You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Neurogenic Voiding Dysfunction (MP48)1 Apr 2020MP48-04 SEVERITY OF LOWER URINARY TRACT SYMPTOMS ASSOCIATED WITH DIABETES DURATION Aman S. Bali*, Leah G. Davis, Jonathan C. Routh, J. Todd Purves, and Charles D. Scales Aman S. Bali*Aman S. Bali* More articles by this author , Leah G. DavisLeah G. Davis More articles by this author , Jonathan C. RouthJonathan C. Routh More articles by this author , J. Todd PurvesJ. Todd Purves More articles by this author , and Charles D. ScalesCharles D. Scales More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000903.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Diabetes mellitus (DM) is a chronic condition that affects over 1 in 6 adults in the United States and is increasingly diagnosed at a younger age. In the genitourinary system, lower urinary tract symptoms (LUTS) are a prominent manifestation of diabetic bladder dysfunction (DBD). However, existing data regarding the exact impact of the duration of DM on specific LUTS is sparse, outdated, and provides conflicting evidence. Our objective for this analysis was therefore to examine the association between the duration of DM and the prevalence and severity of LUTS using current, nationally-representative, population-level data. We hypothesize that that duration of DM is associated with 4 outcomes: overall LUTS, severe irritative LUTS (UUI or nocturia), severe nocturia, and severe UUI. METHODS: We used the 2011-2016 National Health and Nutrition Exam Survey to perform a cross-sectional analysis of diabetic adults between 40 and 79 years of age. Patient-reported questionnaire responses were used to identify DM status, duration of DM, and LUTS. DM duration was calculated by subtracting reported age at diagnosis from age at survey administration. Symptom severity was categorized by self-reported frequency, with severe disease defined as incontinence multiple times weekly or nocturia 3 or more times nightly. A binary indicator variable for overall LUTS was created from questionnaire items assessing general incontinence, stress urinary incontinence, UUI, or nocturia. Adjusted multivariable logistic regression with survey weighting was used to examine the association between DM duration and LUTS within male and female subgroups. RESULTS: Among the unweighted cohort of diabetics, 66.5% (981/1476) met criteria for LUTS. On multivariable analysis, DM duration was not significantly associated with overall LUTS in men or women (odds ratio [OR] 0.99, 95%CI: 0.96-1.01; OR 0.98, 95%CI: 0.96-1.00, respectively). However, among the cohort diabetic females, the odds of severe UUI increased by 6% for each additional year of DM duration (OR 1.06, 95%CI: 1.02-1.1, P=.008). Smoking was associated with increased risk of severe UUI in both male and female diabetics (OR 5.27, 95%CI: 1.73-16.04, P=.004, and OR 2.89, 95%CI 1.41-5.95, P=.005, respectively). CONCLUSIONS: In this exploratory analysis, DM duration was not associated with overall LUTS in multivariable models. However, women had a 6% increased risk of severe UUI for each additional year of DM duration. Given an aging population and rising prevalence of DM, more work is needed to understand the mechanisms of DBD. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e695-e696 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Aman S. Bali* More articles by this author Leah G. Davis More articles by this author Jonathan C. Routh More articles by this author J. Todd Purves More articles by this author Charles D. Scales More articles by this author Expand All Advertisement PDF downloadLoading ...