Today, lighter buildings with a smaller share of seismic force are needed in the construction industry. Given the attractiveness of this construction method for researchers, it led them to conduct more and more accurate experiments to better understand these structures and, in particular, to study the lateral behavior of these structures. The aim of this study has been to calculate reliability index and probability of failure. In addition to this sources of uncertainty in structural system of cold-formed frames with sharp bracing have been ranked by application of reliability analysis method. To do this, considering sources of seismic and structural uncertainty such as spectral acceleration, live load, cross-sectional dimension, and modulus elasticity of steel has been selected. Then reliability analysis methods, FOSM and FORM, have been utilized to estimate the probability of failure based on limit-state function which is defined as relative displacement of floor to allowed limit. Results show that failure probability following a decreasing trend up to two story-floor frames increased up to five-floor frames. As a result of the analysis, it was found that, in the FOSM method, the reliability index increases with increasing floors in cold-rolled steel structures. In the FORM method, by increasing the floors up to the two-story frame, the reliability index has an ascending trend and up to the five-story frame has a descending trend with a very gentle slope. By increasing the distance, the value of the FOSM method reliability index is different from the value of this index in the FORM method to the extent that, in the Type 5 framework, this difference reaches five units. The probabilities of failure in one-story and three-story frames are the highest and the lowest, respectively. Uncertainty in the load applied to the structure was identified as the most important parameter. The uncertainty in the geometry of the members decreases with the increase of classes.