Separation Of Magnetic Particles Research Articles

Design and application of environmentally friendly composite magnetic particles for microplastic extraction from water media

The widespread presence of microplastic particles in aquatic environments requires methods of their extraction from water for counting and analysis and for water purification technologies. In this study, new magnetic composite nanoparticles (FNP) were designed, characterized and explored to be used as magnetic seeds for extracting polyethylene terephthalate microparticles (MPET, 5–30 μm) from water by magnetic sedimentation. The engineered seeds have a complex morphology, with magnetic cores of Fe3O4 dispersed in an environmentally compatible polymer matrix of silicon dioxide, chitosan or gelatine. Mechanisms of the heteroaggregation of FNP and MPET are considered and the main influencing factors (particles concentrations, major ions, duration of the preliminary exposure and of the sedimentation) are studied. The heteroaggregates are removed from water using a gradient magnetic field (Bzmax = 0.44 T) generated by a system of permanent magnets. The mass concentration of magnetic nanoseeds for more than 98 % capture of PET particles in pure and in salted water after 0.5 hour of magnetic sedimentation was detected to be 0.002 g/L. It is two orders of magnitude lower than that reported for uncovered magnetite-based particles. Using magnetic composite seeds with ecofriendly coatings allows to perform a high efficient magnetic separation of microplastic particles from water both for analytical purpose and for potential water cleaning technologies, while strongly reducing the synthetic flocculant sludge volume.

Rapid Measurement of Magnetic Particle Concentrations in Wildland–Urban Interface Fire Ashes and Runoff Using Compact NMR

Wildfires are increasing in size, frequency, and intensity, releasing increased amounts of contaminants, including magnetic particles, into the surrounding environment. The aim of this paper is to develop a sensing method for the detection and quantification of magnetic particles (MPs) in fire ash and fire runoff using a compact Time-Domain Nuclear Magnetic Resonance (TD-NMR) system. The system is made up of custom NMR electronics with a compact and rugged permanent magnet array designed to enable future deployment as an in situ sensor. A signal-to-noise ratio of 25 dB was measured for a single scan, and sufficient data can be acquired in one minute. A linear relationship with an R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> value of 0.9699 was established between transverse relaxation rates and MP concentrations in ash samples. This was validated by testing known dilutions of pure magnetite particles and showing that they fit within the same linear curve. The developed approach was then applied to detect MPs in surface water, where changes in the relaxation rates as high as 400% were observed before and after a wildfire event. MPs were removed from the surface water using a magnetic particle separator to confirm that observed changes were solely due to the presence of MPs. The compact NMR system can be used as a simple and rapid approach to track and quantify the concentrations of magnetic particles released from fire ashes and also from other sources such as discharges from coal ash and other combustion ashes.

Evaluation of Fe-Ni Composite Oxygen Carrier in Coal Chemical Looping Gasification

Although coal chemical looping gasification (CCLG) is a promising technology for the efficient utilization of coal, limited studies concerned about the industrial application of oxygen carrier in CCLG system owing to its performance requirements including high reactivity with solid fuel, high carbon conversion, and good mechanical property. To meet the requirements of oxygen carriers in CCLG system, novel Fe-Ni composite oxygen carrier (OC) samples were successfully prepared. The performances of these OCs were evaluated in a fixed bed reactor, where they were reduced by solid fuel and then fully oxidized by air. Both fixed bed tests and thermodynamic analysis showed that the prepare OCs exhibited high reactivity with coal and syngas selectivity, making them suitable for the CCLG process. Specifically, when the loading amount of NiO was 20 wt%, the Fe-Ni composite OCs achieved the highest carbon conversion (93.03%) and synthesis gas selectivity (73.29%). Additionally, the thermogravimetric data revealed that the Curie temperature of the OCs was higher than 550°C, making them suitable for magnetic separation of the OC particles and carbon residue in the CCLG system.

Magnetic particle separation using current-carrying plates: A novel geometry in magnetophoresis

This paper introduces a novel system designed for the separation and trapping of micro-magnetic particles in a microfluidic setup. The system employs two triangular-shaped current-carrying plates with different electrical currents beneath the microchannel to create a non-uniform magnetic field. This magnetic field efficiently separates and traps the magnetic particles, guiding them along distinct paths within the channel. The study includes a parametric analysis involving electrical current, particle size, magnetic susceptibility of particles, and carrier fluid, in order to identify optimal parameters for achieving maximum efficiency. Specifically, M-450 and Oligo(dT)25 magnetic particles are collected using current-carrying plates with electric currents of 50[mA] and 150[mA], respectively. Moreover, the system's efficiency is further boosted by setting the fluid velocity to 2[μm/s], leading to 99% efficiency in collecting and separating different types of particles. The proposed microchip demonstrates its versatility by enabling the trapping and separation of various particles, with the flexibility to adjust the electrical current value accordingly.

