T2D is a chronic disease that is influenced by different factors. The extent to which degree adverse childhood events (ACEs) can modify the potential to development of T2D is still not explored and therefore represents one of the central questions of the CELLO (childhood escape - late life outcome, DRKS00012419) study. In addition, transgenerational effects were considered in the analyses. The study analyzed the association of self-reported traumatic experiences and T2D disease of refugees from East Prussia, who were displaced from their former homeland at the end of the World War II. In addition, an independent sample consisting of participants of first-generation offspring of refugees was analyzed. Of the 242 refugees, all aged between 73 and 93, 17.36% reported T2D disease, while among the offspring (n = 272), aged between 47 and 73, it was 5.5%, meaning reduced T2D prevalence for both generations compared to the German population of comparable age. In the refugee generation, emotional neglect showed a negative association with development of T2D in later life. In women, separation from close caregivers in childhood showed a negative association with later T2D. In contrast, experiencing emotional abuse in childhood showed a positive association with later T2D. The offspring generation showed no associations of ACEs and reported T2D diagnoses in later life. Our results demonstrate that individual trauma in childhood is responded to with different mechanisms that can lead to both increased and decreased reported T2D diagnoses in adulthood and thus should by no means be considered in a generalized manner.
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