Serum Concentrations Of Serotonin Research Articles

Prospective Clinical Study: Full-Body Blue Irradiation in the Treatment of Atopic Dermatitis.

Ultraviolet-free (UV-free) blue light phototherapy has emerged as a promising option due to its reported efficacy and minimal adverse effects. This study aims to evaluate the effectiveness of full-body blue light irradiation in both adult and pediatric patients with atopic dermatitis (AD), assessing its impact on skin condition and mood regulation by investigating serum concentrations of serotonin and kynurenine pathway metabolites. 20 patients (age 9-45) with moderate and severe AD were included in the study. Treatment consisted of 10 irradiations with Full Body Blue device (453nm). Serum concentrations of serotonin, quinolinic acid, kynurenic acid, tryptophan, and kynurenine were measured before and after irradiations. After 10 sessions of full blue light therapy (453nm) statistically significant improvements were observed in Eczema Area Severity Index (EASI 13.16 vs. 8.65; p = 0.00016), SCORing Atopic Dermatitis (SCORAD 44.99 vs. 23.73; p < 0.00001), Visual Analogue Scale (VAS 6.53 vs. 3.95; p = 0.00251), 10-item pruritus severity scale (13.32 vs. 7.05; p < 0.00001). Moreover, statistically significant decrease in Dermatology Life Quality Index (DLQI) was noted (14.37 vs. 7.42; p = 0.00351). Additionally, increase in the serum concentration of serotonin was observed after completing 10 irradiation sessions (median 139.77mg/ml vs. 274.92mg/ml; p < 0.00001). Blue light may be a promising and safe treatment in patients with AD. It might also positively influence mood. Further investigations are needed to confirm those findings. ClinicalTrials.gov identifier, NCT06516783.

Serotonin, Endorphin Concentrations and Some Hematological Parameters in Male Narghile Smokers

This study was carried out to evaluate the relationship between narghile smoking and serum concentration of serotonin and endorphin and some blood hematological indices in males. Group of smokers composed of 50 voluntary, and control group composed of 36 healthy voluntary. This study was conducted on adults man that ages between (18-25 years). The markers measured in this study were serum serotonin and endorphin and hematological indices (platelets, hematocrit, hemoglobin, and white blood cells).&#x0D; This study showed a significant decrease (P&lt;0.05) in levels of serum serotonin, endorphin and blood platelets, and a significant increase (P&lt;0.05) in levels of in blood hematocrit and hemoglobin and a non-significant increase of white blood cells (P&gt;0.05) in smokers as compared with healthy persons.

Association of plasma concentrations of oxytocin, vasopressin, and serotonin with docility and friendliness of horses

Oxytocin (OXT) and vasopressin (AVP) have been associated with social interaction and affiliative behavior in animals. Additionally, AVP is known to affect socially aggressive behavior. In addition, serotonin has an association with aggressive behaviors. The objectives of this study were (1) to evaluate OXT, AVP, and serotonin concentrations in the plasma of horses of different breeds, sexes, and ages and (2) to determine if the neurotransmitters are associated with horse docility and friendliness. This study was performed at Sangju International Equestrian Center. Blood samples were collected from 23 horses, including 6 Thoroughbreds (11 to 18 yr), 6 Warmbloods (15 to 26 yr), 6 ponies (8 to 17 yr), and 5 Quarter Horses (4 to 12 yr). The group of horses consisted of 13 mares and 10 geldings. The plasma concentrations of OXT and AVP were measured by enzyme-linked immunosorbent assay, and the serum concentration of serotonin was measured by high-performance liquid chromatography. The characteristics of each horse were surveyed by 3 horse trainers. The effects of breed, sex, and age on the concentration of each neurotransmitter were assessed by a 3-way ANOVA with LSD post-hoc analysis. Linear regression analysis was performed to determine if the concentration of neurotransmitters is related to the docility and friendliness of horses. As a result, the concentrations of OXT and AVP did not vary with the breed, sex, or age of horses. However, the serotonin concentration varied depending on the breed and age of horses. Interestingly, there was a trend toward the existence of a correlation between docility and OXT in Thoroughbred horses. However, AVP and serotonin concentrations had no correlation with the docility and friendliness of horses. In conclusion, the docility and friendliness of Thoroughbred might be related with the blood OXT concentration.

Impact of a Specific Amino Acid Composition with Micronutrients on Well-Being in Subjects with Chronic Psychological Stress and Exhaustion Conditions: A Pilot Study.