High-gradient magnetic separation of colloidal uranium oxide particles from soil components in aqueous suspensions

The separation of uranium oxide (UO2) particles from soil-surrogate particles in aqueous suspensions was achieved using filtration enhanced by a magnetic field. Enhanced attraction of paramagnetic UO2 colloids to a ferromagnetic stainless-steel filter placed in a strong magnetic field arises because of the positive magnetic susceptibility of the particles and the high-gradient field generated near ferromagnetic fibers. Enhanced uptake of smaller particles over larger ones occurs through Brownian motion that promotes the collision of particles with the ferromagnetic fibers of the filter. Hence, this work focused on UO2 particles in the colloidal size range. Experiments used a water-cooled electromagnet and an array of permanent magnets. Chemical analysis showed that the magnetic field increased the capture efficiency of uranium particles from a range of 27–53% with the magnet off up to 98% with the magnet on after a single pass of the suspension through the filter. The recovery of the UO2 particles from the filter, however, was more difficult to achieve. Small amounts of UO2, together with significant amounts of background SiO2 particles, were removed from the filter during a first flush with the magnetic field on. A much larger recovery of UO2 was not observed until a second out-of-field flush was performed, which also released some SiO2. The degree to which particle separation was enhanced through the use of multi-stage filtration compared to single pass-through filtration was also examined. A design was suggested that could be used to optimize the separation efficiency for a continuous process.

Frequencies of Diagnostically Significant Polymorphisms of Hereditary Breast Cancer Forms in BRCA1 and BRCA2 Genes in the Kazakh Population.

Breast cancer is the most common form of cancer in women in the world with more than 400,000 deaths each year worldwide. The aim of this study is to compare population frequencies of alleles and genotypes of polymorphic variants of BRCA1 and BRCA2 genes associated with breast cancer risk in an ethnically homogenous Kazakh population with previously studied world populations. The material of the study was DNA isolated from peripheral blood of the enrolled population control group, represented by 1800 conditionally healthy individuals of Kazakh ethnicity. The DNA extraction was possible with the use of M-PVA magnetic particle separation method on the Prepito (PerkinElmer) automatic analyser for extraction of Chemagic Prepito (Wallac, Finland) nucleic acids using the PrepitoDNACytoPure reagent kit. Statistical calculations of allele and genotype frequencies, significance tests, and non-parametric χ2 analysis were carried out using PLINK software. The results favour for the high genetic heterogeneity of the studied polymorphisms, which reflects the specifics of the Kazakh population structure resulted from complex evolutionary and migration processes, as well as the median geographic location between the populations of Asia and Europe. Knowledge of the spectrum and frequency of mutations in BRCA1 and BRCA2 genes predisposing to breast cancer, which are present in varying frequencies in the Kazakh population, will provide a more effective approach to the screening protocol and allow for a faster, less expensive and more accessible genetic testing strategy for the Kazakhstan citizens.

Microfluidic separation of particles by synergistic effect of geometry-induced hydrodynamics and magnetic field

Microfluidic combined with magnetic field have been demonstrated to be the promising solutions for fast and low-damage particles separation. However, the difficulties in the precise layout of magnets and accurate prediction of particle trajectories lead to under and over separation of target particles. A novel particle separation lab-on-chip (LOC) prototype integrated with microstructures and micropolar arrays is designed and characterized. Meanwhile, a numerical model for the separation of magnetic particles by the synergistic effect of geometry-induced hydrodynamics and magnetic field is constructed. The effect of geometry and magnetic field layout on particle deflection is systematically analyzed to implement accurate prediction of particle trajectories. It is found that the separation efficiency of magnetic particles increased from 50.2% to 91.7% and decreased from 88.6% to 85.7% in the range of depth factors from 15 µm to 27 µm and width factors from 30 µm to 60 µm, respectively. In particular, the combined effect of the offset distance of permanent magnets and the distance from the main flow channel exhibits a significant difference from the conventional perception. Finally, the developed LOC prototype was generalized for extension to arbitrary systems. This work provides a new insight and robust method for the microfluidic separation of magnetic particles.

