Changes In Serum Electrolytes Research Articles

Effects of propylene glycol in different doses on metabolic parameters in dairy cows

In the study, the effects of propylene glycol (PG) drenched in different doses in dairy cows with positive energy balance were evaluated on serum metabolic parameters. Twenty-four Simmental dairy cows in 60-190 days of lactation period with positive energy balance were included to this study. PG was drenched 3 h after morning feeding, at a doses of 300 mL (8 dairy cows) and 500 mL (8 dairy cows), once a day, for 3 days. Eight dairy cows were included for control group. Blood samples were collected once before PG drenching, daily after drenching of PG, and finally on day 4. Serum biochemical parameters were determined. With regard to energy metabolism, glucose concentrations from serum biochemical parameters significantly increased on day 3 in 500 mL PG group compared to control group, and there were not significant changes in BHBA and NEFA concentrations. Decreased urea, increased chloride concentrations were determined with within reference limits. In dairy cows with positive energy balance, 500 mL PG oral drenching had positive effect on energy balance as determined by serum glucose measurements, might not have negative effects on hepatic and renal function, and may cause serum electrolyte changes within reference limits.

Long-term complications and outcomes of augmentation cystoplasty in children with neurogenic bladder

Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed. The present study aimed to determine the risks of metabolic complications, malignancy, long-term outcomes and histopathologic changes of native bladder and the augmented intestine after AC in children with neurogenic bladder. Pediatric patients < 18 years who underwent AC between 2000 and 2020 were enrolled. Early postoperative complications, long-term outcomes and histopathologic changes in mucosal biopsies of native bladder and the augmented intestine after AC were reviewed. Twenty-two patients with a mean age of 7.6 ± 4.4 years were included. The ileum was used in 19 patients and the sigmoid colon in 3 patients. The length of hospital stay was 14.8 ± 6.8 days. Post-operatively, the urinary continence rate improved from 22.7 to 81.8% (p < 0.001). Hydronephrosis resolved in 17 of 19 patients. Vesicoureteral reflux resolved in 16 (64.0%) of the refluxing ureter units and was downgraded in 7 (28.0%). Grades of hydronephrosis and reflux significantly improved following AC (p < 0.001). The estimated glomerular filtration rate also significantly increased (p = 0.012). Formation of urinary tract stones was the most frequent late complication (in 8 patients, 36.4%). Life-threatening spontaneous bladder perforation occurred in 1 patient. After a mean follow-up of 13.4 ± 5.9 years, there were no cases of mortality, new-onset symptomatic metabolic acidosis, or changes in serum electrolytes. Of the 17 patients who were followed for > 10 years, no cases of malignancy or metaplastic changes were identified in the native bladder or augmented bowel epithelium. AC is a safe and effective procedure with low surgical and metabolic complication rates. In addition, AC provides a satisfactory continence rate and long-term protection of renal function, increases functional capacity, and regresses reflux and hydronephrosis. Individualized surveillance is recommended for the early identification of urolithiasis and metabolic disturbances.

The protective role of l-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats

Synthetic organic insecticides such as pyrethroids, organophosphates, neonicotinoids, and others have the potential to disrupt ecosystems and are often toxic to humans. Thiamethoxam (TMX), a neonicotinoid insecticide , is a widely used insecticide with neurotoxic potential. l-Carnitine (LC) is regarded as the “gatekeeper” in charge of allowing long-chain fatty acids into cell mitochondria. LC is an endogenous chemical that is renowned for its prospective biological activity in addition to its role in energy metabolism. This study investigated the protective effects of LC against TMX-induced neurotoxicity in male Wistar rats. For 28 days, animals were divided into four groups and treated daily with either LC (300 mg/kg), TMX (100 mg/kg), or both at the aforementioned doses. Our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in TMX-treated rats. TMX also increased the expression of caspase-3 and glial fibrillary acidic protein. In contrast, pretreatment with LC attenuated TMX-induced brain injury by suppressing oxidative stress and proinflammatory cytokines and modulating neurotransmitter levels. It also ameliorated the expression of apoptotic and astrogliosis markers. It could be concluded that LC has antioxidant, anti-inflammatory, anti-astrogliosis, and anti-apoptotic potential against TMX neurotoxicity.Graphical abstract

Effects of isoenergetic supplementation as water use mitigation strategy on water footprint and health of nursing bull calves.

