With the continuous updating and progress of medical equipment, the overdue medical device has problems such as management difficulties, resource waste, and potential security risks. Therefore, this paper used the Kohonen network algorithm to quantitatively evaluate and analyze the surplus value of overdue medical devices. In this paper, the Kohonen network algorithm was used to build a quantitative model of the surplus value of the overdue medical device, and the self-organization characteristics and data-driven learning ability of the Kohonen network were used to predict the surplus value of the equipment more accurately. Support vector machine was used to quantitatively evaluate and predict the surplus value of overdue medical devices, and further optimize the model performance, to provide more accurate and reliable decision support for medical equipment management. The Kohonen network algorithm used in this paper evaluated the correlation between the service life and maintenance cost of eight types of overdue medical devices and quantitatively predicted the surplus value of overdue medical devices with the random forest algorithm. According to the comparison of prediction bias, the maximum deviation between the expected surplus value and the actual surplus value is only 1, and the deviation value by the random forest algorithm is as low as 6, the Kohonen network algorithm in this paper has better prediction performance than the random forest algorithm. In the experiment of comparative analysis and verification by introducing the decision tree algorithm, the average error rate of the Kohonen network algorithm in this paper was only 20.57%, which was far lower than 46.34% of the random forest algorithm and 65.31% of decision tree algorithm. The Kohonen network algorithm used in this paper can effectively quantitatively evaluate and predict the surplus value of overdue medical devices, thus improving the efficiency of medical equipment management, reducing costs, and ensuring patient safety.