Selenium Consumption Research Articles

Association of daily selenium intake and glaucoma: A cross-sectional study.

The association between dietary selenium intake and glaucoma remains unclear. Using data from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES), this study aimed to investigate the relationship between glaucoma and dietary selenium intake. The study included subjects aged 40 years or older who participated in the NHANES dietary intake interview and vision health questionnaire. Diagnosis of glaucoma based on self-reporting or fundus imaging. To investigate the relationship between daily selenium consumption and glaucoma, logistic regression analyses were employed. The potential linear relationship was found using smooth curve fitting. Subgroup analyses were also used. We found higher dietary selenium intake was associated with an increased risk of glaucoma (odds ratio, 1.39; 95% confidence intervals,1.07-1.81) on multivariable analysis. A linear association was found between dietary selenium intake and the occurrence of glaucoma in this population (Pnon-linearity = 0.951). Subgroup analyses showed a stable correlation between dietary selenium intake and the occurrence of glaucoma (all P for interaction > .05).This is the first study to look at the connection between dietary selenium intake and glaucoma based on the data from the 2005 to 2008 NHANES. Our findings suggested that dietary selenium intake maybe positively correlated with the risk of glaucoma in adults older than 40 years old. To find out the potential relationship between dietary selenium intake and glaucoma, More longitudinal studies are required.

Association of Dietary Selenium Intake with Type 2 Diabetes in Middle-Aged and Older Adults in China.

The relationship between distinct dietary selenium intake and type 2 diabetes (T2D) is still a topic of uncertainty. This study examined the relationship between dietary selenium intake and T2D risk among middle-aged and older Chinese adults. Dietary selenium intake was assessed through three 24 h recalls, using data from the China Health and Nutrition Survey. To investigate the relationship and the potential dose-response pattern between selenium intake and the likelihood of developing T2D, we employed both the restricted cubic spline analysis and the Cox proportional hazards model as our analytical tools. A cohort of 5970 participants aged ≥ 50 years was followed for an average of 5.44 years. The results revealed a V-shaped correlation between selenium intake and T2D risk, with the lowest risk observed at approximately 45 µg/day. Below this level, the risk decreased with an increasing selenium intake, while the risk increased between 45 and 100 µg/day. No significant association was found beyond 100 µg/day. These findings suggest that both low and high selenium consumption may increase T2D risk, highlighting the importance of maintaining a balanced selenium intake for T2D prevention.

Association between dietary selenium intake and the prevalence of hypertension: results from the National Health and Nutrition Examination Survey 2003-2018.

The epidemiological evidence regarding the impact of dietary selenium intake on hypertension continues to be a subject of controversy. Our objective is to examine the correlation between dietary selenium intake and the prevalence of hypertension within a substantial and diverse population in the United States. We carried out a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) to assess the association between dietary selenium intake and hypertension prevalence. Weight logistic regression analysis and smooth curve fitting were utilized to explore potential linear relationships. Subgroup analysis was further employed to investigate potential differences in this relationship across populations and assess potential synergies. The study included 32,928 individuals, and the average dietary selenium intake was 1.12 ± 0.53 μg. The prevalence rate of hypertension was 36.55% overall and decreased with the higher dietary selenium intake quartiles (quartiles 1, 40.25%; quartiles 2, 37.71%; quartiles 3, 36.04%, quartiles 4, 32.23%, p < 0.001). Each quartile increase in dietary selenium intake associated with 11% decreased the likelihood of prevalence of hypertension [OR = 0.89; 95% CI: 0.80-1.00; p = 0.0425]. Subgroup analyses revealed that there was no significant correlation between gender, age, body mass index, smoking status, alcohol consumption, and diabetes mellitus in relation to the association between dietary selenium intake and the prevalence of hypertension. The prevalence of hypertension in adults was found to be linearly and negatively correlated with dietary selenium intake. In order to improve the prevention and treatment of hypertension, greater emphasis should be placed on selenium consumption.

