Partial Unilateral Lentiginosis Research Articles

Nevus Spilus, Partial Unilateral Lentiginosis, and Linear and Whorled Nevoid Hypermelanosis: A Comparison of Clinical Features, Course, and Treatment Response.

Skin diseases manifesting as agminated pigmented lesions have overlapping clinical manifestations. Therefore, accurate differentiation is challenging. The clinical characteristics, histopathological findings, and treatment response of patients diagnosed with partial unilateral lentiginosis, nevus spilus, or linear and whorled nevoid hypermelanosis were retrospectively analysed. Each disease demonstrated distinct demographic and clinical characteristics, and the responses to laser treatment varied. The median age at onset varied significantly among the groups: 0.1, 6.6, and 0.5 years in patients with nevus spilus, partial unilateral lentiginosis, and linear and whorled nevoid hypermelanosis, respectively. Regarding the locations of the skin lesions, partial unilateral lentiginosis occurred predominantly on the head and neck, while approximately half of nevus spilus and linear and whorled nevoid hypermelanosis were observed on the extremities. Although linear and whorled nevoid hypermelanosis and partial unilateral lentiginosis share a similar histological feature of basal hyperpigmentation, patients with linear and whorled nevoid hypermelanosis showed the best response to laser treatment, while patients with partial unilateral lentiginosis demonstrated a poor treatment response. The study's data may provide important clues for the differential diagnosis and clinical decision-making regarding the treatment of these agminated pigmented lesions.

AN UNUSUAL ASSOCIATION OF PARTIAL UNILATERAL LENTIGINOSIS AND CENTRAL HETEROCHROMIA

Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder that is characterized by multiple clustered lentigens on a normal skin in a segmental pattern with a sharp demarcation at the midline. Heterochromia is a condition of the eye in which there is variation in iris colour of one or both eyes. There has been multiple associations of PUL and has also been associated with ocular involvement but has never been associated with heterochromia. Herein we report an undocumented association of PUL with central heterochromia.

Partial unilateral lentiginosis: a clinicopathological analysis of 32 cases on the head and neck area in Korea

Partial unilateral lentiginosis (PUL) is a rare acquired circumscribed hyperpigmentation characterized by multiple simple lentigines involving half of the body. Since the previous studies of PUL were mostly based on case reports and the current literature lacks well-designed retrospective studies that involve a large number of cases, PUL is not a well-defined entity, and differential diagnosis with nevus spilus is still difficult. This study aims to evaluate clinical and histopathological characteristics and treatment outcomes of PUL on head and neck area of Koreans. Thirty-two patients with PUL on head and neck area were diagnosed clinicohistopathologically at the Asan Medical Center from 2004 to 2017. Their medical records, photographs, and biopsy specimens were reviewed, and immunohistochemical staining for protein kinase C (PKC)-βΙΙ was evaluated for melanogenic activity. Four patients (12.5%) of PUL had congenital lesions, and 24 (75.0%) had age of onset younger than 10years. Confluency of lentiginous lesions (100%) and mild to moderate background interlesional hyperpigmentation (90.6%) were observed. The lentiginous lesions showed increased melanocytes, melanophages, basal melanins, lentiginous hyperplasia, and perivascular inflammatory cells compared with background interlesional hyperpigmentation, and PKC-βΙΙ was focally positive in 7 of 12 stained PUL lesions. Among the 16 patients who received laser treatments, 10 (62.5%) showed more than 50% of improvement. The findings of this study will allow for improved diagnosis of PUL and understanding of its features, which may facilitate proper management in the future.

Partial unilateral lentiginous and colon polyp in a young male patient

Partial unilateral lentiginosis is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Pigmented macules are usually localized in one half of the body. Associations with café-au-lait spots, cutis marmorata, acanthosis nigricans, nevus depigmentosus, vitiligo, blue nevus, segmental neurofibromatosis, central nervous system diseases, celiac disease, and sickle cell anemia have been reported. We describe a 17-year-old male patient with a partial unilateral lentiginous lesion on the left side of the body and left upper back and incidental polyp in the descending colon.

An incarcerated Amyand's hernia: Shall we apply appendectomy routinely?

Partial unilateral lentiginosis is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Pigmented macules are usually localized in one half of the body. Associations with cafe-au-lait spots, cutis marmorata, acanthosis nigricans, nevus depigmentosus, vitiligo, blue nevus, segmental neurofibromatosis, central nervous system diseases, celiac disease, and sickle cell anemia have been reported. We describe a 17-year-old male patient with a partial unilateral lentiginous lesion on the left side of the body and left upper back and incidental polyp in the descending colon.

Partial unilateral lentiginosis is mosaic neurofibromatosis type 1 or not?