Magnetic density separation of particles in honeycomb-generated wake turbulence

Magnetic density separation (MDS) is a technique for separating granular materials based on mass density. MDS uses magnetically responsive fluids and engineered magnetic fields to create a vertical gradient of apparent mass density inside the fluid. We present a numerical study to investigate the effect of honeycomb wake turbulence on the motion of almost neutrally buoyant spherical particles in a magnetized fluid. A four-way coupled Euler-Lagrange approach is used where particles are effectively treated as finite-size point particles. It is shown that the honeycomb-generated wake turbulence increases the levitation time of the particles. The presence of particles results in an earlier break-up of the individual velocity profiles stemming from the honeycomb cells. The effects of honeycomb geometry and cell Reynolds number on the collective motion of particles and turbulence properties are investigated, where the choice for the best honeycomb is a trade-off between the separation error and the particle flux.

Simultaneous separation of different magnetic particles by sputtering magnetic wires at the bottom of a microchip: Novel geometry in magnetophoresis

In this paper, sputtered magnetic electrodes at the bottom of the microchannel is used to separate different magnetic particles in a microfluidic device, simultaneously. The proposed design consists of a microchannel with a length of 30 mm with three different outlets. The Nickel electrodes with different angles and thicknesses are used to separate different particles. A permanent magnet is used to produce a uniform magnetic field and the presence of the magnetic wires disturbs the uniformity of the magnetic field which leads to magnetic force applied to the magnetic particles in the channel’s environment. In order to validate the results, numerical solution was compared with analytical relations. Important parameters such as microparticle size and characteristic (M−450, Myone, Oligo (dT)25), wire dimensions, wire spacing, wire angle and the flow rate were analyzed. The results show that M−450 particles are affected by greater force in comparison to Myone and Oligo (dT)25 microparticles due to their higher magnetism property and size. It was shown that by increasing the angle of the sputtered wires (at the bottom of the channel), the particle deviation was reduced. Also, the effect of wire thickness of the electrodes is investigated for thicknesses of 10, 15 and 20 μm. The maximum deviation was related to the thickness of 20 μm, thus, the particles were not able to pass off over the electrodes and moves along the wire path. By increasing the distance between the wires from 400 μm to 700 μm, the microparticle deviation was increased. As the flow rate of the inlet fluid increases (from 25 to 75 mm/s), the hydrodynamic force on the microparticles increases and therefore, the particle deviation decreases when crossing off over the electrodes. It is observed that for speed of 50 mm/s, the best separation efficiency (94%) was obtained for the proposed microchip design.

Design and Development of a Traveling Wave Ferro-Microfluidic Device and System Rig for Potential Magnetophoretic Cell Separation and Sorting in a Water-Based Ferrofluid.

The timely detection and diagnosis of diseases and accurate monitoring of specific genetic conditions require rapid and accurate separation, sorting, and direction of target cell types toward a sensor device surface. In that regard, cellular manipulation, separation, and sorting are progressively finding application potential within various bioassay applications such as medical disease diagnosis, pathogen detection, and medical testing. The aim of this paper is to present the design and development of a simple traveling wave ferro-microfluidic device and system rig purposed for the potential manipulation and magnetophoretic separation of cells in water-based ferrofluids. This paper details in full: (1) a method for tailoring cobalt ferrite nanoparticles for specific diameter size ranges (10-20 nm), (2) the development of a ferro-microfluidic device for potentially separating cells and magnetic nanoparticles, (3) the development of a water-based ferrofluid with magnetic nanoparticles and non-magnetic microparticles, and (4) the design and development of a system rig for producing the electric field within the ferro-microfluidic channel device for magnetizing and manipulating nonmagnetic particles in the ferro-microfluidic channel. The results reported in this work demonstrate a proof of concept for magnetophoretic manipulation and separation of magnetic and non-magnetic particles in a simple ferro-microfluidic device. This work is a design and proof-of-concept study. The design reported in this model is an improvement over existing magnetic excitation microfluidic system designs in that heat is efficiently removed from the circuit board to allow a range of input currents and frequencies to manipulate non-magnetic particles. Although this work did not analyze the separation of cells from magnetic particles, the results demonstrate that non-magnetic (surrogates for cellular materials) and magnetic entities can be separated and, in some cases, continuously pushed through the channel based on amperage, size, frequency, and electrode spacing. The results reported in this work establish that the developed ferro-microfluidic device may potentially be used as an effective platform for microparticle and cellular manipulation and sorting.

