Severe Pneumocystis Research Articles

Neurally Adjusted Ventilatory Assist (NAVA) Ventilation in the Management of Severe Refractory Pneumocystis jerovicii Pneumonia

Neurally Adjusted Ventilatory Assist (NAVA) Ventilation in the Management of Severe Refractory Pneumocystis jerovicii Pneumonia

Pharmacokinetics and Adverse Reactions of Various Dosage Regimens of Intravenous Pentamidine in the Treatment of HIV-Associated Pneumocystis carinii Pneumonia

The aim of this study was to compare various dosage regimens of intravenous pentamidine in the treatment of severe HIV-associated Pneumocystis carinii pneumonia. In a prospective open nonrandomised pilot study, we investigated the pharmacokinetics, efficacy and adverse reactions of different maintenance dosages of pentamidine in the treatment of Pneumocystis carinii pneumonia (PcP).

Viral Disease and Islet Cell Dysfunction

To the Editor.— Recent focus has been given to the concept that certain viral diseases may be causally related to islet cell dysfunction of the pancreas. 1-2 The experimental work of Craighead 3 and Muntefering 4 has demonstrated the existence of preferential viral receptor sites for variants of encephalomyocarditis virus on B cells, as opposed to acinar or ductal cells of the pancreas. Isolated observations in man have suggested that such a postulate might be functional in certain instances of congenital rubella infections. 5-6 Nevertheless, there has been no evidence in man that pancreatic involvement could be so extensive as to possibly impair future function. At the University of Florida, a 4-month-old girl with documented combined immune deficiency died of severe necrotizing bacterial pneumonia and Pneumocystis carinii interstitial pneumonia. In addition to severe thymic dysplasia (0.7 g), abnormal lymph nodes, and hypoplastic bone marrow, at necropsy she had massive generalized