Sustainable livestock systems focus on mitigating natural resource use such as water. Dietary management strategies can significantly reduce the water footprint of livestock animals; however, animal health is of concern when animals reduce water intake due to subacute dehydration. To evaluate potential consequences of this nutritional management intervention, a total of 23, 60 ± 3 days old nursing Holstein bull calves, weighing 94.7 ± 12.07 kg, were distributed in a completely randomized design and received one of three diets. Control was a basal diet composed of a non-medicated milk replacer (milk replacer; n = 7), and the additional two diets, were composed of the same non-medicated milk replacer in addition to either lipid [n = 8; milk replacer + menhaden fish oil (3 %)] or soluble carbohydrate [n = 8; milk replacer + corn starch (7%) isoenergetic to fat group] supplements. Animals were offered ad libitum mineral mix and water, as well as 120 g/day of a composite mix of dried microbrewery's spent grains. Data were analyzed as linear and generalized linear mixed models with diet as a fixed effect and animal as random utilizing R studio (R Core Team, 2021, Vienna, Austria; SAS Inst., Cary, NC). Within supplementation groups, lipid supplemented calves had the highest lymphocyte (63.24 vs 57.69 counts/100 lymphocytes; P < 0.033), and lowest neutrophil counts (29.3 vs 35.3 counts/100 lymphocytes; P < 0.047). Supplementation significantly increased total serum protein (P = 0.001) and skin moisture (P < 0.011), with carbohydrate group having the highest skin moisture (5.30 vs 3.99; P < 0.047). Supplementation also decreased fecal fluidity scores (P < 0.001) with no significant change in serum electrolytes (P > 0.256). No significant differences were found amongst treatments for the ingestive behavior (P > 0.338). The carbohydrate-supplemented calves significantly decreased all daily water footprints compared to the control and fat-supplemented groups: blue a 47.55 L decrease, (P < 0.001), green a 265.62 L decrease (P = 0.005), and gray a 55.87 L decrease (P = 0.009) water footprint, as well as total water footprint (369.04 L, P = 0.004). Our results indicate the potential to maintain animal performance while increasing water use efficiency through diet supplementation tailored to mitigate water use, without adverse effects on animal health.

Physiological parameters and serum electrolyte changes after betaine supplementation in lactating Murrah buffaloes during hot-humid season

Betaine acts as a methyl donor in metabolism and serves as an organic osmolyte, which is used by cells for protection against osmotic stress and high temperatures. The present study was carried out to investigate the effect of betaine on physiological parameters and serum electrolyte changes in postpartum lactating Murrah buffaloes during the hot-humid season. The study was performed at the Livestock Farm Complex, N.D.V.S.U., Jabalpur, in 2019. Eighteen postpartum Murrah buffaloes were randomly divided into three groups for the experiment. T1 was a control group. T2 and T3 groups were supplemented with betaine at 50 g/animal/day and 100 g/animal/day, respectively. Betaine was supplemented in the feed from day 5 postpartum and continued up to 4 months. The rectal temperature was found to be significantly lower in the T2 and T3 groups as compared to the T1 group on day 90 postpartum. The pulse rate was lower in the T2 and T3 groups as compared to the control group on day 105 postpartum. It was concluded that betaine improves serum sodium, potassium, and the chloride concentration as compared to the control group and reduces heat stress in lactating buffaloes.

