The prognosis of prolonged (28 days to 3 months post-onset) Disorders of Consciousness (pDoC) due to anoxic brain injury is uncertain. The present study aimed to evaluate long-term outcome of post-anoxic pDoC and identify the possible predictive value of demographic and clinical information. Systematic review and meta-analysis. We evaluated the rates of mortality, any improvement in clinical diagnosis, and recovery of full consciousness at least 6 months after severe anoxic brain injury. A cross-sectional approach searched for differences in baseline demographic and clinical characteristics between survivors and non-survivors, patients improved vs. not-improved, and patients who recovered full consciousness vs. not-recovered. We identified 27 studies. The pooled rates of mortality, any clinical improvement, and recovery of full consciousness were 26%, 26%, and 17%, respectively. Younger age, baseline diagnosis of minimally conscious state vs. vegetative state/unresponsive wakefulness syndrome, higher Coma Recovery Scale-Revised total score, and earlier admission to intensive rehabilitation units were associated with a significantly higher likelihood of survival and clinical improvement. These same variables, except time of admission to rehabilitation, were also associated with recovery of full consciousness. Patients with anoxic pDoC might improve over time up to full recovery of consciousness and some clinical characteristics can help predict clinical improvement. These new insights could support clinicians and caregivers in the decision-making on patient management.