Severe Gastrointestinal Symptoms Research Articles

Endoscopic and pathological manifestations of the gastrointestinal tract in familial amyloidotic polyneuropathy type I (Met30).

To evaluate the characteristic changes in the gastrointestinal tract in familial amyloidotic polyneuropathy (FAP) (Met30), both fibre gastroscopy and colonoscopy studies were performed in FAP (Met30) patients. Microscopic changes were also examined in autopsied and biopsied materials from patients with FAP, and compared with data from autopsied samples from patients with AL amyloidosis, and secondary amyloidosis patients. Endoscopic and histopathological study. Kumamoto University Hospital, Kumamoto, Japan. Nine patients with FAP (Met30) underwent fibre gastroscopy and colonoscopy. Six autopsied and 23 biopsied gastrointestinal samples from FAP patients, four from autopsied amyloidosis (including two myeloma associated form), and two from autopsied secondary amyloidosis patients were examined for histopathological study. Fibre gastroscopy and colonoscopy were employed for macroscopic study. Congo red and H-E staining were performed for histopathological study. Macroscopic changes in the gastrointestinal tract and microscopic differences in the amyloid distribution pattern were compared between the different types of amyloidosis. Fibre gastroscopy and colonoscopy for nine FAP patients revealed that four showed a fine granular appearance in the duodenum, three showed lack of lustre, and two showed mucosal friability in the gastrointestinal tract; however, no macroscopic abnormality was observed in four other FAP patients. Histopathological examination of tissue from FAP patients revealed that, although a small amount of amyloid was recognized in the submucosa perivascular layer, a significant amount of amyloid was seen in and around the nerves of the gastrointestinal tract, but very little in Auerbach's nerve plexus. In total, the amount of deposited amyloid in the tissues was small compared with that in other types of systemic amyloidosis, such as AL and secondary amyloidosis. These results suggest that the major reason why FAP patients show such severe gastrointestinal symptoms, compared with other types of systemic amyloidosis, may be because of the deposition of a significant amount of amyloid in the nerves in the gastrointestinal tract.

A New Rapidly Disintegrating Formulation of Cisapride is Bioequivalent to Standard Cisapride Tablets in the Elderly

Thirty-six healthy, elderly subjects were enrolled in an open-label, randomised, crossover study to determine the relative bioavailability of a new, rapidly disintegrating formulation of cisapride (Propulsid® Quicksolv®) compared with the currently marketed cisapride preparation (Propulsid®). Subjects received a single 10mg dose of each formulation, separated by a 1-week washout period. Blood samples for determination of cisapride concentrations were taken regularly until 48 hours after drug administration. After ingestion of Propulsid Quicksolv, the log-transformed least square means value for area under the plasma concentration-time curve up to the last measurable time-point (AUClast) was 444.9 µg/L·h, AUC extrapolated to infinity (AUC∞) was 488.8 µ,g/L·h, and maximum plasma drug concentration (Cmax) was 43.3 µg/L. After ingestion of Propulsid®, the corresponding values were 449.1 µg/L·h, 513.7 µg/L·h, and 43.9 µg/L, respectively. The limits of the 90% confidence intervals for these log-transformed parameters were all within the range set to declare bioequivalence (80 to 125%). Mild to moderately severe gastrointestinal symptoms occurred in one subject after administration of Propulsid® Quicksolv®. Neither formulation was orally irritating, and no clinically significant changes in vital signs, ECGs or laboratory test parameters were noted. The 10mg Propulsid® Quicksolv® tablet was bioequivalent to the marketed Propulsid® tablet in healthy, elderly subjects and was also a convenient, well-tolerated alternative to the Propulsid® tablet.

