This paper focuses on the complex selection process of worker assistance systems for human-centered manufacturing systems. Due to rising complexity of products and processes in the manufacturing sector, as well as changing work environments, the choice for suitable support systems on the shop floor becomes more difficult. The selection of worker assistance systems is yet not well studied and there is a lack in scientifically based methodologies to assist designers of manufacturing systems in this process. In this work we identify a broad variety of influencing attributes for selecting the most appropriate worker assistance systems depending on each individual field of application. These attributes are building the ground for the development of a morphological box to facilitate the selection process of worker assistance systems. The proposed procedure to use the morphological box is finally explained with a practical example.