Finite element analysis is one of the key steps in evaluating the effectiveness of an isolation system. The aim of this paper is to research the mechanical properties of sliding and rolling friction systems and their application for isolating frame structures. A hybrid seismic isolation system is proposed, which aims to protect the superstructure by reducing dynamic response. The effect of different parameters on the friction coefficient of the isolation bearing was tested using a compression-shear testing machine, and the results showed that various parameters significantly affected the friction coefficient. In addition, a numerical analysis finite element model was established using SAP2000 software to compare the seismic isolation performance of the hybrid isolation system with that of traditional seismic-resistant structures. The results showed that the composite isolation system not only effectively reduced inter-story shear and acceleration, but also slightly enhanced the seismic isolation effect as the friction coefficient decreased.