Severity Of Acne Lesions Research Articles

A cross sectional study evaluating the relationship of acne to androgenetic alopecia subtype and severity.

The circulating androgens have a role in the pathogenesis of both acne vulgaris and androgenetic alopecia; an association between these two have been found previously. The aim of this study is to investigate the relationship of the severity of acne vulgaris lesions to the subtype of AGA; and to validate the relationship between severities of acne vulgaris and AGA. This study was conducted cross-sectionally at five different dermatology clinics. Male and female androgenetic alopecia patients with comorbid acne vulgaris have been included. The age, gender, severity of acne lesions, subtype of androgenetic alopecia and the severity of androgenetic alopecia were noted. The severity of acne lesions were graded according to the Global Acne Severity Scale and androgenetic alopecia was graded according to the Hamilton and Ludwig Scales. SPSS v 21 was used for the statistical analysis. A total of 101 patients have been included (12 male and 89 female). The mean age of the patients with severe acne was statistically significantly lower (p = 0.020). The difference in terms of gender was statistically insignificant (p = 0.388). The severity of acne vulgaris was found to be independent of the severity and of the subtype of AGA; p = 0.623 and 0.870 respectively. Neither a relationship between the severity of androgenetic alopecia and severity of acne; nor a relationship between acne severity and androgenetic alopecia subtype were found in this study. Thus we report that, acne severity is independent of the subtype and stage of the co-existing androgenetic alopecia.

COPPER AND ZINC MICROMINERALS LEVELS IN PATIENTS OF ACNE VULGARIS: A CASE CONTROL STUDY

Acne vulgaris is one of the most commonly occurring inammatory disorders among various skin diseases. It is said to be the gift of pubertal age, however it stays for higher age also. Trace minerals like Copper (Cu) and Zinc (Zn) may play an important role in either cause or severity of Acne vulgaris.Present study aimed to estimate serum copper and zinc in patients of acne vulgaris. 140 acne vulgaris patients of different age group and either sex was enrolled for the study. Result showed that levels of serum Cu and Zn was decreased in patients of Acne vulgaris (94.39±28.861 and 65.39±22.104 respectively). These levels also showed signicant association with different age groups as well as grade of acne. Hence can be concluded these differences may be associated with severity of acne lesions, age and gender

A study of clinical pattern of acne vulgaris – In a tertiary care hospital in India

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units. Sebaceous gland is an important epidermal appendage involved in its pathogenesis. It is one of the most common skin condition of adolescents and adults. In this disease it develops multiple lesions like comedones, papules, nodules, cysts and scars. Factors like androgenetic hormones, amount of sebum secretion, follicular microbial flora, and fat rich diets are responsible for its cause. With this background we conducted this study of clinical pattern of acne vulgaris in a tertiary care hospital in India. To study about the clinical pattern of acne vulgaris in patients attending dermatology OPD in a tertiary care hospital in India.A total of 200 consecutive patients attending the dermatology OPD with clinical features of Acne vulgaris was included in the study. Pregnant women and patients with drug induced acne vulgaris were excluded from the study. This hospital based observational study was carried out from November 2019 to January 2020. The datas were collected in a predesigned proforma which includes age, gender, marital status, age of onset, duration, body sites involved, number and severity of acne lesions, menstrual history, features of androgenicity, post inflammatory hyperpigmentation and scarring of skin.A total of 200 Acne vulgaris patients were studied with 59% males and 41% females. Age group wise, patients above 18 years (51%) followed by 14 to 18 years (38%) were affected. The common body sites involvement were face (45%), trunk (18%) and neck (13%) are mainly involved. Acne grading shows, grade 3(53%), grade 2(21%) were involved. Males with androgenetic features were 20 patients (38%) and females were 33 patients (62%). Total number of patients having androgenetic features were 53(26.5%).

Bacteriological study of Acne Vulgaris in Cairo Egypt

Background: acne vulgaris is chronic inflammatory dermatosis of the pilosebaceous units which is characterized by open and/or closed comedones (blackheads and whiteheads) and inflammatory lesions including papules, pustules, or nodules, in some cases, is accompanied by scarring. Acne is multifactorial disease including increased sebum production, hypercornification of pilosebaceous duct, an abnormality of microbial flora especially colonization of the duct with propionibacterium acne and the production of inflammation. P.acne has been implicated in the pathogenesis of acne for more than 100 years. Objective: the present work was done to determine bacteria involved in acne vulgaris among Egyptian acne patients. Patients and Methods: this study was conducted on one hundred patients with inflammatory acne vulgaris recruited from the Dermatology outpatient clinic of Al-Hussien hospital. Results: in this study, S.epidermidis was higher in normal skin than in acne lesion. But P.acne was higher in acne lesion than in normal skin with significant statistical difference. There was a significant relation between type of organisms isolated and severity of acne lesions in both aerobic and anaerobic state. There was a significant relation between positive acne family history and liability for post acne scar. Even though there was no significant relation between hermonal therapy and severity of acne lesions. We noticed that the majority of female patients with POP history had moderate acne lesions. In this study, the high percentage of S.epidermidis was observed in moderate acne lesion and in normal skin in aeorobic state but high percentage of P.acne was found in moderate acne lesions in anaerobic state. However, P.acne can not be solely held responsible for the initiation of inflammation in inflamed acne lesions or for the variation in its severity. Conclusion: the high percentage of no growth result in this study directs us that the antibiotic treatments are not the most useful treatment for acne and there are other effective methods for treatment whether topical as retenoids or ablative as Lasers. Patient with family history of acne lesion especially first relative (mother) we must keep in mind that they are more susceptible for post acne scar so we should start with the perfect treatment as early as possible to prevent the post acne sequels.

