This paper presents a comprehensive framework for designing in-space propulsion systems, integrating four criteria: global propulsive performance, environmental impact, cost efficiency, and architectural reliability. The study focuses on the emerging class of Orbital Transfer Vehicles to illustrate the application of this method. By examining the synergistic potential of OTVs and greener propellants, the paper addresses different mission scenarios, including LEO, GEO, and lunar missions, with both scientific and commercial objectives. The proposed framework aims to go beyond traditional cost-centric approaches, offering a more complete evaluation method for early design phases. A case study comparing three liquid bipropellant options, pressure-fed MON-3/MMH, 98%-HTP/RP-1, and self-pressurizing N2O/Ethane, demonstrates the utility of the tool. Findings suggest that scientific missions benefit most from 98%-HTP/RP-1, while traditional propellants remain preferable for cost-driven commercial missions to GEO and the Moon, though greener alternatives are competitive for less demanding LEO missions. This innovative framework aims to guide the selection of propulsion systems to achieve greener space missions, aligning traditional performance figures with environmental responsibility.