Chronic work-life stress leads to dysfunction of the hypothalamus–pituitary–adrenal axis, the autonomic nervous system, and the serotonergic system, with resultant impairment of overall well-being. Aim of the study was to improve perceived stress by a specific amino acid composition with micronutrients in the verum versus placebo group. A total of 59 participants (18–65 years) with self-reported perceived chronic stress and exhaustion conditions participated in this randomized, double-blind, placebo-controlled study. The Perceived Stress Questionnaire (PSQ30), amino acid profile, anthropometric, clinical, blood, urine parameters, and dietary intake were assessed. After 12 weeks, the verum group achieved significantly greater improvements in the total PSQ30 score compared with the placebo group. In the verum group, serum taurine concentration, folic acid concentration, urinary magnesium excretion, and the ratio of l-tryptophan to the sum of competing amino acids rose significantly. In the placebo group, serum concentrations of serotonin, protein, and magnesium decreased significantly, whereas the cardiometabolic risk parameters body weight, body mass index, waist circumference, and waist-to-height ratio increased significantly. Compared with placebo, the verum supplementation resulted in a higher improvement in perceived stress. Beneficial effects on the serotonergic system and preventive effects on magnesium homeostasis and some cardiometabolic risk factors were supposed. Additional effects might be caused by the optimized food intake.

The efficacy of sulpiride in patients with anxiety disorders depending on the serum serotonin concentrations

The efficacy of sulpiride in patients with anxiety disorders depending on the serum serotonin concentrations was evaluated. We examined 132 patients with anxiety disorders. The higher levels of serotonin were found in 81 (61.3%) of patients, normal levels in 24 (25.8%) and lower levels in 27 (20.5%). Sulpiride was used in doses from 50 to 400 mg. Average treatment duration was >90 days. The positive effect of sulpiride monotherapy was identified in patients with higher and normal levels of serotonin. No clinical effect of sulpiride was noted in patients with lower serotonin concentrations. The efficacy of sulpiride depends on serum concentrations of serotonin. It can be assumed that serotonin concentration is a marker of sulpiride treatment efficacy in patients with anxiety disorders.

Serotonin in allergic rhinitis: a possible role for behavioural symptoms.

Allergic rhinitis (AR) is a very frequent disease which is not only characterized by nasal symptoms, but also with behavioural changes. This study evaluated the serum serotonin levels in patients with pollen-induced AR during and outside the pollen season.One-hundred-two (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with seasonal AR (SAR) evaluated outside the pollen season and so without allergic inflammation and symptoms, and 46 with SAR evaluated during the pollen season with symptoms. Blood specimens were collected to assess serum concentrations of serotonin and to compare results to scores of a Quality of Life (QoL) questionnaire which was performed in all subjects. Serotonin serum concentrations were higher in AR patients out of pollen season than in (p<0.01). There was a very strong direct relationship between QoL and serotonin concentrations.This preliminary study demonstrates that SAR influences serotonin concentrations and that serum serotonin could serve as a biomarker in AR patients with behavioural symptoms.

Serotonin in allergic rhinitis: a possible role for behavioural symptoms.

Allergic rhinitis (AR) is a very frequent disease which is not only characterized by nasal symptoms, but also with behavioural changes. This study evaluated the serum serotonin levels in patients with pollen-induced AR during and outside the pollen season.One-hundred-two (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with seasonal AR (SAR) evaluated outside the pollen season and so without allergic inflammation and symptoms, and 46 with SAR evaluated during the pollen season with symptoms. Blood specimens were collected to assess serum concentrations of serotonin and to compare results to scores of a Quality of Life (QoL) questionnaire which was performed in all subjects. Serotonin serum concentrations were higher in AR patients out of pollen season than in (p<0.01). There was a very strong direct relationship between QoL and serotonin concentrations.This preliminary study demonstrates that SAR influences serotonin concentrations and that serum serotonin could serve as a biomarker in AR patients with behavioural symptoms.

Serotonin and Neuron-specific Enolase

To investigate the association between serotonin (SER), cholesterol, and neuron-specific enolase (NSE) serum levels with depression after traumatic brain injury (TBI). Seventy-four patients with the diagnosis of TBI were included in our study. Admission computed tomography scans of all patients were analyzed. Serum concentrations of SER, NSE, low-density lipoprotein, and cholesterol were measured within on admission. Serum levels of SER and NSE were also measured at discharge and at the 6-month follow-up evaluation. In addition, serum NSE and SER levels were measured in a control group of 44 healthy volunteers. The TBI patients in our cohort were divided into 3 groups according to their admitting Glasgow Coma Scale and their discharging Glasgow Outcome Scale scores. Likewise, depressive symptoms were characterized using the Diagnostic and Statistical Manual of Mental Disorders criteria and the Mini-International Neuropsychiatric Interview. The measured SER serum levels were significantly lower (P<0.01) in TBI patients compared with the normal controls. Analysis of our data showed no correlation between the levels of SER, NSE, cholesterol, and low-density lipoprotein. The NSE serum levels were found to be elevated in our TBI group. However, these levels were not different between patients with depressive symptomatology. SER and cholesterol serum levels were lower in TBI patients developing depressive symptoms compared with those with no depression in a statistically significant manner. Fifty-seven percent of our patients developed depressive symptomatology. Decreased serum SER concentration may serve as an additional biochemical risk marker of posttraumatic mental disturbances.