Magnetic carbon nanocomposites via the graphitization of glucose and their induction heating

Carbon nanocomposites containing iron-based nanoparticles are attractive materials for the catalyst supports used for magnetic (induction) heating catalysis. The metallic, soft-magnetic iron nanoparticles provide local heating of the support in an alternating magnetic field and ensure rapid magnetic separation of the nanocomposite particles from reaction suspensions. In this work, magnetic carbon nanocomposites were prepared by annealing the precursor particles consisting of iron-oxide nanoparticles dispersed in a carbohydrate matrix. The annealing was conducted at 600 °C and 750 °C in an Ar atmosphere. At both temperatures the carbothermal reduction of iron oxide to Fe/Fe3C was observed; however, at the lower temperature the rate of reduction and the growth of the nanoparticles were considerably slower. The Fe3C was formed in negligible amounts only after a prolonged period of annealing at 600 °C. A detailed structural analysis showed that the Fe/Fe3C nanoparticles catalyze the graphitization of the carbonaceous precursor material already at 600 °C, resulting in the formation of a graphitic shell that surrounds them. This shell is tight enough to prevent the areal oxidation of the encapsulated Fe nanoparticles; their magnetic properties remained unchanged even after 1 year of storage under ambient conditions. At the higher annealing temperature, the growth of the Fe/Fe3C nanoparticles caused bursting of the graphitic shell and thus partially exposed their surfaces to the atmosphere. All the nanocomposites exhibited ferromagnetic behavior in accordance with their compositions. The nanocomposite that was predominantly composed of a graphitic shell, encapsulated Fe nanoparticles and a negligible amount of Fe3C, showed the highest specific absorption rate (760 W/gFe at 274 kHz), even at a relatively low AC-field amplitude (88 mT).

Microfluidic-Assisted CTC Isolation and In Situ Monitoring Using Smart Magnetic Microgels.

Capturing rare disease-associated biomarkers from body fluids can offer an early-stage diagnosis of different cancers. Circulating tumor cells (CTCs) are one of the major cancer biomarkers that provide insightful information about the cancer metastasis prognosis and disease progression. The most common clinical solutions for quantifying CTCs rely on the immunomagnetic separation of cells in whole blood. Microfluidic systems that perform magnetic particle separation have reported promising outcomes in this context, however, most of them suffer from limited efficiency due to the low magnetic force generated which is insufficient to trap cells in a defined position within microchannels. In this work, a novel method for making soft micromagnet patterns with optimized geometry and magnetic material is introduced. This technology is integrated into a bilayer microfluidic chip to localize an external magnetic field, consequently enhancing the capture efficiency (CE) of cancer cells labeled with the magnetic nano/hybrid microgels that are developed in the previous work. A combined numerical-experimental strategy is implemented to design the microfluidic device and optimize the capturing efficiency and to maximize the throughput. The proposed design enables high CE and purity of target cells and real-time time on-chip monitoring of their behavior. The strategy introduced in this paper offers a simple and low-cost yet robust opportunity for early-stage diagnosis and monitoring of cancer-associated biomarkers.

High Gradient Magnetic Separation of Pure Gd2O3 Particles from Pure La2O3 Particles

Rare earth oxides such as La2O3 and Gd2O3 are abundant in waste optical glass. The separation of rare earth oxides is beneficial to the recycling of rare earth resources. In this study, the rare earth oxide Gd2O3 particles were separated from La2O3 particles using high gradient magnetic separation, and the influence of different fluid media (i.e., water, anhydrous ethanol, and their mixture) on the separation results was investigated. By using the measured zeta potential of oxide particles in water/ethanol of different pH and water with different dispersants (Na2SiO3 9H2O, citric acid, Na2CO3, and sodium hexametaphosphate), the DLVO (Derjaguin–Landau–Verwey–Overbeek) potential calculations and their analysis applied to high gradient magnetic separation results were also performed. The results showed that using anhydrous ethanol or adding a dispersant in water as a fluid medium can promote the separation of magnetic Gd2O3 particles under a high-gradient magnetic field. Among the different conditions, anhydrous ethanol can improve the grade of Gd2O3 to 95% from 70% with water. Furthermore, ethanol can be reused after filtration, making it an environmentally friendly fluid medium. Among the four dispersants, sodium hexametaphosphate, Na2SiO3, and Na2CO3 can also increase the separation rate of La2O3 and Gd2O3 to about 95%. The effect of citric acid on the separation performance is slightly worse, and the recovery rate of Gd2O3 is 80%. This study provides a new reference for selecting a fluid medium for magnetic separation.

