Selected CT Scans Research Articles

Adopting Signal Processing Technique for Osteoporosis Detection Based on CT Scan Image

Machine learning (ML) and artificial intelligence (AI) are widely applied in many disciplines including medicine. Pattern recognition or automatization has been successfully implemented in various field studies. Similarly, multiple efforts have been made in medicine to implement AI/ML technology to solve medical problems, for example, for automating osteoporosis detection. In general, the success of AI/ML technology is highly dependent on the amount of available data, especially during the training stage. Feature generation is a common technique that allows the manipulation of available data for the training stages. This paper aims to study the feasibility of adopting signal-processing techniques for feature generation in medical image processing. Signal attributes from signal processing workflow were adopted and applied to image processing of CT and DEXA scanning data to differentiate between normal and osteoporotic bone. Five attributes, namely amplitude, frequency, instantaneous phase, roughness, and first derivative or contrast attributes, have been tested. An attribute index number is formulated to indicate the attribute’s strength at the selected region of interest (ROI). A case study applying these attributes to the CNN model is presented. More than five hundred CT scan images of normal and osteoporosis bone were used during the training stage to test classification performance with and without developed attributes as an input. From the ten selected CT scan images used to test the CNN model, 90% were well predicted in the scenario only utilizing the grayscale as input. However, when including the developed attributes, the CNN can predict all the images well (100% were well predicted). In conclusion, the technique adopted from the signal-processing technique has the potential to enhance feature generation in image processing, whereby the results can be used for the early application of AI/ML in osteoporosis identification. Further research testing this proposed method in different image modalities needs to be conducted to verify the robustness of the proposed method.

Non-Selective Thoracic Computed Tomography in Trauma Patients Results in Injury Severity Score Inflation.

Extensive research relying on Injury Severity Scores (ISS) reports a mortality benefit from routine non-selective thoracic CTs (an integral part of pan-computed tomography (pan-CT)s). Recent research suggests this mortality benefit may be artifact. We hypothesized that the use of pan-CTs inflates ISS categorization in patients, artificially affecting admission rates and apparent mortality benefit. Eight hundred and eleven patients were identified with an ISS >15 with significant findings in the chest area. Patient charts were reviewed and scores were adjusted to exclude only occult injuries that did not affect treatment plan. Pearson chi-square tests and multivariable logistic regression were used to compare adjusted cases vs non-adjusted cases. After adjusting for inflation, 388 (47.8%) patients remained in the same ISS category, 378 (46.6%) were reclassified into 1 lower ISS category, and 45 (5.6%) patients were reclassified into 2 lower ISS categories. Patients reclassified by 1 category had a lower rate of mortality (P < 0.001), lower median total hospital LOS (P < .001), ICU days (P < .001), and ventilator days (P = 0.008), compared to those that remained in the same ISS category. Injury Severity Score inflation artificially increases survival rate, perpetuating the increased use of pan-CTs. This artifact has been propagated by outdated mortality prediction calculation methods. Thus, prospective evaluations of algorithms for more selective CT scanning are warranted.

Asymptomatic COVID-19 infection in multiple trauma patients: incidence and implications

Background: Some studies show a chest CT scan to be superior to reverse transcription-polymerase chain reaction (RT-PCR) studies for diagnosis of COVID-19. Objectives: This study was designed to assess the prevalence of COVID-19-related lung involvement in patients admitted to our trauma center. Methods: In this retrospective study, data from a referral trauma center were reviewed from February 21, 2020, to April 10, 2020. All patients admitted to the hospital for whom a chest CT scan was performed for any reason during the study period were included. Trained physicians screened all CT scans for findings suggestive of COVID-19. Next, blinded radiologists selected CT scans with findings highly suggestive of COVID-19 involvement. The clinical course and outcome and the results of PCR for SARS-CoV-2 were recorded and assessed. Results: A total of 4200 chest CT scans were reviewed. After multiple rounds of exclusion, 24 patients with highly- suggestive findings were reviewed. Only three patients developed COVID-19 symptoms during the course of admission. PCR results were positive in 22 patients (92.6%). Conclusion: We recommend chest CT scans in trauma patients at a high risk of COVID-19 infection, as well as those requiring extensive surgical interventions. Also, a thorough review of the available CT scans before invasive procedures, preferably with the help of an expert radiologist, is highly recommended, even when the results of the COVID-19 laboratory tests are negative.

