Marker-assisted selection (MAS) has emerged as a pivotal technique in crop improvement programs, enabling the identification and incorporation of disease-resistant traits in crops. This review highlights the significance of MAS in enhancing disease resistance, the current state of research, and the challenges faced in its implementation. Various case studies, including successful applications in crops such as rice, wheat, and maize, demonstrate the potential of MAS in sustainable agriculture. The review also discusses the integration of MAS with other modern breeding techniques and emphasizes the need for advanced genomic tools for future advancements in this field. The development of advanced molecular markers, high-throughput screening techniques, and the incorporation of genomic selection approaches have all contributed to recent developments in MAS. Even in intricate polygenic situations, these developments have significantly improved t+he precision and speed of discovering disease-resistant characteristics. Case studies involving important crops such as maize, wheat, and rice show how MAS can be successfully applied to create varieties with improved resistance to certain diseases, significantly lowering crop losses and reduced use of pesticides. These developments have consequences that go beyond the purely technical; they could have a big influence on environmentally friendly agriculture methods, cost effectiveness, and sustainable development. This study addresses the possible future path of MAS in crop breeding and summarizes the major discoveries from current research, highlighting both the successes and difficulties in the field. The body of data highlights MAS as a critical instrument in the toolbox of the contemporary breeder, essential for satisfying the ever-increasing demands of a world that is changing quickly.