasting CAD, non-workers and living in sparsely populated areas (p &lt; 0.05). Predictors of poor QoL – female gender (OR 2.574, 95% CI 1.335–4.961; p = 0.005), obesity (OR 1.984, 95% CI 1.075–3.663; p = 0.028) and long–term CAD (OR 1.006, 95% CI 1.002‒0.010; p = 0.006). Predictors of poor physical health – age ≥ 65 (OR 0,823, 95% CI 0.430–1.576; p = 0.001), obesity (OR 2,050, 95% CI 1.041–4.039; p = 0.038) and long–term CAD (OR 1.005, 95% CI 1.001–1.010; p = 0.027). Predictors of poor mental health – age ≥ 65 (OR 1.973, 95% CI 1.050–3.706; p = 0.035) and living in sparsely populated areas (OR 2.213, 95% CI 1.236–3.962; p = 0.008).Conclusion. Predictors of poor QoL before CABG are female gender, elderly age, obesity, long-term CAD and living in sparsely populated areas.

Research on the Impact of Breathing Exercises and Aerobic Exercises on Quality of Life in Patients with Bronchial Asthma: A Comparative Study

Background: Asthma is defined as a chronic inflammatory disorder of airways characterized by reversible airflow obstruction causing cough, wheeze, chest tightness and shortness of breath Crompton et al7Asthmatic attacks are set up by exposure to specific allergens such as house dust mite, pollen and animal dander. Some other factors are exercise particularly running, dyes, air pollution, infection, cigarette smoke, dry inhaled air, certain foods such as fish, eggs, yeast, and wheat which presumably reach the bronchi via blood stream. There is noticeable increase in healthcare burden from asthma in several areas of world .The most frequently mentioned aims of breathing exercises are to ‘normalize’ breathing pattern by adopting a slower respiratory rate with longer expiration and reduction of hyperventilation and hyperinflation. Training also frequently involves encouraging nasal breathing and a diaphragmatic breathing pattern.AQLQ AND SF36 questionnaire was used as outcome measure.Methods: The sample size of this study was 30 subjects with 15 subjects in each group. The group A was given breathing exercises interventions and group B was given aerobic exercises intervention. A written consent was taken from each before their participation into the study. Asthma Quality of Life Questionnaire (AQLQ) and SF-36 quality of life Questionnaire of both the groups were taken in 0 week and both groups were assigned treatment interventions and after 3 weeks the AQLQ and SF-36 quality of life questionnaire has been repeated.The independent variables in the study were Aerobic Exercises and Breathing Exercises.Conclusion: The breathing exercise intervention was effective in improving the quality of life in asthmatic patients.The aerobic exercise intervention was also effective in improving the quality of life in asthmatic patients.However, the quantum of reduction in lung obstruction and therefore, the overall improvement in quality of life found to be more significant with the aerobic exercise intervention than breathing exercise intervention. Thus,a combination of the breathing exercises and aerobic exercise should be incorporated into the pulmonary rehabilitation program of the asthmatic patients.

Exploring the psychological impact of anxiety, depression, and quality of life in patients with comorbid disease conditions post COVID-19 pandemic era

BackgroundChronic diseases and comorbidity are important predictors of depression and anxiety, the two most common disorders of poor mental health. Meanwhile, the pandemic increases anxiety and depression levels, alongside declined quality of life (QoL), the same way that comorbidities are associated with severity of COVID-19 progression. This study aimed to assess the prevalence of anxiety and depression, as well as the QoL among patients with chronic medical conditions in Amman, Jordan, in the post-pandemic period. MethodsA descriptive, cross-sectional study was conducted among patients with comorbidities using a validated questionnaire consisting of 3 parts. Anxiety and depression prevalence were assessed using the Hospital Anxiety and Depression Scale (HADS), while the QoL in terms of physical, psychological, social, emotional, and general mental health was evaluated using the SF-36 QoL questionnaire. ResultsA total of 150 participants (mean age=55±13 years) were enrolled in the study. Most participants reported a significantly elevated level of borderline abnormal or mild anxiety (44%, P<.0001). The QoL scores indicated relatively poor well-being, particularly in the physical role (29.2±45.5) and emotional role (26.2±4.0) domains (P<.05). Statistical significance was observed between HADS anxiety or depression scores and variables, such as age, education level, and comorbidities. ConclusionThis study's findings provide insights into the adverse psychiatric consequences, high prevalence of anxiety and depressive symptoms, and reduced quality of life among patients with comorbid conditions post-COVID-19 pandemic.

