Blood Serum Selenium Concentrations Research Articles

Comparative characteristics of selenium content in students from different regions of the world

The study was performed to determine Selenium level in a first year foreign students' biosubstrates who came for an education to Peoples' Friendship University of Russia - RUDN University. The number of students who participated in the study was in total 583 and contained of students from North and Tropical Africa, Latin America, the Near and Middle East, East and South-East Asian, Central Asia and Russia (Moscow). The analysis of selenium concentration in hair, blood serum and urine was made with Inductively coupled plasma mass spectrometry (ICPMS). The conducted study demonstrated that the highest hair selenium level was in the Tropical Africa and Latin America students’ samples. The highest selenium concentration in the blood serum and urine characterized Latin America students’ samples. In the result of the study the selenium deficiency was not demonstrated in any participated students’ group.

The effect of consumption of pork enriched by organic selenium on selenium status and lipid profile in blood serum of consumers

The aim of the research was to evaluate the effect of consumption of selenium-enriched pork on selected health indicators of probands. The intake of feed mixture with increased organic selenium at the dose of 0.3 mg.kg−1 probably increases selenium concentration in MSM (musculus semimembranosus). In the pork enriched with organic selenium, the concentration was higher by 1.045 ± 0.10 mg.kg−1 compared with the control group 0.701 ± 0.05 mg.kg−1 at significance P < 0.001. Sixteen participants in the experiment were represented by 8 men at the average age of 41.5 ± 11.9 years and 8 women at the average age of 41.4 ± 7.9 years. All the probands consumed meat enriched with selenium three times a week during one month. By consumption of the enriched pork, there was an increase of the selenium concentration in blood serum of probands traced with selenium increase from 73.19 ± 15.68 μg.L−1 to 73.73 ± 15.13 μg.L−1 (P > 0.05). From the results we can see that consumption of enriched pork with selenium was significantly manifested in lowering of total cholesterol levels, which was associated with LDL cholesterol lowering (P < 0.05). Differences among the HDL cholesterol and triglycerides samples were not significant.

ENHANCEMENT OF FRESHMEN’S ADAPTATION TO HIGH SCHOOL

Aim. The article deals with studying the effect of a complex selenium-containing compound and physio disease-preventing means on the enhancement of biochemical indicators in freshmen living in a selenium-deficient area. Materials and methods. We conducted 12 longitudinal studies with the students of the first and second year studying at Chuvash Universities (n = 180). Selenium concentration in blood serum was established with the help of fluorometry performed according to Golubkina’s interpretation (Fluorat-02-2M). The activity of lipid peroxidation (c.u.) and antioxidant system (c.u.) was studied using induced chemiluminescence (Biochemiluminometer БХЛ-06). Results. The use of Selenes+ together with a disease-preventing photochrome session is accompanied by antioxidant, metabolic, and hemopoietic effects manifested in the increase of antioxidant activity and selenium concentration by 31.1 and 62.5 %, respectively, and the decrease of lipid peroxidation by 4.1–19.7 % compared to control values. The use of Selenes+ together with exercises contributes to less pronounced stress in the cardiovascular system both during the study and exam periods. Conclusion. Therefore, selenium correction of body adaptation with respect to a biogeochemical specifics of a region normalizes the balance between prooxidant and antioxidant elements of the antioxidant protection system and provides an accelerated shift from short-term to long-term adaptation.

Evaluation of the nutritional quality of veal supplemented with organic selenium and its effect on selenium status of people

