Background: AIDS emerged as one of the most important public health issue of the late twentieth and early –first centuries and is now one of the leading cause of global morbidity and mortality. In India, 35% of all reported AIDS cases are among the age group of 15-24 years, indicating the vulnerability of the younger population to the epidemic. Many Adolescents around the world are sexually active and many sexual contacts among them are unprotected, they are at risk of contracting sexually transmitted diseases (STDs) including HIV/AIDS. Objectives: 1. To assess the knowledge of the senior college students regarding Meaning of HIV - AIDS, Incidence of HIV-AIDS, Ways of transmission of HIV –AIDS, Common signs of HIV –AIDS and Common investigations to detect HIV-AIDS 2. To assess the knowledge of the senior college students regarding control and preventive measures of HIV – AIDS (at the individual level, family level and community level) 3. To find out the relationship between the knowledge with the selected demographic variables. Material and Method: descriptive survey approach to assess the knowledge regarding HIV-AIDS among the student studied in the selected senior colleges in Gokhale Education Society, Nashik. Data were collected from 100 students, the structured questionnaire is used to collect data on 27th January 2017. Results: In the present study, 93% of the samples had knowledge about meaning of HIV. Near about 50% of the samples had knowledge about way of transmission, common signs and investigation of HIV-AIDS. More than 50%of the samples had knowledge about when the world AIDS day is celebrated. There was positive correlation found between source of information of the samples and average knowledge score of the samples