An efficient synthesis of 4H-chromeno[4,3-b]furo[2,3-d]pyridine-1-carboxylates as novel tetracyclic coumarin-fused furo-pyridone scaffolds is described. The protocol involves the three-component reaction of 4-chloro-coumarin-3-carbaldehyde, dimethyl acetylenedicarboxylate and isocyanides, followed by the addition of primary amines to produce the corresponding products in 78–92% yield.