In the first stage of our research we found out a higher content of selenium in the meat of calves of experimental group (with added the organic form of selenium to the feed mixture) compared to control group (fed without organic form of selenium). In the second stage of our research we focused on monitoring the impact of selenium enriched veal meat and on selenium concentration in blood serum and the selected biochemical parameters of lipid spectrum of the experimental group of volunteers. Ten people who were participating in the research were at the age range between 29 - 56 years. All the volunteers consumed veal meat enriched with organic selenium for 4 weeks. Before starting the experiment we took venous blood of the volunteers and this blood was considered as a control sample of selenium in blood serum of the experimental group. Selenium concentration in blood serum of the examined group was determined by an average of 58.31 ±5.36 mg.L.-1 and none of them reached the optimal level of selenium. Consequently, we carried out the additional blood sampling after 2 and 4 weeks of the consumption of veal meat. There was registered a slight increasing of selenium status, whereas after the finishing the consumption, we determined the average selenium concentration in blood serum of the experimental group 60.73 ±4.05 mg.L-1. The evaluation of lipid profile of the experimental group showed (after input blood sampling) higher values of total cholesterol level and lower levels of HDL cholesterol. This fact shows the higher risk of starting the cardiovascular diseases. Reported research results didn't show statistically significant changes of blood lipid spectrum of the experimental group. We concluded that the consumption of supplemented veal meat can positively affect the level of selenium in our body and thereby increase it can increase the protective effect against the influence of free radicals.

English

The aim of this study was to determine the effect of selenium concentration in early lactation on mammary gland health and histological characteristics of the udder. The experiment included 30 high-yielding Holstein-Friesian cows. Selenium concentrations in blood and milk serum, and the average somatic cell count in the first and sixth months of lactation were analyzed. After exclusion of the experimental cows from the herd, histological characteristics of the udder were examined (the degree of leukocyte infiltration and the number of granulomas in the parenchyma). The mean selenium concentration in the blood serum was 0.62±0.11 mmol/L and that in the milk serum was 0.12±0.07 mmol/L. Optimal blood levels of selenium were found in 19 cows and suboptimal levels in 11 cows. A significant negative correlation was observed between blood and milk selenium concentrations and somatic cell count in early and mid lactation. There was no relationship between blood selenium concentration, milk selenium concentration and the amount of milk produced. Selenium-deficient cows had a significantly higher milk somatic cell count in early and mid lactation and significantly lower levels of selenium in milk. Upon histological analysis, 120 samples of individual quarters of the udder were grouped according to the degree of leukocyte infiltration and number of granulomas. Results showed that an increase in the degree of leukocyte infiltration and number of granulomas leads to an increase in the proportion of quarters from selenium-deficient cows and a decline in the percentage of quarters from cows exhibiting normal blood selenium concentrations. Selenium has a significant impact on udder health. Changes caused by selenium deficiency occur due to marked inflammation process in the mammary gland.

The pork meat enriched with organic selenium and its effect on selenium concentration and total antioxidant status in healthy volunteers

It is known that organic selenium (Sel Plex) supplemented to pig feed mixture is significant for effective transport of essential element selenium to the food chain. It enables to create important body deposits of selenium in skeletal muscles and it also increases selenium transfer in natural metabolic form of selenomethionine into functional food. The intake of feed mixture with increased organic selenium at the dose of 0.3 mg kg-1 probably increases selenium concentration in MSM (musculus semimembranosus) - experimental selenium group 1.293 mg kg-1 and control group 0.513 mg kg-1 and in MLT (musculus longissimus thoracis) - experimental selenium group 1.364 mg kg-1 and control group 0.506 mg kg-1. The aim of this study was to evaluate the selenium and total antioxidant status (TAS) in a selected group of healthy people. Twenty-five volunteers consumed pork meat enriched with organic selenium three times a week during one month (average age in 9 men was 51.2 years, in 16 women 39.06 years, respectively). Daily selenium intake of 110 ?g was calculated by Alimenta software, version 4.3 on the basis of nutrition statement. Recommended daily selenium intake of 50 - 200 ?g was stated by the World Health Organization (WHO). During the research, the volunteers consumed pork enriched with 35 ?g of selenium. At the begining the mean selenium concentration in blood serum was at 75.41 ? 14.18?g l-1 in men, 75.21 ? 15.20?g l-1 in women. After two weeks of consumption pork enriched with selenium, the average selenium concentration in blood serum in men and women increased to 86.69 ? 11.72 ?g l-1 and 87.93 ? 16.22 ?g l-1 respectively. At the end of the study the average selenium concentration decreased in men and women to 85.75 ? 2.72 ?g l-1 to 84.07 ? 15.62 ?g l-1 respectively. In the selected group of healthy people the total antioxidant status increased from 1,68 mmol.l-1 to 1,86 mmol.l-1 after two weeks of consumption of pork enriched with selenium. However, at the end of the research the decrease in TAS was recorded. Improvement in selenium status has positive impact on human health, and thus our results could contribute to the new trends in the production of functional food.