The effect of selenium supplementation on sonographic findings of salivary glands in papillary thyroid cancer (PTC) patients treated with radioactive iodine: study protocol for a double-blind, randomized, placebo-controlled clinical trial

BackgroundThyroid cancer is a very damaging disease. The most common treatment for this disease includes thyroidectomy and then using radioactive iodine (RAI). RAI has many side effects, including a decrease in salivary secretions, followed by dry mouth and oral and dental injuries, as well as increased inflammation and oxidative stress. Selenium can be effective in these patients by improving inflammation and oxidative stress and by modulating salivary secretions. So far, only one clinical trial has investigated the effect of selenium on thyroid cancer patients treated with radioiodine therapy (RIT) conducted on 16 patients; considering the importance of this issue, to show the potential efficacy of selenium in these patients, more high-quality trials with a larger sample size are warranted.MethodsThis is a parallel double-blind randomized controlled clinical trial that includes 60 patients aged 20 to 65 years with papillary thyroid cancer (PTC) treated with RAI and will be conducted in Seyyed al-Shohada Center, an academic center for referral of patients to receive iodine, Isfahan, Iran. Thirty patients will receive 200 µg of selenium for 10 days (3 days before to 6 days after RAI treatment) and another 30 patients will receive a placebo for the same period. Sonographic findings of major salivary glands, salivary secretions, and sense of taste will be evaluated before and 6 months after 10-day supplementation.DiscussionDue to its anti-inflammatory and antioxidant effects, as well as improving salivary secretions, selenium may improve the symptoms of thyroid cancer treated with radioactive iodine. In past studies, selenium consumption has not reduced the therapeutic effects of radiation therapy, and at a dose of 300 to 500 μg/day, it has not had any significant side effects in many types of cancer under radiation therapy.Trial registrationIranian Registry of Clinical Trials IRCT20201129049534N6. Registered on 16 September 2021.

Selenium Biofortification: Strategies, Progress and Challenges

Selenium (Se) is an essential trace element for humans and animals. Its necessity for plants is still under examination. Due to the contradictory nature of Se and its significance, it has received much interest in recent years. Se deficiency can be harmful to humans, yet almost a billion people are deficient. Its deficiency has been associated with cancers, impairment of organs, and a number of other ailments. The biofortification of plants and livestock is a guaranteed practice to increase human selenium consumption. Strategies such as foliar spraying, the direct application of Se in plants and Se feed, and injections in livestock have been employed. Se biofortification has been shown to have additional beneficial effects in plants and livestock. In plants, it has been reported to mitigate different types of stress and increase yield. In animal biofortification, Se has been shown to reduce the detrimental effects of ailments and promote healthy growth. Se biofortification, nevertheless, confronts a number of difficulties. For instance, the bulk of biofortified products must be prepared before consumption, lowering the Se concentration. The objective of this review is to convey the current understanding of the Se biofortification of plants and animals, as well as its difficulties, taking into account both the detrimental consequences of Se deficiency and benefits of Se biofortification.

Excess selenium intake is associated with microalbuminuria in female but not in male among adults with obesity: Results from NHANES 2009-2018.

Selenium is a critical trace element with antioxidant activities that has been related to the preservation of kidney function. Few studies, however, have looked at the effects of excess selenium on kidneys. The purpose of the present study was performed to investigate the relationship between dietary selenium intake and the prevalence of microalbuminuria in American adults with obesity. A total of 8,547 participants with obesity in the National Health and Nutrition Examination Survey (NHANES) with the age of 19 years or older were included in the present study. Multivariable regression and subgroup analyses were performed to examine the association between dietary selenium and microalbuminuria in the two genders, separately. A selenium intake above the median was defined as high selenium intake. Dietary selenium intake was significantly higher in men compared to women (139.49 μg/day vs. 101.06 μg/day; P < 0.0001). Among female participants, the prevalence of microalbuminuria was significantly higher in participants with a high selenium intake compared with those without a high selenium intake (13.82 vs. 9.96%; P = 0.008), whereas this difference did not exist in male participants (10.79 vs. 11.97%; P = 0.40). Dietary selenium is not significantly correlated with microalbuminuria (P = 0.68) in the male population, whereas each 1 μg/day of increase in selenium consumption was independently associated with a 6h higher risk of microalbuminuria (OR = 1.006; 95% CI, 1.001-1.011, P = 0.01) in females. According to our research, excessive selenium consumption is positively correlated with microalbuminuria in females with obesity, but not in males with obesity.

