Duke University The effects of the a2-agonist clonidine and the a2-antagonist idazoxan were studied with emphasis on the attentional mechanisms subserving interval-timing behavior. Administration of clonidine (0.015 mg/kg IP) to rats trained on a 20-s peak-interval (PI) timing procedure caused a rightward shift in peak functions, whereas idazoxan (0.15 mg/kg IP) caused a leftward shift. Rats were also trained on 10-s and 30-s baseline PI timing procedures in combination with the prior-entry and prior-entry reversal versions of this task that produced leftward shifts and rightward shifts relative to baseline training, respectively. Clonidine (0.025 mg/kg IP) produced a rightward shift in peak functions for all of these behavioral procedures. Taken together, these horizontal shifts in the peak functions indicate a decrease (leftward shift) or an increase (rightward shift) in the latency to start the internal clock that is influenced both by the attentional demands of the task and the effective level of brain norepinephrine. Cognitive accounts of information processing divide atten- tion into three major functions: orienting to sensory events, detecting signals for conscious processing, and maintaining an alert state (Posner & Petersen, 1990). The allocation of attention for the detection of signals for conscious processing may result in the subject attending to the expected spatial location, temporal location, or sensory modality of the signal. As a consequence, if the signal is either in an unexpected location or of an unexpected modality, it will not be processed as rapidly. In contrast, if attention is allocated to maintaining a general state of alertness or arousal, then any signal that is of sufficient intensity will engage conscious processing. An information-processing model of interval timing suggests Trevor B. Penney, Department of Psychology, Columbia University; Mark D. Holder, Department of Psychology, Memorial University of Newfoundland, St. John's, Newfoundland, Canada and Department of Psychology, Okanagan University College, Kelowna, British Columbia, Canada; Warren H. Meck, Department of Psychology: Experimental, Duke University. This research was supported in part by a grant from the Natural Sciences and Engineering Research Council of Canada (A1221). Preliminary reports based on this work were presented at the 64th Annual Meeting of the Eastern Psychological Association, Arlington, Virginia (Penney, Holder, M Meck, 1984). Data from human event-related potential (ERP) para- digms (e.g., Gratton et al., 1990) and animal timing tasks (Meck, 1984) suggest that warning signals serve to prime perceptual processing. Consequently, the use of warning signals can be used to influence a subject's expectation of thc stimulus properties (e.g., modality) of a forthcoming signal presentation. Central nervous system norepinephrine (NE) may accentu- ate activity of neurons that are transmitting the presence of significant stimuli and inhibit the activity of other neurons (Kety, 1970). This could be interpreted as an improvement in the signal-to-noise ratio or an enhancement of sclectivc attention. The selective attention hypothesis was initially based on the behavioral results of lesions to the dorsal noradrenergic bundle (DNAB; e.g., Mason, 1980; Robbins, Everitt, Cole, Archer, & Mohammed, 1985). This pathway originates in the pontine nucleus of the locus coeruleus (LC) and provides innervation to the spinal cord, cerebellum, and many forebrain areas including the caudate-putamen (Mason, 1980). The LC may act as an important gating mechanism for 82
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