Severe Myopia Research Articles

Distortion-Corrected Posterior Ocular Shape in Myopic Eyes Assessed by Ultrawide OCT Detects Deformations Associated With Vision-Threatening Changes.

To develop a quantitative tool for assessing the posterior ocular shape using widefield, volumetric optical coherence tomography (OCT) in eyes with myopia. This observational, cross-sectional study included 178 eyes from 113 participants. Participants underwent a standardized eye examination, including ocular biometry and a custom ultrawide OCT. True ocular shape was reconstructed by tracing the beam propagation from the system to the posterior eye. Gaussian curvature quantified the localized ocular shape, which was further categorized into five distinct categories. An ocular shape irregularity (OSI) was calculated using principal component analysis. Linear regression with breakpoints analyzed the relationship between ocular shape parameters and axial length (AL). Increased curvature mean and variance were associated with more severe myopia (P < 0.001). Curvature categories (convex, normal, concave, and highly concave) differed significantly between the groups (all P < 0.001). Their correlations with AL revealed significant breakpoints between 27.1 and 27.2 mm. OSI, as a single metric for quantifying ocular shape distortion, was associated with more severe myopia (P < 0.001), and its correlation with AL revealed a breakpoint at 27.2 mm with a fourfold increase in slope steepness beyond this pivot. Determination of OSI was highly reproducible and could also be obtained with fewer scans. Eyes exceeding 27.2 mm in length exhibit pronounced shape changes. Our framework can be seamlessly integrated into commercial OCTs for ocular shape deformation detection, which could aid in identifying eyes with pathologic myopia.

Correlation between choroidal thickness and the degree of myopia.

Myopia is a frequent visual problem, and the relationship between choroidal thickness (CT) and the degree of myopia has been a hot topic in myopia research. This work aimed to explore the correlation between CT and the degree of myopia, providing a reference for diagnosing and treating myopia. A cross-sectional study was conducted from September 2021 to December 2022, collecting data from 95 myopic patients aged between 18 and 50 years in the outpatient department. All subjects' CT in the macular center (MC), spherical equivalent (SE), and other ocular parameters were measured. Furthermore, the Pearson correlation coefficient (PCC) analyzed relationships between CT and various factors. The choroid was thickest in the MC and gradually became thinner towards the periphery, with the thinnest region located nasally in the healthy group. In the mild, moderate, and severe myopia groups, the choroid was thickest at 1,000 μm temporal to the fovea, becoming thinner towards the periphery, with the thinnest region located nasally. The MC's CT was correlated with a family history of myopia, SE, axial length (AL), and intraocular pressure (IOP). Meanwhile, there was a negative linear relationship between AL and CT in the MC (standard coefficient (SC) of -0.596, P-value of 0.000, tolerance of 0.217, and variance inflation factor (VIF) of 4.467), and a positive linear correlation between SE and CT in the MC (SC of 0.205, P-value of 0.013, tolerance of 0.257, and VIF of 3.792). This work provided clues for further understanding of the pathogenesis of myopic eyes and served as a scientific basis for early screening and treatment of myopia. Additionally, investigating the correlation between myopia and CT can also yield a reference for developing personalized myopia management strategies, which will help slow down myopia's progression and prevent related complications.

Correlation Between Axial Length and Amplitude of Accommodation in Myopia Patients

Background: Myopia is the most common refractive disorder and is a global concern because it can cause more serious eye problems. Excessive prolonged axial growth of the eyeball can lead to myopia. The amplitude of accommodation is the strength of the eye accommodation during the minimum and maximum accommodation conditions. Based on the above data, the researchers wanted to assess the relationship between eyeball length and accommodation amplitude in myopia patients. Method: The research was conducted at the Hospital of Prof CPL University of North Sumatra from November 2023 to March 2024. Data analysis was done analytically and presented in the form of data tabulation. Result: This study included 54 myopia patients, 27 males and 27 females, who visited the eye clinic. The mean age of the subjects was (52%). The mean age of the subjects was 23 years old with the youngest being 22 years old and the oldest being 24 years old. The mean of axial length for mild myopia, moderate myopia and severe myopia were 24.51 cm, 25.75 cm and 28.38 cm respectively. The lowest NPA value was found in severe myopia (27.33 cm) and the highest in mild myopia (43 cm). The lowest NPC value was found in mild myopia (36.61 cm) and the highest in severe myopia (38.56 cm). There was a significant relationship between eyeball length and accommodation amplitude with a Spearman correlation value of -0.685 as well as after cycloplegic administration with a Spearman correlation value of 0.438. NPA values showed an increase when receiving spherical correction, whether accompanied by cycloplegics or not, and a decrease when not receiving spherical correction. NPC values showed a decrease in all treatments. Conclusion: There is a correlation between axial length and amplitude of accomodation values (NPA and NPC) in patients with myopia.

