Selection Of Test Conditions Research Articles

Microbiological Estimation of Nasal Spray Containing Naltrexone Hydrochloride

Introduction. In order to standardize the quality indicators during the expected shelf life of the developed drug naltrexone hydrochloride in the form of a nasal spray containing a high concentration of poloxamer and benzalkonium chloride as a preservative, a microbiological study was carried out. The possibility of using the membrane filtration method for testing prototypes recommended by the State Pharmacopoeia XIV.Aim. Study and selection of test conditions for the «microbiological purity» indicator of nasal spray samples containing naltrexone hydrochloride.Materials and methods. As an object of research, a naltrexone hydrochloride nasal spray was used. When analyzing the microbiological purity, the membrane filtration method recommended in the State Pharmacopoeia XIV.Results and discussion. As part of the study, it was found that the samples of the drug meet the requirements for a microbiological indicator for drugs of category 2. Testing the suitability of the method for samples of the dosage form showed that the antimicrobial effect of the drug was completely removed by washing the filter, which was proved by inoculation of indicator test microorganisms, the quantitative and qualitative nature of growth, which did not differ from the control without the drug.Conclusion. As a result of the studies carried out, the optimal test conditions for the «Microbiological purity» indicator for the nasal spray containing naltrexone hydrochloride were selected and substantiated.

BACKING UP A TRAILER – AN APPLICATION-BASED VECTOR ANALYSIS PROJECT FOR 2ND YEAR CALCULUS

Abstract – A project for the second year calculus course, ME201, will be presented. Students worked in groups, make measurements using physical prototypes and performed analysis to predict behavior for the physical situation of reversing (backing up) a vehicle attached to a single axle trailer. The objectives of the project were to reinforce concepts from previous courses, including physics (vector components) and linear algebra (matrices), to demonstrate key concepts from the current course (vector products, moment vector), and to generate interest in future courses (sensors and feedback, control systems). This paper will outline the development process for the project, including the design and fabrication of the physical prototypes and the selection of test conditions. Measurements and analysis from the project, including samples of student work, will be presented.

Comparative Analysis of Early Studies on Turkish Whistle Language and a Case Study on Test Conditions

This paper examines the early studies on Turkish Whistle Language and it argues that they have some controversial results. The study considers these issues need to be discussed and searched again in terms of linguistic and phonetic form. Unfortunately, there are few research studies on Turkish whistle language and most of them were performed nearly fifty years ago despite the fact that this language still has been used in Kuskoy region. Therefore, the findings of these early research studies could give valuable information to start to a new research study on the subject. The first scientific study on Turkish Whistle language was performed by a French scientist R.G. Busnel with his multidisciplinary research team in 1967. Some of this research’s results were published in the book. A Turkish scientist O. Baskan also participated in Busnel’s research group and published a paper on TWsL in 1968. However, some assertions such as people having a tendency to understand the Turkish whistle language with three vowels and three consonants have not been in the research results of R.G. Busnel. In addition, a Turkish scientist D. Aksan in Turkey had performed another research at Kuskoy region with his own team. Their test methods were different from the previous ones. This paper analyzes these research results on a comparative basis and presents the common and conflicted issues to discuss the uncertain points. The comparative evaluation of these past research studies aims to highlight the controversial position of the results on Turkish Whistle Language. In this scope, this paper opens a discussion about the selection of test conditions for an acoustic and linguistic analysis of the Turkish whistle language.

Effect of Pressure on the Crystallization of Crude Oil Waxes. I. Selection of Test Conditions by Microcalorimetry

Evaluations of the potential for formation of wax deposits in laboratories generally are performed on stabilized oil samples, that is, at atmospheric pressure and without the presence of light components. Therefore, the effects to two important factors that influence the solubility of waxes, namely light fractions and pressure, are not considered. As a consequence, the results may not reflect what really happens in production lines and equipment. The high-pressure microcalorimetry technique (HPμDSC) is indicated for determining the wax appearance temperature (WAT) and crystallization enthalpy of waxes in oils, but due to the complexity of petroleum systems, the reliability of the results depends on the experimental conditions chosen. This paper reports experiments to evaluate the factors that influence the accuracy of the experimental results for determining the WAT and crystallization enthalpy of samples of Brazilian crude oil and condensate, saturated with different types of gases, by using high pressure microcalorimetry (HPμDSC). The results show that heat flow values of more than twice the baseline oscillation, that is, 48 μW, could be considered as a thermal event. It is fundamental to investigate the gas phase saturation envelope to evaluate the viability of pressurizing the reference cell and to determine the most adequate conditions of temperature for the pressurization of the oil samples. Still better results were obtained without pressurizing the reference cell and with exchange of test aliquots after analysis at 50 bar. The minimum saturation time necessary for the oil and condensate samples evaluated was 180 min, and the ideal mass for analysis was around 100 mg. The most suitable procedure was to pressurize the samples rather than depressurize them, with the deviation between the two procedures being <1 °C. The standard deviation of the values found in the conditions specified was <0.5 °C.

Modelling thermomechanical fatigue life

In the present study five different widely used life models were modified to allow for life prediction under thermomechanical fatigue (TMF) loading conditions. In order to assess the predictive capabilities of the models, life prediction results were compared with TMF data obtained on a stainless steel and a SiC particulate reinforced aluminium alloy. The analysis of the data obtained demonstrated that TMF tests are not sufficient per se to evaluate a life model. It is emphasised that TMF tests chosen for validation of life models should be conducted under loading conditions such that coupling effects between the various damage mechanisms become apparent. The data analysed indicate that appropriate TMF test conditions can be estimated for the case of creep-affected damage evolution. By contrast, selection of test conditions that would clearly reveal other potential couplings, say between oxidation and plasticity, is less straightforward. Unless the tests used to validate a model are designed to account for such effects, non-conservative life prediction may result for actual components despite a seemingly excellent correlation of model predictions with experimentally obtained life data.

The selection of dynamic acceptance test conditions for machine tools

The use of forced vibration tests for the dynamic acceptance of machine tools enables the chatter performance to be assessed for a wide range of cutting conditions, from a single test set-up, this corresponding to a particular configuration of the machine. However, to cover the expected working range of the machine, other test configurations must be considered, for example relative positions of the table and spindle, etc. The factors to be considered in the selection of these test conditions are discussed in relation to test results for various types of machine tools.