Olestra's Effect on Vitamins D and E in Humans Can Be Offset by Increasing Dietary Levels of These Vitamins , ,

One hundred two normal healthy males and females were given 0, 8, 20 or 32 g/d olestra to which had been added graded amounts of vitamins A, D and E for 8 wk in a parallel, double-blind study. The primary purpose of the study was to determine the amounts of vitamins D and E needed to offset the effect of olestra on the availability of these vitamins. Serum concentrations of retinol, carotenoids, 25-hydroxyvitamin D metabolites, α-tocopherol, phylloquinone, lipids, ferritin and total iron, iron-binding capacity and hematology parameters, plasma concentrations of des-γ-carboxyprothrombin and prothrombin, and urinary γ-carboxyglutamic acid (Gla) excretion were measured biweekly. Clinical chemistry and urinalysis parameters, vitamin B12 absorption, and serum 1,25-dihydroxyvitamin D concentration were measured at wk 0 and 8. Serum concentrations of α-tocopherol and 25-hydroxyergocalciferol were restored to control concentration by adding 2.1 mg d-α-tocopheryl acetate and 0.06 μg ergocalciferol per gram of olestra, respectively, to the diet. Olestra reduced serum concentrations of 25-hydroxyergocalciferol, carotenoids and phylloquinone in a dose-responsive manner but did not affect Gla excretion, plasma des-γ-carboxyprothrombin and prothrombin concentrations, overall vitamin D status, vitamin B12 absorption or iron status. Laboratory evaluations showed no olestra-related effects. Subjects in all groups reported mild to moderately severe transient gastrointestinal symptoms. These symptoms did not affect study compliance or the integrity of the data.

Psychiatric Disorder and Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a common yet poorly understood functional bowel disorder. A multi-factorial aetiology has been proposed, and abnormalities in colonic motility, small bowel motility and visceral sensation have been observed experimentally. More recently, attention has turned to a quite distinct abnormality, namely psychological function. Studies have shown that for a significant proportion of the IBS population, co-morbid psychiatric disturbance may be aetiopathological, with the physical abnormalities described occurring in response to stress or anxiety induced experimentally. Others have suggested that psychological distress may occur as a result of severe gastrointestinal symptoms, and that psychosocial factors may be related to the presentation rather than genesis of the symptoms. Many of these studies contain methodological inadequacies which may adversely affect the results obtained. Comparison between studies, which may provide further insight, is often difficult due to inconsisten...

Referral of Asian patients to a GI clinic

This study compared gastrointestinal (GI) symptoms and psychiatric morbidity in consecutive new out-patients presenting to a district general hospital. In a 6-month period 36 patients of South Asian origin were referred to the clinic. They were compared in terms of GI symptoms and psychiatric morbidity with white European controls, both with a large sample of clinic attenders, and with a subsample of 36 matched for age, gender, and diagnosis. A total of 72% (26 of 36) of Asian patients had functional GI disorders compared to 48% (42 of 88) of white patients ( p < 0.05). However, comparisons of matched patients showed that Asian patients with functional GI disorders had less severe GI symptoms than the matched white patients, and fewer had psychiatric disorder (23% of Asians and 42% of white Europeans). These results suggest that the threshold for referral for Asian patients with functional GI disorders to hospital clinics is lower than for white patients. Detection and management of somatization in Asian patients in primary care need to be improved, and referral patterns of general practitioners need to be explored in future research.

Intestinal IgA deposition in Henoch-Schönlein purpura with severe gastro-intestinal manifestations.

In patients with Henoch-Schönlein purpura (HSP) presenting with severe gastro-intestinal (GI) symptoms, IgA deposition was studied in endoscopically obtained mucosal biopsies. A total number of 11 patients (male, 7; female, 4) were enrolled in this study; 7 patients underwent upper GI endoscopy and biopsy 1 underwent sigmoidoscopy and 3 underwent both. Upper GI endoscopy in each patient showed various mucosal changes including redness, petechiae, erosions, and ulcerations, most predominant in the second part of the duodenum. Sigmoidoscopy demonstrated no abnormality in two of four patients. Intestinal deposition of IgA was positive in 7 of 11 patients with HSP. Histological examination showed non-specific inflammation of varying degrees in each patient, but no small vessel vasculitis was observed. IgA deposits were seen in only 2 of 23 control subjects with various GI diseases. Positive rate of IgA deposition per patient was significantly higher in patients with HSP than in controls (P < 0.005). IgA deposition in the GI tract, as in the skin and kidneys, is characteristic of HSP. Intestinal IgA deposition complements the diagnostic criteria of HSP.