Changes of Serum Electrolytes and Serum Vitamin C Levels in a Sample of Iraqi patients Infected with Helicobacter pylori (H. pylori)

Helicobacter pylori (H. pylori) is widespread and involved in the pathogenesis of the majority of stomach and duodenal diseases. Reduced stomach acidity facilitates the initial infection. Electrolytes (sodium, potassium, and chloride) are essential for the production of stomach acid. This study aimed to observe any changes in the levels of serum electrolytes (Na, K, and Cl) and serum vitamin C levels in a sample of Iraqi patients infected with H. Pylori. We studied 30 infected patients with H. Pylori and 30 matched healthy controls. The results revealed that the serum sodium, potassium, and chloride levels were significantly decreased (p = 0.002, 0.003 and 0.0001, respectively) in the patients infected with the H. Pylori group in comparison with those of the healthy controls. Also, vitamin C levels were significantly lower in patients infected with H. Pylori than in the control group (p = 0.001). The present results suggest that these changes may be attributed to or contribute to the infection itself through changes in gastric acidity, and this needs further study.

Adaptive Nutrition Intervention Stabilizes Serum Phosphorus Levels in Hemodialysis Patients: A Multicenter Decentralized Clinical Trial Using Real-World Data

This study aims to evaluate the effect of an adaptive nutritional and educational intervention for patients on hemodialysis (HD) in a routine care setting, using real-world data from electronic health records. Decentralized clinical trial of seven HD facilities recruited patients who have been on HD for over 3months (N=153) for an 8-week adaptive intervention protocol. Patients were divided into four groups: (1) control (2) education intervention (3) meal intervention (4) education and meal interventions. Educational contents were digitally delivered via mobile phones and premade meals tailored on laboratory findings were home-delivered. Changes in serum electrolytes and malnutrition inflammation score (MIS) were analyzed. Meal intervention statistically significantly stabilized serum phosphorus level (β=-0.81mg/dL, 95% confidence interval=[-1.40, -0.22]) at week 8, with increased likelihood of being within target serum value range (odds ratio=1.21, 95% confidence interval=[1.04, 1.40]). Meal group showed better nutritional status (MIS=3.65) than the education group (MIS=5.10) at week 8 (adjusted p<.05). No significant changes were observed in serum potassium level, depression, and self-efficacy. It was demonstrated that an adaptive meal intervention in a real-world care setting may benefit serum phosphorus control and nutritional status of patients on HD, without negative effect on depression levels or self-efficacy. More work is needed to develop an effective educational intervention.

A Prospective Observational Study Among Patients on Long Term Hemodialysis for Changes in Serum Electrolytes with Varying Urine Outputs and Impact of Patient Counselling on their Quality of Life- A Pilot Study

Chronic kidney disease (CKD) is defined as a progressive loss of function occurring over several months to years and is characterized by the gradual replacement of normal kidney architecture with parenchymal fibrosis. End stage renal disease (ESRD) is defined as irreversible decline in a person's own kidney function, which is severe enough to be fatal in the absence of dialysis or transplantation. Since hemodialytic patients with greater urine output have a greater ability to excrete electrolytes, acids, and fluid compared to patients low urine output, they are likely to have less body accumulation of these elements. Health-related quality of life (HRQOL) is a critically important outcome for patients with ESRD.

Alterations of serum electrolytes and biochemical indices of Panagasianodon gigas subjected to different water temperatures and the appropriate temperature range for sustaining life