Effect of Orem's self-care model on the quality of life in adolescents with diabetes type 1: A randomized clinical trial

The present study aims to determine the effect of Orem's self-care model on the quality of life in adolescents with diabetes type 1. A randomized controlled trial was conducted at Guilan University of Medical Sciences in Rasht, Iran. Adolescents diagnosed with type 1 diabetes constituted the study's participants. The research enrolled 80 diabetic patients, divided randomly into two groups: the control group and the intervention group. The study employed four blocks labeled A, B, C, and D, selecting the initial block through a lottery-based method. The intervention group received a series of eight training sessions structured by the Orem’s self-care model. In contrast, the control group received standard routine education without the structured sessions aligned with the aforementioned model. The data collection instruments used in this study comprised a demographic information questionnaire, an Orem’s health status questionnaire, and an SF-36 quality of life questionnaire. The study comprised 80 diabetic type 1 patients, with 40 assigned to the control group and 40 to the intervention group. The average age of the participants was 13.40 (SD=2.25). Notably, a substantial difference was observed in the change of scores about the physical dimension between the intervention and control groups (P=0.03). Additionally, a significant disparity in mental dimension scores was observed between the intervention and control groups (P=0.02). Our investigation demonstrated that the development and execution of an educational training program grounded in the Orem's self-care model yielded an enhancement in the quality of life among adolescent patients diagnosed with type 1 diabetes.

Exploring the psychological impact of anxiety, depression, and quality of life in patients with comorbid disease conditions post COVID-19 pandemic era

BackgroundChronic diseases and comorbidity are important predictors of depression and anxiety, the two most common disorders of poor mental health. Meanwhile, the pandemic increases anxiety and depression levels, alongside declined quality of life (QoL), the same way that comorbidities are associated with severity of COVID-19 progression. This study aimed to assess the prevalence of anxiety and depression, as well as the QoL among patients with chronic medical conditions in Amman, Jordan, in the post-pandemic period. MethodsA descriptive, cross-sectional study was conducted among patients with comorbidities using a validated questionnaire consisting of 3 parts. Anxiety and depression prevalence were assessed using the Hospital Anxiety and Depression Scale (HADS), while the QoL in terms of physical, psychological, social, emotional, and general mental health was evaluated using the SF-36 QoL questionnaire. ResultsA total of 150 participants (mean age=55±13 years) were enrolled in the study. Most participants reported a significantly elevated level of borderline abnormal or mild anxiety (44%, P<.0001). The QoL scores indicated relatively poor well-being, particularly in the physical role (29.2±45.5) and emotional role (26.2±4.0) domains (P<.05). Statistical significance was observed between HADS anxiety or depression scores and variables, such as age, education level, and comorbidities. ConclusionThis study's findings provide insights into the adverse psychiatric consequences, high prevalence of anxiety and depressive symptoms, and reduced quality of life among patients with comorbid conditions post-COVID-19 pandemic.

Prevalence of Low Back Pain and Quality of Life in Healthcare Students

Low back pain is a health problem that can harm several factors related to daily life and work for the entire population. The objective was to evaluate the prevalence of low back pain and quality of life in health students. Descriptive study with a cross-sectional method composed of 74 students enrolled in nine courses related to the health area at a private higher education institution. They were assessed using the participants' general characteristics questionnaire, the Oswestry 2.0 questionnaire and the SF-36 Quality of Life Questionnaire. The majority of participants were female, aged between 20 and 30 years old, single, full-time and evening students and studying Physiotherapy and Medicine. 68.9% reported remaining in a sitting position throughout the day, 81.1% had already had attacks of low back pain during the graduation period and 10.8% were already using analgesic medication due to the presence of low back pain. The SF-36 questionnaire presented domain values ​​between 45 and 63 points. 87.8% of students were classified by the Oswestry 2.0 index as having minimal lumbar disability, 10.9% with moderate disability and 1.3% with severe disability. Most health students have a history of low back pain, but with limitations considered low

The influence of walking in an exoskeleton on rehabilitation of patients with spinal cord injury consequences

