Sensor For Nonenzymatic Glucose Detection Research Articles

Highly sensitive surface plasmon resonance sensor with surface modified MoSe2/ZnO composite film for non-enzymatic glucose detection

The rapid and accurate assessment of glucose concentration has been demonstrated to play a significant role in human health, such as the diagnosis and treatment of diabetes, pharmaceutical research and quality monitoring in the food industry, necessitating further development of the performance for glucose sensor especially at low concentrations. However, glucose oxidase-based sensors suffer from crucial restriction in bioactivity because of their poor environmental tolerance. Recently, catalytic nanomaterials with enzyme-mimicking activity, known as nanozymes, have gained considerable interest to overcome the drawback. In this scenario, we report an inspiring surface plasmon resonance (SPR) sensor for non-enzymatic glucose detection employing ZnO nanoparticles and MoSe2 nanosheets composite (MoSe2/ZnO) as sensing film, featuring desirable advantages of high sensitivity and selectivity, lab-free and low cost. The ZnO was used to specifically recognize and bind glucose, and further signal amplification was realized by incorporating of MoSe2 owing to its larger specific surface area and favorable bio-compatibility, as well as high electron mobility. These unique features of MoSe2/ZnO composite film result in an obvious improvement of sensitivity for glucose detection. Experimental results show that the measurement sensitivity of the proposed sensor could reach 72.17 nm/(mg/mL) and a detection limit of 4.16 μg/mL by appropriately optimizing the componential constitutions of MoSe2/ZnO composite. In addition, the favorable selectivity, repeatability and stability are demonstrated as well. This facile and cost-effective work provides a novel strategy for constructing high-performance SPR sensor for glucose detection and a prospective application in biomedicine and human health monitoring.

Nickel foam electrode decorated with Fe-CdIn2O4 nanoparticles as an effective electrochemical sensor for non-enzymatic glucose detection

The non-enzymatic glucose electrochemical sensors have great significance in the prevention and diagnosis of diabetes. In this work, Fe-CdIn2O4 was grown in situ on the nickel foam with the one step non-aqueous sol-gel method. The nickel foam modified by Fe-CdIn2O4 was directly used to detect glucose. The high specific surface area of the nickel foam enhances the contact surface with glucose, and effectively promotes the transmission of electrons. The 30% Fe-CdIn2O4 had a good electrochemical performance for the detection of glucose when 30% Fe was combined with CdIn2O4. XRD showed that the 30% Fe-CdIn2O4 had better crystallinity. SEM, SEM-Mapping, and TEM showed that the 30% Fe-CdIn2O4 particles grew evenly and exposed abundant active sites. The detection results showed that the 30% Fe-CdIn2O4 had an excellent response to glucose. The linear detection range was wide (0.01–1 mM), the limit detection was low (1.68 μM), the response time was rapid (2.65 s), as well as satisfactory stability, excellent selectivity, and great sensitivity (8992 μA·mM−1·cm−2). Meanwhile, based 30% Fe-CdIn2O4 non-enzymatic electrochemical sensor was used to detect glucose in real human serum, and its detection performance was excellent. This study has practical application value in the detection of glucose in real human serum.

Mn2O3 porous microsheets prepared by a chemical precipitation method as an effective electrochemical sensor for non-enzymatic glucose detection

Mn2O3 porous microsheets prepared by a chemical precipitation method as an effective electrochemical sensor for non-enzymatic glucose detection

Synthesis of NiCo2O4 Nanostructures and Their Electrochemial Properties for Glucose Detection.

In this work, we prepared spinel-type NiCo2O4 (NCO) nanopowders as a low-cost and sensitive electrochemical sensor for nonenzymatic glucose detection. A facile and simple chemical bath method to synthesize the NCO nanopowders is demonstrated. The effect of pH and annealing temperature on the formation mechanism of NCO nanoparticles was systematically investigated. Our studies show that different pHs of the precursor solution during synthesis result in different intermediate phases and relating chemical reactions for the formation of NCO nanoparticles. Different morphologies of the NCO depending on pHs are also discussed based on the mechanism of growth. Electrochemical performance of the prepared NCO was characterized towards glucose, which reveals that sensitivity and selectivity of the NCO are significantly related with the final microstructure combined with constituent species with multiple oxidation states in the spinel structure.

