Serum Mean Platelet Volume Levels Research Articles

Akut Pankreatitte Yeni Bir İnflamatuar Belirteç Olarak Ortalama Trombosit Hacmi ve C-Reaktif Protein ile Başvuru Anındaki Ranson Skoru ile İlişkisi

Aim: The study’s aim is to evaluate mean platelet volume (MPV) as a marker of inflammation in patients
 with acute pancreatitis (AP) and to analyse the relationships among MPV, CRP (C-reactive protein) and
 Ranson’s score.
 Material and Methods: In this study, 119 patients with AP (mean age 53.8 ± 18.0 years) and 88 healthy
 control group (mean age 53.1 ± 6.8 years) were enrolled. Among the patients with AP, 75 were classified
 as having biliary AP, and 44 were classified as having nonbiliary AP. All patients’ demographic data,
 clinical and laboratory findings and Ranson’s scores were examined from the hospital’s database.
 Results: MPV was significantly lower among patients with AP than among the control group (p = 0.001).
 CRP was significantly higher among patients with AP than among the control group (p< 0.001). The
 difference in MPV between the biliary and nonbiliary AP group was statistically not significant. When
 we compared MPV based on patients’ lengths of hospital stay, there was no significant difference. In
 correlation analysis, there was no correlation among CRP, Ranson’s score and serum MPV levels.
 Conclusion: We observed that MPV levels in the AP group were lower than healthy controls. Thus, like
 other inflammation markers, MPV might be a useful marker for AP diagnosis.

Abstract 16996: Relationship of Paravalvular Leak and Mean Platelet Volume With Stroke Risk Following Transcatheter Aortic Valve Replacement

Introduction: Stroke remains a major complication patients may face following Transcatheter Aortic Valve Replacement (TAVR). It has been hypothesized that turbulent flow across persistent paravalvular leak (PVL) may lead to low level hemolysis, a state known to heighten serum thrombotic potential and increase stroke risk. We hypothesized that the presence of paravalvular leak would lead to elevations in serum mean platelet volume (MPV), a marker of platelet activation and aggregation, and thus would heighten stroke risk after TAVR. Methods/Results: We retrospectively reviewed the charts of 322 patients who underwent TAVR at Montefiore Medical Center from January 2015 to January 2019. Stroke was seen in 24 patients (7%) following TAVR and was associated with higher overall mortality (p=<0.001). PVL was recorded in scaling severity of “none”, “trace”, “mild”, “moderate”, and “severe”. “Significant PVL”, defined as the presence of “mild” or greater PVL on initial post-op transthoracic echocardiogram, was found in 72 patients (22.4%). No associations were seen between the presence of significant PVL and stroke after TAVR. Serum MPV values after TAVR were not associated with the presence of significant PVL, nor with an increase in the observed rate of stroke or death on follow-up. Conclusions: Stroke after TAVR is significantly associated with increased mortality. In our dataset, the presence of significant PVL was not associated with increased rate of stroke or elevated serum MPV levels post-TAVR. Moderate and severe PVL are known to generate the greatest amount of hemolysis and were rare in our dataset (combined 1.5%), likely contributing to the lack of significant findings.

Fibromiyalji Sendromunda Serum Ürik Asit ve Ortalama Trombosit Hacmi Düzeylerinin Bilişsel Fonksiyonla İlişkisi

Objective: Patients with fibromyalgia syndrome (FMS) have mild cognitive dysfunction. Higher serum uric acid (UA) levels in some diseases are reported to be associated with cognitive impairment. Mean platelet volume (MPV) is an indicator of platelet activation. Activated platelets may play a role in neuroinflammation and cognitive dysfunction. The purpose of this study was to compare cognitive functions of FMS patients and controls and investigate the relation of serum UA and MPV levels with cognitive functions. Method: Fifty-four patients with FMS and 33 healthy controls were enrolled,retrospectively. Evaluations were performed with Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory(BDI) and to asses phychological status and cognitive impairment Mini Mental State Examination(MMSE) was used in both groups. Results: Mean VAS and sleep quality of FMS group were significantly higher than the control group (p<0.05). Mean MMSE score was statistically significantly lower in the FMS group (p=0.0001). There was not statistically significant correlation between serum UA levels and VAS pain/sleep quality, FIQ, BDI and MMSE scores (p>0.05). No significant correlation was found between serum MPV levels and VAS pain/ sleep quality, FIQ, BDI and MMSE scores (p>0.05) but declined cognitive functions were determined in the FMS group when compared with the control group. Conclusion: Declined cognitive functions were determined in the FMS the FMS group when compared with the control group. Although we did not determine an association of serum uric acid and MPV levels with cognitive functions, larger prospective studies with longer follow up periods are warranted to elucidate the role of these biomarkers in FMS and to determine the factors affecting cognitive functions.