ATROPINE FOR MYOPIA CONTROL: EFFICACY, CHALLENGES AND FUTURE DIRECTIONS

Myopia, or near-sightedness, is rapidly emerging as a major global health issue, with projections indicating that by 2050, it will affect nearly 50% of the world’s population. This condition arises from excessive elongation of the eyeball, leading to blurred vision at a distance and increasing the risk of severe ocular complications, such as retinal detachment and glaucoma. Effective management strategies are critical to mitigating the public health impact of this growing epidemic. Atropine, a muscarinic antagonist, has gained attention for its potential in myopia control. By inhibiting muscarinic acetylcholine receptors (mAChRs) in the eye, atropine slows down axial elongation, the anatomical hallmark of myopia. Low-dose atropine (0.01%) has demonstrated efficacy in clinical trials, such as the ATOM2 study, which showed a 50% reduction in myopia progression with minimal side effects, including photophobia and blurred vision. Meanwhile, the LAMP study indicates that slightly higher concentrations (0.05%) may further balance efficacy and tolerability, especially in children at high risk of severe myopia. Despite these promising results, critical knowledge gaps persist, particularly concerning atropine’s long-term safety, optimal dosing, and the rebound effect, where myopia progression may accelerate after stopping treatment. Ethnic and genetic variability also calls for a more diverse research focus. Future studies should explore combining atropine with other interventions, such as orthokeratology or multifocal lenses, to optimize outcomes. As leading pharmacological option for myopia management, atropine holds potential for integration into multifaceted treatment strategies to address this pressing public health concern. KEYWORDS: Atropine, Myopia, Pediatric Populations, Muscarinic Acetylcholine Receptors, LAMP.

Evaluation of the clinical features of an outpatient cohort with Marfan syndrome

Marfan syndrome is a connective tissue disease with autosomal dominant inheritance and variable clinical presentation. The main clinical manifestations recognition could contribute to early diagnosis and cardiovascular complication prevention. We aimed to evaluate the clinical profile of a Marfan syndrome outpatient cohort. MethodsRetrospective cross-sectional study was carried out with outpatients over 12 years of age whose electronic medical records contained the clinical information and complementary exams necessary for study inclusion. Data were analyzed using descriptive statistics and comparisons were performed using student's t-test and chi-square or Fisher's exact test. P-values<0.05 were considered statistically significant. Results75 patients (29.5 ± 13.4 years) were included and 43(57 %) were female. Positive family history for the syndrome was observed in 55(73 %) patients and ectopia lentis in 37(49 %). Positive systemic score (≥7) was identified in 60(80 %) individuals and the most frequent score components were: skin striae in 64(85 %), scoliosis in 59(79 %), wrist and thumb sign in 45(60 %), moderate or severe myopia in 43(57 %) and plain flat foot in 40(53 %). Cardiovascular symptoms occurred in 17(23 %) patients: dyspnea in 10(13 %) and palpitations in 6(8 %). Mitral valve prolapse was observed in 32(43 %) participants and aortic root dilation (z-score ≥ 2) in 53(71 %), without significant difference between the groups with or without these alterations concerning sex, age, or symptom presence. ConclusionClinical profile of a Marfan syndrome outpatient cohort includes adolescents and young adults, most without cardiovascular symptoms and with a high incidence of skeletal, ophthalmological, and cardiovascular involvement. Recognizing these clinical signs could contribute to early disease diagnosis in the general population.