Feasibility and diagnostic accuracy of using brain attenuation changes on CT to estimate time of ischemic stroke onset

PurposeCT attenuation of ischemic brain reduces with time after stroke onset. We aimed to quantify this relationship and test the feasibility and accuracy of estimating stroke onset time using only CT attenuation of visible ischemic lesions, the CT-Clock Tool.MethodsWe selected CT scans with ischemic lesions representing a range of stroke-onset-to-scan times (elapsed time) from a well-defined stroke trial. We measured the attenuation of ischemic lesions and contralateral normal brain to derive attenuation ratio. We assigned scans to development (75%) or test (25%) datasets. We plotted the relationship between attenuation ratio and elapsed time in the development dataset and derived a best-fit curve. We calculated estimated time in the test dataset using only the attenuation ratio curve. We compared estimated time to elapsed time and derived absolute error for estimated time. We assessed area under the receiver operating characteristic (AUROC) curve for identifying scans ≤ 4.5 h elapsed time.ResultsWe included 342 scans from 200 patients (41% male, median age 83 years). Elapsed time range: 22 min to 36 days. Estimation errors were least at early elapsed times (r = 0.82, p < 0.0001): median absolute error was 23, 106, 1030 and 1933 min for scans acquired ≤ 3, > 3–9, > 9–30 and > 30 h from stroke onset, respectively. AUROC was high at 0.955.ConclusionsIt is feasible to accurately estimate stroke onset time using simple attenuation measures of ischemic brain. Our method was most accurate 0–9 h from onset and may be useful for treatment eligibility assessment, especially where imaging resources are limited.

P113. Pedicle morphology of the lumbar spine in a diverse population

BACKGROUND CONTEXT Recent literature underscores the importance of understanding diverse pedicle isthmus morphology to perform successful transpedicular procedures. These studies suggest that more detailed and reliable measurements of pedicles should be undertaken. However, none of the current literature comprehensively compares average pedicle diameters (PDs), estimated pedicle screw lengths (EPSLs) or transverse pedicle angle (TPA) between diverse racial populations with a standardized study design. PURPOSE We sought to determine how height, weight and race correlated with PD, EPSL and TPA in the lumbar spine between various races: 'Asian', 'Black', 'White' and 'Hispanic/Other.' These data could aid in perioperative planning during instrumented spinal fusion. STUDY DESIGN/SETTING Retrospective chart review. PATIENT SAMPLE CT scans of the abdomen and pelvis performed over a 2-week period (between July 1, 2016 to July 14, 2016) at seven hospitals within a single health system was performed. Data was collected and categorized on the basis of patient-reported racial information, race was categorized as ‘Asian’, ‘Black’, ‘White’, and ‘Hispanic/Other.’ Patients were excluded if they had prior lumbo-sacral laminectomy or fusion, CT imaging that did not allow for visualization of all five lumbar segments, scoliosis involving the lumbar vertebrae with Cobb measurement angle greater than 20°, and patients with spondylolisthesis having greater than 25% slippage. OUTCOME MEASURES N/A METHODS Analysis of over 5,060 lumbar pedicles from randomly selected CT scans on patients who underwent imaging over a two-week period for non-back pain related complaints was conducted. Outer cortical PD (as measured through the isthmus), EPSL (measuring the posterior entry point at the longest distance, which perpendicularly transected the measured isthmic diameter to the anterior cortex) and TPA (midline bisecting vertebral body to the mid-axis of the pedicle bilaterally) were determined. Data was collected and categorized on the basis of patient reported race, height and weight. To determine the significance, we used a mixed analysis of variance and a post hoc analysis. RESULTS Height and weight significantly correlated with PD, whereas BMI did not. The Asian cohort consistently had significantly smaller PD at L1–L5 than Blacks or Whites (p CONCLUSIONS Pedicle anatomy is variable. There are significant differences among races, heights and weights. We suggest using preoperative CT for pedicle screw templating as a safe method for maximizing pullout strength given the variability of pedicles among a diverse population. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.