Association between Selenium Intake and Optimal Sleep Duration: A National Longitudinal Study.

Inconsistent findings have been discovered in studies examining the link between dietary selenium (Se) and sleep. Data were obtained from 17,176 people aged 20 and over who participated in the China Health and Nutrition Survey (CHNS) from 2004 to 2011. Face-to-face interviews were used to measure sleep duration in 2004, 2006, 2009, and 2011. To track dietary Se consumption, a 3-day, 24-h recall was undertaken. In the analysis, multilevel mixed-effects logistic regression was employed. The odds ratios (95% confidence intervals) of optimal sleep duration (7-9 h/day) in the regression of Model 4 were 1.00, 1.01 (0.89-1.15) and 1.19 (1.02-1.38) for the three tertiles of selenium consumption, respectively. Only overweight patients displayed a substantial positive connection between Se intake and the optimal sleep duration in the subgroup analysis. In summary, Se intake was significantly associated with optimal sleep duration.

The Effect of Oral Selenium on the Size of Thyroid Nodules in Patients with Benign Thyroid nodules: A Brief Study

Objective: The thyroid gland is susceptible to the formation of nodules. Therefore, due to the critical role of selenium in the function of the thyroid gland, the impact of this element on the size and volume of this organ and its nodules were examined.&#x0D; Materials and Methods: During three months, two groups consisting of 30 patients with benign thyroid nodules who were referred to Baghaeipour Endocrinology Clinic were given daily doses of 100 and 200 micrograms of selenium, and a control group of 30 people without selenium consumption were assessed.&#x0D; Results: The results of intergroup analysis detected that the mean (±SD) of nodules length in the 100 µg selenium consumer group was 17.13 (±7.9) and 14.93 (±6.01) before and after intervention respectively (P= 0.008). About the nodules height in the 200 µg selenium consumer group, the mean (±SD) was 9.3 (±2.8) and 8.93 (±2.71) before and after intervention in that order (P= 0.001).&#x0D; Conclusion: Our findings suggest that selenium has been effective in the size and volume of the nodule and thyroid gland, as well as the TSH hormone, and further studies are needed to determine its therapeutic approach and efficacy.

Assessment of risks of essential and toxic elements exposure contained in foodstuff for workers of mining and processing industry

Introduction. Based on the average consumption of foodstuff, as well as data of the chemical composition of foodstuff, there are calculated the hazard coefficients and indices, individual risk for men working at the "Erdenet" mining and processing plant in Mongolia. The study aims to assess the health risks of mining and processing workers in Mongolia when exposed to essential Cu, Mo, Se and toxic elements As, Cd, Pb, Hg. Materials and methods. The content of essential and toxic elements in food rations was calculated from the data of multi-element analysis of samples of local foodstuff, conducted by inductively coupled plasma mass spectrometry. 30 samples of foodstuff were examined for the content of elements: essential Cu, Mo, Se and toxic As, Cd, Pb, Hg. The calculation of carcinogenic and non-carcinogenic risk was carried out in accordance with the guidelines P 2.1.10.1920-04. Results. An imbalance of the average daily intake of essential elements with the diet in the body of workers has been established: selenium consumption is 80.23% lower than the recommended norms of physiological needs; while the consumption of molybdenum is exceeded by 40.97%. The main sources of molybdenum are bread and bakery products (73.9%) produced from local raw materials. Limitations. Our study has a number of significant uncertainties related to the identification of the danger of individual toxicants, incomplete ideas about the levels of consumption of vegetables and fruits and their content of essential food substances and contaminants that were not included in the study of chemical composition. Conclusions. The calculated index of the non-carcinogenic hazard of toxic elements for the health of employees was 0.52, where 0.3 is by arsenic. The main contribution to the total HQ is the intake of essential and toxic elements from food (96.86%), while only 3.14% comes from drinking water.

