We compute next-to-next-to-leading order QCD corrections to the partonic processes b → cu¯d\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ c\\overline{u}d $$\\end{document} and b → cc¯s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ c\\overline{c}s $$\\end{document}, which constitute the dominant decay channels in standard model predictions for B-meson lifetimes within the heavy quark expansion. We consider the contribution from the four-quark operators O1 and O2 in the ∆B = 1 effective Hamiltonian. The decay rates are obtained from the imaginary parts of four-loop propagator-type diagrams. We compute the corresponding master integrals using the “expand and match” approach which provides semi-analytic results for the physical charm and bottom quark masses. We show that the dependence of the decay rate on the renormalization scale is significantly reduced after including the next-to-next-to-leading order corrections. Furthermore, we compute next-to-next-to-leading order corrections to the Cabibbo-Kobayashi-Maskawa-suppressed decay channels b → uc¯s\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ u\\overline{c}s $$\\end{document} and b → uu¯d\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$ u\\overline{u}d $$\\end{document}.