To solve the trajectory tracking control problem for a class of nonlinear systems with time-varying parameter uncertainties and unknown control directions, this paper proposed a neural sliding mode control strategy with prescribed performance against event-triggered disturbance. First, an enhanced finite-time prescribed performance function and a compensation term containing the Hyperbolic Tangent function are introduced to design a non-singular fast terminal sliding mode (NFTSM) surface to eliminate the singularity in the terminal sliding mode control and speed up the convergence in the balanced unit-loop neighborhood. This sliding surface guarantees arbitrarily small overshoot and fast convergence speed even when triggering mistakes. Meanwhile, we utilize the Nussbaum gain function to solve the problem of unknown control directions and unknown time-varying parameters and design a self-recurrent wavelet neural network (SRWNN) to handle the uncertainty terms in the system. In addition, we use a non-periodic relative threshold event-triggered mechanism to design a new trajectory tracking control law so that the conventional time-triggered mechanism has overcome a significant resource consumption problem. Finally, we proved that all the closed-loop signals are eventually uniformly bounded according to the stability analysis theory, and the Zeno phenomenon can be eliminated. The method in this paper has a better tracking effect and faster response and can obtain better control performance with lower control energy than the traditional NFTSM method, which is verified in inverted pendulum and ball and plate system.