The effects of selenium supplementation on glycemic control, serum lipoproteins and biomarkers of oxidative stress in infertile women diagnosed with polycystic ovary syndrome undergoing invitro fertilization: A randomized, double-blind, placebo-controlled trial.

This study aimed to evaluate the effects of selenium consumption on metabolic profile among infertile females diagnosed with polycystic ovary syndrome (PCOS). The current randomized, double-blind, placebo-controlled trial was conducted among 40 infertile females with PCOS aged between 18 and 40 years. Patients were randomly allocated to two groups of intervention to receive selenium supplements (200μg/day) or placebo (starch). Fasting blood samples were taken at baseline and after 8 weeks of intervention. Selenium administration significantly decreased fasting glucose (P=0.03), homeostasis model assessment for insulin resistance (P=0.007) and fasting insulin levels (P=0.006), and elevated quantitative insulin sensitivity check index (P<0.001). In addition, selenium supplementation significantly reduced malondialdehyde (MDA) levels (P=0.006). We did not observe any significant effect of selenium supplementation on pregnancy rate, lipid profiles, total antioxidant capacity (TAC) and total glutathione (GSH) levels. Overall, our study demonstrated that selenium supplementation for 8 weeks in infertile women with polycystic ovary syndrome undergoing IVF had beneficial effects on glycemic control and MDA levels, but did not affect pregnancy rate, lipid profiles, TAC and GSH levels. This trial was registered at www.irct.ir as http://www.irct.ir: IRCT201701025623N100.

Changes in soil moisture and temperature modify the toxicity of sodium selenite and sodium selenate for Folsomia candida (Collembola) Willem 1902

Selenium is an essential trace element; therefore, soils are often amended with selenium fertiliser in selenium poor regions to increase the selenium consumption of the population. The amendment form can be sodium selenate and sodium selenite, depending on crop type. Climate change increases the mean temperature and also the frequency of extreme events such as drought and extreme rain. Therefore, testing the effects of different selenium forms outside the range of standard conditions can help predicting the effects of such amendments or selenium pollution. Effects of sublethal concentrations of selenite and selenate were tested on parameters of mortality, reproduction, growth, and oxidative stress parameters of Folsomia candida (Collembola) in case of different climate scenarios. The standard 20 °C and the increased 25 °C temperatures were combined with three different soil moisture conditions: drought, standard water content and increased water content.Selenite was found to be more toxic than selenate. However, the collembolan treated with selenite tolerated the increase of temperature better than those treated with selenate. The temperature increase was additive with selenium treatment in most cases. Drought was found to increase selenium toxicity in general. Also, different water contents had interactions with selenium treatments causing differences in concentration-response curves. Juvenile and egg numbers were decreased in the case of suboptimal water contents; especially drought decreased juvenile and egg numbers. No significant mortality was found under standard conditions, but mortality increased with the different climate scenarios. Results were not conclusive in the case of measurement of lipid peroxidation and glutathione status. In standard conditions, selenium did not have an effect on the juvenile number, but in combination with climate scenarios, from 1 mg Se kg−1 a decrease was found in the juvenile number. Therefore, soil selenium amendments should be carefully planned regarding the effects of changing climate, especially drought.