Refining the criteria for immediate total-body CT after severe trauma

ObjectivesInitial trauma care could potentially be improved when conventional imaging and selective CT scanning is omitted and replaced by immediate total-body CT (iTBCT) scanning. Because of the potentially increased radiation exposure by this diagnostic approach, proper selection of the severely injured patients is mandatory.MethodsIn the REACT-2 trial, severe trauma patients were randomized to iTBCT or conventional imaging and selective CT based on predefined criteria regarding compromised vital parameters, clinical suspicion of severe injuries, or high-risk trauma mechanisms in five trauma centers. By logistic regression analysis with backward selection on the 15 study inclusion criteria, a revised set of criteria was derived and subsequently tested for prediction of severe injury and shifts in radiation exposure.ResultsIn total, 1083 patients were enrolled with median ISS of 20 (IQR 9–29) and median GCS of 13 (IQR 3–15). Backward logistic regression resulted in a revised set consisting of nine original and one adjusted criteria. Positive predictive value improved from 76% (95% CI 74–79%) to 82% (95% CI 80–85%). Sensitivity decreased by 9% (95% CI 7–11%). The area under the receiver operating characteristics curve remained equal and was 0.80 (95% CI 0.77–0.83), original set 0.80 (95% CI 0.77–0.83). The revised set retains 8.78 mSv (95% CI 6.01–11.56) for 36% of the non-severely injured patients.ConclusionsSelection criteria for iTBCT can be reduced from 15 to 10 clinically criteria. This improves the positive predictive value for severe injury and reduces radiation exposure for less severely injured patients.Key Points• Selection criteria for iTBCT can be reduced to 10 clinically useful criteria.• This reduces radiation exposure in 36% of less severely injured patients.• Overall discriminative capacity for selection of severely injured patients remained equal.

Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients

BackgroundImmediate total-body CT (iTBCT) is often used for screening of potential severely injured patients. Patients requiring emergency bleeding control interventions benefit from fast and optimal trauma screening. The aim of this study was to assess whether an initial trauma assessment with iTBCT is associated with lower mortality in patients requiring emergency bleeding control interventions.MethodsIn the REACT-2 trial, patients who sustained major trauma were randomized for iTBCT or for conventional imaging and selective CT scanning (standard workup; STWU) in five trauma centers. Patients who underwent emergency bleeding control interventions following their initial trauma assessment with iTBCT were compared for mortality and clinically relevant time intervals to patients that underwent the initial trauma assessment with the STWU.ResultsIn the REACT-2 trial, 1083 patients were enrolled of which 172 (15.9%) underwent emergency bleeding control interventions following their initial trauma assessment. Within these 172 patients, 85 (49.4%) underwent iTBCT as primary diagnostic modality during the initial trauma assessment. In trauma patients requiring emergency bleeding control interventions, in-hospital mortality was 12.9% (95% CI 7.2–21.9%) in the iTBCT group compared to 24.1% (95% CI 16.3–34.2%) in the STWU group (p = 0.059). Time to bleeding control intervention was not reduced; 82 min (IQR 5–121) versus 98 min (IQR 62–147), p = 0.108.ConclusionsReduction in mortality in trauma patients requiring emergency bleeding control interventions by iTBCT could not be demonstrated in this study. However, a potentially clinically relevant absolute risk reduction of 11.2% (95% CI − 0.3 to 22.7%) in comparison with STWU was observed.Trial registrationClinicalTrials.gov: NCT01523626.

Revisiting the rules for freehand ventriculostomy: a virtual reality analysis.

OBJECTIVE Frontal ventriculostomy is one of the most frequent and standardized procedures in neurosurgery. However, many first and subsequent punctures miss the target, and suboptimal placement or misplacement of the catheter is common. The authors therefore reexamined the landmarks and rules to determine the entry point and trajectory with the best hit rate (HtR). METHODS The authors randomly selected CT scans from their institution's DICOM pool that had been obtained in 50 patients with normal ventricular and skull anatomy and without ventricular puncture. Using a 5 × 5-cm frontal grid with 25 entry points referenced to the bregma, the authors examined trajectories 1) perpendicular to the skull, 2) toward classic facial landmarks in the coronal and sagittal planes, and 3) toward an idealized target in the middle of the ipsilateral anterior horn (ILAH). Three-dimensional virtual reality ventriculostomies were simulated for these entry points; trajectories and the HtRs were recorded, resulting in an investigation of 8000 different virtual procedures. RESULTS The best HtR for the ILAH was 86% for an ideal trajectory, 84% for a landmark trajectory, and 83% for a 90° trajectory, but only at specific entry points. The highest HtRs were found for entry points 3 or 4 cm lateral to the midline, but only in combination with a trajectory toward the contralateral canthus; and 1 or 2 cm lateral to the midline, but only paired with a trajectory toward the nasion. The same "pairing" exists for entry points and trajectories in the sagittal plane. For perpendicular (90°) trajectories, the best entry points were at 3-5 cm lateral to the midline and 3 cm anterior to the bregma, or 4 cm lateral to the midline and 2 cm anterior to the bregma. CONCLUSIONS Only a few entry points offer a chance of a greater than 80% rate of hitting the ILAH, and then only in combination with a specific trajectory. This "pairing" between entry point and trajectory was found both for landmark targeting and for perpendicular trajectories, with very limited variability. Surprisingly, the ipsilateral medial canthus, a commonly reported landmark, had low HtRs, and should not be recommended as a trajectory target.