Visual rehabilitation of a case of keratoglobus with ICL

This case report presents the management of a 21-year-old male with high myopic status and keratoglobus seeking refractive surgery. The patient exhibited severe myopia, poor vision, and diffuse corneal thinning with steepening in both eyes. Preoperative evaluations included corneal topography, anterior chamber depth, and pachymetry measurements. A surgical plan involving toric implantable collamer lenses (ICLs) was devised. Subsequent eye surgeries, with appropriate adjustments, resulted in improved visual acuity. This case underscores the challenges of ICL surgery in keratoglobus, the importance of meticulous preoperative assessment, and the need for individualized surgical approaches.

Comparative study of visual and refractive outcomes of laser assisted in situ Keratomileusis versus small incision lenticule extraction versus implantable collamer lens for moderate to high myopia correction

Background Myopia represents a condition of refraction, in which parallel light rays converge in front of the resting eye retina. Aim To compare the laser assisted in situ keratomileusis (LASIK) visual and refractive outcomes versus small incision lenticule extraction (SMILE) versus implantable collamer lens (ICL) while correcting cases having moderate to high myopia. Patients and methods Our research involved 60 eyes having moderate to severe myopia ranging from –3 to –10 dioptres. They divided into three equal groups, group A: through LASIK, group B: through SMILE, and group C: received an ICL. Preoperative uncorrected visual acuity, Corrected distance visual acuity, and Manifest and cycloplgic refraction assessments were accomplished. Results Postoperative uncorrected visual acuity exhibited no significant variation among groups A and B, yet a significant variation was documented among groups A and C as well as among groups B and C P less than 0.001. The postoperative spherical error showed no significant variation among groups A and B nor among groups B and C yet exhibited significant variation among groups A and C P=0.002. Postoperative astigmatism was no significant variation among groups A as well as B, yet a significant variation was documented among groups A and C in addition to between groups B and C. Postoperative spherical equivalent was a significant variation among groups A and C P less than 0.001 and among groups B and C P less than 0.001. Conclusion Visual outcomes were comparable between LASIK, SMILE, and ICL. The three procedures exhibited superior effectiveness, safety, stability, and accuracy in the treatment of moderate and high myopia.

Cromosome X-linked pigmentary retinosis

To report a clinical case of X-linked Retinitis pigmentosa, highlighting the importance of complementary studies and genetic testing, to the patient and his family, to identify the underlying mutation. A 10-year-old boy was brought to the clinic for refractive changes and difficulty seeing at night (nyctalopia). As a relevant family history, the maternal grandmother had Retinitis pigmentosa and the mother had high myopia (14.0 D). On ophthalmologic examination she had 4/10 corrected vision in both eyes, with moderate to severe myopia. Fundus examination showed diffuse mottled pigmentary changes with multiple yellowish-white dots distributed throughout the midperiphery, with arteriolar attenuation and mild bilateral optic nerve pallor. Autofluorescence showed a hyperautofluorescent ring around the macula and more peripheral hypoautofluorescence. On optical coherence tomography the ellipsoid zone is preserved centrally and these outer layers are thinned towards the periphery. The flash electroretinogram showed a dysfunction of both cones and rods that is not absolute. Regarding the genetic study, a variant in hemizygosis has been identified in the RPGR gene, being this result compatible with X-linked retinitis pigmentosa. In conclusion, it is of high relevance that those patients in whom we suspect a cone and rod dystrophy are extensively studied by a complete ophthalmologic examination, complementary studies, electrophysiologic and fundamentally genetic studies to identify the underlying mutation, since the advent of gene therapy could provide them with a better quality of life.

Clinical Efficacy of MiSight 1 day Soft Contact Lenses in Korean Myopic Children.

This study aimed to investigate the clinical efficacy of MiSight 1 day soft contact lenses (MiSight CL) in Korean children with mild-to-moderate myopia. In addition, the study compared the effects of MiSight CL in children who had or had not previously used orthokeratology contact lenses (Ortho-K). A total of 66 children aged 5 to 16 years, who were prescribed MiSight CL, were included in the study. Based on a myopia degree of -4 diopters (D), children were divided into mild and severe myopia groups to compare the effectiveness of myopia suppression. In addition, 55 eyes previously using Ortho-K were compared with 76 eyes using MiSight CL for the first time. The average follow-up period was 6.58±3.74 months. The average refractive value before using MiSight CL was 3.64±1.56 D, and there was no significant change in the final visit. Comparing myopia suppression between different degrees of myopia and previous use of Ortho-K lenses, there was no significant change in refractive error before and after using MiSight CL (unpaired t test, P >0.05). The main reason for Ortho-K failure was low visual acuity after correction. Regardless of Ortho-K history, children showed good visual acuity after wearing MiSight CL, and no other side effects were observed. MiSight CL effectively inhibited the progression of myopia in Korean children with mild-to-moderate myopia. MiSight CL offer the advantage of easy application, making them a viable alternative when Ortho-K are not suitable.