ABSTRACT The effects of cold and heat shocks on serum electrolyte and biochemical changes in Panagasianodon gigas. Cold shock was conducted as follows: 25–22°C, 25–19°C and 25–13°C; and heat shock: 25–28°C, 25–31°C and 25–37°C. The lowest Na+ was found in the group exposed to 25–13°C and 25–37°C, while the highest Na+ was observed in the 25–31°C group. The K+ significantly increased with decreases in water temperature. The Cl- was significantly decreased and increased when decreasing and increasing water temperature, respectively. The serum CO2 level was affected by cold shock but was not affected by heat shock. The highest and lowest Na+/K+ ratio was found in the group exposed to 25°C–31°C and 25°C–13°C, respectively. Moreover, the Na+/Cl- ratio showed a similar trend to that of the Na+/K+ ratio. Furthermore, the highest (Na+ + K+)/Cl- ratio was found in 25–31°C group. The highest glucose was found in all the cold shock groups. Albumin, globulin, total protein, triglyceride and cholesterol levels were significantly decreased after exposure to cold and heat shocks. These results demonstrated that 25–28°C is the appropriate temperature range for this species whilst other ranges influenced biochemical and physiological indices.

Association of serum electrolyte changes during haemodialysis with stimulation of premature ventricular contractions

BackgroundPatients on haemodialysis are predisposed to heart rhythm disorders, including bradyarrhythmia, atrial fibrillation (AF)/atrial flutter, supraventricular/ventricular arrhythmias and sudden cardiac death (SCD) (Turakhia et al. in Eur Heart J 39:2314–2325, 2018). In addition to the fact that patients on haemodialysis have a high prevalence of underlying cardiac disease, the stress of haemodialysis itself might also contribute to increased rates of arrhythmias and SCD (Samanta et al. in Can J Cardiol 35:1228–1240, 2019).MethodsA Holter 24-h electrocardiogram was set up immediately before the start of haemodialysis for 72 haemodialysis patients (dialysis vintage: 6–8734 days) to record premature ventricular contractions (PVCs) as a marker of arrhythmogenesis for 24 h. Blood samples were also collected every hour during haemodialysis treatment. Each patient was dialyzed against a dialysate consisting of Na+140 mEq/L, K+ 2.0 mEq/L, Ca+ 3.0 mEq/L, Mg2+ 1.0 mEq/L, Cl− 110 mEq/L, CH3COO− 8 mmol/L and HCO3− 30 mEq/L.ResultsThe frequency of PVCs significantly increased in the 4th (80 ± 34 beats/hour, mean ± S.E.), 5th (79 ± 31 beats/hour) and 6th (105 ± 36 beats/hour) hours (F = 5.24, p < 0.00001, n = 72). The lowest left ventricular ejection fraction (LVEF, p = 0.001) and the highest b-type natriuretic peptide (BNP) levels (p = 0.049) were found in patients with the highest PVC counts. There was an association of positive changes in both serum K+ (β ± S.E., 9.7 ± 2.4, p = 0.0002), Mg2+ (43.2 ± 10.3, p = 0.0001) and HCO3− (5.3 ± 1.8, p = 0.005) with the frequency of PVCs for 4 h immediately after dialysis. During the same period, there was an association of lower serum K+ (− 8.37 ± 2.16, p = 0.0003) and higher Ca2+ (73.4 ± 18.0, p = 0.0002) with the frequency of PVCs.ConclusionsHaemodialysis stimulated PVC generation, and this effect was especially prominent during the period immediately after haemodialysis. Some serum electrolyte changes affected this PVC stimulation. A positive change in serum K+ or Mg2+ and a negative change in serum Ca2+ during dialysis are risk factors for stimulating PVCs, particularly in patients with lower serum K+ or higher serum Ca2+ levels at the start of dialysis.

Serum Electrolyte and Metabolic Changes During Conditioning of Autologous Hematopoietic Stem Cell Transplantation in Patients with Autoimmune Diseases: A Prospective Study in a Single Institution.

