In this study, a series of Yb3+ ions doped barium bismuth fluoroborate (BBFB) glasses with chemical composition (70-x) H3BO3+ 5Bi2O3 + 10BaCO3+ 7.5CaF2+ 7.5ZnO+ x Yb2O3 (where x = 0.05, 0.1, 0.25, 0.5, 1, and 2 in wt. %) were prepared by conventional melt quenching technique. The structural, physical, optical, and nuclear radiation shielding parameters were performed and investigated for all glasses. The physical property analysis affirms the stability of the present glasses. The increase of Yb3+ ions’ concentration has directly influenced the glass behaviors against gamma-ray and fast neutrons. X-ray diffraction spectra confirmed the aperiodic nature of the glasses. The density (ρ) increased from 3.26 to 3.94 (gm/cm3) while the molar volume (Vm) decreased from 30.196 to 26.628 (gm/cm−3) for 0.05YbBBFB to 2YbBBFB glasses. The molar refractivity (Rm) decreased from 9.415 to 8.312 (cm3) while the electronic polarizability (αe) varied from 497.86 to 11.781 (10―22 cm3) for all glasses due to the increase of Yb3+ ions’ concentration. Besides, the gamma-ray shielding parameter such as the mass attenuation coefficient (MAC), and the linear attenuation coefficient (LAC), etc. of the present glasses were articulated through the Phy-X/PSD program. Moreover, the effective atomic number (Zeff), the effective electron density (Neff), and the exposure and energy absorption buildup factors (EBF and EABF) parameters were also computed within the energy range of 15 KeV-15 MeV. The overall results revealed that excellent material property was observed for 2YbBBFB glass and this can be suggested for future optical, and gamma-ray shielding applications.