Modeling effect of selenium on broiler chickens’ body

In recent years, based on new scientific data, many countries worldwide have been revising the existing standards for introducing trace elements in mixed feed for highly productive broiler chicken crosses. This also applies to selenium, which is recognized as an indispensable biotic ultramicroelement with a wide range of biological action according to modern classification. However, some aspects of the selenium effects on poultry have not been elucidated yet. We have conducted comprehensive research to deepen and expand modern ideas about the biological role of selenium, its impact on the interior and productive qualities of broiler chickens in the post-embryonic period of ontogenesis. One of the tasks was to study the causal relationship between the level of selenium consumption by broiler chickens and the studied indicators. The research was conducted on broiler chickens of the Cobb 500 cross. During the rearing period, the feeding of broiler chickens of all groups was carried out with dry full-fledged mixed feeds following the existing norms. The poultry of the first control group did not receive selenium supplementation. The poultry of the second experimental group was additionally injected with Selenium at the rate of 0.2 mg/kg, the third of 0.3, and the fourth of 0.4 mg/kg. When conducting a correlation analysis of the obtained experimental data, it was found that there are different levels and directions of relationship between internal and economically valuable features included in the study, which may vary depending on the selenium content in mixed feed for broiler chickens. A scheme of modeling the effect of selenium on broiler chickens’ bodies is proposed.

Survival of Embryos and Fry of Sea Trout (Salmo trutta m. trutta) Growing from Eggs Exposed to Different Concentrations of Selenium during Egg Swelling.

Simple SummarySelenium-poor areas are defined in the Earth. Adequate selenium (Se) consumption enhances the health and growth of organisms, but overdose of it can be harmful and pathogenic. The objective of the study was to investigate Se supplementation effects in the non-feeding stages of fish. Fertilised eggs of sea trout were immersed in water enriched with Se during the egg-swelling period. Se at a concentration from 0.5 to 8 mg Se L−1 slightly impacted the hatching rate. A higher concentration of Se resulted in declined survival of embryos. Accumulation of Se in the body of hatch increased with the increase of element concentration in the aqueous environment during egg swelling. The survival of fry was similar in all groups, while the fry length and weight correlated positively with Se concentration in its body. In Se-poor areas, immersion of fertilised eggs in water enriched with Se during egg swelling can be used to supplement the deficient element to fish in order to improve breeding outcomes in aquaculture.Adequate selenium (Se) availability enhances the health and growth of organisms, but overdose of it can be harmful and pathogenic. The study’s objective was to analyse the impact of short-term exposure of sea trout fertilised eggs to inorganic selenium (SeO2) at concentrations from 0 to 32 mg Se L−1 to find the optimal and toxic dose of Se on early fish development. Se accumulated in the body, embryos’ survival rate, and growth in the first four months of life was examined. Swelling of fertilised eggs in water supplemented with Se at a concentration from 0.5 to 8 mg Se L−1 was associated with a slightly positive impact on the hatching rate. At higher Se concentration, a harmful effect on the survival of the embryo was observed. The survival of fry was similar in all groups, while the fry length and weight correlated positively with Se concentration in its body. Immersion of fertilised eggs in water enriched with Se during egg swelling can constitute a method to supplement the element to non-feeding stages of fish. In selenium-poor areas, this innovative method can be implemented in aquaculture to improve breeding outcomes. Se concentration should be adjusted to the chemical compound, fish species, and Se’s content in the yolk.

Selenium Intake and Glycemic Control in Young Adults With Normal-Weight Obesity Syndrome.

