Interior Douglas‐fir [Pseudotsuga menziesii (Mirb.) Franco] is an economically and ecologically important forest tree species in the Inland Northwest that is universally limited by nutrient availability. A variety of other site conditions also limit forest growth and vigor that complicate our understanding of Douglas‐fir nutrition in the region. In this report, we summarize existing scientific information on nutrition of interior Douglas‐fir and draw conclusions about best management practices. A general N deficiency was confirmed through universal increases in tree growth and nutrient uptake following N fertilization. However, water availability and other nutrients, such as K, S, and B, frequently limit the response to N fertilization. Increasing the probability of a strong fertilizer response within the region requires critical information on site moisture availability, parent material, and foliar K, sulfate‐S, and B concentrations. Such stand and site characteristics should guide management prescriptions, including appropriate harvest operations, slash management, site preparation, fertilization, and stocking levels. Synthesis of the available information on interior Douglas‐fir nutrition and site characteristics provides a set of management guidelines and recommendations.