Body composition estimation from selected slices: equations computed from a new semi-automatic thresholding method developed on whole-body CTscans.

BackgroundEstimating volumes and masses of total body components is important for the study and treatment monitoring of nutrition and nutrition-related disorders, cancer, joint replacement, energy-expenditure and exercise physiology. While several equations have been offered for estimating total body components from MRI slices, no reliable and tested method exists for CT scans. For the first time, body composition data was derived from 41 high-resolution whole-body CT scans. From these data, we defined equations for estimating volumes and masses of total body AT and LT from corresponding tissue areas measured in selected CT scan slices.MethodsWe present a new semi-automatic approach to defining the density cutoff between adipose tissue (AT) and lean tissue (LT) in such material. An intra-class correlation coefficient (ICC) was used to validate the method. The equations for estimating the whole-body composition volume and mass from areas measured in selected slices were modeled with ordinary least squares (OLS) linear regressions and support vector machine regression (SVMR).Results and DiscussionThe best predictive equation for total body AT volume was based on the AT area of a single slice located between the 4th and 5th lumbar vertebrae (L4-L5) and produced lower prediction errors (|PE| = 1.86 liters, %PE = 8.77) than previous equations also based on CT scans. The LT area of the mid-thigh provided the lowest prediction errors (|PE| = 2.52 liters, %PE = 7.08) for estimating whole-body LT volume. We also present equations to predict total body AT and LT masses from a slice located at L4-L5 that resulted in reduced error compared with the previously published equations based on CT scans. The multislice SVMR predictor gave the theoretical upper limit for prediction precision of volumes and cross-validated the results.

Quality Control of a Laser Additive Manufactured Medical Implant by X-Ray Tomography

Abstract Quality control of laser additive manufactured medical implants is of interest, especially if nondestructive quality control can be performed on parts before implantation. X-ray micro-computed tomography (microCT or CT) can be used for defect/porosity analysis as well as for comparing the part surface with its computer-aided design (CAD) file. In both cases, the limited use of CT is partly due to the variation in scan types and the quality of scans that can occur. We present a simple method demonstrating the use of a light metal casting as a reference porosity sample, to confirm good CT image quality and to quantify minimum detectable pore size for the selected CT scan settings. This makes a good comparison for additive manufactured parts, since castings generally contain more porosity. A full part-to-CAD comparison shows how the part is compared with its CAD file, as a second-quality control. The accuracy of the CAD variance is given by the minimum detectable pore size. Finally, the part is sect...

Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial

Published work suggests a survival benefit for patients with trauma who undergo total-body CT scanning during the initial trauma assessment; however, level 1 evidence is absent. We aimed to assess the effect of total-body CT scanning compared with the standard work-up on in-hospital mortality in patients with trauma. We undertook an international, multicentre, randomised controlled trial at four hospitals in the Netherlands and one in Switzerland. Patients aged 18 years or older with trauma with compromised vital parameters, clinical suspicion of life-threatening injuries, or severe injury were randomly assigned (1:1) by ALEA randomisation to immediate total-body CT scanning or to a standard work-up with conventional imaging supplemented with selective CT scanning. Neither doctors nor patients were masked to treatment allocation. The primary endpoint was in-hospital mortality, analysed in the intention-to-treat population and in subgroups of patients with polytrauma and those with traumatic brain injury. The χ(2) test was used to assess differences in mortality. This trial is registered with ClinicalTrials.gov, number NCT01523626. Between April 22, 2011, and Jan 1, 2014, 5475 patients were assessed for eligibility, 1403 of whom were randomly assigned: 702 to immediate total-body CT scanning and 701 to the standard work-up. 541 patients in the immediate total-body CT scanning group and 542 in the standard work-up group were included in the primary analysis. In-hospital mortality did not differ between groups (total-body CT 86 [16%] of 541 vs standard work-up 85 [16%] of 542; p=0.92). In-hospital mortality also did not differ between groups in subgroup analyses in patients with polytrauma (total-body CT 81 [22%] of 362 vs standard work-up 82 [25%] of 331; p=0.46) and traumatic brain injury (68 [38%] of 178 vs 66 [44%] of 151; p=0.31). Three serious adverse events were reported in patients in the total-body CT group (1%), one in the standard work-up group (<1%), and one in a patient who was excluded after random allocation. All five patients died. Diagnosing patients with an immediate total-body CT scan does not reduce in-hospital mortality compared with the standard radiological work-up. Because of the increased radiation dose, future research should focus on the selection of patients who will benefit from immediate total-body CT. ZonMw, the Netherlands Organisation for Health Research and Development.