Numerous endogenous functions related to antioxidant processes, reproduction, and thyroid metabolism, as well as actions related to glycemic control, have been attributed to selenium. This study aimed to evaluate whether dietary selenium consumption is associated with variables of glycemic control in a sample of young Brazilian adults with Normal-Weight Obesity (NWO) syndrome. This was a cross-sectional study that evaluated 270 individuals with adequate body weight and excess body fat, who had their body composition assessed by dual-energy X-ray absorptiometry. Socioeconomic, health, and lifestyle questionnaires and three 24-h food records were applied. Glycemic control markers were also evaluated. The prevalence of inadequate selenium intake was analyzed by the Estimated Average Requirement (EAR) cut-point method. The prevalence of disturbances in glycemic control markers according to selenium consumption was compared by either the chi-square or the Fisher's exact test, with individuals classified according to the EAR values for selenium. The associations were evaluated by multiple linear regressions, using the backward strategy. The mean ± standard deviation (SD) age was 23.7 ± 3.3 years, and the mean ± SD daily selenium intake was 59.2 ± 26.4 μg. The overall prevalence of inadequate selenium intake was 59.2%. Individuals with selenium intakes below the EAR (≤45 μg/day) showed higher concentrations of glycated hemoglobin (HbA1c) (P = 0.002) and a higher prevalence of disturbances in HbA1c than those with selenium intakes above the EAR (>45 μg/day) (P = 0.001). Dietary selenium intake was directly associated with female sex (β = 19.95, 95% CI 5.00 to 34.89; P = 0.001) and weight (β = 6.69, 95% CI 0.56 to 12.81; P = 0.010), and inversely associated with the percentage of total body fat (β = −0.80, 95% CI −1.56 to −0,04; P = 0.010) and HbA1c (β = −7.41, 95% CI −13.06 to −1.75; P = 0.010). Considering the noticeable young age of the individuals evaluated and the high frequency of disturbances in HbA1c concentrations in those with selenium consumption below the recommendation, it is suggested that adequate dietary intake or supplementation of this micronutrient should be guaranteed to prevent future possible complications associated with glycemic control disturbances.

Association of Selenium Intake and Development of Depression in Brazilian Farmers.

Introduction: Depression and deficiency in the consumption of micronutrients are a public health problem, especially in the rural population. The deficiency in selenium consumption affects mental health, contributing to the development of major depressive disorders. Thus, this study aimed to evaluate selenium intake and its association with depressive symptoms in farmers in southeastern Brazil.Material and Methods: Epidemiological, cross-sectional, and analytical study with 736 farmers aged between 18 and 59. A semistructured questionnaire was used to collect sociodemographic, lifestyle and clinical condition data. For evaluation of food intake, three 24-h recalls were applied, and for identification of depressive episodes, the Mini-International Neuropsychiatric Interview was conducted.Results: A total of 16.1% (n = 119) of the farmers presented symptoms of major depressive episodes, 5.8% (n = 43) presented symptoms of current depressive episodes, and 10.3% (n = 76) presented symptoms of recurrent major depressive episodes. Sociodemographic factors associated with depression were gender (p < 0.001), marital status (p = 0.004), and socioeconomic class (p = 0.015). The consumption of high doses of selenium was associated with a reduction of ~54% in the chances of occurrence of depression (OR = 0.461; 95% CI = 0.236–0.901).Conclusion: High selenium intake is associated with a lower prevalence of depression even after adjusting for sociodemographic variables, lifestyle, and pesticide intoxication. The findings of this study contributed to highlighting the high prevalence of depression in rural areas and its relationship with selenium intake.

Biofortification of chervil with selenium

Relevance.Production of functional food with high levels of antioxidant status and selenium is essential for human protection against viral and cardiovascular diseases as well as cancer.Methods.Evaluation of the efficiency in foliar sodium selenate biofortification (25. 50 and 75 mg Se/L) was achieved on three chervil genotypes.Results.Intervarietal differences in biofortification level was demonstrated: from 15.5 to 31.1 for 25 mg Se/L dose; from 36.9 to 64.6 for 50 mg Se/L dose; and from 72.9 to 130 for 75 mg Se/L dose. At the chosen doses, selenium supply did not affect significantly the yield, antioxidant properties and photosynthetic content of chervil. Total antioxidant activity was in the range from 30 to 42 mg GAE/g d.w., phenolics content from 9 to 13 mg GAE/g d.w, flavonoids from 5 to 12 mg-eq quercetin/g d.w., ascorbic acid from 33 to 66 mg/100 g fresh w. High levels of carotene were a typical feature of Se fortified and non-fortified chervil. A direct correlation was recorded between phenolics content and total antioxidant activity (r=+0.954, P&lt;0.01), and between water soluble compounds and nitrates accumulation (r=+0.920, P&lt;0.01). Biofortification with selenium did not affect significantly the mineral content of plants. Consumption of 100 g of fresh chervil leaves, fortified with selenium, provides from 50 to 75% of the adequate selenium consumption level and from 16 to 20% of potassium. Taking into account that both selenium and potassium normalize heart activity, the new functional food product may be recommended for prophylactics and treatment of cardiovascular diseases and for the human selenium status optimization.

