An air suspension system of semi-trailer trucks controlled by semi-active fuzzy logic control is proposed and researched to reduce the dynamic load coefficient (DLC) of the wheel axles. A dynamical model described by a nonlinear system with 7-DOF of the vehicle and a Simulink program developed in Matlab software are applied to simulate the DLC values under different operation conditions. The fuzzy control is then applied to control damping coefficients of the air suspension system. The obtained results show that semi-active air suspension of semi-trailer truck is overall superior to passive air suspension. The DLC values are also significantly decreased in all cases of the road surface roughness, over a range of vehicle velocity and the different loaded conditions. Particularly, under vehicle fully loaded condition, the DLC value of the tractor driver is greatly reduced by 27.4 % at speed of 27.5 m/s on the ISO level B road.