Simple SummaryIn Central Italy Apennine sheep represent the most bred species, which is still bred today in a semi-extensive manner, exploiting the natural pastures. However, the increase in summer aridity induces a decrease in the pastoral value of the grasslands, resulting in poor animal performance and production. Only research-derived innovation can support farmers’ economy in order to maintain the pastoral activities. The objective of this study was to evaluate the effects of cereals supplementation on body condition score and metabolic hormones profile in milking ewes grazing on semi-natural pastures on mid mountain rangelands. Our findings showed that feed supplementation preserves grazing ewes from the usual lowering of the body state associated to the lactation period and sustains the metabolic status of animals. Taken together, our results could represent a helpful instrument in the farm management practices.This study aimed to investigate the effects of feed supplementation on body condition score (BCS) and different metabolic hormones concentration in lactating sheep reared in Italian Central Apennine pastures during the grazing summer period. In this study, 24 Comisana x Appenninica pluriparous ewes from June until August were divided into two homogenous groups: the control group (UNS) was free to graze, while the other group (SUP), in addition to grazing, was supplemented with 600 g/day/head of cereals. At the start of the supplementation and at an interval of 9–10 days until the end of experimentation, BCS evaluation and blood withdrawal to assay nesfatin-1, insulin, glucagon, leptin, triiodothyronine and cortisol levels were performed. Univariable analysis showed no remarkable differences between the groups, while multivariable analysis suggested that the UNS group was characterized by a lower BCS and greater nesfatin-1 than the SUP group. These findings can be considered in relation to milk production, which shows a clear better persistence in the SUP group. Our results indicate that nutritional supplementation has protected ewes from the usual lowering of the body state linked to lactation and provides a good maintenance of milk production, determining also a better overall body and metabolic state of the animals, which is important at the beginning of the sexual season.