Obturator hernia: Current diagnosis and treatment

Obturator hernia is a rare pelvic hernia for which both diagnosis and therapy are difficult. Because symptoms are nonspecific and specific physical findings are often obscure, diagnosis of obturator hernia is often delayed until laparotomy for bowel obstruction. Strangulation is frequent, and mortality remains high (25%). Primary closure of the hernia defect is difficult because adjacent tissues are not easily mobilized. Although a variety of techniques have been described, surgical repair has not been standardized. We report a case of bilateral obturator hernia with incarceration in association with bilateral femoral hernia in which these problems were satisfactorily addressed. The hernias were diagnosed by computed tomography (CT) scan and repaired with synthetic mesh placed in the preperioneal space. This technique is well suited to unilateral and bilateral combinations of obturator, inguinal, and femoral hernias. CT scan in the work-up of severe gastrointestinal symptoms with weight loss may lead to a diagnosis of occult hernia, thereby allowing elective repair and, hopefully, a reduction in mortality risk. We recommend CT scan for suspected obturator hernia and preperitoneal mesh repair of noninfected cases.

Gastrointestinal motility disorders in patients with diabetes mellitus.

Disturbed gastric and small intestinal motility is an often overlooked clinical problem. Delayed gastric emptying of liquid and/or solid food in patients with type 1 and type 2 diabetes (gastroparesis diabeticorum) occurs in approximately 50% of the patients. Also, the interdigestive gastric and small intestinal motility is often affected. There is only a weak correlation between symptoms and objectively measurable motor disturbances. Patients with severe upper gastrointestinal symptoms usually have disturbed motility, but most patients with impaired motility are asymptomatic. Recent studies have clearly shown that, in addition to autonomic neuropathy, acute metabolic derangements are likely to contribute to disturbed motility. Elevated glucose levels impair gastric and small intestinal motility during fasting and after food intake. Hyperinsulinemia per se has effects similar to hyperglycaemia on the stomach and small bowel, and may be a mediator of the effects of hyperglycaemia in healthy subjects. The impact of insulin on motility in diabetic patients is still unclear. Treatment of the gastric motility disorder should include a stabilization of gastric emptying. Different therapeutic modes may be useful, e.g. application of prokinetic drugs and optimizing the metabolic situation.

Reversibility of nephrotoxicity and severe gastrointestinal symptoms associated with FK506 immunosuppression in liver transplant recipients

Reversibility of nephrotoxicity and severe gastrointestinal symptoms associated with FK506 immunosuppression in liver transplant recipients

Duodenal Findings on Ultrasound in Children with Schonlein—Henoch Purpura and Gastrointestinal Symptoms

SummaryAbdominal ultrasonic examination was performed in 14 patients with Schonlein‐Henoch purpura (SHP). Thickening of the duodenal wall was observed in nine (82%) of the 11 with such gastrointestinal (GI) symptoms as severe abdominal pain or bleeding. The thickened duodenal wall showed a high echogenicity. Enlargement of the duodenal lumen was seen in seven (64%) patients with GI symptoms. These findings had been observed in four patients before SHP was diagnosed on the basis of the peculiar skin lesions. In three cases of SHP without GI symptoms, those changes were absent. Four cases of ulcerative colitis, three of bacterial enterocolitis (two Yersinia and one Klebsiella), and five without SHP and any GI problems did not exhibit such duodenal abnormalities. On subsequent endoscopic study, mucosal edema and multiple hemorrhagic erosions were seen, especially at the second portion of the duodenum in two cases of SHP. Biopsy specimens from the duodenum of those cases showed leukocytoclastic vasculitis, suggested by the ultrasound (US) findings. It is important to consider the duodenal changes carefully when US is performed in patients with severe GI symptoms of unknown origin. The characteristic duodenal findings described suggest the differential diagnosis of SHP, which usually requires no surgical intervention.