AB075. The relationship between benign prostatic hyperplasia/lower urinary tract symptoms and mean platelet volume: the role of metabolic syndrome

ObjectiveThe aim of the present study was to investigate the relationship among serum mean platelet volume (MPV) levels, benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and metabolic syndrome (MetS), and study the potential role of serum MPV levels in BPH/LUTS progression in an indirect manner.MethodsA total of 551 Men aged 45-year-old or older with moderate to severe LUTS due to benign prostatic enlargement (BPE) were recruited into the present study by consecutive routine physical examination programs. Urologic evaluation included transrectal ultrasound, International Prostate Symptom Score and maximum urinary flow rate (Qmax). Overnight fasting venous blood specimens were collected and serum levels of prostate-specific antigen, fasting blood glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglyceride and C-reactive protein were recorded. In addition, mean platelet volume was determined by automated hematology analyzer. We divided subjects into two groups according to the presence of MetS. We also took the MPV values as a categorical variable and divided subjects into two groups (≥11.8 or <11.8 fL) or four groups according to the different levels of MPV (9.3–11.0, 11.1–11.5, 11.6–11.9, 12.0–12.5 and ≥12.5 fL). The clinical characteristics and parameters of BPH/LUTS in different groups were measured and compared to identify their relationships.ResultsMetS was diagnosed in 37.0% of the subjects. There were significant interactive correlation among the number of positive MetS components, CRP, MPV and parameters of BPH/LUTS. The ratio of PV ≥31 mL and Qmax <10.6 mL/s were positively correlated with the increased level of MPV. Additionally, the odds ratio (OR) in relation to PV ≥31 mL and Qmax <10.6 mL/s significantly rose as the level of MPV increased after adjusting for age, with a suggesting of a threshold effect at 12.0–12.5 fL for PV ≥31 mL (OR 2.678, 95% CI, 1.425–5.035) and at >12.5 fL for Qmax <10.6 mL/s (OR 3.190, 95% CI, 1.768–5.755). However, only the value of MPV more than 12.5 fL still showed statistically significant effect on Qmax <10.6 mL/s after adjusting for age and the presence of MetS (OR 2.164, 95% CI, 1.162–4.032).ConclusionsOur results add to the evidence that chronic inflammation is a candidate mechanism at the crossroad between MetS and BPH/LUTS, and the presence of elevated MPV may serve as a predictor of MetS-induced inflammation in the progression of BPH/LUTS.

The Relationship between Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms and Mean Platelet Volume: The Role of Metabolic Syndrome

Objective: The aim of the present study was to investigate the relationship among serum mean platelet volume (MPV) levels, benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and metabolic syndrome (MetS), and study the potential role of serum MPV levels in BPH/LUTS progression in an indirect manner. Methods: Five hundred fifty-one men aged 45 or older with moderate to severe LUTS due to benign prostatic enlargement were recruited into this study by consecutive routine physical examination programs. Urologic evaluation included transrectal ultrasound, International Prostate Symptom Score and maximum urinary flow rate (Qmax). Overnight fasting venous blood specimens were collected and serum levels of prostate-specific antigen, fasting blood glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglyceride and C-reactive protein (CRP) were recorded. In addition, MPV were determined by automated hematology analyzer. We divided subjects into 2 groups according to the presence of MetS. We also took the MPV values as a categorical variable and divided subjects into 2 groups (≥11.8 or <11.8 fl) or 4 groups according to the different levels of MPV (9.3-11.0, 11.1-11.5, 11.6-11.9, 12.0-12.5 and ≥12.5 fl). The clinical characteristics and parameters of BPH/LUTS in different groups were measured and compared to identify their relationships. Results: MetS was diagnosed in 37.0% of the subjects. There were significant interactive correlation among the number of positive MetS components, CRP, MPV and parameters of BPH/LUTS. The ratio of PV ≥31 ml and Qmax <10.6 ml/s were positively correlated with the increased level of MPV. Additionally, the OR in relation to PV ≥31 ml and Qmax <10.6 ml/s significantly rose as the level of MPV increased after adjusting for age, suggesting of a threshold effect at 12.0-12.5 fl for PV ≥31 ml (OR 2.678, 95% CI 1.425-5.035) and at >12.5 fl for Qmax <10.6 ml/s (OR 3.190, 95% CI 1.768-5.755). However, only the value of MPV more than 12.5 fl still showed statistically significant effect on Qmax <10.6 ml/s after adjusting for age and the presence of MetS (OR 2.164, 95% CI 1.162-4.032). Conclusions: Our results add to the evidence that chronic inflammation is a candidate mechanism at the crossroad between MetS and BPH/LUTS, and the presence of elevated MPV may serve as a predictor of MetS-induced inflammation in the progression of BPH/LUTS.