Objective: to substantiate the expediency of including training walking in an exoskeleton in the complex rehabilitation of patients with severe motor dysfunctions of the lower limbs due to spinal cord injury (SCI).Methods: 120 patients (84 men and 36 women, age 37.1 ± 8.40 years) with the consequences of SCI at the level of thoracic and lumbar spine who were in the hospital at the second stage of medical rehabilitation were examined. The duration of injury ranged from 1 year to 19 years (77.8 ± 4.05 months). All patients were divided into two groups (80 and 40 patients), comparable by sex, age, duration and severity of injury. Training walking in exoskeleton have been added in the group I rehabilitation program. ASIA, SCIM III scales and SF-36 quality of life questionnaire were used to evaluate the effectiveness of the rehabilitation measures.Results: there was an increase in the total score on SCIM III by 3.20 ± 0.50 (p = 0.05) in group I, which indicates an increase in the level of functioning and daily activity of patients. Positive dynamics was revealed when assessing the quality of life using SF-36 questionnaire: sum index reflecting the psychological component of health increased from 56,0 to 59,5 points (p = 0,05). Group II also showed positive dynamics of the analyzed indicators, but the changes by the end of the rehabilitation course were not statistically significant.Conclusion: the use of exoskeleton training walking at the second stage of medical rehabilitation increases the effectiveness of rehabilitation measures and improves the quality of life of patients with severe motor dysfunctions of the lower limbs due to spinal cord injury (SCI).

Prospective analysis of the impact of Chronic Kidney Disease on patients and caregivers

Introduction. Chronic kidney disease (CKD) has a high incidence, prevalence and morbidity and mortality among the world population, negatively impacting the biopsychosocial aspects of patients and family caregivers. Objective. To evaluate the association between the mental health of caregivers and CKD patients on dialysis. Method. A prospective cohort study, the sample included patients with CKD on dialysis at the University Hospital of the Federal University of Juiz de Fora (UFJF) and their family caregivers from 2015 to 2019. The instruments used for data collection were a sociodemographic questionnaire, the Perceived Social Support Scale (EPSS), the Hospital Anxiety and Depression Scale (HADS), the Lipp Stress Symptom Inventory (LISS), the SF-36 Quality of Life Questionnaire (SF-36), the Fatigue Pictogram. Results. Most patients were on haemodialysis for more than 4 years and were female, middle-aged, and black. Most caregivers were female, middle-aged and white. The participants in both groups predominantly married people with low levels of education. The general levels of mental health and quality of life (QoL) between patients and caregivers were similar. Conclusion. The mental health of patients and their family caregivers was similarly and negatively affected by CKD; therefore, treatment and interdisciplinary mental health care measures are urgent for this population.

Impact of insomnia and its correction on quality of life of persons with disabilities

Aim. To study the effect of insomnia on the severity of the condition and on the quality of life in patients with disabilities.Materials and methods. A prospective cohort study was conducted from 2019 to 2022, in which 100 patients took part. Patients with acute cerebrovascular accident (ACV) were selected as a clinical model of persons with disabilities. Two groups were formed from the total number of patients included in the study. 50 patients with acute cerebrovascular accident and suffering from insomnia constituted the main group, which was divided into 2 subgroups by a simple choice according to the random sampling rule in the Statistica 12 program. MG1 – the main subgroup 1–26 people who received, as part of complex therapy, a course of short-term (five sessions) cognitive-behavioral therapy for insomnia in combination with doxylamine at a dose of 15 mg 15–30 minutes before bedtime for 10 days. The second subgroup of the main group of patients (MG2) – 24 people who received only standard treatment. The comparison group (GS) (50 people) and a part (48 %) of the patients of the main group (24 people) also received only standard treatment for the underlying disease. All patients were assessed using the SF-36 Quality of Life Questionnaire, the Perrudet-Badoux, Mendelsohn, Chiche Subjective Wellbeing Scale (PSS), sleep quality questionnaires (Pittsburgh Sleep Quality Questionnaire and the Insomnia Severity Scale).Results and conclusions. Against the background of the treatment in the main group 1, there was a reduction in insomnia, as well as an improvement in the quality of life on all scales of the quality of life questionnaire and more pronounced than in the comparison group and the main group 2. Thus, the correction of insomnia in addition to the basic therapy of post-stroke patients with limited opportunities allows you to achieve a more significant result of treatment than the use of only basic therapy for patients.