Duodenal findings on ultrasound in children with Schonlein-Henoch purpura and gastrointestinal symptoms.

Abdominal ultrasonic examination was performed in 14 patients with Schonlein-Henoch purpura (SHP). Thickening of the duodenal wall was observed in nine (82%) of the 11 with such gastrointestinal (GI) symptoms as severe abdominal pain or bleeding. The thickened duodenal wall showed a high echogenicity. Enlargement of the duodenal lumen was seen in seven (64%) patients with GI symptoms. These findings had been observed in four patients before SHP was diagnosed on the basis of the peculiar skin lesions. In three cases of SHP without GI symptoms, those changes were absent. Four cases of ulcerative colitis, three of bacterial enterocolitis (two Yersinia and one Klebsiella), and five without SHP and any GI problems did not exhibit such duodenal abnormalities. On subsequent endoscopic study, mucosal edema and multiple hemorrhagic erosions were seen, especially at the second portion of the duodenum in two cases of SHP. Biopsy specimens from the duodenum of those cases showed leukocytoclastic vasculitis, suggested by the ultrasound (US) findings. It is important to consider the duodenal changes carefully when US is performed in patients with severe GI symptoms of unknown origin. The characteristic duodenal findings described suggest the differential diagnosis of SHP, which usually requires no surgical intervention.

Effect of Cisapride Therapy for Severe Dyspepsia on Gastrointestinal Symptoms and Quality of Life: General Discussion

Quality of life measures have received little attention in evaluation of therapy for dyspepsia. To examine the effect of cisapride on gastrointestinal symptoms and quality of life measures, we studied eight patients with chronic, severe dyspepsia, before and after therapy with cisapride (20 mg three times daily) for 12 months. Gastrointestinal (GI) Total Symptom Score (TSS), Overall Patient Assessment (OPA), and quality of life by both trait (Minnesota Multiphasic Personality Inventory (MMPI)) and physical function (Sickness Impact Profile (SIP)) were measured at base line and at month 12 of cisapride therapy. Results showed significant improvement in TSS, OPA, and the MMPI Depression and Anxiety scales (all, p < 0.05). Improvement in the SIP physical dimension score approached significance (p = 0.065). We conclude that, in this group of patients with severe dyspepsia, both GI symptoms and quality of life measures improved with 12 months of cisapride therapy. These quality of life measures may prove useful in evaluating the efficacy of drug treatment for dyspepsia.

The spectrum of CFTR mutations in south-west German cystic fibrosis patients

The cystic fibrosis transmembrane conductance regulator (CFTR) gene of 110 cystic fibrosis (CF) patients from the south-west of Germany was screened for 12 different mutations. This analysis resulted in an identification of 79% of all CF mutations and a complete genotype in 66% of the families. The most common mutation found was delta F508 (67%). Another 5 mutations accounted for a further 12.5% (4% G542X; 3% R553X; 3% N1303K; 2% 1717-1 G-->A; 0.5% G551D) whereas 6 mutations (R117H, A455E, delta I507, S549I, S549N, and R1162X) were not found. Fifty-four (49%) patients were delta F508 homozygotes and 18 (16.5%) were compound heterozygotes for delta F508 and one of the rarer mutations. These frequencies differ slightly from those found in the north of Germany and considerably from those reported from the south of Europe, which seems to be consistent with a north to south decline of the relative abundance of delta F508. Two patients, age 6 and 25 years, were compound heterozygotes for G542X and N1303K. The clinical features of the 6 year old were characterised by severe gastrointestinal and as yet only mild pulmonary complications whereas the 25 year old manifested severe pulmonary and gastrointestinal symptoms indicating that the N1303K mutation of the C-terminal CFTR nucleotide binding fold significantly impairs protein function in both the pancreas and the lungs.

