The conventional circuit paradigm, utilizing a small set of gates to construct arbitrary quantum circuits, is hindered by significant noise. In the quantum Fourier transform, for instance, the standard gate paradigm employs two CNOT gates for the partial CPhase. In contrast, some quantum computers can directly implement such operations using their native interaction, resulting in less noisy gates. Unfortunately, coherent errors degrade the performance of these gates. In Clifford gates such as the CNOT, these errors can be addressed through randomized compiling (RC). However, RC does not apply to the non-Clifford multi-qubit native implementations described above. The present work introduces and experimentally demonstrates a technique called ‘Pseudo Twirling’ (PST) to address coherent errors. We demonstrate experimentally that integrating PST with the ‘Adaptive KIK’ quantum error mitigation method enables the simultaneous mitigation of noise and coherent errors in multi-qubit non-Clifford gates.