Partial unilateral lentiginosis (PUL) is a rare pigmentation disorder characterized by numerous lentigines with sharp margins in the midline in one or more dermatomes. Its segmental pattern suggests that this presentation accompanied by café-au-lait spots, Lisch nodule or neurofibromas has a close relationship with mosaic neurofibromatosis type 1 or segmental neurofibromatosis (NF) in particular. In a group of 16 patients with PUL, who presented at the dermatology outpatient clinic between 1998 and 2015, an examination was made of consanguineous marriage in the family history, the presence of a similar lesion or NF in first-degree relatives, neurofibroma in the physical examination, the involvement pattern, axillary/inguinal freckling and the presence and number of café-au-lait spots. The ophthalmological examination investigated Lisch nodule and optic glioma. The skeletal system was examined for NF involvement. Of 16 patients, 13 (81.2%) were female and three (18.8%) were male with a mean age of 31.19 years (range, 15-48). There was no family history of PUL in any case. Consanguineous marriage was absent in 15 patients (93.8%). While there were accompanying café-au-lait spots in three patients (18.8%). Lisch nodule was an accompanying finding in three patients (18.8%). Axillary freckling was detected in four (25%) patients. Neurofibroma was found in only one patient. Although café-au-lait spots, axillary freckling, neurofibroma and Lisch nodule were present in a small number of the patients, the presence of the findings may be considered to be specific to NF suggests that PUL is a variant of mosaic NF-1. Genetic studies will help to further elucidate this subject.

Partial Unilateral Lentiginoses

The authors present a case of a rare pigmentation disorder, partial unilateral lentiginosis (PUL), which is characterized by multiple lentigines located in only one side of the body with histopathology of lentigine.

The distribution pattern of segmental vitiligo: clues for somatic mosaicism

Segmental vitiligo is characterized by a unilateral and localized distribution. So far, the underlying mechanism is still an enigma. To get an insight into the aetiopathogenesis of segmental vitiligo by comparison with the distribution pattern of dermatoses with a possible mosaic or neurogenic background. In this retrospective observational study the distribution pattern of 724 unilateral, linear or band-shaped control lesions was compared with 181 segmental vitiligo lesions. Clinical photographs were used to score similarities according to a defined grading system (scale ranging from 0 for no similarities to 4 for complete similarity). Control lesions were evaluated both individually and after grouping into different cell types. In general, only a minority of cases (36·9%), showed similarities (grade 1-4) between control lesions and segmental vitiligo. Grade 2-4 similarities were seen mainly in segmental lentiginosis (73·7%, P < 0·001). The best grade for correspondence (grade 3-4) was observed significantly more only in segmental lentiginosis (36·8% vs. 3·5%, P<0·001) and epidermal naevus verrucosus (12·5% vs. 3·7%, P=0·008) compared with the other control lesions. The distribution pattern of segmental vitiligo significantly overlapped those of other disorders originating from melanocytes. Our results demonstrate that the distribution pattern of segmental vitiligo is not entirely similar to any other skin disease, although some mosaic skin disorders have more overlap with segmental vitiligo than others. The remarkable clinical similarity with several cases of mosaic diseases involving melanocytes supports the hypothesis that cutaneous mosaicism may be involved in segmental vitiligo.

Low-Fluence Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser for the Treatment of Facial Partial Unilateral Lentiginosis in Koreans

Established pigment lasers have been used in partial unilateral lentiginosis (PUL) have shown unsatisfactory results. To determine the effectiveness and safety of low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) laser treatment of PUL in Koreans. Ten Korean patients with facial PUL were treated with 1,064-nm QS Nd:YAG laser, 7-mm spot size, 1.5- to 2.5-J/cm(2) fluence at 2-week intervals. Standard digital photographs were taken under the same condition at baseline and at each follow-up visit. Independent dermatologists evaluated the photographs. All patients completed a questionnaire to assess their subjective satisfaction with the laser treatment using a 5-point grading system. Degree of pain was assessed using a visual analog scale (0-10). Any complications and side effects were recorded at each visit. Patients were followed up every 4weeks for 12weeks after the last laser treatment. Five of 10 patients (50%) had achieved excellent improvement (76-100%) at the end of treatment, and the remaining 50% had good improvement (51-75%). In patient self-evaluation of the degree of improvement of PUL, nine (90%) assessed it as very much to much improved (>50% improvement), and 1 (10%) assessed it as moderate (50-75%). Subjects rated the pain associated with laser treatment at a mean score of 3.3 (range: 1-5) on a scale of 1 to 10. Mottled hypopigmentation developed in two patients. At follow-up, 12weeks after the last laser session, all of the patients had partial recurrence, which wqw resolved with one to two sessions of laser treatment. Low-fluence 1,064-nm QS Nd:YAG laser treatment for facial PUL in Koreans showed improvement with no significant side effects. We recommend the low-fluence 1,064-nm QS Nd:YAG laser as a treatment option for facial PUL.