Bacteriological study of Acne Vulgaris in Cairo Egypt

Background: acne vulgaris is chronic inflammatory dermatosis of the pilosebaceous units which is characterized by open and/or closed comedones (blackheads and whiteheads) and inflammatory lesions including papules, pustules, or nodules, in some cases, is accompanied by scarring. Acne is multifactorial disease including increased sebum production, hypercornification of pilosebaceous duct, an abnormality of microbial flora especially colonization of the duct with propionibacterium acne and the production of inflammation. P.acne has been implicated in the pathogenesis of acne for more than 100 years. Objective: the present work was done to determine bacteria involved in acne vulgaris among Egyptian acne patients. Patients and Methods: this study was conducted on one hundred patients with inflammatory acne vulgaris recruited from the Dermatology outpatient clinic of Al-Hussien hospital. Results: in this study, S.epidermidis was higher in normal skin than in acne lesion. But P.acne was higher in acne lesion than in normal skin with significant statistical difference. There was a significant relation between type of organisms isolated and severity of acne lesions in both aerobic and anaerobic state. There was a significant relation between positive acne family history and liability for post acne scar. Even though there was no significant relation between hermonal therapy and severity of acne lesions. We noticed that the majority of female patients with POP history had moderate acne lesions. In this study, the high percentage of S.epidermidis was observed in moderate acne lesion and in normal skin in aeorobic state but high percentage of P.acne was found in moderate acne lesions in anaerobic state. However, P.acne can not be solely held responsible for the initiation of inflammation in inflamed acne lesions or for the variation in its severity. Conclusion: the high percentage of no growth result in this study directs us that the antibiotic treatments are not the most useful treatment for acne and there are other effective methods for treatment whether topical as retenoids or ablative as Lasers. Patient with family history of acne lesion especially first relative (mother) we must keep in mind that they are more susceptible for post acne scar so we should start with the perfect treatment as early as possible to prevent the post acne sequels.

Acne update: 2004.

Acne vulgaris is a common skin disorder among children and young adults that carries enormous financial and psychosocial impact. Contemporary therapies attempt to address factors underlying acne as a disorder of the pilosebaceous unit. These longstanding paradigms regarding pathogenesis and treatment continue to evolve in light of recent work on this ubiquitous disease. This review focuses on new literature that has emerged regarding the biology of the folliculosebaceous unit, the identification of particular mediators responsible for inflammatory acne, the use of topical and systemic retinoids in acne therapy, and approaches to address the emergence of antibiotic-resistant Propionibacterium acnes strains. In addition, the use of several novel therapeutic avenues is discussed, including combination therapies, lipoxygenase inhibitors, and lasers. As the understanding of the factors that initiate and exacerbate acne vulgaris continues to increase, so does the diversity of therapeutic options. Rational use of available treatment options based on the type and severity of acne lesions is a key component of successful acne therapy and allows the physician who treats adolescents with acne to provide optimum care.

Comparison of the effect on acne with a combiphasic desogestrel-containing oral contraceptive and a preparation containing cyproterone acetate

Objective: To investigate the effect of a combiphasic oral contraceptive containing ethinylestradiol and desogestrel (combiphasic EE/DSG) on acne, compared with a preparation containing ethinylestradioland cyproterone acetate (EE35/CPA).Methods: An open, randomized, group-comparative, multicenter study was carried out, with 172 women randomized to treatment with either combiphasic EE/DSG (25μg desogestrel and 40 μg ethinylestradiol for 7 days followed by 125 μg desogestrel and 30 μg ethinylestradiol for 15 days) or EE35/CPA (2.0 mg cyproterone acetate and 35 μg ethinylestradiolfor 21 days). Assessments were performed at pretreatment and after cycles 3 and 6.Results: The number of comedones, papules, pustules and nodules significantly decreased in both groups overthe 6-month study. Compared with pretreatment (= 100%), the relative numbers of comedones, papules, pustules and nodules at cycle 6 significantly decreased to 37%, 38%, 19% and 12.5% in the combiphasicEE/DSG group and to 24%, 36%, 17% and 1% in the EE35/CPA group, respectively. All reductions were statistically significant (p ≤ 0.003) at both cycles 3 and 6, except for nodules at cycle 6 withcombiphasic EE/DSG, which probably resulted from differences between the treatment groups at baseline. There were no statistically significant differences between the two treatments. In both groups, themajority of women with severe acne shifted to a less severe acne category.Conclusions: Combiphasic EE/DSG progressively reduced the number and severity of acne lesions during the six cyclesof treatment. The reduction in acne with the combiphasic oral contraceptive was comparable to a preparation containing the antiandrogen cyproterone acetate.

Abrasive Cleansing in the Management of Acne Vulgaris

The comparative effectiveness of an abrasive cleaner and the same cleansing agent without the abrasive granules was evaluated using a bilateral paired comparison method in 44 patients with acne vulgaris. Lesion counts and an appraisal of the severity of disease were made every two weeks for a total of eight weeks. An equal reduction in both the number and severity of acne lesions was seen with each test product. Substantial differences between the adverse effects of these two products were not observed.

The prevalence of acne vulgaris in adolescence.

SUMMARY.— We examined 1555 school children aged 8 to 18 and graded them according to the presence and severity of acne lesions on the face and neck. Comedones were present in a large proportion of even the youngest children and were virtually universal by the mid-teens. Clinical acne appeared 2 years earlier in girls than boys and the maximum prevalence was reached at age 14 in girls and 16 in boys. Thereafter the prevalence of the more severe grades of acne continued to increase steadily in boys, but declined in girls. The age of the menarche in girls did not affect the severity of acne which ultimately developed. More girls than boys sought medical advice despite the generally milder form of the disease in girls.