The Grothendieck monoid of an exact category is a monoid version of the Grothendieck group. We use it to classify Serre subcategories of an exact category and to reconstruct the topology of a noetherian scheme. We first construct bijections between (i) the set of Serre subcategories of an exact category, (ii) the set of faces of its Grothendieck monoid, and (iii) the monoid spectrum of its Grothendieck monoid. By using (ii), we classify Serre subcategories of exact categories related to a finite dimensional algebra and a smooth projective curve. For this, we determine the Grothendieck monoid of the category of coherent sheaves on a smooth projective curve. By using (iii), we introduce a topology on the set of Serre subcategories. As a consequence, we recover the topology of a noetherian scheme from the Grothendieck monoid.