Serum Levels Of High Sensitivity Research Articles

The Effect of Combination of Turmeric and Black Pepper Extracts in Osteoarthritis of the Knee

The management of osteoarthritis (OA) remains a challenge. Curcumin is basically a spice that is known for its anti-inflammatory properties. In vitro studies suggest that curcumin could be beneficial for cartilage in OA. Piperine, derived from black pepper, is added to Curcumin to increase its bioavailability. The aim of this randomized, double blind trial was to evaluate the effects of combination curcumin plus piperine in knee OA patients.A total of 43patients were randomly assigned to receive the fixed dose combination (curcumin 500 mg plus piperine 5 mg) or placebo twice daily for three months and was evaluated using a Western Ontario MacMaster (WOMAC) score. Results revealed the serum levels of High Sensitivity C - reactive protein (HS-CRP)and Human Cross Linked C-Telopeptide of Type II Collagen (CTX-II) were changedafter 3 months of treatment. In conclusions: The treatment with curcumin was globally well tolerated. It significantly decreased the WOMAC score and NSAIDS uses. Serum level of CTXII significantly reduced (p<0.001) and tended to decrease serum HS-CRP. In addition, curcumin significantly reduced body mass index,this may point toward that curcuminoids has role in weight reduction,and hence, lower risk of OA

The effect of 12 weeks of aerobic training on serum levels high sensitivity C-reactive protein, tumor necrosis factor-alpha, lipid profile and anthropometric characteristics in middle-age women patients with type 2 diabetes

AimsThe aim of this study was to investigate the effect of 12 weeks of aerobic training on serum levels of high sensitivity C- reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), lipid profile and anthropometric characteristics in middle-aged women patients with type-2 diabetes. MethodsA quasi-experimental study, 20 women patients with type-2 diabetes (mean age, 50.25 ± 4.36 years, Body mass index, 25.51 ± 2.91 kg/m2, and body fat percentage 23.67 ± 3.05%) were randomly categorized into two experimental and control groups. The protocol aerobic training included eight-minute jogging and eight-minute running with 75–85 percent maximum heart rate reserve in the first session. Per both sessions, one minute added to running time and it increased up to 32 min after 12 weeks. Blood sampling and anthropometric measurements, 24 h before and 48 h after the last training session were conducted. ResultThe result showed a significant reduction in hs-CRP and TNF-α in the experimental than control group (P = 0.01). Exercise training-treated patients showed a significant decrease in TG, LDL and increase HDL in comparison with baseline and the control group (P < .05). The results also showed a significant decrease in weight, body mass index, body fat percentage, and waist–hip ratio (P values 0.02, 0.03, 001, 0.04 respectively) following the 12 weeks aerobic training. ConclusionIt seems that long-term aerobic training, improved some important anthropometric and biochemical parameters in patients with type-2 diabetes. These observations give a new insight into the mechanisms by which aerobic training can reduce the cardiovascular risk in diabetes.

Study of Lipid Profile and High Sensitivity C Reactive Protein in Women with Polycystic Ovary Syndrome

Background: This study was undertaken to assess the lipid profile parameters and serum levels of high sensitivity C reactive protein (hsCRP) in women with polycystic ovary syndrome. (PCOS). Methods: 80 women diagnosed with PCOS based on Rotterdam ESHRE/ASRM criteria and 40 age matched healthy controls were selected for the study. Anthropometric and biochemical parameters like serum lipid profile and hsCRP were evaluated among these women. Results: Women with PCOS were found to have significantly higher levels of total cholesterol, triglycerides, LDL-C and hsCRP and significantly lower levels of HDL-C as compared to controls. Conclusions: Targeted screening and timely interventions to reduce cardiovascular risk in women with PCOS is necessary to attenuate the complications of the disease.

Serum levels of high sensitivity C reactive protein and malondialdehyde in chronic kidney disease

Background: Chronic kidney disease cases are at increased risk for progression to end stage renal disease and accelerated atherosclerosis, with premature cardiovascular morbidity and mortality being the more frequent outcome. Aim: The study was taken up to find if there is any association between nontraditional cardiovascular risk markers like high sensitivity C reactive protein (marker of inflammation) and malondialdehyde (marker of lipid peroxidation) with the progression of chronic kidney disease. Methodology: The study included 44 pre dialysis chronic kidney disease cases and 44 healthy controls. Serum levels of creatinine, high sensitivity C reactive protein and malondialdehyde were estimated in both groups. The mean estimated glomerular filtration rate(eGFR) in chronic kidney disease patients was calculated by the MDRD formula. Results: The mean eGFR in cases was found to be 23.65 14.99 ml/min by MDRD formula. The serum hsCRP and malondialdehyde levels in cases was 11.8 7.24 mg/L and 3.02 1.24 nmol/ml respectively. Conclusion: There was a significant negative correlation (p<0.001) between high sensitivity C-reactive protein and malondialdehyde with eGFR. A highly significant positive correlation was found between serum hsCRP and malondialdehyde (p<0.001) in chronic kidney disease underlining the synergism between oxidative stress and inflammation, perpetuating to further deterioration of renal function and enhancing the predisposition to cardiovascular risk with the progression of chronic kidney disease.

Statin treatment, carotid atherosclerotic plaque macrophage infiltration and circulating inflammatory markers.

BackroundStatin treatment is considered as first line therapy in patients with atherosclerotic disease. We evaluated the effect of pre-treatment with statins on carotid plaque infiltration by macrophages and on the circulating levels of proinflammatory cytokines in patients who underwent carotid endarterectomy.Patients and MethodsOne hundred fourteen patients were enrolled; 89 men and 25 women (mean age 67±8 years; range 42-83 years). Fifty three patients (46%) were on statin treatment at least 3 months before endarterectomy and 61 (54%) had never received statin treatment. The serum levels of high sensitivity C reactive protein (hsCRP), serum amyloid A (SAA), tumor necrosis factor α (TNFα), interleukin (IL)-1β and IL-6 were evaluated preoperatively. The intensity of macrophage infiltration was evaluated by immunochemistry, using the monoclonal antibody CD 68. The area of the plaque covered by macrophages was measured as a proportion of the whole plaque area, using a custom designed image tool analysis.ResultsPatients on statins had lower serum total cholesterol levels (172±50 vs 194±35 mg/dl, p= 0.014), lower low density cholesterol levels (103±44 vs 123±31 mg/dl, p= 0.010) and lower serum hsCRP levels (1.8 [1.1-3.4] vs 3.4 [1.3-4.9] mg/l, p= 0.03), while SAA, TNFα, IL-6 and IL-1β levels did not differ between the 2 groups. The infiltration of atherosclerotic plaque by macrophages was similar in statin treated patients and in controls (0.55±0.15% vs 0.49±0.19%, p= 0.21).ConclusionPatients on statins have similar macrophage accumulation in their carotid atherosclerotic plaques compared with patients not on statins. Inflammatory markers were also similar in both groups except for hsCRP which was significantly lower in those taking statins.