Psychotherapy and chronic pain management: a quantitative study evaluating the contribution of psychotherapy to quality of life and treatment compliance in chronic disease patients

BackgroundThe psychology of pain is an important field of study that focuses on understanding the psychological factors associated with pain and developing effective approaches to its management. Pain is a complex sensation that affects a person’s phys-ical and mental well-being, and psychological factors can have a significant impact on the perception, response and coping with pain. This research study examines the contribution of psychotherapy in managing chronic pain and improving quality of life and treatment adherence.Participants and procedureThe sample consisted of 87 participants who completed the McGill Pain Assessment Questionnaire, SF-36 Quality of Life questionnaire, and the Morisky Medication Adherence Scale (MMAS-8) questionnaire. Two groups were created: one group received psychotherapy to manage pain and illness, while the other group either did not receive psychotherapy or had no contact with this therapeutic method.ResultsThe results showed that patients who received psychotherapy had higher scores in the dimensions of mental health, vitali-ty, general health, physical pain, physical functioning, and social functioning compared to patients who did not receive psy-chotherapy. Statistical analysis confirmed significant differences between the two groups. Additionally, psychotherapy was associated with higher treatment adherence, as indicated by the mean scores of patients receiving psychotherapy compared to those who did not.ConclusionsThis suggests that psychotherapy can contribute to increased treatment adherence. The results clearly show that patients who received psychotherapy have significantly higher levels of mental health, vitality, general health and functioning com-pared to patients who did not receive psychotherapy.

Monitoring the change in the quality of life of patients with post-COVID syndrome by influence on their functional status

Coronavirus disease 2019 (COVID-19) is still a major medical concern. Patients who have recovered from the infection from COVID-19 face the ordeal of post-covid syndrome. In these patients, there is a decrease in physical abilities, in particular musculoskeletal complications and post-traumatic stress, depression and chronic fatigue, which impair their quality of life. This necessitates long-term rehabilitation, which supports recovery after hospitalization. Treatment through movement is part of the rehabilitation measures contributing to the functional recovery of patients with post-covid syndrome. To study how the functional capabilities of these patients improve and how their quality of life is affected, we created a set of physical exercises to be performed at home for 6 months. At baseline and at the end of the study, patients completed the SF-36 quality of life questionnaire. The aim of the study was to track the changes in the quality of life of patients with post-covid syndrome by influencing their functional state. Our study found a decline in the quality of life of the examined patients. After the application of the kinesitherapy program, the functional status of the patients improved, their functional independence was optimized, which contributed to the improvement of the quality of life of the post-covid patients syndrome.

FRI055 LYNC-LD: Prospective Multicenter Natural History Study Of Lipodystrophy Syndromes To Determine Prevalence, Incidence And Predictors Of Diabetes And Severe Hypertriglyceridemia, And Their Complications