Assessment of selenium and vitamin E deficiencies in dairy herds and clinical disease in calves.

Because of the very low concentrations of selenium in the dry matter of grass, grass silage, hay and maize silage Slovenian dairy herds need to be supplemented with selenium. Selenium in the form of mineral and feed mixtures maintained adequate mean (sd) blood serum selenium concentrations of 43.9 (27.6) to 65.3 (18.5) micrograms/litre in lactating cows, but in late lactation and in the dry period when only mineral mixtures were used, about 60 per cent of the cows had marginal serum selenium concentrations, mainly because of the low intake of the mineral supplement. In 18 herds which were either unsupplemented or irregularly supplemented with selenium, the mean (sd) concentrations in blood serum were 13.7 (5.5) micrograms/litre and 17.4 (9.2) micrograms/litre, respectively, for selenium and 2.98 (2.72) mg/litre and 1.62 (1.73) mg/litre for vitamin E, indicating that under extensive farming conditions in Slovenia the lack of both micronutrients may be responsible for nutritional muscular dystrophy in calves. Among 37 clinical cases, cardiorespiratory signs predominated in 25 of the calves and skeletal myopathy was dominant in 12. A very low mean serum selenium concentration [9.7 (7.2) micrograms/litre] and typically high activities of aspartate aminotransferase (AST) [1125 (373) U/litre] and creatine kinase (CK) [9169 (3681) U/litre) were observed for the myocardial form of the disease, and 2797 (550) U/litre and 22,650 (13,500) U/litre were observed for the skeletal form of the disease. A highly significant (P < 0.0001) difference in the selenium concentration of liver dry matter between the regularly supplemented [402 (207) micrograms/kg] and irregularly supplemented [173 (69) micrograms/kg] herds was observed. If a minimum value of 300 micrograms/kg of liver dry matter is accepted as the criterion for the determination of adequate selenium status, 93 per cent of the samples from the irregularly supplemented herds were selenium deficient. A similar proportion was estimated to be selenium deficient when the criterion was taken to be 30 micrograms selenium/litre of blood serum.

Maternal Transfer and Retention of Supplemental Selenium in Neonatal Calves

Selenium concentrations in blood serum of heifer calves from dams fed 0, 1, or 5mg supplemental selenium daily during the dry period were compared. Dry cows were fed corn silage top dressed with a soybean meal mineral mix containing the desired amount of selenium. At birth, calves were assigned to one of six treatments in a 3 × 2 factorial arrangement. Calf treatments were 0, 1 (at birth), or 2 (at birth and 14 days of age) injections of selenium/vitamin E with feeding of starter commencing at 14 or 28 days of age. Dosage per injection was .078mg selenium and 5.4 IU vitamin E per kilogram body weight. Selenium concentrations of blood serum of cows at parturition were 14, 32, and 58 ppb for cows fed 0, 1, and 5mg selenium per day. Amount of selenium fed to cows affected selenium concentrations in blood serum of their calves with those from cows fed 5mg selenium having the greatest concentrations. Calves from cows fed no supplemental selenium showed increased selenium in serum at day 28 and 42 when given one or two injections of selenium. Two injections, however, were necessary to elicit a response in calves from cows fed 1mg per day. Selenium in blood serum of calves from cows fed 5mg per day was not elevated when calves were given one or two injections of selenium. Prepartum selenium supplementation of the dam elevated selenium of blood serum in the calf at birth. The increased concentration of selenium in blood serum caused by maternal supplementation reduced the amount of selenium taken up in serum of calves injected with additional selenium.

Myotonic dystrophy and selenium.

ABSTRACT. The correlation between selenium concentration in blood serum and the severity of the disease was investigated in 22 patients with myotonic dystrophy. Their serum concentrations of selenium and some other trace elements were compared with those of a control grup. It was found that the selenium concentration decreased in parallel with progression of the illness.