Benign and Malignant Thyroid Incidentalomas Are Rare in Routine Clinical Practice: A Review of 97,908 Imaging Studies.

Thyroid nodules incidentally identified on imaging are thought to contribute to the increasing incidence of thyroid cancer. We aim to determine the true rate of incidental thyroid nodule reporting, malignancy rates of these nodules, and to compare these findings with rates of detection by dedicated radiology review. A cross-sectional analysis was done to determine the prevalence of thyroid nodules in radiologist reports by analyzing all reports for CT, PET, and MRI scans of the head, neck, and chest as well as neck ultrasounds performed at a tertiary care center from 2007 to 2012. Retrospective chart review was performed on patients with a reported thyroid nodule to determine clinical outcomes of these nodules. Radiology reports were compared with dedicated radiology review of 500 randomly selected CT scans from the study group to determine the difference between clinical reporting and actual prevalence of thyroid nodules. 97,908 imaging studies met inclusion criteria, and 387 (0.4%) thyroid incidentalomas were identified on radiology report. One hundred and sixty three (42.1%) of these nodules were worked up with fine-needle aspiration, diagnosing 27 thyroid cancers (0.03% of all studies, 7.0% of reported incidentalomas). The prevalence of incidentalomas clinically reported was 142/100,000 CT scans, 638/100,000 MRIs, 358/100,000 PET scans, and 6,594/100,000 ultrasounds. In contrast, review of CT scans screening for thyroid nodules had a prevalence of 10%. Routine clinical reporting of incidental thyroid nodules is far less common than on dedicated review. These data contradict the notion that incidentalomas contribute significantly to rising thyroid cancer rates.

Repeat CT-scan assessment of lymph node motion in locally advanced cervical cancer patients.

In cervical cancer patients the nodal clinical target volume (CTV, defined using the major pelvic blood vessels and enlarged lymph nodes) is assumed to move synchronously with the bony anatomy. The aim of this study was to verify this assumption by investigating the motion of the major pelvic blood vessels and enlarged lymph nodes visible in CT scans. For 13 patients treated in prone position, four variable bladder-filling CT scans per patient, acquired at planning and after 40 Gy, were selected from an available dataset of 9-10 CT scans. The bladder, rectum, and the nodal-vessels structure containing the iliac vessels and all visible enlarged nodes were delineated in each selected CT scan. Two online patient setup correction protocols were simulated. The first corrected bony anatomy translations and the second corrected translations and rotations. The efficacy of each correction was calculated as the overlap between the nodal-vessels structure in the reference and repeat CT scans. The motion magnitude between delineated structures was quantified using nonrigid registration. Translational corrections resulted in an average overlap of 58 ± 13% and in a range of motion between 9.9 and 27.3 mm. Translational and rotational corrections significantly improved the overlap (64 ± 13%, p value = 0.007) and moderately reduced the range of motion to 7.6-23.8 mm (p value = 0.03). Bladder filling changes significantly correlated with the nodal-vessels motion (p < 0.001). The motion of the nodal-vessels was large, nonrigid, patient-specific, and only moderately synchronous with the bony anatomy. This study highlights the need for caution when reducing the CTV-to-PTV (PTV planning target volume) margin of the nodal CTV for highly conformal radiation techniques.

Doctor, is a CT scan safe for my child?