Effect of Lens Deviation on Peripheral Defocus and Optic Quality in Adolescents With Moderate and Severe Myopia.

The aim of this study was to analyze the effects of lens deviation on peripheral defocus and optic quality in adolescents with moderate and severe myopia. This prospective study enrolled 81 children (81 eyes). The spherical equivalent was -5.0≤SE≤-6.0 diopter. The participants were divided into two subgroups based on their eccentricity (inferior temporal) after wearing the lenses for 12 months. Between them, the low eccentric subgroup (A) had a total eccentric distance of less than 0.5 mm, and the moderate and severe eccentric subgroup (B) had a total eccentric distance of ≥0.5 mm. Peripheral defocus and eccentricity were measured before and after wearing the lenses, and the Spearman test was used to compare the parameters. Parameters such as the total peripheral defocus (TRDV) were significantly lower in subgroup B than in subgroup A after 12 months of orthokeratology lens usage. The axial length growth (ΔAL) in subgroup A was higher than that in subgroup B. Axial length growth, TRDV, and other parameters were significantly associated with eccentricity. The modulation transfer function cutoff and Strehl ratio were also significantly associated with eccentricity. Greater eccentricity within a certain range can induce greater periretinal defocus and improve the ΔAL.

The Importance of the Type of Posterior Staphyloma in the Development of Myopic Maculopathy.

The objective of this paper was to determine how different types of posterior staphyloma (PS) may affect the appearance and degree of myopic maculopathy. A cross-sectional study was conducted, in which 467 eyes from 246 highly myopic patients [axial length (AL) ≥ 26 mm] were studied. A complete ophthalmic exploration was carried out on all patients, including imaging tests. The presence of macular PS was established as the main comparison variable between groups (macular PS vs. non-macular PS vs. non-PS). The variables analyzed included age, AL, decimal best-corrected visual acuity (BCVA), Atrophy (A)/Traction (T)/Neovascularization (N) components according to the ATN grading system, and the presence of severe pathologic myopia (PM). Out of the total, 179 eyes (38.3%) presented macular PS, 146 eyes presented non-macular PS (31.2%), and 142 eyes showed no PS (30.4%). The group without PS was significantly younger than macular PS and non-macular PS groups (53.85 vs. 66.57 vs. 65.20 years; p < 0.001 each, respectively). There were no age differences between PS groups. Eyes with macular PS (31.47 ± 2.30 mm) were significantly longer than those with non-macular PS (28.68 ± 1.78 mm, p < 0.001) and those without PS (27.47 ± 1.34 mm, p < 0.001). BCVA was significantly better in the non-PS group (0.75 ± 0.27) compared to the non-macular PS (0.56 ± 0.31) and macular PS groups (0.43 ± 0.33), with p < 0.001 each. Eyes without PS showed significantly lower A and T components (1.31 ± 0.96 and 0.30 ± 0.53, respectively) than non-macular PS (2.21 ± 0.75 and 0.71 ± 0.99, respectively, p < 0.001 each) and macular PS eyes (2.83 ± 0.64 and 1.11 ± 1.10, respectively, p < 0.001 each). The N component was lower in non-PS eyes vs. non-macular PS eyes (0.20 ± 0.59 vs. 0.47 ± 0.83, p < 0.001) and as compared to the macular PS group (0.68 ± 0.90, p < 0.01). Additionally, the N component was significantly lower in the non-macular PS group than in the macular PS one (p < 0.05). The prevalence of severe PM was different between groups (p < 0.001). It was higher among macular PS eyes (138/179) when compared to other groups (p < 0.001, each), followed by the non-macular PS eyes (40/146) and being the lowest in the non-PS group (20/142). To conclude, macular PS is associated with a more advanced maculopathy, worse vision, and higher rates of severe PM.