A hematopoietic stem cell transplant (HSCT) includes a conditioning regimen which may cause unwanted metabolic changes. We analyzed the changes in electrolytes, glucose, urea, and glomerular filtration rate in patients with multiple sclerosis (MS) who underwent an autologous HSCT employing the "Mexican method." Serum and urinary electrolytes, blood glucose, creatinine, uric acid, and estimated glomerular filtration rate (eGFR) were prospectively assessed on days -11, -9, and 0 in a group of 75 patients with MS receiving an autologous HSCT employing the "Mexican method," which includes high doses of both cyclophosphamide (Cy, 200 mg/kg) and rituximab (1000 mg). The median age of the patients was 46 years, with a range of 20-65. Baseline data were defined at day -11 of the HSCT. There were significant changes in serum and urinary electrolytes, which diminished substantially after the delivery of high-dose Cy; 12 patients (16%) developed hyponatremia and 2 had hyponatremia-induced seizures, which resulted in hospital admissions. A comparison of baseline blood metabolites with those obtained after the full Cy dosage (day 0) revealed a significant increase in blood glucose and uric acid levels with an associated decrease in serum calcium, sodium, and potassium levels. The salient findings were drug-induced hyponatremia and hyperglycemia. Significant changes in serum electrolytes, blood glucose, creatinine, uric acid, and estimated glomerular filtration rate (eGFR) were observed in patients given autologous HSCT for MS employing high-dose Cy. Some of these changes may have clinical consequences, mainly those derived from iatrogenic hyponatremia. No evidence of damage to renal function was observed at day 0.

Effects of double intravenous furosemide administration at different doses on clinical variables, electrocardiographic indices and serum electrolytes in miniature donkeys.

The intravenous (IV) usage of diuretics such as furosemide may cause changes in clinical variables, electrocardiographic (ECG) indices and some serum electrolytes concentrations in miniature donkeys. The purpose of this study was to evaluate the effects of double intravenous (IV) administration of furosemide at different doses on the clinical variables, ECG indices and serum electrolytes levels in miniature donkeys. A total of 21 clinically and para-clinically healthy miniature donkeys with a mean age of 6.00 ± 1.00 years and weight of 95.00 ± 5.00 kg were used. The animals were randomly divided into three groups of control (normal saline) and low- (1.00 mg kg-1) and high-dose (2.00 mg kg-1) of furosemide. Two IV injections with 12-hr interval were administered in each animal. The clinical and ECG parameters were measured at 0 (baseline), 2 (T2), 24 (T24) and 48 (T48) hr after drug administration. Serum concentrations of electrolytes were measured at T0, T24 and T48. The results of this study showed no changes in clinical variables (heart rate, rectal temperature and respiratory rate) and ECG indices (amplitude and duration of P, QRS and T waves and duration of PR, QT and RR intervals) as well as no significant changes in serum electrolytes (sodium, potassium, chloride, phosphorus, calcium and magnesium) levels. Although no significant effect on clinical variables, electrolytes levels and ECG indices after double IV administration of furosemide (1.00 and 2.00 mg kg-1) in miniature donkeys was observed, absence of these effects does not mean that furosemide had no pharmacological effect.

Electrolyte level changes and their correlation with echocardiographic parameters in patients with acute coronary syndrome patients as compared to healthy individuals in Iraq

Acute coronary syndrome (ACS), a common complication of coronary heart disease. Serum electrolytes changes in ACS have not been studied extensively and there is paucity of information in the literature in this regard, electrolyte imbalance is one of the probable causes of ventricular tachycardia in patients with ACS. 143 people were included in study divided to 93 patients and 50 as control groups. Study group comprised confirmed diagnosis of recent onset of ACS. The blood samples of both groups were analyzed for Serum electrolytes (Na+, K+) by flame-photometry (Bio-Lab Diagnostic kit). Serum levels of glucose and lipid profile were obtained by calorimetry. There was statistically significant increase in serum sodium and potassium levels in across all age groups &amp; in both sexes of study group compared to control group. The mean (± SD) value of serum sodium and potassium concentrations was found non-significantly higher in Female group than Male group, (Pvalue=0.3 ). t-test revealed there was no significant difference in the mean±SD levels of serum sodium and potassium in the presence or absence of diabetes mellitus, Dyslipidemia, Hypertension, Smoking, and obesity, there were non-significant difference in mean (±SD) values of serum Na and K levels among stages of diastolic dysfunction. The mean (±SD) values of serum sodium and potassium concentrations were increased with increase MR severity. The study showed that there was non-significant positive correlation between age values and serum k levels (r = 0.2) (P= 0.1), while there was non-significant negative correlation between age values and serum Na levels (r = - 0.04), (P = 0.8). Non-significant inverse relationship was noted between serum Na, K concentrations and left ventricular ejection Fraction (LVEF) (r = -0.04, -0.3) (P = 0.8, 0.07). In conclusion, early assessment of serum electrolyte concentration is needed in order to implement proper supplementation and serve as important aid in diagnosis of ACS. The value of serum sodium and potassium concentrations increased with increased MR severity.