Medical professionals and international organizations have promoted radiation protection for patients since the early 1900s when organizations such as the British Roentgen Society and American Roentgen Ray Society were founded.1 However, it was the 2007 article by Brenner and Hall2 and the release of such publications as the National Council on Radiation Protection and Measurement's Report 160 that prompted the much needed public debate in the media and by the public on increasing radiation exposure from CT scans.3,4 Within the past 15 months, three large epidemiological studies, including the most recent one by Miglioretti et al,5 have assessed the risk of cancer due to CT imaging in children.6,7 The purpose of this commentary is to consider whether the Miglioretti article and the other two research studies on radiation protection in children should impact parents' perception of CT safety for their child. Do these articles help answer a parent's most common and difficult question, “Doctor, is a CT scan safe for my child?” The Miglioretti study had 3 main findings: estimates of the rates of CT scan use in children younger than 15 years from a population comprising 4 857 736 child-years; estimates of organ and effective doses using a credible new measure based on sex- and age-specific computational anatomic phantoms in a subpopulation of 744 randomly selected CT scans; and assessment of the projected excess lifetime cancer risk attributed to CT scans in this population.5

Systematic review and meta-analysis of routine total body CT compared with selective CT in trauma patients

BackgroundFull-body CT scanning is increasingly being used in the initial evaluation of severely injured patients. We sought to analyse the literature to determine the benefits of full-body scanning in terms...

Whole‐body computed tomography in the initial assessment of trauma patients: Is there optimal criteria for patient selection?

To describe the use of whole-body computed tomography (WBCT) at this Major Trauma Centre; to determine independent predictors of multi-region injury; and to evaluate the accuracy of the decision to perform WBCT in detecting multi-region injury. A prospective cohort study was performed at a single Major Trauma Centre in New South Wales, Australia. All adult patients who triggered trauma team activation and required an initial CT scan were studied. Primary outcome was the presence of multi-region injury. Logistic regression with stepwise selection was used to derive a prediction model for the need for WBCT based on our primary outcome. Receiver operator characteristic (ROC) analysis was used to compare the accuracy of the derived model and the clinical decision to perform WBCT. Six hundred and sixty patients were studied. WBCT scanning rate was 9.3% of all trauma activations. Of the patients who underwent WBCT, 31/98 (32.0%) had multi-region injury compared with 31/562 (5.5%) who underwent selective CT scanning (P < 0.001). Predictors of multi-region injuries were GCS <9 (OR 3.0, 95% CI 1.3-7.0, P = 0.01), full trauma activation (OR 2.9, 95% CI 1.5-5.3, P = 0.001), fall >5 m (OR 4.8, 95% CI 1.8-13.4, P = 0.003) and pedal cyclist (OR 3.0, 95% CI 1.2-7.5, P = 0.02). Area under ROC curve for the clinical decision to perform WBCT was 0.70 (95% CI 0.63-0.76) compared with 0.74 (95% CI 0.67-0.80) for the prediction model. The decision to perform WBCT scans in trauma should be at the discretion of the treating clinician. Applying a prediction rule would increase the number of WBCT scans performed without improving overall accuracy.

A multicenter, randomized controlled trial of immediate total-body CT scanning in trauma patients (REACT-2).

BackgroundComputed tomography (CT) scanning has become essential in the early diagnostic phase of trauma care because of its high diagnostic accuracy. The introduction of multi-slice CT scanners and infrastructural improvements made total-body CT scanning technically feasible and its usage is currently becoming common practice in several trauma centers. However, literature provides limited evidence whether immediate total-body CT leads to better clinical outcome then conventional radiographic imaging supplemented with selective CT scanning in trauma patients. The aim of the REACT-2 trial is to determine the value of immediate total-body CT scanning in trauma patients.Methods/designThe REACT-2 trial is an international, multicenter randomized clinical trial. All participating trauma centers have a multi-slice CT scanner located in the trauma room or at the Emergency Department (ED). All adult, non-pregnant, severely injured trauma patients according to predefined criteria will be included. Patients in whom direct scanning will hamper necessary cardiopulmonary resuscitation or who require an immediate operation because of imminent death (both as judged by the trauma team leader) are excluded. Randomization will be computer assisted. The intervention group will receive a contrast-enhanced total-body CT scan (head to pelvis) during the primary survey. The control group will be evaluated according to local conventional trauma imaging protocols (based on ATLS guidelines) supplemented with selective CT scanning. Primary outcome will be in-hospital mortality. Secondary outcomes are differences in mortality and morbidity during the first year post trauma, several trauma work-up time intervals, radiation exposure, general health and quality of life at 6 and 12 months post trauma and cost-effectiveness.DiscussionThe REACT-2 trial is a multicenter randomized clinical trial that will provide evidence on the value of immediate total-body CT scanning during the primary survey of severely injured trauma patients. If immediate total-body CT scanning is found to be the best imaging strategy in severely injured trauma patients it could replace conventional imaging supplemented with CT in this specific group.Trial RegistrationClinicalTrials.gov: (NCT01523626).