A facile and sensitive electrochemical sensor for non-enzymatic glucose detection based on three-dimensional flexible polyurethane sponge decorated with nickel hydroxide

A novel three-dimensional nickel hydroxide/polyurethane (Ni(OH)2/PU) electrode was prepared by a simple and environmentally friendly method and used for non-enzymatic detection of glucose. The Ni(OH)2/PU electrode was obtained by one-pot hydrothermal method of loading nickel hydroxide on a cheap, easily available and flexible polyurethane sponge, which is facile and energy-saving. The porous structure of the polyurethane sponge provides a large surface area and a rich electrochemical active site for the electrode, which is beneficial to the oxidation reaction of glucose on the surface of the electrode with Ni(OH)2. The Ni(OH)2/PU electrode structure was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The cyclic voltammetry test was used to study the catalytic performance of Ni(OH)2/PU electrode for oxidation of glucose and the chronoamperometry was used to investigate the detection performance of Ni(OH)2/PU electrode on glucose. The results indicate that this non-enzymatic glucose sensor had a high sensitivity of 2845 μA mM−1 cm−2, a low detection limit of 0.32 μM (S/N = 3), a detection range of 0.01–2.06 mM and response time of less than 5 s. In addition, the Ni(OH)2/PU electrode had excellent selectivity, reproducibility and stability and also exhibited effective detection of glucose in fetal bovine serum (FBS). In summary, Ni(OH)2/PU electrode had broad prospects as an excellent candidate for non-enzymatic glucose sensors. The study also opens up a facile and energy-saving approach for preparing three-dimensional (3D) functionalized polymer electrode via hydrothermal method as electrochemical sensors.

Electrodeposition of nickel on electrospun carbon nanofiber mat electrode for electrochemical sensing of glucose

In this study, a novel non-enzymatic glucose sensor was successfully produced using nickel electrodeposition on an oil free carbon nanofiber (CNF) mat prepared by electrospinning method. The as-prepared Ni/CNF mat electrode was studied by means of scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). The characterization results showed that not only was nickel coating electrodeposited on the CNF mat but also the nickel coating was uniformly deposited on the CNF mat electrode. The electrochemical properties of Ni/CNF mat were evaluated using cyclic voltammetry (CV) and amperometry measurements. It was found that the Ni/CNF mat electrode had good electrocatalytic activity toward the oxidation of glucose and demonstrated a wide linear range of 0.002–5 mM, a low detection limit of 0.57 µM, a rapid response time (2 s), a high selectivity with no interference from other oxidable species, good reproducibility and long-term stability. Moreover, the prepared sensor was used to identify glucose in real sample species. Therefore, Ni/CNF mat electrode due to good analytical performance, cost effective and simple preparation method can be proposed as a promising sensor for non-enzymatic glucose detection.

A novel nanohybrid of gold nanoparticles anchored copper sulfide nanosheets as sensitive sensor for nonenzymatic glucose detection

In this study, we developed a sensitive glucose sensor by hybridizing abundant gold nanoparticles on surface of copper sulfide nanosheets supported three-dimensional framework. The sensor showed high activity and long-term stability towards glucose oxidation. In this context, is was recognized an adequate sensitivity of 0.059 mA μM−1 cm-2, wide linear detection range of 1.98–976.56 μM, along with low LOD of 7.62 μM. Besides, the sensor also presented high selectivity and good retention of around 85.9% after long-term operation of 1800s. These results may be assumed to the synergistic effects produced by the combination between gold nanoparticles and copper sulfide nanosheets, as well as the formation of hierarchical 3D architecture, which promoted electroactive surface area, charge transfer, electrolyte penetration, and ion diffusion, thereby leading to the enhancement of catalytic activity. Our work may open a new option for developing highly catalytic material for glucose sensor in analytical purposes.

Novel nanoneedle structures of zinc-doped cobalt hydroxide as a self-supported sensor for sensitive glucose detection

In this study, we developed a novel nanoneedle-like structure of zinc-doped cobalt hydroxide supported by three-dimensional porous architecture (Zn-Co-OH/3DNF) via a facile approach. The hybrid was successfully applied as a binder-free and self-supported sensor for nonenzymatic glucose detection in alkaline medium. The hybrid can detect glucose with a wide linear detection range of 10–3535 μM, low detection limit of 8.33 μM, and an acceptable sensitivity of 0.0061 mA μM−1 cm-2. In addition, the hybrid exhibited good selectivity, long-term stability, and durability. The obtained results may be due to the synergistic effect produced by the combination between zinc and Co-OH in the form of large-area nanoneedle-like structures, together with the high conductivity and large surface area of 3D supporting material; thereby improving electroactive sites, charge conductivity, and electrolyte diffusion. The achieved results suggested a novel approach for developing potential sensor with the improved performance towards glucose detection in analytical applications.