Abstract Disclosure: M.C. Foss de Freitas: Advisory Board Member; Self; PTC Therapeutics. D.S. Rosenberg: None. M. Celik Guler: None. M. Yosef: None. S. Khalatbari: None. R. Carman: None. A. DillGomes: None. M. Ashmus: None. C. Spino: None. B. Akinci: Advisory Board Member; Self; Aegerion Pharmaceuticals, Regeneron Pharmaceuticals. Consulting Fee; Self; Aegerion Pharmaceuticals, Regeneron Pharmaceuticals, AstraZeneca, Lilly USA, LLC, Merck &amp; Co., Novartis Pharmaceuticals, Novo Nordisk, Boehringer Ingelheim, Sanofi, Servier. R.J. Brown: Grant Recipient; Self; Regeneron Pharmaceuticals. E.A. Oral: Consulting Fee; Self; Regeneron Pharmaceuticals, Aegerion Pharmaceuticals, Ionis Pharmaceuticals Inc., Third Rock Ventures, Rejuvenate Inc. Grant Recipient; Self; Regeneron Pharmaceuticals, Aegerion Pharmaceuticals, Ionis Pharmaceuticals Inc., Novo Nordisk, Rhythm pharmaceuticals, Fractyl Laboratories, GID Dynamics. Other; Self; Aegerion Pharmaceuticals. Background: Lipodystrophy syndromes are rare disorders characterized by selective deficiency of adipose tissue leading to insulin resistance, diabetes mellitus, dyslipidemia and hepatic steatosis. We are conducting a comprehensive, multicenter and international observational registry study to document the natural history and prevalence of lipodystrophy syndromes in the contemporary era. Methods: All participants clinically diagnosed with a lipodystrophy syndrome, excluding HIV-associated lipodystrophy, at the participating centers may be enrolled. Once enrolled, demographic information and detailed medical history are obtained by the study team and from the participant. Patients are followed with reevaluations every 12 months. Participant questionnaires include the Patient Health Questionnaire (PHQ-9), the generalized anxiety disorder 7-item scale (GAD-7), the RAND SF-36 quality of life questionnaire, and a brief pain inventory (BPI). Univariable and multivariable repeated measure analyses were performed. Results: 148 individuals were enrolled from March 2018 to March 2022 (data-cut) with baseline age: 42 ± 15 years, 82% female, and BMI: 27.6 ± 6.5 kg/m2. Familial partial lipodystrophy is the most prevalent diagnosis (n=93, 65%), followed by congenital generalized lipodystrophy (n=13, 9.1%). There was a high prevalence of diabetes mellitus (77%), hypertriglyceridemia (82%), and hepatic steatosis (69%). 25% had at least one pancreatitis episode reported, with first episode of pancreatitis reported at age 30 ± 13 years. Cirrhosis was observed in 10% of the participants, with age of onset 39 ± 13 years. We observed a high incidence of depression and anxiety (47 and 45%) from medical history evaluation. The pain severity score (PSS) calculated from the BPI was positively associated with depression (PHQ9; p&amp;lt;0.0001) and anxiety (GAD-7; p=0.0003) adjusted for follow-up time. Patients with mild/moderate pain (PSS ≤4) showed a significant positive association with several Quality of Life (QoL) scores, such as physical functioning, limitation to physical health, limitation with emotional problems, and lack of energy/fatigue, social functioning, and general health (p&amp;lt;0.001 for all associations). During follow-up, we observed a decrease in triglyceride levels (from 585 ± 802 at baseline to 480 ± 486 mg/dL at year 3 (n=28)), while HbA1c increased from 7.4 ± 1.9 at baseline to 8.2 ± 2.1 % at year 3 (n=28). We observed 6 (4%) deaths during the 4-year follow-up. Conclusion: Our data may help clinicians, scientists, and patients with medical evaluation and decision-making in the clinical environment and provide insight into natural history as regulators evaluate new drugs. Presentation: Friday, June 16, 2023

Unexpected changes and associated factors of care burden among caregivers of cancer patients one year after COVID-19 outbreak

PurposeThe study aimed to evaluate the changes in the care burden and quality of life of caregivers of cancer patients and correlates of care burden during the COVID-19 pandemic. MethodsThis cross-sectional study used the census sampling technique with 260 cancer patients and their caregivers during January to March 2020 in northeast Iran. Data collection tools included the Novak and Guest Care Burden Scale, the SF-36 Quality of Life Questionnaire, and the Stress, Anxiety, and Depression Scale (DASS-21). Data were analyzed using descriptive and inferential statistics (independent t-test and multiple linear regression analysis). ResultsBaseline scores of care burden and quality of life in caregivers suggested mild to moderate care burden and a reasonable quality of life and moderate levels of stress, anxiety, and depression in patients. The post-outbreak mean scores of care burden and quality of life significantly decreased and increased, respectively (p < .001). Regression analysis showed that 39.3% of the changes in the care burden score during the pandemic could be predicted by studied variables. In exchange for increasing the quality-of-life score and daily care hours, the care burden score decreases and increases. The burden of care in caregivers was also related to the type of cancer. Care burden in the caregivers of patients with breast and neurological malignancies was lower than the caregivers of patients with gastrointestinal cancer (p < .05). ConclusionDespite the results obtained, supportive and educational interventions are needed to reduce the caregiver burden and improve the quality of life of caregivers and measure its impact on levels of psychological distress in their patients clinically.