Radiological correlation between the anterior ethmoidal artery and the supraorbital ethmoid cell.

The anterior ethmoidal artery is an important landmark in functional endoscopic sinus surgery. We undertook this study to determine the reliability of identification of the artery on the coronal CT scan and to determine whether a correlation exists between the pneumatisation of the suprabullar recess and the vertical distance of the artery from the base skull. 50 randomly selected CT scans were studied. The anterior ethmoidal artery was identified on each side and the vertical distance between the artery and the base skull was measured. The orbital beak and the superior oblique muscle were used as landmarks to identify the artery. The CT scans were divided into two groups based on whether the supraorbital cell was present or absent. These groups were each further subdivided into 3 groups depending on the vertical distance between the anterior ethmoidal artery and the base skull. The anterior ethmoidal artery was reliably identified in 97% of the cases. When the supraorbital cell was absent, the mean distance between the artery and the base skull was 1.5 mm; while when the cell was present, the mean distance was 4.86 mm. When these groups were evaluated for statistical significance, the p value was 0.000 (highly significant). The orbital beak and superior oblique muscle are reliable landmarks to identify the anterior ethmoidal artery. There exists a strong correlation between the vertical distance of the artery from the base skull and the presence of the supraorbital ethmoid cell.

Operative Timing and Management of Spinal Injuries in Multiply Injured Patients

Spinal injuries occurring in polytrauma patients are caused by high impact trauma. Due to high velocity mechanism, trauma of the vertebral column may be accompanied by injuries of adjacent body cavities such as thorax, abdomen, and pelvis. Neurologic examination is mandatory and has to be documented preferably using the ASIA/IMSOP-classification. Clinical symptoms may point towards spinal injury. However, absence of clinical symptoms is not sufficient to rule out spinal injuries. Two diagnostic pathways may be followed to assess the spine: (1) Conventional X-ray diagnostics of the entire spine followed by selective CT scanning of suspected lesions and CT scanning of the upper cervical spine region C0-C3 in unconscious patients. (2) Whole body polytrauma-multislice-spiral-CT scanning from head to pelvis without conventional Xray playing the key role in the algorithm of modern ER management. In this study, 287 polytrauma patients with associated spinal injuries were analyzed prospectively from a cohort group of 731 polytrauma patients treated from 2002 to 2004 in our institution. Indications for surgery include neurologic deficit, instability, as well as malalignment and dislocation. In polytraumatized patients, indication for primary surgery is given in complex spinal injuries with associated vascular, neurologic, or organ injuries as well as multilevel spinal fractures or unstable spinal injuries. In patients with unstable spinal injuries cardio-pulmonary instability and life threatening intracranial pressure are contra - indications for immediate spinal surgery. On the day of injury ventral spondylodesis of unstable cervical spine fractures of C3-C7 and dorsal spondylodesis of unstable thoraco-lumbar fractures using internal fixator are the standard procedures. Polytrauma patients benefit from early stabilization of spinal fractures including reduction of ventilation and ICU treatment, pneumonia rate, general complications, as well as hospital stay. However, it is controversial if mortality rate and neurologic outcome are affected by the time point of operative stabilization.

Isolated Blunt Splenic Trauma in Adults

Several CT scan scores have been proposed to discriminate between splenic injuries requiring surgical intervention, and those that may be treated conservatively. The aim of this study is to compare three selected CT scan scores (Buntain, Mirvis, Resciniti) in their ability to correctly define the proper course of therapy following splenic injury. 44 adult patients presenting an isolated splenic trauma, confirmed by CT scan on admission and treated solely according to clinical criteria, have been studied. The 44 CT scans were retrospectively classified according to the three CT scan scoring systems. Correlation with the treatment performed allows the specificity and sensitivity of each score to be calculated and compared. The best score (Resciniti) uses a combination of parenchymal and intra-abdominal liquid scores. The use of such a scoring system alone to dictate therapy would have resulted in either an increased rate of surgical intervention, or an unacceptable rate of failure of conservative treatment. However, the determination of the expected rate of failure of conservative treatment can be useful in determining the level and frequency of serial surveillance examinations.