Mushroom poisoning by Chlorophyllum molybdites in the Midwest United States

The paper describes two incidents of poisoning by the mushroom Chlorophyllum molybdites and reviews the literature covering this organism, a common agent of mushroom poisoning in many countries and the most common cause of mushroom poisoning in North America. Both poisoning incidents occurred in adults and were associated with severe gastrointestinal symptoms including profuse diarrhea, vomiting and intestinal pain. In each case, hospitalization was required. An unusual aspect of one case was the development of signs and symptoms suggestive of muscarine poisoning. The review includes a description of the mushroom, the geographic distribution of cases, the signs and symptoms of poisoning and its treatment, the toxic principles, particularly susceptible populations, and the variations in response associated with cooking C. molybdites and with individual idiosyncrasies. For identification of C. molybdites, the reader is alerted to the inappropriateness of some books, including many written in Europe, and is warned of the occasional finding of sterile mushrooms that lack its characteristic green basidiospores. Spores, as allergens, are discussed and simple rules are given for eaters of wild mushrooms.

Functional abnormalities of the gastrointestinal tract in patients with spinal cord injuries: evaluation with imaging procedures.

One quarter of patients with spinal cord injuries eventually have severe chronic gastrointestinal symptoms. Because there are about 1.5 million such patients in the United States, major chronic gastrointestinal symptoms will develop in approximately 400,000 patients, all of whom are likely to need the services of radiologists. These gastrointestinal abnormalities, however, are quite different from the gastrointestinal problems that occur in the general population. For this reason, the imaging methods used for diagnosis in these patients are also different from those used with persons who do not have spinal cord injuries. The purpose of this review is to describe the role of diagnostic imaging in patients with severe chronic gastrointestinal symptoms associated with spinal cord injury.

Analysis of prognostic factors and survival in patients with ovarian cancer treated with second-line hexamethylmelamine (altretamine)

Hexamethylmelamine (altretamine, HMM) 260 mg/m 2/day p.o. for 14 days followed by a 14-day drug-free interval was administered to 52 outpatients with advanced ovarian cancer who had previously been treated with chemotherapy. Prior to HMM, 92% (48/52) of these patients had received cisplatin and cyclophosphamide with or without doxorubicin. Two more patients received other cisplatin-based regimens. At the completion of HMM therapy, 15% (8/52) displayed no evidence of disease (NED). Of these eight patients, five are still alive 32 to 82 months after altretamine therapy (median follow-up of 46 months). At 41 months, one patient died of intercurrent illness with no clinical evidence of recurrence; the other two patients died of their disease at 21 and 31 months following HMM therapy. The median survival of the total group was 11 months: nine months for patients who did not respond to altretamine and 46+ months for patients with NED after altretamine ( p < 0.05). Intermittent oral administration of single-agent altretamine was well tolerated: eight patients reported moderate gastrointestinal symptoms, and only one patient reported severe gastrointestinal symptoms. Moderate neurologic toxicity was reported by five patients. No WBC fell below 2000 mm 3 and platelet counts fell below 100,000 mm 3 in only three patients; no patient experienced severe hematologic toxicity. In this series of patients, the overall response (15%) was comparable to or better than those reported for more toxic chemotherapeutic regimens. On the basis of these data and those reported by other investigators, HMM warrants consideration as a reasonable option in the management of recurrent or persistent ovarian cancer.

Intestinal Motility in Symptomatic Children with Fundoplication

Fundoplication alters the anatomy of the lower esophageal sphincter but should have no direct effects on motility distal to the sphincter. Of 55 children referred for evaluation of symptoms consistent with upper gastrointestinal motor dysfunction, 28 had undergone fundoplication 6 months to 4 years earlier to treat severe gastroesophageal reflux that had failed medical management. All 28 children had symptoms that were unchanged or worsened after fundoplication. In all children, we studied fasting and fed antroduodenal motility, and compared results from groups with and without fundoplication. Abnormalities in antroduodenal motility were found in 25 of 28 of the fundoplication group and in 25 of 27 of unoperated children. We found a wide range of abnormalities, but there were no differences in the types of severity of abnormalities between groups. In summary, in children with severe functional gastrointestinal symptoms, antroduodenal manometry uncovered physiological abnormalities, and fundoplication failed to relieve symptoms. These data suggest that preoperative intestinal manometry could identify children unlikely to benefit from fundoplication.

