ABSTRACTThis experimental and numerical study proposes hybrid retrofit alternatives involving multiple contemporary techniques to upgrade the fundamental seismic response characteristics of multistory reinforced concrete frame (MSRCF) structures. The impact of thin high‐performance reinforced concrete (HPRC) jackets on the concrete framing system's seismic response is first investigated through shake table testing (STT). The performance of the HPRC‐retrofitted frame is then compared with another STT campaign conducted for fabric‐reinforced cementitious matrix (FRCM)–retrofitted frame. The STT results indicated that at the same input ground motion intensity that caused failure for the FRCM‐retrofitted frame, the curvature ductility and interstory drift ratio of the HPRC‐retrofitted specimen were reduced by 79% and 87%, respectively. Upon verifying the fiber‐based modeling technique of HPRC and FRCM alternatives through STT, the study probabilistically assesses the seismic performance of a benchmark MSRCF building considering different hybrid retrofit alternatives by combining each technique with a self‐centering energy dissipation (SCED) bracing system. Following a systematic seismic assessment framework, it is concluded that the performance‐cost index of the less disruptive HPRC‐SCED option exceeded that of the FRCM‐SCED by 36%, confirming its preference among the considered alternatives for upgrading the seismic response of MSRCF deficient in stiffness, strength, and ductility.