Alleviating the burden on amputees in terms of high-level control of their prosthetic devices is an open research challenge. EMG-based intention detection presents some limitations due to movement artifacts, fatigue, and stability. The integration of exteroceptive sensing can provide a valuable solution to overcome such limitations. In this paper, a novel semiautonomous control system (SCS) for wrist–hand prostheses using a computer vision system (CVS) is proposed and validated. The SCS integrates object detection, grasp selection, and wrist orientation estimation algorithms. By combining CVS with a simulated EMG-based intention detection module, the SCS guarantees reliable prosthesis control. Results show high accuracy in grasping and object classification (≥97%) at a fast frame analysis frequency (2.07 FPS). The SCS achieves an average angular estimation error ≤18° and stability ≤0.8° for the proposed application. Operative tests demonstrate the capabilities of the proposed approach to handle complex real-world scenarios and pave the way for future implementation on a real prosthetic device.