Relationship between the serum concentrations of serotonin and lipids and aggression in dogs

The serum concentrations of serotonin and lipids — triglycerides, total cholesterol, low density lipoprotein, high density lipoprotein and very low density lipoprotein — were determined in 18 normal dogs and...

Hyperoxaemia does not change concentrations of serotonin and beta‐thromboglobulin in blood of healthy humans

Background: The mechanisms of oxygen‐induced effects on blood vessels (vasoconstriction in hyperoxaemia and vasodilatation during hypoxaemia) are uncertain. Many investigators have suggested that the vasoconstriction seen during hyperoxia/hyperoxaemia is mediated through the endothelium as a result of either increased release or activity of vasoconstrictors (oxygen radicals, endothelin, norepinephrine, angiotensin II, or serotonin (5‐HT)), or reduced activity of vasodilators (prostaglandin E2 and nitric oxide). Serotonin has been assumed to have a central role. Methods: Eight healthy volunteers were exposed to FiO2 of 1.0 for 20 min and serum concentrations of serotonin and activated platelets were measured (indicated by concentrations of β‐thromboglobulin (β‐TG)). Results. During hyperoxaemia in humans, serum concentrations of serotonin and β‐TG remained unchanged. Conclusion: If serotonin is involved in oxygen‐induced vasoconstriction, the mechanism is more likely to be either a potentiating effect of serotonin on other vasoconstrictors or increased activity of serotonin on its receptor.

Relationship between climacteric symptoms and serum serotonin levels in postmenopausal women

Objective: The aim of the study was to evaluate the possible relationship between climacteric symptoms and serum serotonin concentrations in postmenopausal women.Materials and methods:We studied 39 women who attended the Department of Gynecological Endocrinology in Poznan because of climacteric complaints. We evaluated climacteric symptom severity with the use of the Kupperman scaleand we measured 17β-estradiol, follicle stimulating hormone (FSH) and serotonin serum concentrations by radioimmunoassay.Results: The mean serum serotonin concentration in the studied womenwas 48.9 ng/ml (standard deviation, SD ± 24.1 ng/ml). The mean serum serotonin concentration in the group of patients with mild climacteric symptoms was 97.7 ng/ml (SD ± 16.6 ng/ml), and inthe group of patients with moderate and severe climacteric symptoms was 36.2 ng/ml (SD ± 24.1 ng/ml). The difference between the two groups was statistically significant (Mann-Whitney test, p <0.05). There was no difference in serum serotonin concentrations between patients with or without specific symptoms (Mann-Whitney test, p > 0.05).Conclusions: Serum serotonin concentrationsin postmenopausal women are related to the severity of climacteric symptoms.

Effect of tropisetron on circulating catecholamines and other putative biochemical markers in serum of patients with fibromyalgia

Objective: The aim of the study was to assess the influence of the 5-HT3-receptor antagonist tropisetron on circulating catecholamines as biochemical markers of the activity of the sympathoadrenal system in fibromyalgia. Moreover, serum concentrations of serotonin, somatomedin C, oxytocin, calcitonin-gene-related-peptide, calcitonin and cholecystokinin were assayed as putative markers in pain-related disorders like primary fibromyalgia. Methods: In 96 patients, who met the ACR classification criteria for fibromyalgia, and in 20 sex and age matched controls concentrations of dopamine, noradrenaline, adrenaline, serotonin and tropisetron were assayed in serum by HPLC with electrochemical detection. All other transmitters were determined by ELISA. Results: There was with the exception of tropisetron, calcitonin and dopamine, no correlation between doses of tropisetron 5, 10, 15 mg respectively and significant changes in circulating transmitters or other transmitters as putative biochemicals markers in primary fibromyalgia. Regarding the prediction of pain reduction to tropisetron, patients with elevated dopamine and/or reduced plasma 5-HT concentrations tended to show a higher response rate. Conclusion: Despite these partly disappointing results another prospective pilot study with selected patients vs. age and sex matched controls, double blind and with comparison of other 5-HT3-receptor antagonists e.g. dolasetron and granisetron e.g. after i.v. bolus injection is suggested. Still the data obtained in this preliminary paper provide some evidence regarding the present discussion on subgroups of patients with primary fibromyalgia.

Serotonin antibodies in relation to immune activation in major depression

Serum antibodies against serotonin and gangliosides, the serum concentration of serotonin in addition to indicators of immune activation, such as acute phase proteins (apps) and interleukin-6 (IL-6), were investigated in 20 major depressed patients and 32 normal controls. Antibody-positive sera against serotonin and gangliosides were increased in patients with major depression in comparison to normal controls. Serum concentrations of serotonin were significantly lower in depressed patients. These changes were accompanied by acute phase response characterized by elevated concentration of apps and IL-6. Compared with patients showing positive response to antidepressant treatment, patients with treatment-resistant depression (TRD) had antibodies against serotonin and gangliosides that were twice as high, as well as a significantly higher IL-6 concentration. The results suggest that alterations in the serotoninergic system may be related to immune activation in major depression and especially in treatment-resistant depression. © 1997 John Wiley & Sons, Ltd.