Evaluation and application of a Chinese version symptom questionnaire for visual dysfunctions (CSQVD) in school-age children

ObjectiveTo develop and evaluate a Chinese version of the Symptom Questionnaire for Visual Dysfunctions (CSQVD) to quantify visual dysfunction symptoms in school-age children with various eye diseases, and to explore the relationship between ophthalmological disorders and visual dysfunction symptoms. MethodsFollowing standard scale adaptation procedures, the Symptom Questionnaire for Visual Dysfunctions (SQVD) was translated into Chinese (CSQVD). We employed random sampling to survey 198 outpatients aged 7–18 to assess the psychometric properties of the CSQVD. Using the reliable and validated questionnaire, we evaluated the determinants of visual dysfunction symptoms among 406 school-age patients at an eye center. The CSQVD scores were correlated with demographic and clinical variables, including gender, age, eye position, refractive power, and best-corrected visual acuity. Univariate analysis identified potential risk factors, followed by binary logistic regression and multiple linear regression analysis on factors with a P-value <0.05. ResultsThe CSQVD scale's critical ratio (CR) values ranged from 6.028 to 10.604. The Cronbach's Alpha coefficient was 0.779, and Spearman-Brown split-half reliability was also 0.779. The I-CVI varied from 0.83 to 1.000, the S-CVI/Ave was 0.857, and the KMO value was 0.821. Multifactorial regression analysis indicated that high myopia (OR ​= ​5.744, 95% CI [1.632, 20.218], P ​= ​0.006) and amblyopia (OR ​= ​9.302, 95% CI [1.878, 46.058], P ​= ​0.006) were significant predictors of CSQVD symptoms. Multiple linear regression analysis showed that BCVA of amblyopic eyes (B ​= ​−5.052, 95% CI [−7.779, 2.325], P ​= ​0.000) and SE power (B ​= ​−0.234, 95% CI [−0.375, 0.205], P ​= ​0.001) significantly affected the CSQVD scale scores. ConclusionsThe Chinese version of the SQVD scale (CSQVD) demonstrates good feasibility, discriminatory power, validity, and reliability in assessing Chinese school-aged children. Furthermore, those who have severe myopia and amblyopia reported more visual dysfunction symptoms.

Visual functions, ocular characteristics and visual quality of life in patients with homocystinuria

ABSTRACT Background Homocystinuria (HCU) is a rare metabolic disease that affects many organs, including the eyes. Aims: to assess visual functions, ocular characteristics, visual quality of life and time from the onset of ocular manifestations to HCU-diagnosis in patients with HCU. Material and methods Eighteen patients underwent ophthalmological examinations and visual quality of life questionnaires. Results Best corrected decimal visual acuity was median 1.0 (range amaurosis - 1.3) right eye and 1.0 (range amaurosis -1.3) left eye. Five patients presented with severe myopia as first HCU manifestation, duration to HCU diagnosis was mean 13.6 years (range 2-25). Two patients had suffered ectopia lentis as first HCU manifestation, HCU diagnosis was established mean 8.0 years (range 7-9) later. One patient had suffered both from thrombosis and ectopia lentis prior to diagnosis. Another four patients suffered thromboembolic events before diagnosis. Median VFQ-25 composite score was 93 (68-98). Conclusions The prevalence of myopia, ectopia lentis and monocular blindness was high in HCU-patients, which was reflected in their visual quality of life. Diagnosis was often delayed after the first ocular manifestation, increasing the risk of other severe non-ocular complications.