Hierarchical cobalt nanorods shelled with nickel oxide vertically attached 3D architecture as non-binder and free-standing sensor for sensitive non-enzymatic glucose detection

A hierarchical nanohybrid based on vertical cobalt oxide nanorods shelled with nickel oxide supported on a three-dimensional foam was prepared by a simple synthetic procedure. The unique nanoarchitecture along with superior conductivity and synergistic effect between components made hybrid become as a sensitive non-binder and free-standing sensor for non-enzymatic glucose detection at low concentration. In this regard, the hybrid exhibited excellent electrocatalytic activity towards glucose oxidation with a wide linear detection range of 1 μM to 2 mM, excellent sensitivity of 4.86 μA/(mM ⋅ cm2), low detection limit of 1.07 μM, and rapid response time of < 5 s in 0.1 M KOH. Furthermore, the hybrid displayed high selectivity to glucose without poisonous effect from common interferents, such as ascorbic acid, dopamine, uric acid, oxalic acid, urea, KCl, and Na2SO4. The results were therefore highly potential for the development of a novel sensor with the improved electrochemical performance towards glucose sensing applications.

Co-MOF nanosheet array: A high-performance electrochemical sensor for non-enzymatic glucose detection

It is important to construct and develop non-noble-metal nanoarray architecture for sensitive and selective detection of glucose. In this paper, we testify the hydrothermal synthesis of Co-MOF nanosheet array on nickel foam from aqueous Co2+ and terephthalic acid. The resulting Co-MOF array on Ni foam (Co-MOF/NF) exhibits strong activity for glucose oxidation electrocatalysis in alkaline media. As a promising enzymatic-free sensing, the speedy amperometric response of < 5 s, high sensitivity of 10,886 μA mM−1 cm-2 and low detection limit of 1.3 nM (signal/noise = 3) are obtained in the Co-MOF/NF. Our study shows that the material possesses long-time stability and great reproducibility and may be used for the glucose detection in human blood serum and fruit juice.

Three-Dimensional Dendrite Cu–Co/Reduced Graphene Oxide Architectures on a Disposable Pencil Graphite Electrode as an Electrochemical Sensor for Nonenzymatic Glucose Detection

Three-dimensional (3D) copper–cobalt (Cu–Co)/reduced graphene oxide (rGO) hierarchical architectures are electrochemically deposited over a pencil graphite electrode (PGE), and the modified PGE is directly exploited as a binder-free and disposable electrode for high performance nonenzymatic glucose sensors. The morphological features substantiate that the Cu–Co nanostructures display a 3D, open, porous, interconnected network architecture, in which the rGO layers are tightly pinned among the nanofeelers. Owing to the benefits of dendrite architectures and optimized composition, Cu–Co/rGO/PGE demonstrates better glucose oxidation behavior under alkaline conditions. Being a nonenzymatic glucose sensor, Cu–Co/rGO/PGE demonstrates excellent gluose detection properties with considerable chloride poisoning resistance. The excellent analytical performance of Cu–Co/rGO/PGE comprehends its application in human serum samples. Thus, this report paves constructive opportunities for the development of disposable, envi...

Uniform and Homogeneous Growth of Copper Nanoparticles on Electrophoretically Deposited Carbon Nanotubes Electrode for Nonenzymatic Glucose Sensor

The multiwalled carbon nanotubes thin-film-based electrode was fabricated by electrophoretic deposition and modified with copper (Cu) nanoparticles to fabricate Cu/CNTs nanocomposite sensor for nonenzymatic glucose detection. The expensive glassy carbon electrode was replaced by fluorine-doped tin oxide glass containing CNTs film to confine the Cu nanoparticles growth by electrodeposition through cyclic voltammetry (CV). The ultraviolet visible and X-ray diffraction analysis revealed the successful deposition of Cu nanoparticles on the CNTs-modified electrode. The atomic force microscopy images confirmed the morphology of electrodeposited Cu on CNTs film as uniformly dispersed particles. The electrocatalytic activity of electrode to the glucose oxidation was investigated in alkaline medium by CV and amperometric measurements. The fabricated sensor exhibited a fast response time of less than 5 s and the sensitivity of 314 μA mM−1 cm−2 with linear concentration range (0.02–3.0 mM) having detection limit 10.0 μM. Due to simple preparation of sensor, Cu/CNTs nanocomposite electrodes are a suitable candidate for reliable determination of glucose with good stability.