Study of changes in serum sodium and potassium levels in term and preterm neonates following phototherapy

Background: Neonatal hyperbilirubinemia is a common physical finding in the first week of life. It is a common cause of hospital readmission during neonatal period. Phototherapy is an important treatment modality. However, it has some complications; amongst them serum electrolyte changes are a common complication. Objective of this study is to determine the changes in serum sodium and potassium in neonates before and after phototherapy and compare the occurrence of these changes in relation to gestational age and birth weight.Methods: In a prospective hospital based comparative study both term and preterm neonates admitted in neonatal intensive care unit receiving phototherapy at Cheluvamba hospital Mysore from July 2021 to April 2022 (10 months) were studied. A predesigned proforma aided the enrolment of new-borns into the study. Serum bilirubin and electrolytes and a comparative study was made between before and after phototherapy groups to determine the incidence of electrolyte imbalance.Results: The study group included 100 neonates. Incidence of low-birth-weight babies was 28% and preterm 22%. Mean birth weight and gestational age was 2.91±0.65 kg and 38.43±1.96 week respectively. The incidence of hyponatremia post phototherapy was found to be 9% which was more in low birth weight and preterm neonates (p&lt;0.001) and was statistically significant. The incidence of potassium changes was found to be non-significant.Conclusions: The study shows that neonates under phototherapy are at higher risk of hyponatremia. This risk is greater in premature and low birth weight babies and hence this group of babies should be closely monitored for electrolyte changes and managed accordingly.

A STUDY ON RELATIONSHIP BETWEEN SERUM ELECTROLYTE LEVELS AND FEBRILE CONVULSION IN CHILDREN IN A TERTIARY CARE CENTRE

Introduction: Febrile seizure (FS) is the most common cause of convulsions in children seen in between 6 to 60 months of age. Fever plays an important role in causing disturbances in uid and electrolyte balance which alters the mechanism of seizure activity and its threshold. To ndAim: out the relationship between serum electrolytes (calcium, magnesium, sodium, potassium) and simple febrile convulsion. Materials and Method: This cross sectional study was conducted on 120 children of age between 6 to 60 months. 60 children had fever with convulsion(cases) and 60 children had fever without convulsion(control). Serum level of sodium, potassium, calcium, magnesium were statistically analysed between both the groups In our study the difference in serum sodium, potassium, calcium levels in between case and control group are statisticallyResults: signicant, the p-value being &lt;0.001, 0.017, 0.03 respectively. Our study concludes that changes in serum electrolytes may have aConclusion: role in the development of simple febrile convulsion and measurement of the serum electrolytes in a child with febrile seizures may help in predicting seizure recurrence within the same febrile illness.

Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia

IntroductionCancer and its treatment using various chemotherapeutic agents can have many adverse side effects. These side effects often result in significant changes in haematological and biochemical composition of blood. As a result, the regular monitoring of serum biochemical and haematological changes plays an important role in management of disease. The present study aimed to determine the relationship between haematological and biochemical changes in neutropenic cancer patients following chemotherapy. Specifically we evaluated the association between neutrophil count and serum proteins and electrolytes. MethodsFor this purpose we analysed retrospectively collected laboratory results from two independent patient cohorts. Each cohort was divided into a control group consisting of patients with normal haematological parameters and a study group which included patients with reduced neutrophil counts. Neutropenic patients (study group) were cancer patients on chemotherapy. Results and conclusionBlood samples of cancer patients in study group showed reduction in haemoglobin, neutrophils and platelets. Neutropenic group showed a significant reduction in serum albumin, total protein, calcium, and potassium. Our results show that patients with severe neutropenia had pronounced changes in serum protein and electrolytes and increased incidence of abnormal serum protein and electrolyte level. The changes in the neutrophil counts showed a positive correlation with the changes in serum protein and electrolyte levels. A similar trend was seen in both the patient cohorts: the discovery set (176 patients) and the validation set (200 patients). Taken together our results suggest that chemotherapy-induced neutropenia is associated with dysregulation in haemoglobin, platelets, serum proteins and electrolytes.

Changes in Serum Electrolytes, Urea and Creatinine in Nicotiana tabacum-treated Rats

Tobacco, which is a product of Nicotiana tabacum, has nicotine as its principal phytochemical. Nicotine has been reported to be an addictive drug and the leading cause of tobacco addiction worldwide with consequent renal implications. Therefore, this study was conducted to investigate the effect of the aqueous extract of Nicotiana. tabacum on serum electrolytes, urea and creatinine levels as indices of renal function in male rats. A total of 18 male wistar rats weighing 140-230g were used for this study. The animals were randomly divided into three groups (A, B and C), containing 6 rats each. Group A served as control while Group B and C were orally administered sublethal doses of 20 and 30 mg/kg body weight of the Nicotiana. tabacum extract respectively once per day for three weeks. At the end of the experimental period, all the animals were sacrificed. Blood samples were collected for biochemical assay.The results showed a significant increase (p&lt;0.05) in the serum concentration of sodium, potassium and urea levels of rats treated with the extract when compared with the control. However, serum concentrations of chloride, bicarbonate and creatinine showed no significant appreciable differences between the treated groups and the control group (p&lt;0.05).In conclusion, the study showed that aqueous extract of Nicotiana tabacum is associated with renal dysfunction with consequent hypernatremia and hyperkalemia, and may also suggest impaired urea clearance by the kidneys in male wistar rats.

Changes in Serum Electrolytes Following Permanent or Temporary Ileostomy

Background: Patients with ileostomies are well known to be susceptible to extracellular fluid volume depletion as a result of fluid and solute losses that are greater than intake. However, electrolyte disorders accompanying these episodes of volume depletion are not well delineated. Objective: To find out serum electrolytes changes observed in patients undergone permanent or temporary ileostomy. Method: This prospective observational study was carried out in the Department of Colorectal Surgery, BSMMU, Dhaka, from January 2018 to December 2018. Fifty patients underwent permanent or temporary ileostomy and postoperatively treated with intravenous fluid and electrolytes at least up to 3rd POD along with gradual resumption of oral intake or ileostomy feeding and managed at least for 5 days were included in this study. Electrolyte was measured preoperatively and 3rd and 5th POD and observed the changes. Result: Males were predominant than females (1.17:1). Most of the patients were in age group 31 – 40 years. Mean age was 42.4±12.5 years. Serum sodium (Na) and serum potassium (K) were reduced at POD 3 and at POD 5 compared to pre-operative level. Serum sodium concentration was 136.6±3.75 mmol/L pre operatively and reduced to 135.1 ±2.98 mmol/L at 3rd POD and 134.8±3.04 mmol/L at 5th POD. Similarly, serum potassium concentration was 4.0±0.49 mmol/L pre operatively and reduced to 3.8±0.70 mmol/L at 3rd POD and 3.8±0.50 mmol/L at 5th POD. Both serum Na and serum K level reduced significantly in POD 3 and in POD 5 in comparison to pre-operative values (p&lt;0.05). Regarding serum Cl and serum HCO3 level no statistically significant difference were observed (p&gt;0.05). Conclusion: Serum sodium and potassium concentration reduced statistically significantly after permanent ileostomy. Bangladesh Med Res Counc Bull 2021; 47(1): 78-81

Comparison of Serum Selenium Levels Between Patients with Newly Diagnosed Atrial Fibrillation and Normal Controls.