Refractive Lens Exchange after Implanted Collamer Lens: A Case Report

Introduction: Myopia stands as a prevalent ametropic condition. Posing ongoing challenges for ophthalmologists. Surgery to correct refractive errors is a primary intervention for severe myopia, encompassing procedures like the removal of the crystalline lens coupled with the placement of an intraocular lens (IOL), and the insertion of phakic IOL. The Implantable Collamer Lens (ICL) is commonly utilized in the posterior chamber but carries potential risks including the disruption of the eye’s normal function, potentially leading to conditions like cataracts and glaucoma. Methods and Purpose: This case report explains a single case patient with ICL that includes previous clinical condition, current condition, steps of surgical procedure, and follow-up after procedure. Case Illustration: We present the case of a 66-year-old male patient who came to the hospital for refractive surgery due to a cataract with a history of implantable collamer lens (ICL) for high myopia. Cataract surgery was performed after an explanation of the ICL followed by an implanted capsular tension ring (CTR) and IOL. Discussion: Several cases of patients using ICL will have complications such as glaucoma and cataracts. Determining ICL design will influence the progression of these complications. An explanation procedure by tuck and pull method is needed for age-related cataract patients. Conclusion: ICL is a safe procedure for high myopia patients. Explanation of ICL can be performed by several medical conditions.

PRESERFLO MicroShunt in Severe Myopia: A Case Report and Review of the Literature.

The PRESERFLO™ MicroShunt (MP; Santen Inc., Osaka, Japan) is a minimally invasive bleb surgery (MIBS) manufactured to treat primary open-angle glaucoma (POAG), with lower postoperative adverse effects than with conventional filtering surgeries. We describe here the case study of a 58-year-old woman who presented with bilateral severe myopia with bilateral advanced POAG and unreached target pressure under quadritherapy, who was successfully managed by PM surgery. A review of the literature completes our observation. At presentation, the patient had a spherical equivalent of - 7.50 RE and - 7.75 LE with an IOP of 22 mmHg right and left eye (RLE) under quadritherapy, and with severe bilateral visual field loss, including scotomas within the central 5°. The patient presented with systemic hypertension treated with an antihypertensive drug. Two selective laser trabeculoplasties (SLT), performed 3 months apart, were first tried on the LE, without any change in IOP at 2 months. After considering the high risk of postoperative complications, a PM operation was proposed, with a targeted IOP in the mid-fifteens RLE. The patient's eyes underwent PM surgery with mitomycin C (MMC) MMC0.2 mg/mL for 3 minutes without any complications. The LE required 2 consecutive needlings with 1 mL MMC0.2 mg/mL. At 24 months after surgery, the two eyes gave successful results without the need for any additional medical therapy, and with well-functioning conjunctival blebs. The PM was an effective alternative to the gold standard trabeculectomy in our severely myopic patient. A comparative study between conventional filtering operations and this MIBS in highly myopic patients would confirm our observation.

PAX6 gene promoter methylation is correlated with myopia in Chinese adolescents: a pilot sutdy

ABSTRACT Purpose A large number of epidemiological studies have shown that myopia is a complex disease involving genetic, environmental, and behavioral factors. The purpose of this study was to explore the role of PAX6 gene methylation in myopia in Chinese adolescents. Methods Eighty junior high school students were divided into four groups based on their vision test results: mild myopia, moderate myopia, severe myopia, and non-myopia control. The methylation level of PAX6 gene promoter was detected by bisulfate pyrosequencing. Results The methylation level of PAX6 gene in myopia group (8.06% ± 1.43%) was slightly but significantly higher than that in non-myopia controls (7.26% ± 1.17%). In addition, PAX6 gene methylation levels presented a decreasing pattern along with the aggravation of myopia. Post-hoc analysis indicated significant inter-group differences for the mild myopia group and other groups (All p < .05). In the subgroup analysis by gender, the methylation level of PAX6 gene promoter in girls was higher than that in boys (p = .023). The ROC curves showed a high accuracy of PAX6 gene methylation to predict mild myopia (AUC (95% CI) = 0.828 (0.709–0.947), p < .001). Conclusions The methylation of PAX6 gene might play a role in the onset and progression of myopia in Chinese adolescents. And this could potentially explore the potential molecular mechanisms of juvenile myopia in the future.