Partial unilateral lentiginosis associated with nevus of Ota

To the Editor: A 25-year-old otherwise healthy female was referred to our department for the evaluation of pigmented facial lesions. Localized hyperpigmentation over the right eye had been present since birth. In the last 4 years, she noticed development of ipsilateral multiple brown lentigines extending onto the right forehead, temple, and eyelids, as well as a progressive blue-gray pigmentation on the right eyelid and tip of the nose.

Speckled Lentiginous Nevi: No Longer One Single Disorder

I read with interest the arguments presented by Barysch and Dummer1 on how to distinguish speckled lentiginous nevi from segmental lentiginosis. I agree that such criteria are important because these disorders are sometimes confused. However, I would like to make the following annotations.

Naevus Lentiginosus Linearis: A Distinct Skin Disorder

© 2010 The Authors. doi: 10.2340/00015555-0810 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Congenital naevi of the melanocytic system include numerous types, which differ in their clinical appearance, pattern of distribution, and histopathological features (1). Examples are large congenital melanocytic naevus, macular naevus spilus, papular naevus spilus, cafe-aulait macules of neurofibromatosis 1, cafe-au-lait macules arranged in broad bands as noted in McCune-Albright syndrome, partial unilateral lentiginosis, naevus achromicus (naevus depigmentosus), phylloid hypermelanosis, and phylloid hypomelanosis (1–3). We describe here two patients with a systematized pigmentary naevus that differed from all naevi reported so far.

Bilateral segmental lentiginosis associated with malignant melanomas

Bilateral segmental lentiginosis associated with malignant melanomas

Partial unilateral lentiginosis colocalized with naevus depigmentosus

Clinical and Experimental DermatologyVolume 33, Issue 3 p. 337-339 Partial unilateral lentiginosis colocalized with naevus depigmentosus S. I. In, S. I. In Department of Dermatology, Ajou University School of Medicine, Suwon, South KoreaE-mail: micales@korea.comSearch for more papers by this authorH. Y. Kang, H. Y. Kang Department of Dermatology, Ajou University School of Medicine, Suwon, South KoreaE-mail: micales@korea.comSearch for more papers by this author S. I. In, S. I. In Department of Dermatology, Ajou University School of Medicine, Suwon, South KoreaE-mail: micales@korea.comSearch for more papers by this authorH. Y. Kang, H. Y. Kang Department of Dermatology, Ajou University School of Medicine, Suwon, South KoreaE-mail: micales@korea.comSearch for more papers by this author First published: 16 April 2008 https://doi.org/10.1111/j.1365-2230.2007.02586.xCitations: 15 Conflict of interest: none declared. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume33, Issue3May 2008Pages 337-339 RelatedInformation

Nevus spilus maculosus vs. partial unilateral lentiginosis

Journal of the European Academy of Dermatology and VenereologyVolume 21, Issue 5 p. 713-713 Nevus spilus maculosus vs. partial unilateral lentiginosis R Happle, R Happle Department of Dermatology, Philipp University of Marburg, Marburg, Germany.Search for more papers by this author R Happle, R Happle Department of Dermatology, Philipp University of Marburg, Marburg, Germany.Search for more papers by this author First published: 22 March 2007 https://doi.org/10.1111/j.1468-3083.2006.02010.xCitations: 4 Deutschhaus-Str. 9, 35033 Marburg, Germany, tel. +49 6421 2862908; fax +49 6421 2862898; E-mail: [email protected] DOI: 10.1111/j.1468-3083.2006.02010.x Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume21, Issue5May 2007Pages 713-713 RelatedInformation

Bilateral segmental lentiginosis associated with malignant melanomas

Bilateral segmental lentiginosis associated with malignant melanomas

Partial unilateral lentiginosis with ipsilateral ocular nevus

Partial unilateral lentiginosis with ipsilateral ocular nevus

Bilateral segmental neurofibromatosis with gastric carcinoma

Neurofibromatosis type 1 (NF1) is an autosomal-dominant disorder characterized by café-au-lait spots, neurofibromas, intertriginous freckles, and Lisch nodules in the iris. Segmental neurofibromatosis is fundamentally a mosaic variant of NF1. A 66-year-old man visited us with bilateral segmental neurofibromatosis (SN) on the torso. He had multiple neurofibromas on the back bilaterally and on the right abdomen, and partial unilateral lentiginosis on the left abdomen and left back. The patient had noticed the development of papules and nodules on the right abdomen and bilaterally on the back 6 years previously, and had been diagnosed with early gastric carcinoma 5 years previously. To our knowledge, this is only the third reported case of SN associated with internal malignant tumours.

Segmental Lentiginosis within Nevoid Hypopigmentation

Segmental Lentiginosis within Nevoid Hypopigmentation

Bilateral Segmental Neurofibromatosis with Partial Unilateral Lentiginosis -Case Report with Review of the Literature-

Bilateral Segmental Neurofibromatosis with Partial Unilateral Lentiginosis -Case Report with Review of the Literature-