Self-rating Depression Scale In Patients Research Articles

Нейропатичний біль при анкілозивному спондиліті та особливості психопатологічного реагування

The purpose of the work was to study the features of psychopathological symptoms in ankylosing spondylitis with and without neuropathic pain. Materials and methods. We clinically examined 142 patients treated between 2019 and 2022 who were diagnosed with ankylosing spondylitis according to the modified New York criteria. These patients were divided into two groups: the first group had the signs of neuropathic pain; the second group had no signs. The study of the psycho-emotional sphere was carried out using the The Zung Self-Rating Depression Scale, scales for assessing the level of personal and reactive anxiety by S. Spilberger, and the Mini Mental State Examination questionnaire was used to determine cognitive function. Results and discussion. It was found that the basis of psychopathological reactions in ankylosing spondylitis are mild and moderate depressive and anxiety symptoms: the average score on The Zung Self-Rating Depression Scale in patients without neuropathic pain was 48.1 ± 13.1 points, and in patients with neuropathic pain – 58.1 ± 4.6 points (p<0.01). 28.9% had no signs of depression, 45.1% showed signs of mild depression, and 26.0% – moderate depression. In 41.5% of patients without neuropathic pain, no signs of depression were found, in 40.4% – mild depression, in 18.1% – moderate, in patients with neuropathic pain – 4.2%, 54.2%, and 41.6%, respectively. The average value of the reactive anxiety index in the examined was 47.2 ± 12.2 points, in patients without neuropathic pain – 45.5 ± 12.7 points, in patients with neuropathic pain – 50.4 ± 10.5 points (p<0.05); personal anxiety indicator was 45.5 ± 10.1, 43.7 ± 10.6 and 49.0 ± 8.2 points, respectively (p<0.05). A low level of reactive anxiety in patients with neuropathic pain was found in 2.1%, without neuropathic pain – in 13.8% (p<0.05); medium – respectively in 31.3% versus 36.2% (p>0.05), high – respectively in 66.6% versus 50.0% (p<0.05). There were significantly more patients with low levels of personal anxiety among those who did not have neuropathic pain – 20.2% versus 6.3% (p<0.05), and with high levels – among patients with neuropathic pain: 56.2% versus 38.3% (p<0.05). The average value of the Mini Mental State Examination index in all patients was 27.46 ± 1.77 points; in patients with neuropathic pain – 26.29 ± 1.39 points, without neuropathic pain – 28.06 ± 1.64 points (p<0.01). Conclusion. Correlation analysis made it possible to establish the presence of significant correlations between expressiveness of neuropathic pain and depression and anxiety. Depressive and anxious manifestations in ankylosing spondylitis reflect psychopathological reactions to severe disease, pain and somatic discomfort, and personal anxiety as a stable personality characteristic, in ankylosing spondylitis patients primarily reflects the formation of patho-characteristic features as a result of long-term somatogenic influence. Cognitive impairment is probably mediated by depressive and anxiety symptoms and the influence of pain syndrome. The presence of a neuropathic component of the pain syndrome is a factor that aggravates the state of the psycho-emotional sphere, which justifies the feasibility of prescribing psychopharmacological therapy for ankylosing spondylitis

Linaclotide for treating patients with irritable bowel syndrome with predominant constipation: a multicentre study of real-world data in China.

Introduction:Linaclotide, a guanylate cyclase C agonist that improves the symptoms of irritable bowel syndrome with predominant constipation (IBS-C), has been recently approved for IBS-C treatment. This study aimed to report real-world data on linaclotide treatment in China.Methods:This was a prospective multicentre study of the effectiveness of linaclotide treatment in patients with IBS-C from 10 primary medical institutions. Changes in defecation, abdominal symptoms, the IBS symptom severity scale (IBS-SSS), IBS quality of life questionnaire (IBS-QOL), Zung Self-Rating Anxiety Scale and Self-Rating Depression Scale in patients were evaluated to determine the drug’s clinical efficacy and safety.Results:We enrolled 97 patients (mean age: 52.39 ± 13.99 years), 55 of whom were women (56.7%). In terms of efficacy, the number of the patients’ defecation per week and Bristol stool form scale scores significantly increased at week 4 and week 12 compared with the values at the baseline. The baseline average IBS-SSS score was 211.01 ± 81.23. Of the patients, 24 had severe IBS-C, and their IBS-SSS scores at week 4 (51.81 ± 54.42) and week 12 (9.3 ± 30.39) significantly decreased and showed a pronounced improvement. The IBS-QOL total scores at week 4 and week 12 gradually decreased compared with that at the baseline and the QOL significantly improved. Treatment satisfaction rate was 79.3% in week 4 and 100% in week 12, showing a gradually increased satisfaction and significant differences. However, 11 cases (11.3%) had diarrhoea.Conclusion:Linaclotide has proved to be a safe and effective drug to improve IBS-C symptoms and severity.

Effects of cognitive behavioral therapy on negative emotions and treatment compliance in patients with coronary heart disease

Objective To explore the effects of cognitive behavioral therapy on negative emotions and treatment compliance in patients with coronary heart disease. Methods From June 2015 to June 2017, we selected 86 patients with coronary heart disease at Beijing Longfu Hospital as subjects by convenience sampling. All of patients were divided into observation group (n=43) and control group (n=43) with the random number table. Control group carried out routine nursing. On the basis of routine nursing, observation group implemented cognitive behavioral therapy. The intervention effects were evaluated with the Self-rating Anxiety Scale (SAS) , Self-rating Depression Scale (SDS) and self-designed compliance questionnaire. Results After intervention, the scores of SAS and SDS of patients in observation group were lower than those in control group with statistical differences (P<0.05) . Patient compliance of observation group was better than that of control group after intervention with a statistical difference (P<0.05) . Conclusions Cognitive behavioral therapy can improve patients' anxiety, depression, patients' treatment compliance which has great clinical significance. Key words: Coronary disease; Cognitive behavioral therapy; Negative emotions; Anxiety; Depression; Patient compliance

Effects of solution-focused approach on negative emotions among chronic subdural hematoma patients with trepanation and drainage

Objective To explore the effects of solution-focused approach on improving negative emotions among chronic subdural hematoma patients with trepanation and drainage. Methods From January to December 2017, a total of 100 chronic subdural hematoma inpatients in Beijing Tiantan Hospital of Capital Medical University were divided into control group and observation group by the random number table, 50 cases in each group. Control group carried out routine nursing. On the basis of that in control group, observation group provided health education by five-step of solution focused approach. Patients of two groups were evaluated with the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) on admission and at discharge. Results The scores of SAS and SDS of patients in observation group were (35.00±5.222) and (37.28±5.091) respectively at discharge lower than those [ (38.40±6.550) and (41.26±7.001) ]in control group with significant differences (P<0.05) . Conclusions Solution-focused approach can improve negative emotions among chronic subdural hematoma patients with trepanation and drainage. It is worth to be popularized and applied in clinic. Key words: Hematoma, subdural; Anxiety; Depression; Health education; Solution-focused approach