Dynamic behavior of a magnetorheological fluid radial-flow-based energy absorber considering apparent slip boundary condition

Accurate theoretical models play a key role in the development of magnetorheological energy absorbers (MREAs). Traditionally, the apparent slip caused by non-uniformity interface (i.e., the separation of carrier fluid and magnetic particles at the wall) of the working medium is often ignored for simplifying theoretical models. However, the apparent slip influence the cross-sectional flow and decreased the theoretical accuracy of the damping force for MREA applied in the impact absorption area. In this study, a dynamic model with apparent slip boundary condition for radial-flow-based MREA was proposed. The effect of apparent slip layer thickness on the dynamic behavior of an MREA was qualitatively and quantitatively compared in terms of the following three aspects: (1) with the Power-Law constitutive model, theoretical models of the dynamic characteristics of the magnetorheological fluid (MRF) squeeze and MREA are presented based on the apparent slip boundary condition with the MRF behavior of the Navier–Stokes equation; (2) the accuracy of the theoretical model to predict MREA peak force and boundary velocity with different slip-layer thicknesses; and (3) global agreement of the dynamic force and range curves between the modeling and experimental results. The results show that the absolute values of the relative errors in the two models with a 2- and 0-µm thick slip layer were less than 3.73 and 7.41%, respectively, and that a 2-µm thickness can help predict the actual dynamic characteristic more efficiently under accidental collision loading conditions.

The BigFLUX Magnetic Matrix Technology

The Magnetic separation of ultra-fine ore particles has always posed a challenge to the JONES/WHIMS process. Despite many advances in this technology, no effective improvement has been made to its core component: The Magnetic Matrix. The current approach to separate ultra-fine particles teaches that the gap of the matrix and its teeth size must be smaller than usual in order to accommodate the small size of the particles. However, practice proved this approach to be far from ideal. The closing of the gap between grooved plates, whose teeth are smaller, drastically reduces the flow area, reduces the feed capacity, and makes the matrices prone to clogging. In addition, smaller teeth reduce the magnetic field and its gradient, leading to poor results with ultra-fine ore particles. This research proves that bigger teeth are better suited for high intensity magnetic separation of ultra-fines because they avoid matrix clogging thanks to the larger slurry flow area. Additionally, bigger teeth amplify the magnetic field “Bmax” and increases the magnetic gradient “Grad (∆B /∆X)”. The positive results of this new “BigFLUX Matrix” technology, are being displayed in several mining operations worldwide, increasing metallurgical recovery and producing high quality concentrates and low iron content sand from iron ore tailings.

Numerical simulation of effectively driving the trajectory of magnetic particles in a Newtonian fluid using a uniform magnetic field

Herein, the interaction and relative motion of two circular magnetic particles in a static flow and planar Poiseuille flow is investigated via numerical simulation. A two-dimensional numerical model is constructed based on Maxwell’s finite element method, fully considering the interactions between particles and particles, particles and magnetic fields, and particles and flow fields. First, the motion state and action mechanism of the magnetic particles in contact state in the static fluid are analyzed under a vertical magnetic field; then, the simulation results are verified via experiments. Based on the motion state of the magnetic particles in the planar Poiseuille flow, the feasibility of effectively controlling the trajectory of magnetic particles in the planar Poiseuille flow using a magnetic field is discussed. In the static flow, the vertical magnetic field was unable to separate the contacting magnetic particles; thus, the magnetic field cannot effectively control magnetic particles in static flows. In the planar Poiseuille flow, the free contact and separation of magnetic particles was effectively controlled by the combined action of the magnetic field and the fluid. This study provides insights into the interactions among magnetic particles in static flows and summarizes a set of methods for effectively controlling two circular magnetic particles.

