This paper investigates the influence of vertical seismic accelerations on the seismic response of RC bridges through numerical simulations using an enhanced non-linear numerical model. Results confirm that the incorporation of vertical accelerations, either through actual records or scaled horizontal records, can considerably modify the seismic response and the collapse mechanism. In the case of actual vertical records, the vertical component significantly contributes to premature structural deterioration, intensifying demand and accelerating failure mechanisms. On the other hand, the study underscores the inadequacy of using scaled horizontal records to represent vertical accelerations, as suggested by some seismic codes, as it not only distorts seismic response evaluation but also alters failure modes. The analysis of vertical vibration reveals higher displacements, increasing flexural demand on the deck, and leading to a progressive loss of vertical support at the central column. The research establishes the need to accurately account for vertical seismic accelerations in bridge design evaluations, as their impact on structural response and failure mechanisms cannot be underestimated. The work highlights the importance of a highly detailed 3D numerical model in assessing traditional parameters and capturing complex collapse mechanisms arising from material and geometric nonlinearities.