Production of Methylselenocysteine in Saccharomyces cerevisiae LG6 by continuous fermentation

Methylselenocysteine (SeMCys) is a seleno amino acid. The Saccharomyces cerevisiae LG6 has been used for the production of SeMCys by continuous fermentation. Glucose media with different initial sodium selenite concentrations were tested to obtain optimal medium and fermentation parameters. The maximal specific growth rate and specific selenium consumption rate (SSCR) were calculated to be 0.162 h−1 and 0.47 mg / g h−1 respectively. The continuous fermentation was optimised by feeding medium at different dilution rates. Simultaneously, sodium selenite solution was pumped into the fermenter and the flow rate was controlled by SSCR. After optimization, the final organic selenium productivity and intracellular selenium content were greatly improved, and which reached 17.88 mg / L h−1 and 4.454 mg / g respectively. Speciation analysis of the selenium yeast showed that 58% of total selenium compounds were in the form of SeMCys. The final concentration of SeMCys reached 5.746 mg / g.

Antitumor Activity of Selenium and Search Parameters for Its New Potentially Active Derivatives

The trace element selenium is known to manifest antitumor activity. There is a relationship between the development of cancer and selenium content in food. Recent data demonstrated the necessity of increasing selenium consumption for the prevention and treatment of oncological diseases. Certain features of cancer cells and potential targets of selenium therapy are discussed. Both natural forms of selenium, namely, element Se, sodium selenite, L-selenocystine, L-selenomethionine, and L-methylselenocysteine, and synthetic ones, methylseleninic acid and imidoselenocarbamate derivatives, which display antitumor activity due to the generation of methylselenol and hydrogen selenide, the main anticarcinogenic metabolites, are reviewed. New promising anticancer selenium compounds, diacetophenonyl selenide, 2-methylselanyl-1-phenylethanol, and amino acids 2-amino-3-selanyl butanoic acid and 2-amino-3-(methylselanyl) butanoic acid are discussed.

Association between magnesium, selenium and zinc consumption and lipid profile of brazilian adolescents

Association between magnesium, selenium and zinc consumption and lipid profile of brazilian adolescents

Effect of foliar sodium selenite biofortification on cauliflower yield, nutritional value and antioxidant status

Relevance. Biofortification of agricultural crops with selenium is considered to be the most promising method for the human selenium status optimization.Methods. Effect of foliar biofortification of cauliflower, Polyarnaya Zvezda cv, with sodium selenate of different concentrations on yield, selenium content and biochemical characteristics of plants were investigated.Results. Enrichment of plants with selenium increased yield by 1.23-1.31 times, sugar content – 1.6 times, ascorbic acid concentration – 1.52-2 times. On the contrary, the treatment did not affect pholyphenol content and antioxidant activity of ethanolic extracts of plants. Selenium accumulation levels decreased according to inflorescences &gt; leaves &gt; roots. Sodium selenate solution at 75 mg/L concentration increased mass of cauliflower leaves 1.9 times and roots – 1.5 times. Consumption of 100 g of cauliflower fortified with 50 mg/L sodium selenate solution provided 100% of the daily adequate selenium consumption level. Utilization of higher sodium selenate concentrations ensured 127% and 418% of the daily adequate consumption level in case of 75 mg/L and 100 mg/L concentrations respectively. Taking into account insignificant differences between sugar content and antioxidants in cauliflower inflorescences fortified with different doses of selenium the most suitable concentration to be used was 50 mg/L.