High-effective magnetic hydrocycloning equipment for magnetite ore processing

A new method and equipment for magnetic hydrocycloning are proposed, which make it possible to extract the magnetic fraction from a polydisperse suspension with a high specific productivity and separation efficiency without preliminary classification by size. An alternating magnetic field source is coaxially superimposed on top of the hydrocyclone so that the magnet-like lines intersect the suspension flow rotating in the cylindrical part of the hydrocyclone. In this case, the gradient of the magnetic field inside the body of the hydrocyclone is directed opposite to the direction of the summed vectors of the centrifugal force and gravitational force, and the magnetic fraction (product) is redirected through a drain tube for the concentrate outlet. It is possible to adjust the operating mode of the magnetic hydrocyclone for adjusting the total area of the outlet holes in the drain tube by moving an insert with slot-like cuts, which changes the overlap area of the holes. The magnetic hydrocyclone is recommended for processing ferruginous quartzite and other types of ores with pronounced magnetic properties. The results of the effective separation of magnetic and nonmagnetic particles at different magnetic field densities are presented, and the dependence of the magnetic fraction recovery on the size of the initial suspension feed is described. A method is proposed for estimating the possibility of extracting magnetic particles at preset parameters, for example, the geometric dimensions of the magnetic hydrocyclones at the varied values of the magnetic field density and particle flow velocity. The formula for the calculation is given, which establishes the equality, when the particle overcomes the internal space of the hydrocyclone and is extracted into the concentrate.

Separation and trapping of magnetic particles by insertion of ferromagnetic wires inside a microchip: Proposing a novel geometry in magnetophoresis

In this study, by placing two ferromagnetic wires with different diameters inside the microchannel, a non-uniform magnetic field is generated. The magnetic force of this non-uniform field, separates different magnetic particles from each other and collects them in different parts of the channel. Using this system, we are able to collect and separate different particles from each other with an efficiency of 97%. This phenomenon depends on parameters such as wire diameter and its magnetic sensitivity, external magnetic field intensity, particle magnetic sensitivity, particle size and magnetic sensitivity of the carrier fluid. Here, these parameters are examined individually for magnetic particles (M-280 and M-450) and the optimum parameters are specified. Then, by comparing various cases, a system, for simultaneous separation and trapping is proposed. In addition, one of the magnetophoresis problems, which is interaction forces between magnetic particles investigated for the proposed system. The effects of effective parameters such as the distance between the wires and the fluid velocity are optimized to obtain maximum efficiency. Particle M-280 and M-450 are collected by wires with diameter of 100[μm] and 50[μm] respectively. The optimum distance between two wires is 800[μm], so their magnetic field distribution have positive effect on each other. Also, to maximize the system efficiency the fluid velocity is set to 11[mm/s]. By selecting these parameters as obtained values, the system efficiency is optimized. By changing wire diameter or magnetic field intensity, the proposed microchip can be used for separation and trapping of different particles.

Magnetic spirals: an innovative approach for enhancing the separation of ferro- and para-magnetic particles

ABSTRACT Spirals are one of the most widely used beneficiation equipment in mineral processing industry. The prerequisite to improve spirals' performance is to understand the forces that affect valuable and gangue minerals' separation. This paper investigates how magnetic properties of particles can be used to achieve a sharper separation of magnetic and non-magnetic particles in spirals. To this end, separation behavior of a synthetic mixed magnetite and quartz particles in the presence and absence of magnetic field was investigated via analyzing variations in the forces that affect particles’ separation in a spiral. Changes in Zero force line were considered as the reference point in the studies. In this regard an innovative magnetic-spiral was designed and fabricated. A magnetic force was added to separation process of the selected spiral. This, increased fine particles grade and recovery up to 8.5% and 7.5% respectively.

Population features of alleles and genotypes frequency distribution of polymorphic genetic markers of antipsychotic medications pharmacokinetics in the Kazakh population.

The presented article is relevant, as the main goals of schizophrenia treatment are to achieve a response to psychopharmacotherapy, reduction and stabilization of psychopathological symptoms, qualitative remission, which in general implies the creation of a stable quality of life for the patient. The purpose of the study was to evaluate the population features of the frequency distribution of alleles and genotypes of polymorphic genetic variants of according to genome-wide association studies analysis of pharmacokinetics-associated antipsychotic medications, in an ethnically homogeneous Kazakh population. The research material was deoxyribonucleic acid (DNA) isolated from the peripheral blood of 1,800 conditionally healthy persons of Kazakh nationality. DNA isolation was carried out by the magnetic polyvinyl alcohol magnetic particle separation method. The analysis of the frequency distribution of the studied genotypes in the Kazakh population showed their compliance with the Hardy-Weinberg equilibrium for all studied polymorphisms (p > .05). The obtained results showed that CYP2C19 (rs4244285, rs4986893) polymorphisms occurs in Kazakhs significantly more often than European and a number of Asian populations, which significantly affects the decrease in effectiveness and increases the risk of side complications during therapy with antipsychotic medications in the Kazakh population.