Serum Helicobacter Pylori Antibody Research Articles

Clinical application of latex immunoturbidimetric assay in the determination of serum Helicobacter pylori antibody

Clinical application of latex immunoturbidimetric assay in the determination of serum Helicobacter pylori antibody

Role of Helicobacter pylori in Nasal Polyp Formation: A Case- Control Study in Tehran, Iran

Role of Helicobacter pylori in Nasal Polyp Formation: A Case- Control Study in Tehran, Iran The etiological factors for nasal polyps include infection, inflammation or an imbalance of a metabolic pathway. This study was designed to compare serum Helicobacter pylori antibodies and H. pylori–DNAs between cases of nasal polyp and controls (nasal fracture).

Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer

Gastric cancer is the second leading cause of cancer-related mortality in the world. Recently, serum Helicobacter pylori antibodies and pepsinogen (PG) have been used for gastric cancer screening. The incidence of gastric cancer in Bhutan is reported to be quite high compared with that in neighbouring countries. In this study, 381 subjects from three areas of Bhutan were assessed for gastric mucosal atrophy and serological parameters. Anti-H. pylori IgG, PG I, PG II and cytotoxin-associated gene A (CagA) antibodies were measured using ELISA. Subjects were classified into four groups according to H. pylori and PG seropositivity: Group A (H. pylori-negative/PG-negative), Group B (H. pylori-positive/PG-negative), Group C (H. pylori-positive/PG-positive) and Group D (H. pylori-negative/PG-positive). The prevalence of H. pylori in the 381 subjects was 71.1% (271/381), with high infection rates found in rural areas. The PG I/II ratio was significantly inversely correlated with the atrophy score in the antrum and the corpus (P<0.001). Multivariate analysis showed that the PG status was significantly associated with the presence of atrophy in the corpus. The prevalence of the PG-positive status was significantly higher among H. pylori-positive subjects than among H. pylori-negative subjects (P<0.001). Based on the ABC method, Group B was the most dominant, followed by Group A, Group C and Group D. The high incidence of gastric cancer in Bhutan can be attributed to the high prevalence of H. pylori infection and gastric mucosal atrophy.

Assessment of Degree of Health of the Stomach by Concomitant Measurement of Serum Pepsinogen and Serum Helicobacter Pylori Antibodies

The stomach was assessed by measuring serum pepsinogen (PG) and Helicobacter pylori (Hp) antibodies by immunoassay, based on the findings of upper gastrointestinal endoscopy performed on the same day. The assessment involved 1,636 individuals who visited the hospital for general medical checkups. Those negative for Hp antibodies and PG were grouped in group A, Hp-positive/PG-negative subjects were included in group B, and PG-positive subjects in group C. Group A comprised 660 subjects (40.3%), group B 514 (31.4%), and group C 462 (28.2%). Gastric cancer was detected in 0.87% (4/462) in group C, 0.19% (1/514) in group B, and 0% (0/660) in group A. All four patients with gastric adenoma were in group C. Hyperplastic polyps were detected most frequently in group C followed by group B, while there were no cases in group A. By contrast, most fundic gland polyps were found in group A. The detection rate of peptic ulcers was highest in group B, while that of reflux esophagitis was highest in group A. These findings suggest that the "degree of health" of the stomach can be assessed by measuring serum PG and Hp antibodies.

Advanced gastric cancer associated with nodular gastritis in a young patient.

A 20-year-old female underwent an endoscopy for epigastralgia that revealed many small, elevated nodules in the antrum that were diagnosed as nodular gastritis. The endoscopy also showed an ulcerative lesion with an uneven round wall at the greater curvature of the middle corpus. Biopsy of the ulcerative lesion yielded a diagnosis of poorly differentiated adenocarcinoma. A distal gastrectomy was performed on the basis of a diagnosis of gastric cancer associated with nodular gastritis. The intraoperative findings revealed serosal invasion of the gastric cancer and the patient tested positive for peritoneal cytology. The pathological findings revealed poorly differentiated adenocarcinoma showing invasive growth with fibrosis on the corpus and large and superficial lymphoid follicles on the miliary nodules at the antrum. The patient was positive for Helicobacter pylori infection by both the serum Helicobacter pylori antibody and histopathological findings.

Prevalence of Helicobacter pylori infection in children from urban and rural West Virginia.

Our objective was to evaluate the prevalence rate of Helicobacter pylori (HP) in children from urban and rural areas of West Virginia. In all, 1164 blood samples were collected from children who attended a local health fair, pediatric clinics, and emergency departments of four different hospitals located in urban and rural counties. Socioeconomic status was determined in 303 children. Serum HP antibody (IgG) was measured by enzyme immunoassay (EIA). A total of 468 (40%) samples were HP positive. HP acquisition correlated with increasing age, family crowding, and community location (urban/rural) but not with gender, water source used (city/well), or socioeconomic status. The prevalence rate of HP in the children of West Virginia is higher than any data previously reported from the United States. The results correlated with only few socioeconomic criteria, suggesting that other factors may contribute to the increased prevalence of HP infection in the children of West Virginia.