THE IMPACT OF THE MOVEMENT CONTROL ORDER PHASES ON THE QUALITY OF LIFE AMONG MALAYSIAN UNIVERSITY STUDENTS

This study measured the impact of the different phases during movement control order on the quality of life among local Malaysian university students aged &gt;18 years old. An online survey was distributed through a social media platform during the movement control order (MCO; 20 April to 12 May 2020) and conditional movement control order (CMCO; 12 to 20 May 2020). The same participants completed the SF-36 quality of life questionnaire that assessed the overall physical health, mental health, and eight domains which are physical functioning (PF), physical role functioning (RF), bodily pain (BP), general health perceptions (GH), vitality (V), social role functioning (SF), emotional role functioning (EF), and mental health (MH) in both phases. A total of 523 participants (Male = 222, female = 301) completed the survey. A Wilcoxon signed-rank test showed that there was a significant difference in participants’ quality of life between the MCO and CMCO phases. It was revealed in comparison to the CMCO phase, the participants reported lower in both health-related and mental quality of life for PF (Z = -13.79, p &lt;.001), RF (Z = -13.59, p &lt;.001), BP (Z = -11.64, p &lt;.001), GH (Z = -12.97, p &lt;.001), V (Z = -13.15, p &lt;.001), SF (Z = -15.19, p &lt;.001), EF (Z = -13.71, p &lt;.001), and MH (Z = -8.47, p &lt;.001). In overall university students' quality of life, a better score was shown in physical health quality of life (Z = -13.98, p &lt;.001) and mental health quality of life (Z = -13.21, p &lt;.001) during CMCO compared to MCO phase. Variance experiences through the COVID-19 pandemic faced by university students during both phases of movement control order and conditional movement control order were noted to have an impact on their quality of life.

The Quality of Life of Trauma Patients with Splint Immobilization

Background: Different countries have used different methods to reduce trauma-related mortality and its complications. Objectives: Splint is a temporary and conventional method of fixing an injured organ. Therefore, evaluating the quality of life in trauma patients with splint immobilization is important. Methods: This prospective study was performed on 287 trauma patients with splint immobilization in two baseline periods and one month later in Haft-e-Tir and Rasoul-e-Akram hospitals. The Data collection tool was the SF-36 quality of life questionnaire. Paired t-test was used to assess the changes in the quality of life. SPSS version 21 was used for statistical analysis. Results: The mean quality of life in the study's first phase was 76.31 ± 9.42, and one month after splint immobilization was 76.13 ± 8.98, and there was no significant difference between the two phases. The Splint immobilization of the patients significantly affected the quality of life in 5 out of 8 dimensions. Still, the intervention increased the scores in 3 dimensions and decreased scores in 2 dimensions. The results showed that social performance (P = 0.01), energy and vitality (P &lt; 0.001), and emotional health (P &lt; 0.001) increased, and physical performance (P = 0.01) and general health (P = 0.001) decreased, and they were significantly different in the two phases. There were no significant differences between emotional limitation, physical limitation, and pain in the two phases of the study. Conclusions: Splint immobilization of patients improved the quality of life in 5 out of 8 dimensions. After a month, the trauma-related mental and physical shock did not disappear, and even the patients were more sensitive to quality-of-life questions due to time spent with splint immobilization and familiarity with its limitations. The patients tried to reflect on their dissatisfaction with splint immobilization.

Investigatıon of the effect of weight loss after laparoscopic sleeve gastrectomy on cobb angle, waist and back pain: a prospective study

BackgroundIn many studies, it has been stated that obesity causes severe increases in the risks of disc degeneration, vertebral fracture, low back, and back pain. One of the most effective treatment options for obesity is bariatric surgery. ObjectivesIn this study, the effect of weight loss on these parameters was investigated by evaluating the Cobb angle, low back, and back pain. SettingUniversity Hospital MethodsA total of 89 patients were included in the study. Laparoscopic sleeve gastrectomy (SG) was performed on all patients. In addition, Cobb angle, height, weight, and body mass index (BMI) measurements were recorded at each visit. Investigating the quality and quantity of low back pain and the loss of function caused by the patients; visual analog scale (VAS), Oswestry Low Back Pain Disability Questionnaire (OLBPDQ), Roland-Morris Disability Questionnaire (RMDQ), and SF-36 Quality of Life Questionnaire (SF36) were administered. ResultsAccording to the preoperative Cobb angles, the decrease in the 6th month (P = .029) and 12th month (P = .007) measurements after the operation was found to be statistically significant (P < .05), but it was found to be clinically insignificant. When the changes in RMDQ, OLBPDQ, VAS, and SF-36 scores were examined, the decrease in the 6th month (P = .001) and 12th month (P = .001) scores after the operation was found to be significant compared to the preoperative scores (P < .01). ConclusionsIn this study, weight loss after SG improved for patients with chronic low back and back pain and significantly improved their quality of life.