In this study, we investigated two-proton radioactivity using the effective liquid drop model with varying mass asymmetry shapes and effective inertia coefficients (VMAS-EFF). Gaudin’s expression term for Coulomb potential energy is replaced in the current study’s calculation of potential energy. The VMAS-EFF combination predicts the half-life with the lowest standard deviation ( σ =1.03) compared to other models and previous constant mass asymmetry with Werner-inertial Wheeler’s coefficient combinations. The lowest standard deviation value indicates that the VMAS-EFF combination is suitable for reproducing the experimental data. We extended the half-life predictions to another 54 nuclei and compared them with six theoretical model predictions and two empirical formula predictions. The present work also investigated the decay possibilities using quantum tunnelling by computing the driving potential (V-Q) for various states of angular momentum l = 0, 2, 3, and 4. Found that 6Be, 6B, 8C, 12O,15,16Ne, 19Mg, 22Si, 26S, 30Ar 38,39Ti, 40V, 42Cr, 45Fe, 48,49Ni, 54Zn, 58,59,60Ge and 64Se nuclei have a high chance of emission for two protons, while 7B, 10N, 14F, 17Na, 24P, 28Cl,32K, 34Ca, 36,37Sc, 44Mn, 47Co, 52Cu, 56,57,58Ga, 61,62As nuclei have a lower chance for two proton than one proton decay. The computation of separation energy findings agree well with the driving potential findings.