Intestinal Motility in Symptomatic Children with Fundoplication

Summary.Fundoplication alters the anatomy of the lower esophageal sphincter but should have no direct effects on motility distal to the sphincter. Of 55 children referred for evaluation of symptoms consistent with upper gastrointestinal motor dysfunction, 28 had undergone fundoplication 6 months to 4 years earlier to treat severe gastroesophageal reflux that had failed medical management. All 28 children had symptoms that were unchanged or worsened after fundoplication. In all children, we studied fasting and fed antroduodenal motility, and compared results from groups with and without fundoplication. Abnormalities in antroduodenal motility were found in 25 of 28 of the fundoplication group and in 25 of 27 of unoperated children. We found a wide range of abnormalities, but there were no differences in the types or severity of abnormalities between groups. In summary, in children with severe functional gastrointestinal symptoms, antroduodenal manometry uncovered physiological abnormalities, and fundoplication failed to relieve symptoms. These data suggest that preoperative intestinal manometry could identify children unlikely to benefit from fundoplication.

Gastrointestinal symptoms in anorexia nervosa: A prospective study

Neither the natural history of gastrointestinal symptoms in patients with anorexia nervosa nor their response to refeeding have been well studied. We hypothesized that gastrointestinal symptoms in anorexia nervosa will decrease during refeeding despite high caloric intake, suggesting that delayed gastric emptying, where present, is a result rather than a cause of anorexia nervosa. Study goals were (a) to determine the type and frequency of gastrointestinal symptoms, (b) to follow symptoms during refeeding prospectively, and (c) to develop guidelines for gastrointestinal testing and intervention in hospitalized anorectic patients. Sixteen consecutive patients with anorexia nervosa were rated on 12 gastrointestinal symptoms before and after nutritional rehabilitation and followed up throughout treatment. All patients reported multiple gastrointestinal symptoms on admission; all symptoms except belching improved during treatment despite large calorie increases (p < 0.0002); significant improvements occurred in appetite, bloating, constipation, vomiting, and diarrhea; and no patients required endoscopy, x-ray evaluation, or antipeptic regimens. We conclude that although severe gastrointestinal symptoms are common in anorexia nervosa, they improve significantly with refeeding. Specific gastrointestinal studies should be reserved for patients who do not gain weight or who have indications of independent digestive disease.

PROGNOSTIC FACTORS IN THE HEMOLYTIC-UREMIC SYNDROME

During 1972–1986 142 children were treated. Most of them were infants (73%). Prodromal symptoms lasted 1-16 days and usually involved the gastrointestinal tract. Severe gastrointestinal symptoms had poor prognostic significance. Convulsions, coma and hypertension which did not resolve after correction of hypervolemia were also features of poor prognosis. Laboratory findings at onset such as hyperkaliemia exceeding 7 mmol/L and acidosis with bicarbonate levels below 12 mmol/L were associated with a worse prognosis. 80% of children required peritoneal dialysis. Delay in the starting of dialysis after 5th day of anuria was a further poor prognostic factor. The total mortality rate reached 25.4%. This high mortality rate was due to the severe clinical course, to the late diagnosis and delay in dialysis treatment. The greatest risk of death existed in the first 3 weeks from onset. They were followed up from several months to 14 years. Twelve children developed chronic renal failure (11,3%). Discriminant analysis revealed the following factors to be associated with the development of chronic renal failure: delay indialysis, onset of disease in spring/summer months, older age, duration of acute renal failure, older age, duration of hemolysis and peak level of creatinine.