Introduction: Peptic ulcer is known as a psychosomatic disease that is closely related to anxiety and stress. This research aimed to compare the effectiveness of mindfulness-based cognitive therapy and emotion-oriented therapy on anxiety sensitivity in patients with peptic ulcers. Method: This semi-experimental study was conducted based on a pre-test-post-test-follow-up design and a control group. In total, 45 peptic ulcer patients who had referred to specialized and sub-specialized gastroenterology clinics in Mashhad, Iran in 2023 were enrolled in the study. The participants were selected by available sampling method and randomly replaced in two experimental groups and one control group (n=15). The experimental groups received intervention in the form of eight 90-minute sessions of emotion-focused therapy and mindfulness-based cognitive therapy. The control group did not receive training during the research. Participants completed the Taylor and Cox (1998) Anxiety Sensitivity Questionnaire before, immediately after, and three months after the interventions. The obtained data were analyzed by repeated measure ANOVA in SPSS software. Results: The findings showed that emotion-focused therapy and mindfulness-based cognitive therapy were effective on the anxiety sensitivity of patients with peptic ulcer (P<0.001). However, no significant difference was observed between the effectiveness of the two treatment approaches (P=0.78). Conclusion: The results showed that emotion-focused therapy and mindfulness-based cognitive therapy can be used to improve anxiety-related factors among patients with peptic ulcers.