Atrial fibrillation (AF) is the most common sustained dysrhythmia in the elderly population. It is estimated to affect more than 30 million people worldwide. AF occurs when abnormal electrical impulses start to activate in the atria and override the heart's natural pacemaker, which can no longer control the heart's rhythm. Since atrial contractility is impaired in AF, blood flow in the atria becomes stasis over time and causes thrombus formation. This thrombus causes the risk of embolism and causes complications such as stroke. Therefore, it is a fundamental cause of cardiovascular mortality and morbidity. The diagnosis of AF is usually made with the help of electrocardiography (ECG). The absence of P waves in ECG and irregular R-R interval is sufficient for diagnosis. AF is most commonly associated with advanced age, hypertension, diabetes mellitus, thyroid dysfunction, obesity, alcohol use, physical inactivity, and underlying ischemic heart diseases. As well as to all these usual risk factors, electrolyte disorders and mineral deficiencies also play an essential role in the etiology of AF. Previous studies have clearly demonstrated that serum electrolyte changes have a role in the etiology of AF. These include electrolytes such as serum magnesium, calcium, potassium, and chloride. However, there is not enough information in the literature about the effects of trace elements on AF. Selenium is a trace element that plays an important role in many systems in the human body. It has a vital role in inflammation, regulation of antioxidant reactions, and fibrosis of tissues in both animals and humans. It is known that selenium deficiency causes many cardiovascular diseases such as heart failure, coronary artery disease, and arrhythmia. Our study aimed to compare serum selenium levels in newly diagnosed AF patients with the healthy control group.

Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Serum Electrolyte Levels in Patients with Type 2 Diabetes: A Pairwise and Network Meta-Analysis of Randomized Controlled Trials.

Previous studies have reported that sodium-glucose co-transporter 2 (SGLT2) inhibitors (SGLT2is) affect levels of serum electrolytes, especially magnesium. This study aimed to integrate direct and indirect trial evidence to maximize statistical power to clarify their overall and comparative effects in patients with type 2 diabetes (T2D). We systematically searched PubMed, EMBASE, CENTRAL, and ClinicalTrials.gov up to January 2021 to identify eligible randomized controlled trials (RCTs) of SGLT2is that reported mean changes in serum electrolytes, including magnesium, sodium, potassium, phosphate, and calcium. We performed both random-effects pairwise and network meta-analyses to calculate the weighted mean difference (WMD) and 95% confidence intervals (CI). In total, we included 25 RCTs involving 28,269 patients with T2D and 6 SGLT2is. Compared with placebo, SGLT2is were significantly associated with elevations in serum magnesium by 0.07 mmol/L (95% CI, 0.06 to 0.08 mmol/L) and serum phosphate by 0.03 mmol/L (95% CI, 0.02 to 0.04 mmol/L). Our network meta-analysis showed no evidence of significantly superior efficacy of any specific SGLT2 inhibitor over the others, although dapagliflozin was associated with a larger increment in serum magnesium (WMD=0.16 mmol/L) compared with other SGLT2is. Similarly, no statistically detectable differences among the effects of SGLT2is on serum levels of other electrolytes were detected. SGLT2is significantly increased serum magnesium and phosphate levels, consistent with a class effect of SGLT2 inhibition. However, further investigations of long-term efficacy and safety in patients with T2D with different clinical phenotypes are needed.