Correlation of Refractive Error with Anisometropia Development in Early Childhood

This study aims to investigate the relationship between the type and severity of refractive error and anisometropia development in preschool children. Retrospective cohort study. Data from Maccabi Healthcare Services, Israel's second-largest Health Maintenance Organization (HMO), were analyzed. The study included all isometropic children aged 1 to 6 years, re-examined for refraction at least 2 years following their initial examination between 2012 and 2022. Anisometropia was defined as a ≥1 diopter interocular difference in spherical equivalent. Relationships were assessed using logistic regression models adjusted for key sociodemographic factors. Among 33,496 isometropic children (51.2% male, mean age 3.2 ± 1.5 years), the prevalences of emmetropia, myopia, and hyperopia were 26.7% (n = 8944), 4.2% (n = 1397), and 69.1% (n = 23,155), respectively. Over a mean follow-up period of 5.1 ± 2.4 years, 2593 children (7.7%) were diagnosed with anisometropia. Adjusted odds ratios (ORs) for anisometropia gradually increased with baseline refractive error severity, reaching 13.90 (5.32-36.34) in severe myopia and 4.19 (3.42-5.15) in severe hyperopia. This pattern was also evident in cylindrical anisometropia, where ORs increased with greater baseline astigmatism, peaking at 12.10 (9.19-15.92) in children with high astigmatism (≥3 D). Associations remained consistent in sensitivity and subgroup analyses including across both sexes and when using a stricter anisometropia criterion. Children aged 1 to 6 years, initially without anisometropia but showing increasing severity of myopia, hyperopia, or astigmatism, are more likely to develop anisometropia. This underscores the importance of follow-up refractive measurements within this population to promptly diagnose and treat anisometropia and prevent potential visual complications.

Astigmatism and maternal myopia as important factors affecting success rate of DIMS lens treatment

ObjectiveTo assess the efficacy of myopia control spectacle lenses (defocus incorporated multiple segments/DIMS) in slowing myopia progression among a diverse Central European paediatric population and investigate the contribution of baseline...

Characterization of Corneal Biomechanics Using CORVIS ST Device in Different Grades of Myopia in a Sample of Middle Eastern Ethnicity.

To characterize corneal biomechanical properties using the CORVIS-ST device in myopic individuals. This prospective cross-sectional study included patients with myopia. Our study included 154 eyes of 154 myopic patients aged between 18 and 40 years, with stable refraction for at least 2 years. A full ophthalmological examination and corneal tomography were performed using a Pentacam HR device. Corneal biomechanical parameters were assessed using the CORVIS-ST device in mild, moderate, severe, and extreme myopia groups. Statistically significant differences were observed in the DA ratio (p = 0.033), SP-A (p=0.009), CBI (p=0.041), SSI (p=0.000), and Peak distance (p = 0.032). In correlation with different Corvis ST biomechanical variables, SE was found to be correlated with DA ratio(r=-0.191, p=0.018), SP-A(r=0.199, p=0.013) and SSI(r=-0.336, p=0.000), while in multiple regression analysis, SE was found to be independently correlated with SSI and peak distance(p=0.036,0.038 respectively) while the grade of myopia was found to be independently correlated with SP-A(p=0.034). SSI, Peak distance, and SP-A were independently related to SE and myopia grade, confirming the hypothesis that eyes with higher myopia are more deformable and less stress resistant.

Correlation Between Axial Length And Melatonin Serum Levels (Mel) In Teenagers With Myopia

Abstract&#x0D; Introduction &amp; Objectives : To determine correlation between axial length and melatonin serum levels (mel) in teenagers with myopia&#x0D; Methods : This research is an analytic observational with a case control design. A total of 52 subjects with myopia eyes in the study and control group.&#x0D; Results : The average melatonin level in the case group was 179.67 pg/mL (SD = 146.48 pg/mL) in the control group, the average was 111.56 pg/mL (SD = 48.72 pg/mL). Melatonin levels were highest in the group of subjects with severe myopia with an average of 250.36 pg/mL (SD = 304.89), moderate myopia with an average of 188.93 pg / mL (SD = 131 pg/mL), and the lowest melatonin levels in the emmetropic group with a mean of 111.56 pg/mL (SD = 48.72 pg/mL). Using the Kruskal Wallis test showed that there were differences in melatonin levels based on the degree of myopia (p = 0.278). Melatonin levels differed significantly between emmetropic subjects with mild myopia (p = 0.014), moderate myopia (p = 0.012). However, there was no difference in melatonin levels between subjects with emmetropia and severe myopia (p = 0.338)&#x0D; Conclusion : There was no significant correlation between melatonin levels and axial length (p = 0.401) and the degree of myopia (p = 0.055)